{"id":"https://openalex.org/W2790733063","doi":"https://doi.org/10.1093/bib/bby010","title":"Open-source chemogenomic data-driven algorithms for predicting drug\u2013target interactions","display_name":"Open-source chemogenomic data-driven algorithms for predicting drug\u2013target interactions","publication_year":2018,"publication_date":"2018-01-26","ids":{"openalex":"https://openalex.org/W2790733063","doi":"https://doi.org/10.1093/bib/bby010","mag":"2790733063","pmid":"https://pubmed.ncbi.nlm.nih.gov/29420684"},"language":"en","primary_location":{"id":"doi:10.1093/bib/bby010","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bby010","pdf_url":"https://academic.oup.com/bib/article-pdf/20/4/1465/30119747/bby010.pdf","source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},"type":"review","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://academic.oup.com/bib/article-pdf/20/4/1465/30119747/bby010.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101997668","display_name":"Ming Hao","orcid":"https://orcid.org/0000-0001-7618-1934"},"institutions":[{"id":"https://openalex.org/I4210109390","display_name":"National Center for Biotechnology Information","ror":"https://ror.org/02meqm098","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I2800548410","https://openalex.org/I4210109390"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ming Hao","raw_affiliation_strings":["National Center for Biotechnology Information, NLM, NIH, 8600 Rockville Pike, Bethesda, MD 20894, USA"],"affiliations":[{"raw_affiliation_string":"National Center for Biotechnology Information, NLM, NIH, 8600 Rockville Pike, Bethesda, MD 20894, USA","institution_ids":["https://openalex.org/I4210109390"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040349721","display_name":"Stephen H. Bryant","orcid":null},"institutions":[{"id":"https://openalex.org/I4210109390","display_name":"National Center for Biotechnology Information","ror":"https://ror.org/02meqm098","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I2800548410","https://openalex.org/I4210109390"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stephen H Bryant","raw_affiliation_strings":["National Center for Biotechnology Information, NLM, NIH, 8600 Rockville Pike, Bethesda, MD 20894, USA"],"affiliations":[{"raw_affiliation_string":"National Center for Biotechnology Information, NLM, NIH, 8600 Rockville Pike, Bethesda, MD 20894, USA","institution_ids":["https://openalex.org/I4210109390"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100413382","display_name":"Yanli Wang","orcid":"https://orcid.org/0009-0007-5480-3158"},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210109390","display_name":"National Center for Biotechnology Information","ror":"https://ror.org/02meqm098","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I2800548410","https://openalex.org/I4210109390"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Yanli Wang","raw_affiliation_strings":["National Center for Biotechnology Information, NLM, NIH, 8600 Rockville Pike, Bethesda, MD 20894, USA","National Institutes of Health. His"],"affiliations":[{"raw_affiliation_string":"National Center for Biotechnology Information, NLM, NIH, 8600 Rockville Pike, Bethesda, MD 20894, USA","institution_ids":["https://openalex.org/I4210109390"]},{"raw_affiliation_string":"National Institutes of Health. His","institution_ids":["https://openalex.org/I1299303238"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5100413382"],"corresponding_institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210109390"],"apc_list":{"value":4011,"currency":"USD","value_usd":4011},"apc_paid":{"value":4011,"currency":"USD","value_usd":4011},"fwci":4.7023,"has_fulltext":true,"cited_by_count":41,"citation_normalized_percentile":{"value":0.95670072,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":96,"max":99},"biblio":{"volume":"20","issue":"4","first_page":"1465","last_page":"1474"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.9871000051498413,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.7641433477401733},{"id":"https://openalex.org/keywords/identification","display_name":"Identification (biology)","score":0.6250137090682983},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.5391327142715454},{"id":"https://openalex.org/keywords/drug-discovery","display_name":"Drug discovery","score":0.5056922435760498},{"id":"https://openalex.org/keywords/source-code","display_name":"Source code","score":0.4978044033050537},{"id":"https://openalex.org/keywords/ranking","display_name":"Ranking (information retrieval)","score":0.4549614191055298},{"id":"https://openalex.org/keywords/data-science","display_name":"Data science","score":0.41058918833732605},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.405516117811203},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.3540157675743103},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.18704882264137268}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.7641433477401733},{"id":"https://openalex.org/C116834253","wikidata":"https://www.wikidata.org/wiki/Q2039217","display_name":"Identification (biology)","level":2,"score":0.6250137090682983},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.5391327142715454},{"id":"https://openalex.org/C74187038","wikidata":"https://www.wikidata.org/wiki/Q1418791","display_name":"Drug