{"id":"https://openalex.org/W2776230120","doi":"https://doi.org/10.1093/bib/bbx172","title":"Link synthetic lethality to drug sensitivity of cancer cells","display_name":"Link synthetic lethality to drug sensitivity of cancer cells","publication_year":2017,"publication_date":"2017-12-15","ids":{"openalex":"https://openalex.org/W2776230120","doi":"https://doi.org/10.1093/bib/bbx172","mag":"2776230120","pmid":"https://pubmed.ncbi.nlm.nih.gov/29300844"},"language":"en","primary_location":{"id":"doi:10.1093/bib/bbx172","is_oa":false,"landing_page_url":"https://doi.org/10.1093/bib/bbx172","pdf_url":null,"source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100614956","display_name":"Ruiping Wang","orcid":"https://orcid.org/0000-0001-8065-4028"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ruiping Wang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100560968","display_name":"Yue Han","orcid":"https://orcid.org/0009-0001-2819-1991"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yue Han","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025129892","display_name":"Zhangxiang Zhao","orcid":"https://orcid.org/0000-0001-7467-7223"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Zhangxiang Zhao","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102934588","display_name":"Fan Yang","orcid":"https://orcid.org/0000-0003-4307-2875"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Fan Yang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100344100","display_name":"Tingting Chen","orcid":"https://orcid.org/0000-0002-0089-9402"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tingting Chen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037285225","display_name":"Wenbin Zhou","orcid":"https://orcid.org/0000-0003-1220-6797"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Wenbin Zhou","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080662928","display_name":"Xianlong Wang","orcid":"https://orcid.org/0000-0001-8195-2027"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Xianlong Wang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032948942","display_name":"Lishuang Qi","orcid":"https://orcid.org/0000-0002-2991-6544"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lishuang Qi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043417955","display_name":"Wenyuan Zhao","orcid":"https://orcid.org/0000-0002-6477-9434"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Wenyuan Zhao","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087055335","display_name":"Zheng Guo","orcid":"https://orcid.org/0000-0003-4466-6026"},"institutions":[{"id":"https://openalex.org/I156144747","display_name":"Harbin Medical University","ror":"https://ror.org/05jscf583","country_code":"CN","type":"education","lineage":["https://openalex.org/I156144747"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Zheng Guo","raw_affiliation_strings":["Corresponding authors: Yunyan Gu, Department of Systems Biology, College of Bioinformatics Science and Technology, Harbin Medical University, Harbin 150086, China or Training Center for Students Innovation and Entrepreneurship Education, Harbin Medical University, Harbin 150086, China. Tel.: +86451-86699584"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Corresponding authors: Yunyan Gu, Department of Systems Biology, College of Bioinformatics Science and Technology, Harbin Medical University, Harbin 150086, China or Training Center for Students Innovation and Entrepreneurship Education, Harbin Medical University, Harbin 150086, China. Tel.: +86451-86699584","institution_ids":["https://openalex.org/I156144747"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5069723993","display_name":"Yunyan Gu","orcid":"https://orcid.org/0000-0001-5693-4126"},"institutions":[{"id":"https://openalex.org/I156144747","display_name":"Harbin Medical University","ror":"https://ror.org/05jscf583","country_code":"CN","type":"education","lineage":["https://openalex.org/I156144747"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yunyan Gu","raw_affiliation_strings":["Corresponding authors: Yunyan Gu, Department of Systems Biology, College of Bioinformatics Science and Technology, Harbin Medical University, Harbin 150086, China or Training Center for Students Innovation and Entrepreneurship Education, Harbin Medical University, Harbin 150086, China. Tel.: +86451-86699584"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Corresponding authors: Yunyan Gu, Department of Systems Biology, College of Bioinformatics Science and