{"id":"https://openalex.org/W2609070191","doi":"https://doi.org/10.1093/bib/bbx045","title":"In silico polypharmacology of natural products","display_name":"In silico polypharmacology of natural products","publication_year":2017,"publication_date":"2017-03-31","ids":{"openalex":"https://openalex.org/W2609070191","doi":"https://doi.org/10.1093/bib/bbx045","mag":"2609070191","pmid":"https://pubmed.ncbi.nlm.nih.gov/28460068"},"language":"en","primary_location":{"id":"doi:10.1093/bib/bbx045","is_oa":false,"landing_page_url":"https://doi.org/10.1093/bib/bbx045","pdf_url":null,"source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5029470846","display_name":"Jiansong Fang","orcid":"https://orcid.org/0000-0002-6998-5384"},"institutions":[{"id":"https://openalex.org/I117532281","display_name":"Guangzhou University of Chinese Medicine","ror":"https://ror.org/03qb7bg95","country_code":"CN","type":"education","lineage":["https://openalex.org/I117532281"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jiansong Fang","raw_affiliation_strings":["Institute of Clinical Pharmacology, Guangzhou University of Chinese Medicine, Guangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Clinical Pharmacology, Guangzhou University of Chinese Medicine, Guangzhou, China","institution_ids":["https://openalex.org/I117532281"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100326615","display_name":"Chuang Liu","orcid":"https://orcid.org/0000-0002-9749-1592"},"institutions":[{"id":"https://openalex.org/I163151501","display_name":"Hangzhou Normal University","ror":"https://ror.org/014v1mr15","country_code":"CN","type":"education","lineage":["https://openalex.org/I163151501"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chuang Liu","raw_affiliation_strings":["Alibaba Research Center for Complexity Sciences at the Hangzhou Normal University, Hangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Alibaba Research Center for Complexity Sciences at the Hangzhou Normal University, Hangzhou, China","institution_ids":["https://openalex.org/I163151501"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100341210","display_name":"Qi Wang","orcid":"https://orcid.org/0000-0001-7626-676X"},"institutions":[{"id":"https://openalex.org/I117532281","display_name":"Guangzhou University of Chinese Medicine","ror":"https://ror.org/03qb7bg95","country_code":"CN","type":"education","lineage":["https://openalex.org/I117532281"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qi Wang","raw_affiliation_strings":["Institute of Clinical Pharmacology, Guangzhou University of Chinese Medicine, Guangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Clinical Pharmacology, Guangzhou University of Chinese Medicine, Guangzhou, China","institution_ids":["https://openalex.org/I117532281"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068090270","display_name":"Ping Lin","orcid":"https://orcid.org/0000-0001-8982-8397"},"institutions":[{"id":"https://openalex.org/I24185976","display_name":"Sichuan University","ror":"https://ror.org/011ashp19","country_code":"CN","type":"education","lineage":["https://openalex.org/I24185976"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ping Lin","raw_affiliation_strings":["National Key Laboratory of Biotherapy and Cancer Center, West China Hospital, West China Medical School, Sichuan University, Chengdu, Sichuan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Key Laboratory of Biotherapy and Cancer Center, West China Hospital, West China Medical School, Sichuan University, Chengdu, Sichuan, China","institution_ids":["https://openalex.org/I24185976"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5021122269","display_name":"Feixiong Cheng","orcid":"https://orcid.org/0000-0002-1736-2847"},"institutions":[{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Feixiong Cheng","raw_affiliation_strings":["Department of Biomedical Informatics, Vanderbilt University Medical Center in Nashville (United States)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Informatics, Vanderbilt University Medical Center in Nashville (United States)","institution_ids":["https://openalex.org/I901861585"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5021122269"],"corresponding_institution_ids":["https://openalex.org/I901861585"],"apc_list":{"value":4011,"currency":"USD","value_usd":4011},"apc_paid":null,"fwci":11.2627,"has_fulltext":false,"cited_by_count":158,"citation_normalized_percentile":{"value":0.98939721,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":100},"biblio":{"volume":"19","issue":"6","first_page":"1153","last_page":"1171"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10252","display_name":"Microbial Natural Products and Biosynthesis","score":0.996399998664856,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.9865999817848206,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/systems-pharmacology","display_name":"Systems pharmacology","score":0.7409219741821289},{"id":"https://openalex.org/keywords/systems-biology","display_name":"Systems