{"id":"https://openalex.org/W2791285756","doi":"https://doi.org/10.1093/bib/bby011","title":"Evaluation of tools for highly variable gene discovery from single-cell RNA-seq data","display_name":"Evaluation of tools for highly variable gene discovery from single-cell RNA-seq data","publication_year":2018,"publication_date":"2018-01-30","ids":{"openalex":"https://openalex.org/W2791285756","doi":"https://doi.org/10.1093/bib/bby011","mag":"2791285756","pmid":"https://pubmed.ncbi.nlm.nih.gov/29481632"},"language":"en","primary_location":{"id":"doi:10.1093/bib/bby011","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bby011","pdf_url":"https://academic.oup.com/bib/article-pdf/20/4/1583/30119512/bby011.pdf","source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},"type":"review","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://academic.oup.com/bib/article-pdf/20/4/1583/30119512/bby011.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5045137247","display_name":"Shun H. Yip","orcid":"https://orcid.org/0000-0003-4027-2927"},"institutions":[{"id":"https://openalex.org/I4210125099","display_name":"Mayo Clinic in Arizona","ror":"https://ror.org/03jp40720","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210125099"]},{"id":"https://openalex.org/I4210157777","display_name":"Vitalant","ror":"https://ror.org/057kyc739","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210157777"]},{"id":"https://openalex.org/I889458895","display_name":"University of Hong Kong","ror":"https://ror.org/02zhqgq86","country_code":"HK","type":"education","lineage":["https://openalex.org/I889458895"]}],"countries":["HK","US"],"is_corresponding":false,"raw_author_name":"Shun H Yip","raw_affiliation_strings":["Junwen Wang, 13400 E Shea Blvd., Scottsdale, AZ 85259, USA","Mayo Medical School, Mayo Clinic and the College of Health Solutions, Arizona State University","Department of Psychiatry, Centre for Genomic Sciences and State Key Laboratory in Cognitive and Brain Sciences in the LKS Faculty of Medicine, the University of Hong Kong"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Junwen Wang, 13400 E Shea Blvd., Scottsdale, AZ 85259, USA","institution_ids":["https://openalex.org/I4210157777"]},{"raw_affiliation_string":"Mayo Medical School, Mayo Clinic and the College of Health Solutions, Arizona State University","institution_ids":["https://openalex.org/I4210125099"]},{"raw_affiliation_string":"Department of Psychiatry, Centre for Genomic Sciences and State Key Laboratory in Cognitive and Brain Sciences in the LKS Faculty of Medicine, the University of Hong Kong","institution_ids":["https://openalex.org/I889458895"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018516395","display_name":"Pak C. Sham","orcid":"https://orcid.org/0000-0002-2533-7270"},"institutions":[{"id":"https://openalex.org/I4210125099","display_name":"Mayo Clinic in Arizona","ror":"https://ror.org/03jp40720","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210125099"]},{"id":"https://openalex.org/I4210157777","display_name":"Vitalant","ror":"https://ror.org/057kyc739","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210157777"]},{"id":"https://openalex.org/I889458895","display_name":"University of Hong Kong","ror":"https://ror.org/02zhqgq86","country_code":"HK","type":"education","lineage":["https://openalex.org/I889458895"]}],"countries":["HK","US"],"is_corresponding":false,"raw_author_name":"Pak Chung Sham","raw_affiliation_strings":["Mayo Medical School, Mayo Clinic and the College of Health Solutions, Arizona State University","Department of Psychiatry, Centre for Genomic Sciences and State Key Laboratory in Cognitive and Brain Sciences in the LKS Faculty of Medicine, the University of Hong Kong","Junwen Wang, 13400 E Shea Blvd., Scottsdale, AZ 85259, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mayo Medical School, Mayo Clinic and the College of Health Solutions, Arizona State University","institution_ids":["https://openalex.org/I4210125099"]},{"raw_affiliation_string":"Department of Psychiatry, Centre for Genomic Sciences and State Key Laboratory in Cognitive and Brain Sciences in the LKS Faculty of Medicine, the University of Hong Kong","institution_ids":["https://openalex.org/I889458895"]},{"raw_affiliation_string":"Junwen Wang, 13400 E Shea Blvd., Scottsdale, AZ 85259, USA","institution_ids":["https://openalex.org/I4210157777"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100704433","display_name":"Junwen Wang","orcid":"https://orcid.org/0000-0002-4432-4707"},"institutions":[{"id":"https://openalex.org/I4210125099","display_name":"Mayo Clinic in Arizona","ror":"https://ror.org/03jp40720","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210125099"]},{"id":"https://openalex.org/I4210157777","display_name":"Vitalant","ror":"https://ror.org/057kyc739","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210157777"]},{"id":"https://openalex.org/I889458895","display_name":"University of Hong Kong","ror":"https://ror.org/02zhqgq86","country_code":"HK","type":"education","lineage":["https://openalex.org/I889458895"]}],"countries":["HK","US"],"is_corresponding":true,"raw_author_name":"Junwen Wang","raw_affiliation_strings":["Department of Psychiatry, Centre for Genomic Sciences and State Key Laboratory in Cognitive and Brain Sciences in the LKS Faculty of Medicine, the University of Hong Kong","Junwen Wang, 13400 E Shea Blvd., Scottsdale, AZ 85259, USA","Mayo Medical School, Mayo Clinic and the College of Health Solutions, Arizona State University"],"raw_orcid":"https://orcid.org/0000-0002-4432-4707","affiliations":[{"raw_affiliation_string":"Department