discovery","level":2,"score":0.5056922435760498},{"id":"https://openalex.org/C43126263","wikidata":"https://www.wikidata.org/wiki/Q128751","display_name":"Source code","level":2,"score":0.4978044033050537},{"id":"https://openalex.org/C189430467","wikidata":"https://www.wikidata.org/wiki/Q7293293","display_name":"Ranking (information retrieval)","level":2,"score":0.4549614191055298},{"id":"https://openalex.org/C2522767166","wikidata":"https://www.wikidata.org/wiki/Q2374463","display_name":"Data science","level":1,"score":0.41058918833732605},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.405516117811203},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.3540157675743103},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.18704882264137268},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C111919701","wikidata":"https://www.wikidata.org/wiki/Q9135","display_name":"Operating system","level":1,"score":0.0},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000071185","descriptor_name":"Pharmacogenomic Testing","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D000071185","descriptor_name":"Pharmacogenomic Testing","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D000071185","descriptor_name":"Pharmacogenomic Testing","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D000071185","descriptor_name":"Pharmacogenomic Testing","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":false},{"descriptor_ui":"D000071185","descriptor_name":"Pharmacogenomic Testing","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":false},{"descriptor_ui":"D000071185","descriptor_name":"Pharmacogenomic Testing","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":false},{"descriptor_ui":"D000076722","descriptor_name":"Drug Development","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D000076722","descriptor_name":"Drug Development","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D000076722","descriptor_name":"Drug Development","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D000076722","descriptor_name":"Drug Development","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":false},{"descriptor_ui":"D000076722","descriptor_name":"Drug Development","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":false},{"descriptor_ui":"D000076722","descriptor_name":"Drug Development","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055808","descriptor_name":"Drug Discovery","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D055808","descriptor_name":"Drug Discovery","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D055808","descriptor_name":"Drug Discovery","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D055808","descriptor_name":"Drug Discovery","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":false},{"descriptor_ui":"D055808","descriptor_name":"Drug Discovery","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":false},{"descriptor_ui":"D055808","descriptor_name":"Drug Discovery","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":false},{"descriptor_ui":"D058492","descriptor_name":"Drug Repositioning","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D058492","descriptor_name":"Drug Repositioning","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D058492","descriptor_name":"Drug Repositioning","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D058492","descriptor_name":"Drug Repositioning","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":false},{"descriptor_ui":"D058492","descriptor_name":"Drug Repositioning","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":false},{"descriptor_ui":"D058492","descriptor_name":"Drug Repositioning","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1093/bib/bby010","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bby010","pdf_url":"https://academic.oup.com/bib/article-pdf/20/4/1465/30119747/bby010.pdf","source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},{"id":"pmid:29420684","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29420684","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in bioinformatics","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:6781586","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6781586","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Brief Bioinform","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1093/bib/bby010","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bby010","pdf_url":"https://academic.oup.com/bib/article-pdf/20/4/1465/30119747/bby010.pdf","source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Partnerships for the goals","score":0.4099999964237213,"id":"https://metadata.un.org/sdg/17"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337372","display_name":"U.S. National Library of