biology","score":0.662898063659668},{"id":"https://openalex.org/keywords/cheminformatics","display_name":"Cheminformatics","score":0.5877563953399658},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.567726194858551},{"id":"https://openalex.org/keywords/in-silico","display_name":"In silico","score":0.5304683446884155},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.5281755328178406},{"id":"https://openalex.org/keywords/drug-discovery","display_name":"Drug discovery","score":0.5086930394172668},{"id":"https://openalex.org/keywords/drug-repositioning","display_name":"Drug repositioning","score":0.430231511592865},{"id":"https://openalex.org/keywords/modelling-biological-systems","display_name":"Modelling biological systems","score":0.43006646633148193},{"id":"https://openalex.org/keywords/genomics","display_name":"Genomics","score":0.4200349450111389},{"id":"https://openalex.org/keywords/data-science","display_name":"Data science","score":0.40729519724845886},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.29482072591781616},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.23621153831481934},{"id":"https://openalex.org/keywords/drug","display_name":"Drug","score":0.2153879702091217},{"id":"https://openalex.org/keywords/pharmacology","display_name":"Pharmacology","score":0.13106730580329895},{"id":"https://openalex.org/keywords/genome","display_name":"Genome","score":0.09928816556930542}],"concepts":[{"id":"https://openalex.org/C2779446555","wikidata":"https://www.wikidata.org/wiki/Q7663877","display_name":"Systems pharmacology","level":3,"score":0.7409219741821289},{"id":"https://openalex.org/C152662350","wikidata":"https://www.wikidata.org/wiki/Q815297","display_name":"Systems biology","level":2,"score":0.662898063659668},{"id":"https://openalex.org/C68762167","wikidata":"https://www.wikidata.org/wiki/Q910164","display_name":"Cheminformatics","level":2,"score":0.5877563953399658},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.567726194858551},{"id":"https://openalex.org/C2775905019","wikidata":"https://www.wikidata.org/wiki/Q192572","display_name":"In silico","level":3,"score":0.5304683446884155},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5281755328178406},{"id":"https://openalex.org/C74187038","wikidata":"https://www.wikidata.org/wiki/Q1418791","display_name":"Drug discovery","level":2,"score":0.5086930394172668},{"id":"https://openalex.org/C103637391","wikidata":"https://www.wikidata.org/wiki/Q5308921","display_name":"Drug repositioning","level":3,"score":0.430231511592865},{"id":"https://openalex.org/C137866125","wikidata":"https://www.wikidata.org/wiki/Q4299308","display_name":"Modelling biological systems","level":3,"score":0.43006646633148193},{"id":"https://openalex.org/C189206191","wikidata":"https://www.wikidata.org/wiki/Q222046","display_name":"Genomics","level":4,"score":0.4200349450111389},{"id":"https://openalex.org/C2522767166","wikidata":"https://www.wikidata.org/wiki/Q2374463","display_name":"Data science","level":1,"score":0.40729519724845886},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.29482072591781616},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.23621153831481934},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.2153879702091217},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.13106730580329895},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.09928816556930542},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D001688","descriptor_name":"Biological Products","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D001688","descriptor_name":"Biological Products","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D001688","descriptor_name":"Biological Products","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D016503","descriptor_name":"Drug Delivery Systems","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016503","descriptor_name":"Drug Delivery Systems","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016503","descriptor_name":"Drug Delivery Systems","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049490","descriptor_name":"Systems Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049490","descriptor_name":"Systems Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049490","descriptor_name":"Systems Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D064798","descriptor_name":"Polypharmacology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D064798","descriptor_name":"Polypharmacology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D064798","descriptor_name":"Polypharmacology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1093/bib/bbx045","is_oa":false,"landing_page_url":"https://doi.org/10.1093/bib/bbx045","pdf_url":null,"source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},{"id":"pmid:28460068","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28460068","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in