{"id":"https://openalex.org/W2508542625","doi":"https://doi.org/10.1093/bib/bbw073","title":"miRNA\u2013miRNA crosstalk: from genomics to phenomics","display_name":"miRNA\u2013miRNA crosstalk: from genomics to phenomics","publication_year":2016,"publication_date":"2016-08-21","ids":{"openalex":"https://openalex.org/W2508542625","doi":"https://doi.org/10.1093/bib/bbw073","mag":"2508542625","pmid":"https://pubmed.ncbi.nlm.nih.gov/27551063"},"language":"en","primary_location":{"id":"doi:10.1093/bib/bbw073","is_oa":false,"landing_page_url":"https://doi.org/10.1093/bib/bbw073","pdf_url":null,"source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},"type":"review","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5076495142","display_name":"Juan Xu","orcid":"https://orcid.org/0000-0002-3709-4165"},"institutions":[{"id":"https://openalex.org/I156144747","display_name":"Harbin Medical University","ror":"https://ror.org/05jscf583","country_code":"CN","type":"education","lineage":["https://openalex.org/I156144747"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Juan Xu","raw_affiliation_strings":["College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, China"],"affiliations":[{"raw_affiliation_string":"College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, China","institution_ids":["https://openalex.org/I156144747"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064912043","display_name":"Tingting Shao","orcid":"https://orcid.org/0000-0002-7033-727X"},"institutions":[{"id":"https://openalex.org/I156144747","display_name":"Harbin Medical University","ror":"https://ror.org/05jscf583","country_code":"CN","type":"education","lineage":["https://openalex.org/I156144747"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Tingting Shao","raw_affiliation_strings":["College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, China"],"affiliations":[{"raw_affiliation_string":"College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, China","institution_ids":["https://openalex.org/I156144747"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071524164","display_name":"Na Ding","orcid":"https://orcid.org/0000-0003-2343-9625"},"institutions":[{"id":"https://openalex.org/I156144747","display_name":"Harbin Medical University","ror":"https://ror.org/05jscf583","country_code":"CN","type":"education","lineage":["https://openalex.org/I156144747"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Na Ding","raw_affiliation_strings":["College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, China"],"affiliations":[{"raw_affiliation_string":"College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, China","institution_ids":["https://openalex.org/I156144747"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100389127","display_name":"Yongsheng Li","orcid":"https://orcid.org/0000-0003-1914-0727"},"institutions":[{"id":"https://openalex.org/I156144747","display_name":"Harbin Medical University","ror":"https://ror.org/05jscf583","country_code":"CN","type":"education","lineage":["https://openalex.org/I156144747"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yongsheng Li","raw_affiliation_strings":["College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, China"],"affiliations":[{"raw_affiliation_string":"College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, China","institution_ids":["https://openalex.org/I156144747"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100445596","display_name":"Xia Li","orcid":"https://orcid.org/0000-0002-9794-2648"},"institutions":[{"id":"https://openalex.org/I156144747","display_name":"Harbin Medical University","ror":"https://ror.org/05jscf583","country_code":"CN","type":"education","lineage":["https://openalex.org/I156144747"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Xia Li","raw_affiliation_strings":["College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, China"],"affiliations":[{"raw_affiliation_string":"College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, China","institution_ids":["https://openalex.org/I156144747"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5100445596"],"corresponding_institution_ids":["https://openalex.org/I156144747"],"apc_list":{"value":4011,"currency":"USD","value_usd":4011},"apc_paid":null,"fwci":1.5175,"has_fulltext":false,"cited_by_count":31,"citation_normalized_percentile":{"value":0.80767148,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":99},"biblio":{"volume":"18","issue":"6","first_page":"bbw073","last_page":"bbw073"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10515","display_name":"Cancer-related molecular mechanisms research","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11482","display_name":"RNA modifications and cancer","score":0.9993000030517578,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/microrna","display_name":"microRNA","score":0.7174577116966248},{"id":"https://openalex.org/keywords/crosstalk","display_name":"Crosstalk","score":0.6668305397033691},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.5919851660728455},{"id":"https://openalex.org/keywords/genomics","display_name":"Genomics","score":0.5365298986434937},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.4738008379936218},{"id":"https://openalex.org/keywords/phenomics","display_name":"Phenomics","score":0.4650145173072815},{"id":"https://openalex.org/keywords/gene-regulatory-network","display_name":"Gene regulatory network","score":0.4518902897834778},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.35589951276779175},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.33242911100387573},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.2426617443561554},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.22934183478355408},{"id":"https://openalex.org/keywords/genome","display_name":"Genome","score":0.2013857066631317},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.16214382648468018}],"concepts":[{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.7174577116966248},{"id":"https://openalex.org/C169822122","wikidata":"https://www.wikidata.org/wiki/Q230187","display_name":"Crosstalk","level":2,"score":0.6668305397033691},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5919851660728455},{"id":"https://openalex.org/C189206191","wikidata":"https://www.wikidata.org/wiki/Q222046","display_name":"Genomics","level":4,"score":0.5365298986434937},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4738008379936218},{"id":"https://openalex.org/C98108635","wikidata":"https://www.wikidata.org/wiki/Q6497275","display_name":"Phenomics","level":5,"score":0.4650145173072815},{"id":"https://openalex.org/C67339327","wikidata":"https://www.wikidata.org/wiki/Q1502576","display_name":"Gene