Technology, Harbin Medical University, Harbin 150086, China or Training Center for Students Innovation and Entrepreneurship Education, Harbin Medical University, Harbin 150086, China. Tel.: +86451-86699584","institution_ids":["https://openalex.org/I156144747"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5069723993","https://openalex.org/A5087055335"],"corresponding_institution_ids":["https://openalex.org/I156144747"],"apc_list":{"value":4011,"currency":"USD","value_usd":4011},"apc_paid":null,"fwci":0.322,"has_fulltext":false,"cited_by_count":17,"citation_normalized_percentile":{"value":0.61124952,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"20","issue":"4","first_page":"1295","last_page":"1307"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11914","display_name":"PARP inhibition in cancer therapy","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11914","display_name":"PARP inhibition in cancer therapy","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.9925000071525574,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9919999837875366,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/synthetic-lethality","display_name":"Synthetic lethality","score":0.8837270736694336},{"id":"https://openalex.org/keywords/lethality","display_name":"Lethality","score":0.8538239002227783},{"id":"https://openalex.org/keywords/drug","display_name":"Drug","score":0.6321076154708862},{"id":"https://openalex.org/keywords/cancer","display_name":"Cancer","score":0.5887207984924316},{"id":"https://openalex.org/keywords/sensitivity","display_name":"Sensitivity (control systems)","score":0.5639352798461914},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.3544372320175171},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.2620207965373993},{"id":"https://openalex.org/keywords/pharmacology","display_name":"Pharmacology","score":0.23084256052970886},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.10684666037559509},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.10380503535270691},{"id":"https://openalex.org/keywords/dna-repair","display_name":"DNA repair","score":0.09099221229553223}],"concepts":[{"id":"https://openalex.org/C2778502085","wikidata":"https://www.wikidata.org/wiki/Q7662767","display_name":"Synthetic lethality","level":4,"score":0.8837270736694336},{"id":"https://openalex.org/C20379349","wikidata":"https://www.wikidata.org/wiki/Q1720706","display_name":"Lethality","level":2,"score":0.8538239002227783},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.6321076154708862},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5887207984924316},{"id":"https://openalex.org/C21200559","wikidata":"https://www.wikidata.org/wiki/Q7451068","display_name":"Sensitivity (control systems)","level":2,"score":0.5639352798461914},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3544372320175171},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2620207965373993},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.23084256052970886},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.10684666037559509},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.10380503535270691},{"id":"https://openalex.org/C134935766","wikidata":"https://www.wikidata.org/wiki/Q210538","display_name":"DNA repair","level":3,"score":0.09099221229553223},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0},{"id":"https://openalex.org/C24326235","wikidata":"https://www.wikidata.org/wiki/Q126095","display_name":"Electronic engineering","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000071184","descriptor_name":"Pharmacogenomic Variants","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000071184","descriptor_name":"Pharmacogenomic Variants","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000071184","descriptor_name":"Pharmacogenomic Variants","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000072020","descriptor_name":"Synthetic Lethal Mutations","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000072020","descriptor_name":"Synthetic Lethal Mutations","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000072020","descriptor_name":"Synthetic Lethal Mutations","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000076722","descriptor_name":"Drug Development","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000076722","descriptor_name":"Drug Development","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000076722","descriptor_name":"Drug Development","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009004","descriptor_name":"Monosaccharide