{"id":"https://openalex.org/W2573434464","doi":"https://doi.org/10.1093/bib/bbw142","title":"A landscape of synthetic viable interactions in cancer","display_name":"A landscape of synthetic viable interactions in cancer","publication_year":2016,"publication_date":"2016-12-15","ids":{"openalex":"https://openalex.org/W2573434464","doi":"https://doi.org/10.1093/bib/bbw142","mag":"2573434464","pmid":"https://pubmed.ncbi.nlm.nih.gov/28096076"},"language":"en","primary_location":{"id":"doi:10.1093/bib/bbw142","is_oa":false,"landing_page_url":"https://doi.org/10.1093/bib/bbw142","pdf_url":null,"source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5069723993","display_name":"Yunyan Gu","orcid":"https://orcid.org/0000-0001-5693-4126"},"institutions":[{"id":"https://openalex.org/I156144747","display_name":"Harbin Medical University","ror":"https://ror.org/05jscf583","country_code":"CN","type":"education","lineage":["https://openalex.org/I156144747"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yunyan Gu","raw_affiliation_strings":["Department of Systems Biology, College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, China"],"affiliations":[{"raw_affiliation_string":"Department of Systems Biology, College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, China","institution_ids":["https://openalex.org/I156144747"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108140113","display_name":"Ruiping Wang","orcid":"https://orcid.org/0009-0007-2135-0797"},"institutions":[{"id":"https://openalex.org/I156144747","display_name":"Harbin Medical University","ror":"https://ror.org/05jscf583","country_code":"CN","type":"education","lineage":["https://openalex.org/I156144747"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ruiping Wang","raw_affiliation_strings":["Department of Systems Biology, College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, China"],"affiliations":[{"raw_affiliation_string":"Department of Systems Biology, College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, China","institution_ids":["https://openalex.org/I156144747"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100560968","display_name":"Yue Han","orcid":"https://orcid.org/0009-0001-2819-1991"},"institutions":[{"id":"https://openalex.org/I156144747","display_name":"Harbin Medical University","ror":"https://ror.org/05jscf583","country_code":"CN","type":"education","lineage":["https://openalex.org/I156144747"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yue Han","raw_affiliation_strings":["Department of Systems Biology, College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, China"],"affiliations":[{"raw_affiliation_string":"Department of Systems Biology, College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, China","institution_ids":["https://openalex.org/I156144747"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037285225","display_name":"Wenbin Zhou","orcid":"https://orcid.org/0000-0003-1220-6797"},"institutions":[{"id":"https://openalex.org/I156144747","display_name":"Harbin Medical University","ror":"https://ror.org/05jscf583","country_code":"CN","type":"education","lineage":["https://openalex.org/I156144747"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wenbin Zhou","raw_affiliation_strings":["Department of Systems Biology, College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, China"],"affiliations":[{"raw_affiliation_string":"Department of Systems Biology, College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, China","institution_ids":["https://openalex.org/I156144747"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025129892","display_name":"Zhangxiang Zhao","orcid":"https://orcid.org/0000-0001-7467-7223"},"institutions":[{"id":"https://openalex.org/I156144747","display_name":"Harbin Medical University","ror":"https://ror.org/05jscf583","country_code":"CN","type":"education","lineage":["https://openalex.org/I156144747"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhangxiang Zhao","raw_affiliation_strings":["Department of Systems Biology, College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, China"],"affiliations":[{"raw_affiliation_string":"Department of Systems Biology, College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, China","institution_ids":["https://openalex.org/I156144747"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100344105","display_name":"Tingting Chen","orcid":"https://orcid.org/0000-0002-3918-5132"},"institutions":[{"id":"https://openalex.org/I156144747","display_name":"Harbin Medical University","ror":"https://ror.org/05jscf583","country_code":"CN","type":"education","lineage":["https://openalex.org/I156144747"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Tingting Chen","raw_affiliation_strings":["Department of Systems Biology, College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, China"],"affiliations":[{"raw_affiliation_string":"Department of Systems Biology, College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, China","institution_ids":["https://openalex.org/I156144747"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100320622","display_name":"Yuanyuan