{"id":"https://openalex.org/W2467398568","doi":"https://doi.org/10.1093/bib/bbw050","title":"Estimation of random effects and identifying heterogeneous genes in meta-analysis of gene expression studies","display_name":"Estimation of random effects and identifying heterogeneous genes in meta-analysis of gene expression studies","publication_year":2016,"publication_date":"2016-06-26","ids":{"openalex":"https://openalex.org/W2467398568","doi":"https://doi.org/10.1093/bib/bbw050","mag":"2467398568","pmid":"https://pubmed.ncbi.nlm.nih.gov/27345525"},"language":"en","primary_location":{"id":"doi:10.1093/bib/bbw050","is_oa":false,"landing_page_url":"https://doi.org/10.1093/bib/bbw050","pdf_url":null,"source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},"type":"review","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101891754","display_name":"Umaporn Siangphoe","orcid":"https://orcid.org/0000-0002-0560-6314"},"institutions":[{"id":"https://openalex.org/I184840846","display_name":"Virginia Commonwealth University","ror":"https://ror.org/02nkdxk79","country_code":"US","type":"education","lineage":["https://openalex.org/I184840846"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Umaporn Siangphoe","raw_affiliation_strings":["Department of Biostatistics, Virginia Commonwealth University, One Capitol Square, Seventh Floor, 830 East Main Street, Richmond, Virginia, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biostatistics, Virginia Commonwealth University, One Capitol Square, Seventh Floor, 830 East Main Street, Richmond, Virginia, USA","institution_ids":["https://openalex.org/I184840846"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5070476953","display_name":"Kellie J. Archer","orcid":"https://orcid.org/0000-0003-1555-5781"},"institutions":[{"id":"https://openalex.org/I184840846","display_name":"Virginia Commonwealth University","ror":"https://ror.org/02nkdxk79","country_code":"US","type":"education","lineage":["https://openalex.org/I184840846"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kellie J. Archer","raw_affiliation_strings":["Department of Biostatistics, Virginia Commonwealth University, One Capitol Square, Seventh Floor, 830 East Main Street, Richmond, Virginia, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biostatistics, Virginia Commonwealth University, One Capitol Square, Seventh Floor, 830 East Main Street, Richmond, Virginia, USA","institution_ids":["https://openalex.org/I184840846"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5101891754"],"corresponding_institution_ids":["https://openalex.org/I184840846"],"apc_list":{"value":4011,"currency":"USD","value_usd":4011},"apc_paid":null,"fwci":0.2407,"has_fulltext":false,"cited_by_count":11,"citation_normalized_percentile":{"value":0.54002714,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"18","issue":"4","first_page":"bbw050","last_page":"bbw050"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.9993000030517578,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.9993000030517578,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11468","display_name":"Genetic Mapping and Diversity in Plants and Animals","score":0.9926000237464905,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9796000123023987,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/random-effects-model","display_name":"Random effects model","score":0.7016962766647339},{"id":"https://openalex.org/keywords/meta-analysis","display_name":"Meta-analysis","score":0.6355149745941162},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5806959867477417},{"id":"https://openalex.org/keywords/sample-size-determination","display_name":"Sample size determination","score":0.549565315246582},{"id":"https://openalex.org/keywords/expression","display_name":"Expression (computer science)","score":0.4732035994529724},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.45289909839630127},{"id":"https://openalex.org/keywords/variance","display_name":"Variance (accounting)","score":0.44902053475379944},{"id":"https://openalex.org/keywords/statistical-power","display_name":"Statistical power","score":0.44216644763946533},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.43158113956451416},{"id":"https://openalex.org/keywords/multiple-comparisons-problem","display_name":"Multiple comparisons problem","score":0.42902493476867676},{"id":"https://openalex.org/keywords/microarray-analysis-techniques","display_name":"Microarray analysis techniques","score":0.42712998390197754},{"id":"https://openalex.org/keywords/statistical-hypothesis-testing","display_name":"Statistical hypothesis