Transport Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009004","descriptor_name":"Monosaccharide Transport Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009004","descriptor_name":"Monosaccharide Transport Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009687","descriptor_name":"Nuclear Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009687","descriptor_name":"Nuclear Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009687","descriptor_name":"Nuclear Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D010750","descriptor_name":"Phosphoproteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D010750","descriptor_name":"Phosphoproteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D010750","descriptor_name":"Phosphoproteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016315","descriptor_name":"Proto-Oncogene Proteins c-abl","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016315","descriptor_name":"Proto-Oncogene Proteins c-abl","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016315","descriptor_name":"Proto-Oncogene Proteins c-abl","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019008","descriptor_name":"Drug Resistance, Neoplasm","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019008","descriptor_name":"Drug Resistance, Neoplasm","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019008","descriptor_name":"Drug Resistance, Neoplasm","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030541","descriptor_name":"Databases, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030541","descriptor_name":"Databases, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030541","descriptor_name":"Databases, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050857","descriptor_name":"Synaptotagmins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D050857","descriptor_name":"Synaptotagmins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D050857","descriptor_name":"Synaptotagmins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1093/bib/bbx172","is_oa":false,"landing_page_url":"https://doi.org/10.1093/bib/bbx172","pdf_url":null,"source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},{"id":"pmid:29300844","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29300844","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in bioinformatics","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8299999833106995,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"awards":[{"id":"https://openalex.org/G3957965801","display_name":"\u80bf\u7624\u60a3\u8005\u5916\u5468\u8840\u4e2d\u7684mRNA\u3001miRNA\u3001DNA\u7532\u57fa\u5316\u7279\u5f81\u6a21\u5f0f\u53ca\u5176\u4e0e\u80bf\u7624\u5fae\u73af\u5883\u7684\u8c03\u63a7\u7f51\u7edc","funder_award_id":"81372213","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G4148500085","display_name":"\u57fa\u4e8e\u591a\u80bd-\u86cb\u767d\u8d28\u836f\u7269\u805a\u96c6\u4f53\u6784\u5efa\u65b0\u578b\u63a7\u91ca\u7cfb\u7edf\u7684\u7814\u7a76","funder_award_id":"21534008","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G4655669100","display_name":"\u57fa\u4e8e\u57fa\u56e0\u95f4\u9057\u4f20\u4e92\u4f5c\u89e3\u6790\u764c\u75c7\u9776\u5411\u836f\u7269\u8010\u836f\u673a\u5236","funder_award_id":"61673143","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G7557971074","display_name":"\u57fa\u4e8e\u836f\u7269\u8bf1\u5bfc\u7684\u8010\u836f\u7ec6\u80de\u7cfb\u8bc6\u522b\u4e34\u5e8a\u76f8\u5173\u7684\u80bf\u7624\u8010\u836f\u5206\u5b50\u6807\u5fd7\u4e0e\u836f\u6548\u9884\u6d4b\u6807\u5fd7","funder_award_id":"81572935","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":68,"referenced_works":["https://openalex.org/W19078547","https://openalex.org/W1749623888","https://openalex.org/W1895317372","https://openalex.org/W1964619587","https://openalex.org/W1968295028","https://openalex.org/W1971875278","https://openalex.org/W1985923121","https://openalex.org/W1989654707","https://openalex.org/W2001673920","https://openalex.org/W2005895632","https://openalex.org/W2006733085","https://openalex.org/W2008229568","https://openalex.org/W2010391389","https://openalex.org/W2011159055","https://openalex.org/W2014097228","https://openalex.org/W2018518196","https://openalex.org/W2019367530","https://openalex.org/W2029346055","https://openalex.org/W2030467705","https://openalex.org/W2043398720","https://openalex.org/W2045953361","https://openalex.org/W2050086663","https://openalex.org/W2071890257","https://openalex.org/W2082202339","https://openalex.org/W2087012714","https