bioinformatics","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320310226","display_name":"Genomic Health","ror":"https://ror.org/05njgh475"},{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":186,"referenced_works":["https://openalex.org/W608794511","https://openalex.org/W613187787","https://openalex.org/W1544009106","https://openalex.org/W1782395661","https://openalex.org/W1799607368","https://openalex.org/W1831052262","https://openalex.org/W1855299742","https://openalex.org/W1880949099","https://openalex.org/W1894322524","https://openalex.org/W1906327883","https://openalex.org/W1928035006","https://openalex.org/W1963907665","https://openalex.org/W1964755431","https://openalex.org/W1965379872","https://openalex.org/W1965694039","https://openalex.org/W1965743421","https://openalex.org/W1967692894","https://openalex.org/W1972843887","https://openalex.org/W1975875968","https://openalex.org/W1977099733","https://openalex.org/W1978370150","https://openalex.org/W1978486653","https://openalex.org/W1979385086","https://openalex.org/W1979881273","https://openalex.org/W1982420329","https://openalex.org/W1982545168","https://openalex.org/W1983198554","https://openalex.org/W1984084871","https://openalex.org/W1985043972","https://openalex.org/W1986832739","https://openalex.org/W1988096090","https://openalex.org/W1988377311","https://openalex.org/W1993352447","https://openalex.org/W1993554808","https://openalex.org/W1994586548","https://openalex.org/W1994849223","https://openalex.org/W1995857893","https://openalex.org/W1995919174","https://openalex.org/W1999862493","https://openalex.org/W2006017285","https://openalex.org/W2008289103","https://openalex.org/W2012576981","https://openalex.org/W2018518196","https://openalex.org/W2018796817","https://openalex.org/W2019252486","https://openalex.org/W2019799017","https://openalex.org/W2020573863","https://openalex.org/W2021548614","https://openalex.org/W2023560061","https://openalex.org/W2023610534","https://openalex.org/W2027844138","https://openalex.org/W2029211775","https://openalex.org/W2029757179","https://openalex.org/W2029980980","https://openalex.org/W2030104903","https://openalex.org/W2033019354","https://openalex.org/W2033577259","https://openalex.org/W2033906815","https://openalex.org/W2040369353","https://openalex.org/W2042210471","https://openalex.org/W2043629638","https://openalex.org/W2043764300","https://openalex.org/W2044002635","https://openalex.org/W2044433401","https://openalex.org/W2048736765","https://openalex.org/W2049988693","https://openalex.org/W2050113624","https://openalex.org/W2052685738","https://openalex.org/W2053717624","https://openalex.org/W2059069581","https://openalex.org/W2069027667","https://openalex.org/W2070785261","https://openalex.org/W2070930739","https://openalex.org/W2073504782","https://openalex.org/W2077648184","https://openalex.org/W2077704652","https://openalex.org/W2078653892","https://openalex.org/W2080642200","https://openalex.org/W2080878119","https://openalex.org/W2080886752","https://openalex.org/W2084164487","https://openalex.org/W2084704174","https://openalex.org/W2088226047","https://openalex.org/W2088548720","https://openalex.org/W2088629793","https://openalex.org/W2089023822","https://openalex.org/W2089383319","https://openalex.org/W2090439098","https://openalex.org/W2090703365","https://openalex.org/W2094215391","https://openalex.org/W2095867585","https://openalex.org/W2096021562","https://openalex.org/W2096576371","https://openalex.org/W2098967508","https://openalex.org/W2099536383","https://openalex.org/W2099768941","https://openalex.org/W2104871495","https://openalex.org/W2104916446","https://openalex.org/W2107371806","https://openalex.org/W2107723674","https://openalex.org/W2110121513","https://openalex.org/W2110151487","https://openalex.org/W2112411768","https://openalex.org/W2114843025","https://openalex.org/W2118151336","https://openalex.org/W2121604817","https://openalex.org/W2121906867","https://openalex.org/W2122863289","https://openalex.org/W2123159115","https://openalex.org/W2123454534","https://openalex.org/W2124679671","https://openalex.org/W2130867651","https://openalex.org/W2131272506","https://openalex.org/W2131321938","https://openalex.org/W2139340483","https://openalex.org/W2139648620","https://openalex.org/W2139736926","https://openalex.org/W2143784594","https://openalex.org/W2144642115","https://openalex.org/W2147084722","https://openalex.org/W2148145769","https://openalex.org/W2148262706","https://openalex.org/W2148671784","https://openalex.org/W2151089147","https://openalex.org/W2152687832","https://openalex.org/W2152927656","https://openalex.org/W2153838454","https://openalex.org/W2157122000","https://openalex.org/W2158394019","https://openalex.org/W2165188181","https://openalex.org/W2166273484","https://openalex.org/W2166948894","https://openalex.org/W2173073476","https://openalex.org/W2176533785","https://openalex.org/W2180467040","https://openalex.org/W2185500533","https://openalex.org/W2195653324","https://openalex.org/W2202954603","https://openalex.org/W2204