of Psychiatry, Centre for Genomic Sciences and State Key Laboratory in Cognitive and Brain Sciences in the LKS Faculty of Medicine, the University of Hong Kong","institution_ids":["https://openalex.org/I889458895"]},{"raw_affiliation_string":"Junwen Wang, 13400 E Shea Blvd., Scottsdale, AZ 85259, USA","institution_ids":["https://openalex.org/I4210157777"]},{"raw_affiliation_string":"Mayo Medical School, Mayo Clinic and the College of Health Solutions, Arizona State University","institution_ids":["https://openalex.org/I4210125099"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5100704433"],"corresponding_institution_ids":["https://openalex.org/I4210125099","https://openalex.org/I4210157777","https://openalex.org/I889458895"],"apc_list":{"value":4011,"currency":"USD","value_usd":4011},"apc_paid":null,"fwci":7.5399,"has_fulltext":true,"cited_by_count":225,"citation_normalized_percentile":{"value":0.98112887,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":96,"max":100},"biblio":{"volume":"20","issue":"4","first_page":"1583","last_page":"1589"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11289","display_name":"Single-cell and spatial transcriptomics","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11289","display_name":"Single-cell and spatial transcriptomics","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.9919000267982483,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9861999750137329,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/rna-seq","display_name":"RNA-Seq","score":0.7679727673530579},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.5997008085250854},{"id":"https://openalex.org/keywords/rna","display_name":"RNA","score":0.5854495167732239},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.5520107746124268},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.5486035943031311},{"id":"https://openalex.org/keywords/population","display_name":"Population","score":0.5428550243377686},{"id":"https://openalex.org/keywords/cell","display_name":"Cell","score":0.5183601975440979},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.5152790546417236},{"id":"https://openalex.org/keywords/embryonic-stem-cell","display_name":"Embryonic stem cell","score":0.49783849716186523},{"id":"https://openalex.org/keywords/single-cell-analysis","display_name":"Single-cell analysis","score":0.4373212456703186},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.3183659315109253},{"id":"https://openalex.org/keywords/transcriptome","display_name":"Transcriptome","score":0.18147772550582886},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.06910860538482666}],"concepts":[{"id":"https://openalex.org/C107397762","wikidata":"https://www.wikidata.org/wiki/Q2542347","display_name":"RNA-Seq","level":5,"score":0.7679727673530579},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5997008085250854},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.5854495167732239},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.5520107746124268},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5486035943031311},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.5428550243377686},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.5183601975440979},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5152790546417236},{"id":"https://openalex.org/C145103041","wikidata":"https://www.wikidata.org/wiki/Q1151519","display_name":"Embryonic stem cell","level":3,"score":0.49783849716186523},{"id":"https://openalex.org/C2776950831","wikidata":"https://www.wikidata.org/wiki/Q15635432","display_name":"Single-cell analysis","level":3,"score":0.4373212456703186},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3183659315109253},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.18147772550582886},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.06910860538482666},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000081246","descriptor_name":"RNA-Seq","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":false},{"descriptor_ui":"D000081246","descriptor_name":"RNA-Seq","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":false},{"descriptor_ui":"D000081246","descriptor_name":"RNA-Seq","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":false},{"descriptor_ui":"D000081246","descriptor_name":"RNA-Seq","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014644","descriptor_name":"Genetic Variation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014644","descriptor_name":"Genetic Variation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014644","descriptor_name":"Genetic Variation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014644","descriptor_name":"Genetic Variation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016000","descriptor_name":"Cluster Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016000","descriptor_name":"Cluster Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016000","descriptor_name":"Cluster Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016000","descriptor_name":"Cluster Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":false},{"descriptor_ui":"D030561","descriptor_name":"Databases, Nucleic Acid","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":false},{"descriptor_ui":"D030561","descriptor_name":"Databases, Nucleic Acid","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":false},{"descriptor_ui":"D030561","descriptor_name":"Databases, Nucleic Acid","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":false},{"descriptor_ui":"D030561","descriptor_name":"Databases, Nucleic