://openalex.org/W2092258505","https://openalex.org/W2099505694","https://openalex.org/W2099787654","https://openalex.org/W2102702938","https://openalex.org/W2103386635","https://openalex.org/W2108068107","https://openalex.org/W2117486942","https://openalex.org/W2121665844","https://openalex.org/W2122769974","https://openalex.org/W2133102806","https://openalex.org/W2137906640","https://openalex.org/W2140593657","https://openalex.org/W2144940507","https://openalex.org/W2148373230","https://openalex.org/W2160584334","https://openalex.org/W2162893512","https://openalex.org/W2164432702","https://openalex.org/W2167269875","https://openalex.org/W2171972386","https://openalex.org/W2220553089","https://openalex.org/W2236856444","https://openalex.org/W2308659819","https://openalex.org/W2318905487","https://openalex.org/W2321815569","https://openalex.org/W2344714812","https://openalex.org/W2472733817","https://openalex.org/W2489126592","https://openalex.org/W2508320259","https://openalex.org/W2522417827","https://openalex.org/W2526309682","https://openalex.org/W2559588208","https://openalex.org/W2573434464","https://openalex.org/W2618439945","https://openalex.org/W2624963583","https://openalex.org/W2626127376","https://openalex.org/W2915975108","https://openalex.org/W2949363897","https://openalex.org/W3098487500","https://openalex.org/W4212942074","https://openalex.org/W4249205058","https://openalex.org/W6600744685","https://openalex.org/W6668789115","https://openalex.org/W6673538246"],"related_works":["https://openalex.org/W2116506288","https://openalex.org/W3093199425","https://openalex.org/W1508071893","https://openalex.org/W2123596976","https://openalex.org/W3097247875","https://openalex.org/W4280520494","https://openalex.org/W2161566038","https://openalex.org/W2518938096","https://openalex.org/W4362639343","https://openalex.org/W4238916956"],"abstract_inverted_index":{"Synthetic":[0],"lethal":[1],"(SL)":[2],"interactions":[3,25,41,57,72,89,95,132,182],"occur":[4],"when":[5],"alterations":[6,116],"in":[7,16],"two":[8],"genes":[9,110,113,196],"lead":[10],"to":[11,51,154],"cell":[12,143,160,176],"death":[13],"but":[14,149,234],"alteration":[15],"only":[17,128,203,221],"one":[18,204],"of":[19,61,90,107,122,130,172,231],"them":[20],"is":[21,49],"not":[22,220],"lethal.":[23],"SL":[24,40,56,71,94,103,131,181,212],"provide":[26],"a":[27,223],"new":[28,224],"strategy":[29],"for":[30,65,163,191,226,242],"molecular-targeted":[31],"cancer":[32,62,123,142,159,175,243],"therapy.":[33,244],"Currently,":[34],"there":[35],"are":[36,117],"few":[37],"drugs":[38],"targeting":[39],"that":[42,105,127],"entered":[43],"into":[44],"clinical":[45],"trials.":[46],"Therefore,":[47],"it":[48],"necessary":[50],"investigate":[52],"the":[53,75,102,112,134,140,150,158,192,200,211,215,228],"link":[54],"between":[55,214],"and":[58,87,111,185],"drug":[59,66,108,120,137,232,240],"sensitivity":[60,121,138,233],"cells":[63],"systematically":[64],"development":[67],"purpose.":[68],"We":[69,125],"identified":[70],"by":[73],"integrating":[74,93],"high-throughput":[76],"data":[77,86,145,162,171],"from":[78,96,146],"The":[79],"Cancer":[80],"Genome":[81],"Atlas,":[82],"small":[83],"hairpin":[84],"RNA":[85],"genetic":[88],"yeast.":[91],"By":[92],"other":[97],"studies,":[98],"we":[99,178],"tested":[100],"whether":[101],"pairs":[104],"consist":[106],"target":[109],"with":[114,119,194,202],"genomic":[115],"related":[118],"cells.":[124],"found":[126,179],"6.26%\u223c34.61%":[129],"showed":[133,187],"expected":[135],"significant":[136],"using":[139,157],"pooled":[141],"line":[144,161],"different":[147],"tissues,":[148],"proportion":[151],"increased":[152],"significantly":[153,188],"approximately":[155],"90%":[156],"each":[164],"specific":[165],"tissue.":[166],"From":[167],"an":[168],"independent":[169],"pharmacogenomics":[170],"41":[173],"breast":[174],"lines,":[177],"three":[180],"(ABL1-IFI16,":[183],"ABL1-SLC50A1":[184],"ABL1-SYT11)":[186],"better":[189],"prognosis":[190],"patients":[193,201],"both":[195],"being":[197,206],"altered":[198],"than":[199],"gene":[205,216],"altered,":[207],"which":[208],"partially":[209],"supports":[210],"effect":[213],"pairs.":[217],"Our":[218],"study":[219],"provides":[222],"way":[225],"unraveling":[227],"complex":[229],"mechanisms":[230],"also":[235],"suggests":[236],"numerous":[237],"potentially":[238],"important":[239],"targets":[241]},"counts_by_year":[{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2}],"updated_date":"2026-07-15T18:14:33.161393","created_date":"2025-10-10T00:00:00"}