Zhang","orcid":"https://orcid.org/0000-0001-6972-5606"},"institutions":[{"id":"https://openalex.org/I156144747","display_name":"Harbin Medical University","ror":"https://ror.org/05jscf583","country_code":"CN","type":"education","lineage":["https://openalex.org/I156144747"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yuanyuan Zhang","raw_affiliation_strings":["Department of Systems Biology, College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, China"],"affiliations":[{"raw_affiliation_string":"Department of Systems Biology, College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, China","institution_ids":["https://openalex.org/I156144747"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030580072","display_name":"Fuduan Peng","orcid":"https://orcid.org/0000-0003-4068-530X"},"institutions":[{"id":"https://openalex.org/I156144747","display_name":"Harbin Medical University","ror":"https://ror.org/05jscf583","country_code":"CN","type":"education","lineage":["https://openalex.org/I156144747"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Fuduan Peng","raw_affiliation_strings":["Department of Systems Biology, College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, China"],"affiliations":[{"raw_affiliation_string":"Department of Systems Biology, College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, China","institution_ids":["https://openalex.org/I156144747"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021171211","display_name":"Haihai Liang","orcid":"https://orcid.org/0000-0003-4446-7035"},"institutions":[{"id":"https://openalex.org/I156144747","display_name":"Harbin Medical University","ror":"https://ror.org/05jscf583","country_code":"CN","type":"education","lineage":["https://openalex.org/I156144747"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Haihai Liang","raw_affiliation_strings":["Department of Pharmacology, Harbin Medical University, Harbin, China"],"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Harbin Medical University, Harbin, China","institution_ids":["https://openalex.org/I156144747"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032948942","display_name":"Lishuang Qi","orcid":"https://orcid.org/0000-0002-2991-6544"},"institutions":[{"id":"https://openalex.org/I156144747","display_name":"Harbin Medical University","ror":"https://ror.org/05jscf583","country_code":"CN","type":"education","lineage":["https://openalex.org/I156144747"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lishuang Qi","raw_affiliation_strings":["Department of Systems Biology, College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, China"],"affiliations":[{"raw_affiliation_string":"Department of Systems Biology, College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, China","institution_ids":["https://openalex.org/I156144747"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043417955","display_name":"Wenyuan Zhao","orcid":"https://orcid.org/0000-0002-6477-9434"},"institutions":[{"id":"https://openalex.org/I156144747","display_name":"Harbin Medical University","ror":"https://ror.org/05jscf583","country_code":"CN","type":"education","lineage":["https://openalex.org/I156144747"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wenyuan Zhao","raw_affiliation_strings":["Department of Systems Biology, College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, China"],"affiliations":[{"raw_affiliation_string":"Department of Systems Biology, College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, China","institution_ids":["https://openalex.org/I156144747"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023998618","display_name":"Da Yang","orcid":"https://orcid.org/0000-0002-8336-9457"},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Da Yang","raw_affiliation_strings":["Department of Pharmaceutical Sciences and Department of Computational & Systems Biology, University of Pittsburgh, Pittsburgh, PA, USA"],"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Sciences and Department of Computational & Systems Biology, University of Pittsburgh, Pittsburgh, PA, USA","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5087055335","display_name":"Zheng Guo","orcid":"https://orcid.org/0000-0003-4466-6026"},"institutions":[{"id":"https://openalex.org/I129708740","display_name":"Fujian Medical University","ror":"https://ror.org/050s6ns64","country_code":"CN","type":"education","lineage":["https://openalex.org/I129708740"]},{"id":"https://openalex.org/I156144747","display_name":"Harbin Medical University","ror":"https://ror.org/05jscf583","country_code":"CN","type":"education","lineage":["https://openalex.org/I156144747"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Zheng Guo","raw_affiliation_strings":["Department of Systems Biology, College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, China","Key Laboratory of Ministry of Education for Gastrointestinal Cancer, Department of Bioinformatics, Fujian Medical University, Fuzhou, China"],"affiliations":[{"raw_affiliation_string":"Department of Systems Biology, College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, China","institution_ids":["https://openalex.org/I156144747"]},{"raw_affiliation_string":"Key