Acid","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":false},{"descriptor_ui":"D059010","descriptor_name":"Single-Cell Analysis","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":false},{"descriptor_ui":"D059010","descriptor_name":"Single-Cell Analysis","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":false},{"descriptor_ui":"D059010","descriptor_name":"Single-Cell Analysis","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":false},{"descriptor_ui":"D059010","descriptor_name":"Single-Cell Analysis","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1093/bib/bby011","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bby011","pdf_url":"https://academic.oup.com/bib/article-pdf/20/4/1583/30119512/bby011.pdf","source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},{"id":"pmid:29481632","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29481632","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in bioinformatics","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:6781572","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6781572","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Brief Bioinform","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1093/bib/bby011","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bby011","pdf_url":"https://academic.oup.com/bib/article-pdf/20/4/1583/30119512/bby011.pdf","source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G1273647794","display_name":null,"funder_award_id":"1U01CA220378","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G2978832434","display_name":null,"funder_award_id":"1U54CA210180","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G988240626","display_name":null,"funder_award_id":"2P30CA015083","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2791285756.pdf","grobid_xml":"https://content.openalex.org/works/W2791285756.grobid-xml"},"referenced_works_count":34,"referenced_works":["https://openalex.org/W839653734","https://openalex.org/W1978703721","https://openalex.org/W1981509058","https://openalex.org/W1989367702","https://openalex.org/W2007439698","https://openalex.org/W2010653277","https://openalex.org/W2023887100","https://openalex.org/W2025828346","https://openalex.org/W2032920995","https://openalex.org/W2069089843","https://openalex.org/W2112058982","https://openalex.org/W2114104545","https://openalex.org/W2128227827","https://openalex.org/W2131271579","https://openalex.org/W2135937351","https://openalex.org/W2137526110","https://openalex.org/W2149573463","https://openalex.org/W2152239989","https://openalex.org/W2179438025","https://openalex.org/W2190545194","https://openalex.org/W2323326409","https://openalex.org/W2343956310","https://openalex.org/W2410823939","https://openalex.org/W2508929473","https://openalex.org/W2511262512","https://openalex.org/W2516455020","https://openalex.org/W2540833380","https://openalex.org/W2588569583","https://openalex.org/W2598326928","https://openalex.org/W2755506013","https://openalex.org/W2950541340","https://openalex.org/W2997205122","https://openalex.org/W4252232449","https://openalex.org/W6728888212"],"related_works":["https://openalex.org/W4394426846","https://openalex.org/W4200033037","https://openalex.org/W4394543623","https://openalex.org/W3213655218","https://openalex.org/W4394560977","https://openalex.org/W1966678537","https://openalex.org/W2381724992","https://openalex.org/W2942193912","https://openalex.org/W4255420075","https://openalex.org/W2101986440"],"abstract_inverted_index":{"Traditional":[0],"RNA":[1],"sequencing":[2],"(RNA-seq)":[3],"allows":[4,48,64],"the":[5,49,65],"detection":[6,50,66],"of":[7,43,51,67,84],"gene":[8,20,52,61],"expression":[9,53],"variations":[10],"between":[11,133],"two":[12],"or":[13],"more":[14],"cell":[15,78],"populations":[16],"through":[17],"differentially":[18],"expressed":[19],"(DEG)":[21],"analysis.":[22,131],"However,":[23],"genes":[24,68],"that":[25,69,119],"contribute":[26,70],"to":[27,72],"cell-to-cell":[28,73],"differences":[29],"are":[30,38,141,145],"not":[31],"discoverable":[32],"with":[33],"RNA-seq":[34,36,46],"because":[35],"samples":[37],"obtained":[39],"from":[40,104],"a":[41,76,82,125],"mixture":[42],"cells.":[44,87],"Single-cell":[45],"(scRNA-seq)":[47],"in":[54,92,121,138],"each":[55],"cell.":[56],"With":[57],"scRNA-seq,":[58],"highly":[59],"variable":[60],"(HVG)":[62],"discovery":[63],"strongly":[71],"variation":[74],"within":[75],"homogeneous":[77],"population,":[79],"such":[80],"as":[81],"population":[83],"embryonic":[85],"stem":[86],"This":[88],"analysis":[89,123],"is":[90],"implemented":[91],"many":[93],"software":[94,106],"packages.":[95],"In":[96],"this":[97],"study,":[98],"we":[99],"compare":[100],"seven":[101],"HVG":[102,122],"methods":[103,134],"six":[105],"packages,":[107],"including":[108],"BASiCS,":[109],"Brennecke,":[110],"scLVM,":[111],"scran,":[112],"scVEGs":[113],"and":[114,135,143],"Seurat.":[115],"Our":[116],"results":[117],"demonstrate":[118],"reproducibility":[120],"requires":[124],"larger":[126],"sample":[127],"size":[128],"than":[129],"DEG":[130],"Discrepancies":[132],"potential":[136],"issues":[137],"these":[139],"tools":[140],"discussed":[142],"recommendations":[144],"made.":[146]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":28},{"year":2024,"cited_by_count":39},{"year":2023,"cited_by_count":39},{"year":2022,"cited_by_count":34},{"year":2021,"cited_by_count":32},{"year":2020,"cited_by_count":23},{"year":2019,"cited_by_count":23},{"year":2018,"cited_by_count":3}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}