695023","https://openalex.org/W2214873049","https://openalex.org/W2216761081","https://openalex.org/W2217812737","https://openalex.org/W2219058605","https://openalex.org/W2219362984","https://openalex.org/W2227583040","https://openalex.org/W2256942906","https://openalex.org/W2259538443","https://openalex.org/W2265131395","https://openalex.org/W2277007946","https://openalex.org/W2283422149","https://openalex.org/W2284302357","https://openalex.org/W2284926981","https://openalex.org/W2294856928","https://openalex.org/W2295730657","https://openalex.org/W2300203480","https://openalex.org/W2302088846","https://openalex.org/W2318276819","https://openalex.org/W2325179027","https://openalex.org/W2337558949","https://openalex.org/W2398999308","https://openalex.org/W2401216400","https://openalex.org/W2401931320","https://openalex.org/W2402506318","https://openalex.org/W2418194773","https://openalex.org/W2435483024","https://openalex.org/W2443187137","https://openalex.org/W2464666556","https://openalex.org/W2474546929","https://openalex.org/W2482736996","https://openalex.org/W2490223361","https://openalex.org/W2502470328","https://openalex.org/W2507626327","https://openalex.org/W2511624203","https://openalex.org/W2512415588","https://openalex.org/W2520699286","https://openalex.org/W2522129328","https://openalex.org/W2522920646","https://openalex.org/W2524749194","https://openalex.org/W2535520139","https://openalex.org/W2537623931","https://openalex.org/W2557486166","https://openalex.org/W2570618306","https://openalex.org/W2579340176","https://openalex.org/W2591212789","https://openalex.org/W2609659483","https://openalex.org/W2915975108"],"related_works":["https://openalex.org/W2048384644","https://openalex.org/W4386563820","https://openalex.org/W3129407679","https://openalex.org/W1963702345","https://openalex.org/W631732704","https://openalex.org/W1977623644","https://openalex.org/W2347089309","https://openalex.org/W1511119527","https://openalex.org/W2185904291","https://openalex.org/W2127864418"],"abstract_inverted_index":{"Natural":[0],"products":[1,84,106,178,225],"with":[2,28],"polypharmacological":[3,57,97],"profiles":[4,58,101],"have":[5],"demonstrated":[6],"promise":[7,199],"as":[8,111],"novel":[9],"therapeutics":[10],"for":[11,54,78,123,139,184],"various":[12,116],"complex":[13],"diseases,":[14],"including":[15],"cancer.":[16],"Currently,":[17],"many":[18],"gaps":[19],"exist":[20],"in":[21,226],"our":[22],"knowledge":[23],"of":[24,43,59,71,82,90,102,127,141,165,168,176,187,200,223],"which":[25,29],"compounds":[26],"interact":[27],"targets,":[30],"and":[31,41,46,69,74,98,119,137,153,179,203,219],"experimentally":[32],"testing":[33],"all":[34],"possible":[35],"interactions":[36,143],"is":[37],"infeasible.":[38],"Recent":[39],"advances":[40,70],"developments":[42],"systems":[44,75,99,120,155,169,192],"pharmacology":[45,76,170],"computational":[47,72,135],"(in":[48],"silico)":[49],"approaches":[50,77,136,171],"provide":[51],"powerful":[52],"tools":[53,73,138],"exploring":[55],"the":[56,88,96,166,174,185,191,198,217,227],"natural":[60,83,105,128,177,224],"products.":[61,129],"In":[62,158],"this":[63],"review,":[64],"we":[65,160,196],"introduce":[66],"recent":[67],"progresses":[68],"identifying":[79],"drug":[80],"targets":[81],"by":[85,144,172],"focusing":[86,145],"on":[87,146],"development":[89,186],"targeted":[91],"cancer":[92,112,181,201,228],"therapy.":[93],"We":[94,114,130],"survey":[95],"immunology":[100],"five":[103,147],"representative":[104],"that":[107,206],"are":[108],"being":[109],"considered":[110],"therapies.":[113],"summarize":[115],"chemoinformatics,":[117],"bioinformatics":[118],"biology":[121,156,193],"resources":[122],"reconstructing":[124],"drug-target":[125,142],"networks":[126],"then":[131],"review":[132],"currently":[133],"available":[134],"prediction":[140],"domains:":[148],"target-based,":[149],"ligand-based,":[150],"chemogenomics-based,":[151],"network-based":[152],"omics-based":[154],"approaches.":[157],"addition,":[159],"describe":[161],"a":[162],"practical":[163],"example":[164],"application":[167],"integrating":[173],"polypharmacology":[175],"large-scale":[180],"genomics":[182],"data":[183],"precision":[188],"oncology":[189],"under":[190],"framework.":[194],"Finally,":[195],"highlight":[197],"immunotherapies":[202],"combination":[204],"therapies":[205],"target":[207],"tumor":[208],"ecosystems":[209],"(e.g.":[210],"clones":[211],"or":[212],"'selfish'":[213],"sub-clones)":[214],"via":[215],"exploiting":[216],"immunological":[218],"inflammatory":[220],"'side'":[221],"effects":[222],"post-genomics":[229],"era.":[230]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":13},{"year":2024,"cited_by_count":16},{"year":2023,"cited_by_count":22},{"year":2022,"cited_by_count":25},{"year":2021,"cited_by_count":24},{"year":2020,"cited_by_count":16},{"year":2019,"cited_by_count":17},{"year":2018,"cited_by_count":15},{"year":2017,"cited_by_count":5}],"updated_date":"2026-07-19T07:52:34.831488","created_date":"2025-10-10T00:00:00"}