Laboratory of Ministry of Education for Gastrointestinal Cancer, Department of Bioinformatics, Fujian Medical University, Fuzhou, China","institution_ids":["https://openalex.org/I129708740"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":13,"corresponding_author_ids":["https://openalex.org/A5023998618","https://openalex.org/A5087055335"],"corresponding_institution_ids":["https://openalex.org/I129708740","https://openalex.org/I156144747","https://openalex.org/I170201317"],"apc_list":{"value":4011,"currency":"USD","value_usd":4011},"apc_paid":null,"fwci":0.8336,"has_fulltext":false,"cited_by_count":19,"citation_normalized_percentile":{"value":0.7658328,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"19","issue":"4","first_page":"bbw142","last_page":"bbw142"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.9993000030517578,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9968000054359436,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/synthetic-lethality","display_name":"Synthetic lethality","score":0.6297318935394287},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.6239190101623535},{"id":"https://openalex.org/keywords/cancer","display_name":"Cancer","score":0.6176198124885559},{"id":"https://openalex.org/keywords/pharmacogenomics","display_name":"Pharmacogenomics","score":0.6007001996040344},{"id":"https://openalex.org/keywords/exome","display_name":"Exome","score":0.5494319200515747},{"id":"https://openalex.org/keywords/genome","display_name":"Genome","score":0.4877053201198578},{"id":"https://openalex.org/keywords/drug-resistance","display_name":"Drug resistance","score":0.4710127115249634},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.4547745883464813},{"id":"https://openalex.org/keywords/cancer-cell","display_name":"Cancer cell","score":0.4432179629802704},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.3527222275733948},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.32599329948425293},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.27319836616516113},{"id":"https://openalex.org/keywords/exome-sequencing","display_name":"Exome sequencing","score":0.26848283410072327},{"id":"https://openalex.org/keywords/mutation","display_name":"Mutation","score":0.23301264643669128},{"id":"https://openalex.org/keywords/dna-repair","display_name":"DNA repair","score":0.08635994791984558}],"concepts":[{"id":"https://openalex.org/C2778502085","wikidata":"https://www.wikidata.org/wiki/Q7662767","display_name":"Synthetic lethality","level":4,"score":0.6297318935394287},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.6239190101623535},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.6176198124885559},{"id":"https://openalex.org/C170734499","wikidata":"https://www.wikidata.org/wiki/Q1152227","display_name":"Pharmacogenomics","level":2,"score":0.6007001996040344},{"id":"https://openalex.org/C10590036","wikidata":"https://www.wikidata.org/wiki/Q417664","display_name":"Exome","level":5,"score":0.5494319200515747},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.4877053201198578},{"id":"https://openalex.org/C114851261","wikidata":"https://www.wikidata.org/wiki/Q12147416","display_name":"Drug resistance","level":2,"score":0.4710127115249634},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4547745883464813},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.4432179629802704},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3527222275733948},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.32599329948425293},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.27319836616516113},{"id":"https://openalex.org/C16671776","wikidata":"https://www.wikidata.org/wiki/Q5420592","display_name":"Exome sequencing","level":4,"score":0.26848283410072327},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.23301264643669128},{"id":"https://openalex.org/C134935766","wikidata":"https://www.wikidata.org/wiki/Q210538","display_name":"DNA repair","level":3,"score":0.08635994791984558}],"mesh":[{"descriptor_ui":"D005804","descriptor_name":"Genes, Lethal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005804","descriptor_name":"Genes, Lethal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005804","descriptor_name":"Genes, Lethal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009363","descriptor_name":"Neoplasm Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009363","descriptor_name":"Neoplasm Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009363","descriptor_name":"Neoplasm Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010597","descriptor_name":"Pharmacogenetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010597","descriptor_name":"Pharmacogenetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010597","descriptor_name":"Pharmacogenetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019008","descriptor_name":"Drug Resistance, Neoplasm","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019008","descriptor_name":"Drug Resistance, Neoplasm","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019008","descriptor_name":"Drug