testing","score":0.41615256667137146},{"id":"https://openalex.org/keywords/statistics","display_name":"Statistics","score":0.31968075037002563},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.2951362729072571},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.2779621481895447},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.260159432888031},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.24603432416915894},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.15250998735427856},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.11561954021453857}],"concepts":[{"id":"https://openalex.org/C168743327","wikidata":"https://www.wikidata.org/wiki/Q1826427","display_name":"Random effects model","level":3,"score":0.7016962766647339},{"id":"https://openalex.org/C95190672","wikidata":"https://www.wikidata.org/wiki/Q815382","display_name":"Meta-analysis","level":2,"score":0.6355149745941162},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5806959867477417},{"id":"https://openalex.org/C129848803","wikidata":"https://www.wikidata.org/wiki/Q2564360","display_name":"Sample size determination","level":2,"score":0.549565315246582},{"id":"https://openalex.org/C90559484","wikidata":"https://www.wikidata.org/wiki/Q778379","display_name":"Expression (computer science)","level":2,"score":0.4732035994529724},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.45289909839630127},{"id":"https://openalex.org/C196083921","wikidata":"https://www.wikidata.org/wiki/Q7915758","display_name":"Variance (accounting)","level":2,"score":0.44902053475379944},{"id":"https://openalex.org/C96608239","wikidata":"https://www.wikidata.org/wiki/Q1199823","display_name":"Statistical power","level":2,"score":0.44216644763946533},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.43158113956451416},{"id":"https://openalex.org/C183905921","wikidata":"https://www.wikidata.org/wiki/Q1038757","display_name":"Multiple comparisons problem","level":2,"score":0.42902493476867676},{"id":"https://openalex.org/C8415881","wikidata":"https://www.wikidata.org/wiki/Q6839217","display_name":"Microarray analysis techniques","level":4,"score":0.42712998390197754},{"id":"https://openalex.org/C87007009","wikidata":"https://www.wikidata.org/wiki/Q210832","display_name":"Statistical hypothesis testing","level":2,"score":0.41615256667137146},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.31968075037002563},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2951362729072571},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.2779621481895447},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.260159432888031},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.24603432416915894},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.15250998735427856},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.11561954021453857},{"id":"https://openalex.org/C144133560","wikidata":"https://www.wikidata.org/wiki/Q4830453","display_name":"Business","level":0,"score":0.0},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.0},{"id":"https://openalex.org/C121955636","wikidata":"https://www.wikidata.org/wiki/Q4116214","display_name":"Accounting","level":1,"score":0.0},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D012107","descriptor_name":"Research Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012107","descriptor_name":"Research Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012107","descriptor_name":"Research Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015201","descriptor_name":"Meta-Analysis as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015201","descriptor_name":"Meta-Analysis as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015201","descriptor_name":"Meta-Analysis as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016678","descriptor_name":"Genome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016678","descriptor_name":"Genome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016678","descriptor_name":"Genome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1093/bib/bbw050","is_oa":false,"landing_page_url":"https://doi.org/10.1093/bib/bbw050","pdf_url":null,"source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},{"id":"pmid:27345525","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27345525","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in