Medicine","ror":"https://ror.org/0060t0j89"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2790733063.pdf","grobid_xml":"https://content.openalex.org/works/W2790733063.grobid-xml"},"referenced_works_count":70,"referenced_works":["https://openalex.org/W363319864","https://openalex.org/W1541232310","https://openalex.org/W1597238753","https://openalex.org/W1607745684","https://openalex.org/W1895993106","https://openalex.org/W1971106435","https://openalex.org/W1971315259","https://openalex.org/W1977870309","https://openalex.org/W1979537657","https://openalex.org/W1984014392","https://openalex.org/W1987219048","https://openalex.org/W1987802039","https://openalex.org/W1991919884","https://openalex.org/W1992407562","https://openalex.org/W1995449922","https://openalex.org/W2003100469","https://openalex.org/W2004629718","https://openalex.org/W2009313526","https://openalex.org/W2033906815","https://openalex.org/W2035557827","https://openalex.org/W2056440002","https://openalex.org/W2058491998","https://openalex.org/W2059868939","https://openalex.org/W2062941476","https://openalex.org/W2063149926","https://openalex.org/W2078139501","https://openalex.org/W2081709350","https://openalex.org/W2086286404","https://openalex.org/W2087064593","https://openalex.org/W2093313266","https://openalex.org/W2098318720","https://openalex.org/W2106029302","https://openalex.org/W2108069034","https://openalex.org/W2109991441","https://openalex.org/W2111094216","https://openalex.org/W2126671570","https://openalex.org/W2135007932","https://openalex.org/W2139736926","https://openalex.org/W2144000913","https://openalex.org/W2144769066","https://openalex.org/W2152454589","https://openalex.org/W2153185448","https://openalex.org/W2153838454","https://openalex.org/W2154718035","https://openalex.org/W2162011385","https://openalex.org/W2165674132","https://openalex.org/W2167212630","https://openalex.org/W2233800101","https://openalex.org/W2256119113","https://openalex.org/W2256553158","https://openalex.org/W2259538443","https://openalex.org/W2293547369","https://openalex.org/W2297764176","https://openalex.org/W2336169581","https://openalex.org/W2554328263","https://openalex.org/W2558825838","https://openalex.org/W2566823781","https://openalex.org/W2576544908","https://openalex.org/W2584828984","https://openalex.org/W2614433385","https://openalex.org/W2620820557","https://openalex.org/W2729788619","https://openalex.org/W2753550436","https://openalex.org/W2939293777","https://openalex.org/W2940601839","https://openalex.org/W2980375059","https://openalex.org/W3005432465","https://openalex.org/W3027412285","https://openalex.org/W4229812168","https://openalex.org/W6737788487"],"related_works":["https://openalex.org/W2188500270","https://openalex.org/W2303858293","https://openalex.org/W2915512527","https://openalex.org/W2798198862","https://openalex.org/W51364034","https://openalex.org/W2798997222","https://openalex.org/W2793336762","https://openalex.org/W2091548507","https://openalex.org/W2480711475","https://openalex.org/W2368816706"],"abstract_inverted_index":{"While":[0],"novel":[1],"technologies":[2],"such":[3],"as":[4],"high-throughput":[5],"screening":[6],"have":[7,73,81],"advanced":[8],"together":[9],"with":[10,136],"significant":[11],"investment":[12],"by":[13,60,150,170],"pharmaceutical":[14],"companies":[15],"during":[16],"the":[17,20,61,90,101,118,182,218],"past":[18],"decades,":[19],"success":[21,102],"rate":[22],"for":[23,34,123,141,223],"drug":[24,38,57,78,87,114],"development":[25],"has":[26],"not":[27],"yet":[28],"been":[29,74],"improved":[30],"prompting":[31],"researchers":[32,198],"looking":[33],"new":[35,177],"strategies":[36],"of":[37,55,92,103,120,172],"discovery.":[39,88],"Drug":[40],"repositioning":[41,115],"is":[42,64],"a":[43,176],"potential":[44,56,121,215],"approach":[45],"to":[46,76,83,109,197,202,209,213],"solve":[47],"this":[48,127,190],"dilemma.":[49],"However,":[50],"experimental":[51],"identification":[52,119],"and":[53,67,100,153,166,195],"validation":[54],"targets":[58,122],"encoded":[59],"human":[62,104],"genome":[63,105],"both":[65],"costly":[66],"time-consuming.":[68],"Therefore,":[69],"effective":[70,111],"computational":[71,134],"approaches":[72],"proposed":[75],"facilitate":[77],"repositioning,":[79],"which":[80],"proved":[82],"be":[84,193],"successful":[85],"in":[86,112,162,181,217],"Doubtlessly,":[89],"availability":[91],"open-accessible":[93],"data":[94],"from":[95],"basic":[96],"chemical":[97],"biology":[98],"research":[99,185],"sequencing":[106],"are":[107,226],"crucial":[108],"develop":[110],"silico":[113],"methods":[116],"allowing":[117],"existing":[124,205],"drugs.":[125],"In":[126],"work,":[128],"we":[129],"review":[130,191],"several":[131],"chemogenomic":[132],"data-driven":[133],"algorithms":[135,149,161,169,206,212],"source":[137,221],"codes":[138,222],"publicly":[139],"accessible":[140],"predicting":[142],"drug-target":[143],"interactions":[144],"(DTIs).":[145],"We":[146,157,187],"organize":[147],"these":[148,168],"model":[151,154],"properties":[152],"evolutionary":[155],"relationships.":[156],"re-implemented":[158],"five":[159],"representative":[160],"R":[163],"programming":[164],"language,":[165],"compared":[167],"means":[171],"mean":[173],"percentile":[174],"ranking,":[175],"recall-based":[178],"evaluation":[179],"metric":[180],"DTI":[183,224],"prediction":[184],"field.":[186],"anticipate":[188],"that":[189],"will":[192],"objective":[194],"helpful":[196],"who":[199],"would":[200],"like":[201],"further":[203],"improve":[204],"or":[207],"need":[208],"choose":[210],"appropriate":[211],"infer":[214],"DTIs":[216],"projects.":[219],"The":[220],"predictions":[225],"available":[227],"at:":[228],"https://github.com/minghao2016/chemogenomicAlg4DTIpred.":[229]},"counts_by_year":[{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":8},{"year":2019,"cited_by_count":7},{"year":2018,"cited_by_count":3}],"updated_date":"2026-04-21T08:09:41.155169","created_date":"2025-10-10T00:00:00"}