Resistance, Neoplasm","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1093/bib/bbw142","is_oa":false,"landing_page_url":"https://doi.org/10.1093/bib/bbw142","pdf_url":null,"source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},{"id":"pmid:28096076","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28096076","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in bioinformatics","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8299999833106995,"id":"https://metadata.un.org/sdg/3"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":45,"referenced_works":["https://openalex.org/W1520240761","https://openalex.org/W1895317372","https://openalex.org/W1924307033","https://openalex.org/W1971724749","https://openalex.org/W1984154404","https://openalex.org/W2001673920","https://openalex.org/W2005895632","https://openalex.org/W2006733085","https://openalex.org/W2009612742","https://openalex.org/W2011474181","https://openalex.org/W2015360671","https://openalex.org/W2018518196","https://openalex.org/W2018824652","https://openalex.org/W2039274123","https://openalex.org/W2041635849","https://openalex.org/W2043398720","https://openalex.org/W2050086663","https://openalex.org/W2052474826","https://openalex.org/W2055532123","https://openalex.org/W2058957446","https://openalex.org/W2068971862","https://openalex.org/W2070190477","https://openalex.org/W2082202339","https://openalex.org/W2103386635","https://openalex.org/W2106292881","https://openalex.org/W2117486942","https://openalex.org/W2120866811","https://openalex.org/W2122769974","https://openalex.org/W2133102806","https://openalex.org/W2137531873","https://openalex.org/W2137906640","https://openalex.org/W2141674733","https://openalex.org/W2157899948","https://openalex.org/W2158804744","https://openalex.org/W2161363609","https://openalex.org/W2164298117","https://openalex.org/W2171297405","https://openalex.org/W2171972386","https://openalex.org/W2318188375","https://openalex.org/W2318806991","https://openalex.org/W2407075689","https://openalex.org/W2461427403","https://openalex.org/W2489126592","https://openalex.org/W2515153059","https://openalex.org/W6640234127"],"related_works":["https://openalex.org/W2556874318","https://openalex.org/W1557353121","https://openalex.org/W3093199425","https://openalex.org/W2370955888","https://openalex.org/W2983922222","https://openalex.org/W145014062","https://openalex.org/W3113316772","https://openalex.org/W2106723893","https://openalex.org/W2125327283","https://openalex.org/W2142017030"],"abstract_inverted_index":{"Synthetic":[0],"viability,":[1],"which":[2,27,131],"is":[3,179],"defined":[4],"as":[5],"the":[6,14,65,83,116,142,180,186,202,206,216],"combination":[7,219],"of":[8,17,85,188],"gene":[9,20],"alterations":[10],"that":[11,115,162],"can":[12,124],"rescue":[13],"lethal":[15],"effects":[16],"a":[18,24,53],"single":[19],"alteration,":[21,72],"may":[22],"represent":[23],"mechanism":[25],"by":[26,63,95],"cancer":[28,41,93,129,143,196],"cells":[29,122],"resist":[30],"targeted":[31],"drugs.":[32],"Approaches":[33],"to":[34,43,56,121,192,209],"detect":[35,57],"synthetic":[36,58],"viable":[37],"(SV)":[38],"interactions":[39,87,118,190],"in":[40,91,135,195],"genome":[42],"investigate":[44],"drug":[45,60,165,193,211,218],"resistance":[46,61,166,194,212],"are":[47,119],"still":[48],"scarce.":[49],"Here,":[50],"we":[51,159],"present":[52],"computational":[54],"method":[55],"viability-induced":[59],"(SVDR)":[62],"integrating":[64,96,141],"multidimensional":[66],"data":[67,107,138,145],"sets,":[68],"including":[69],"copy":[70],"number":[71],"whole-exome":[73],"mutation,":[74],"expression":[75],"profile":[76],"and":[77,108,123,153,168,213],"clinical":[78,126],"data.":[79,112],"SVDR":[80,163,178],"comprehensively":[81],"characterized":[82],"landscape":[84],"SV":[86,117,189],"across":[88],"8580":[89],"tumors":[90],"32":[92],"types":[94],"The":[97],"Cancer":[98,148,155],"Genome":[99],"Atlas":[100],"data,":[101],"small":[102],"hairpin":[103],"RNA-based":[104],"functional":[105],"experimental":[106],"yeast":[109],"genetic":[110],"interaction":[111],"We":[113],"revealed":[114],"favorable":[120],"predict":[125,210],"prognosis":[127],"for":[128,185,204,220],"patients,":[130],"were":[132],"robustly":[133],"observed":[134],"an":[136],"independent":[137],"set.":[139],"By":[140],"pharmacogenomics":[144],"sets":[146],"from":[147],"Cell":[149],"Line":[150],"Encyclopedia":[151],"(CCLE)":[152],"Broad":[154],"Therapeutics":[156],"Response":[157],"Portal,":[158],"have":[160],"demonstrated":[161],"enables":[164],"prediction":[167],"exhibits":[169],"high":[170],"reliability":[171],"between":[172],"two":[173],"databases.":[174],"To":[175],"our":[176],"knowledge,":[177],"first":[181],"genome-scale":[182],"data-driven":[183,199],"approach":[184,200],"identification":[187],"related":[191],"cells.":[197],"This":[198],"lays":[201],"foundation":[203],"identifying":[205],"genomic":[207],"markers":[208],"successfully":[214],"infers":[215],"potential":[217],"anti-cancer":[221],"therapy.":[222]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":3}],"updated_date":"2026-01-13T01:12:25.745995","created_date":"2025-10-10T00:00:00"}