bioinformatics","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":75,"referenced_works":["https://openalex.org/W71228264","https://openalex.org/W594141172","https://openalex.org/W602559536","https://openalex.org/W656838156","https://openalex.org/W748577627","https://openalex.org/W1530839606","https://openalex.org/W1533335653","https://openalex.org/W1546952499","https://openalex.org/W1577460570","https://openalex.org/W1587447328","https://openalex.org/W1910607297","https://openalex.org/W1967046314","https://openalex.org/W1968886567","https://openalex.org/W1974573031","https://openalex.org/W1975129554","https://openalex.org/W1978172027","https://openalex.org/W1981768609","https://openalex.org/W1981849943","https://openalex.org/W1988172012","https://openalex.org/W1989688078","https://openalex.org/W1990748933","https://openalex.org/W1998712640","https://openalex.org/W1999362203","https://openalex.org/W2000084758","https://openalex.org/W2000359198","https://openalex.org/W2003862733","https://openalex.org/W2008458159","https://openalex.org/W2009979246","https://openalex.org/W2020541351","https://openalex.org/W2029878633","https://openalex.org/W2030223911","https://openalex.org/W2030582688","https://openalex.org/W2035887798","https://openalex.org/W2048529464","https://openalex.org/W2056613924","https://openalex.org/W2062356051","https://openalex.org/W2081098333","https://openalex.org/W2082786279","https://openalex.org/W2094953050","https://openalex.org/W2100239923","https://openalex.org/W2103365735","https://openalex.org/W2107328434","https://openalex.org/W2109553965","https://openalex.org/W2110065044","https://openalex.org/W2114729479","https://openalex.org/W2116455948","https://openalex.org/W2116634113","https://openalex.org/W2118258530","https://openalex.org/W2126257259","https://openalex.org/W2128361433","https://openalex.org/W2128640268","https://openalex.org/W2131093545","https://openalex.org/W2137526110","https://openalex.org/W2139168999","https://openalex.org/W2140141449","https://openalex.org/W2144426506","https://openalex.org/W2145816995","https://openalex.org/W2146026944","https://openalex.org/W2151975241","https://openalex.org/W2152155643","https://openalex.org/W2154449833","https://openalex.org/W2154981570","https://openalex.org/W2158198121","https://openalex.org/W2158262405","https://openalex.org/W2158698691","https://openalex.org/W2160697532","https://openalex.org/W2161498177","https://openalex.org/W2211558999","https://openalex.org/W2315123323","https://openalex.org/W3102660612","https://openalex.org/W3104583603","https://openalex.org/W4245935093","https://openalex.org/W4297918764","https://openalex.org/W4388319941","https://openalex.org/W6678779088"],"related_works":["https://openalex.org/W3003558595","https://openalex.org/W2035798565","https://openalex.org/W1986765826","https://openalex.org/W2316908264","https://openalex.org/W2115979595","https://openalex.org/W1976797354","https://openalex.org/W2088387197","https://openalex.org/W2113330311","https://openalex.org/W2585981346","https://openalex.org/W154531455"],"abstract_inverted_index":{"Combining":[0],"effect":[1,35],"sizes":[2,36],"from":[3,24],"individual":[4],"studies":[5],"using":[6],"random-effects":[7,105],"meta-analysis":[8,53],"models":[9,107],"are":[10],"commonly":[11],"applied":[12],"in":[13,26,67,93,104,130,145],"high-dimensional":[14],"gene":[15,116,147],"expression":[16,117,148],"data.":[17,118,149],"However,":[18],"unknown":[19],"study":[20],"heterogeneity":[21,33],"can":[22,37],"arise":[23],"inconsistencies":[25],"sample":[27],"quality":[28],"and":[29,57,77,89,108,126,143],"experimental":[30],"conditions.":[31],"High":[32],"of":[34,41,54,84,86,141],"reduce":[38],"statistical":[39],"power":[40],"the":[42,68,101,124,131],"models.":[43],"In":[44],"this":[45],"study,":[46],"we":[47],"describe":[48,90],"three":[49],"hypothesis-testing":[50],"frameworks":[51],"for":[52,99,111,115],"microarray":[55],"data,":[56],"review":[58],"several":[59],"existing":[60,127],"meta-analytic":[61,106,128],"techniques":[62,129],"that":[63],"have":[64],"been":[65],"used":[66],"genomic":[69,132],"setting.":[70],"These":[71],"include":[72],"P-value-based":[73],"methods,":[74],"rank-based":[75],"methods":[76,88,92,98,122],"effect-size-based":[78],"methods.":[79],"We":[80,95,119,134],"then":[81],"discuss":[82],"limitations":[83],"some":[85],"these":[87],"random-effects-based":[91],"detail.":[94],"introduce":[96],"two":[97],"estimating":[100],"inter-study":[102],"variance":[103],"another":[109],"method":[110],"identifying":[112],"heterogeneous":[113],"genes":[114],"compared":[120],"various":[121],"with":[123],"standard":[125],"framework.":[133],"demonstrate":[135],"our":[136],"results":[137],"through":[138],"a":[139],"series":[140],"simulations":[142],"application":[144],"Alzheimer's":[146]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1}],"updated_date":"2026-07-14T23:27:15.235271","created_date":"2025-10-10T00:00:00"}