regulatory network","level":4,"score":0.4518902897834778},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.35589951276779175},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.33242911100387573},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2426617443561554},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.22934183478355408},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.2013857066631317},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.16214382648468018},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D059467","descriptor_name":"Transcriptome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D059467","descriptor_name":"Transcriptome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D059467","descriptor_name":"Transcriptome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1093/bib/bbw073","is_oa":false,"landing_page_url":"https://doi.org/10.1093/bib/bbw073","pdf_url":null,"source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},{"id":"pmid:27551063","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27551063","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in bioinformatics","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":73,"referenced_works":["https://openalex.org/W144423133","https://openalex.org/W426664351","https://openalex.org/W863742587","https://openalex.org/W1794859269","https://openalex.org/W1963803603","https://openalex.org/W1972785590","https://openalex.org/W1974254202","https://openalex.org/W1980389572","https://openalex.org/W1980948656","https://openalex.org/W1983737927","https://openalex.org/W1983804343","https://openalex.org/W1988886103","https://openalex.org/W2001475320","https://openalex.org/W2006097492","https://openalex.org/W2008652897","https://openalex.org/W2014946489","https://openalex.org/W2023177020","https://openalex.org/W2023833090","https://openalex.org/W2026356250","https://openalex.org/W2034768496","https://openalex.org/W2038707074","https://openalex.org/W2040191060","https://openalex.org/W2045075564","https://openalex.org/W2047291819","https://openalex.org/W2050869737","https://openalex.org/W2055660539","https://openalex.org/W2062290101","https://openalex.org/W2065750619","https://openalex.org/W2066081464","https://openalex.org/W2074695498","https://openalex.org/W2075329854","https://openalex.org/W2078191220","https://openalex.org/W2079282224","https://openalex.org/W2080291144","https://openalex.org/W2081113032","https://openalex.org/W2082171629","https://openalex.org/W2084168100","https://openalex.org/W2090648161","https://openalex.org/W2092289529","https://openalex.org/W2094276973","https://openalex.org/W2100084025","https://openalex.org/W2110231709","https://openalex.org/W2111471510","https://openalex.org/W2111989422","https://openalex.org/W2111997778","https://openalex.org/W2112785261","https://openalex.org/W2113661251","https://openalex.org/W2113834894","https://openalex.org/W2113974339","https://openalex.org/W2116617206","https://openalex.org/W2122184692","https://openalex.org/W2124666089","https://openalex.org/W2126949412","https://openalex.org/W2131059244","https://openalex.org/W2134975289","https://openalex.org/W2135059404","https://openalex.org/W2137734450","https://openalex.org/W2141222510","https://openalex.org/W2141306411","https://openalex.org/W2143693563","https://openalex.org/W2145361279","https://openalex.org/W2152508639","https://openalex.org/W2155044281","https://openalex.org/W2157658494","https://openalex.org/W2162674813","https://openalex.org/W2164290176","https://openalex.org/W2165764599","https://openalex.org/W2167018551","https://openalex.org/W2167663414","https://openalex.org/W2170647698","https://openalex.org/W2233413639","https://openalex.org/W2258129851","https://openalex.org/W4233310067"],"related_works":["https://openalex.org/W2561772691","https://openalex.org/W3034470721","https://openalex.org/W2006348395","https://openalex.org/W2053510513","https://openalex.org/W1988035834","https://openalex.org/W2052257689","https://openalex.org/W2110436540","https://openalex.org/W1598357174","https://openalex.org/W2744636379","https://openalex.org/W2802662098"],"abstract_inverted_index":{"The":[0],"discovery":[1],"of":[2,11,103,113,115],"microRNA":[3],"(miRNA)-miRNA":[4],"crosstalk":[5,54,114],"has":[6],"greatly":[7],"improved":[8],"our":[9],"understanding":[10],"complex":[12],"gene":[13],"regulatory":[14],"networks":[15,30],"in":[16,58,124],"normal":[17],"and":[18,39,121],"disease-specific":[19],"physiological":[20],"conditions.":[21],"Numerous":[22],"approaches":[23],"have":[24,67],"been":[25,69],"proposed":[26],"for":[27,111],"modeling":[28,85],"miRNA-miRNA":[29,53,74,83,131],"based":[31],"on":[32,96],"genomic":[33],"sequences,":[34],"miRNA-mRNA":[35],"regulation,":[36],"functional":[37],"information":[38],"phenomics":[40],"alone,":[41],"or":[42,61],"by":[43],"integrating":[44],"heterogeneous":[45,101],"data.":[46,105],"In":[47,76],"addition,":[48],"it":[49],"is":[50],"expected":[51],"that":[52],"can":[55],"be":[56],"reprogrammed":[57],"different":[59],"tissues":[60],"specific":[62],"diseases.":[63],"Thus,":[64],"transcriptome":[65],"data":[66],"also":[68],"integrated":[70],"to":[71,91,99],"construct":[72],"context-specific":[73],"networks.":[75],"this":[77,125],"review,":[78],"we":[79,94,107],"summarize":[80],"the":[81,97],"state-of-the-art":[82],"network":[84],"methods,":[86],"which":[87],"range":[88],"from":[89],"genomics":[90],"phenomics,":[92],"where":[93],"focus":[95],"need":[98],"integrate":[100],"types":[102],"omics":[104],"Finally,":[106],"suggest":[108],"future":[109],"directions":[110],"studies":[112],"noncoding":[116],"RNAs.":[117],"This":[118],"comprehensive":[119],"summarization":[120],"discussion":[122],"elucidated":[123],"work":[126],"provide":[127],"constructive":[128],"insights":[129],"into":[130],"crosstalk.":[132]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":8},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":1}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}
