{"id":"https://openalex.org/W2218713587","doi":"https://doi.org/10.1093/bib/bbv089","title":"Statistical methods for detecting differentially methylated regions based on MethylCap-seq data","display_name":"Statistical methods for detecting differentially methylated regions based on MethylCap-seq data","publication_year":2015,"publication_date":"2015-10-09","ids":{"openalex":"https://openalex.org/W2218713587","doi":"https://doi.org/10.1093/bib/bbv089","mag":"2218713587","pmid":"https://pubmed.ncbi.nlm.nih.gov/26454095"},"language":"en","primary_location":{"id":"doi:10.1093/bib/bbv089","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbv089","pdf_url":"https://academic.oup.com/bib/article-pdf/17/6/926/8280081/bbv089.pdf","source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://academic.oup.com/bib/article-pdf/17/6/926/8280081/bbv089.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5053189585","display_name":"Deepak Nag Ayyala","orcid":"https://orcid.org/0000-0002-7251-580X"},"institutions":[{"id":"https://openalex.org/I2802841970","display_name":"The Ohio State University Wexner Medical Center","ror":"https://ror.org/00c01js51","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2802841970"]},{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Deepak N. Ayyala","raw_affiliation_strings":["Department of Statistics, The Ohio State University, 1958 Neil Avenue, Columbus, OH 43210-1247, USA","The Ohio State University Wexner Medical Center","Department of Statistics, The Ohio State University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Statistics, The Ohio State University, 1958 Neil Avenue, Columbus, OH 43210-1247, USA","institution_ids":["https://openalex.org/I52357470"]},{"raw_affiliation_string":"The Ohio State University Wexner Medical Center","institution_ids":["https://openalex.org/I2802841970"]},{"raw_affiliation_string":"Department of Statistics, The Ohio State University","institution_ids":["https://openalex.org/I52357470"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038323128","display_name":"David Frankhouser","orcid":"https://orcid.org/0000-0002-8233-5853"},"institutions":[{"id":"https://openalex.org/I2802841970","display_name":"The Ohio State University Wexner Medical Center","ror":"https://ror.org/00c01js51","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2802841970"]},{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David E. Frankhouser","raw_affiliation_strings":["The Ohio State University Wexner Medical Center","Department of Statistics, The Ohio State University, 1958 Neil Avenue, Columbus, OH 43210-1247, USA","Department of Statistics, The Ohio State University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Ohio State University Wexner Medical Center","institution_ids":["https://openalex.org/I2802841970"]},{"raw_affiliation_string":"Department of Statistics, The Ohio State University, 1958 Neil Avenue, Columbus, OH 43210-1247, USA","institution_ids":["https://openalex.org/I52357470"]},{"raw_affiliation_string":"Department of Statistics, The Ohio State University","institution_ids":["https://openalex.org/I52357470"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082152676","display_name":"Javkhlan-Ochir Ganbat","orcid":null},"institutions":[{"id":"https://openalex.org/I2802841970","display_name":"The Ohio State University Wexner Medical Center","ror":"https://ror.org/00c01js51","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2802841970"]},{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Javkhlan-Ochir Ganbat","raw_affiliation_strings":["Department of Statistics, The Ohio State University","Department of Statistics, The Ohio State University, 1958 Neil Avenue, Columbus, OH 43210-1247, USA","The Ohio State University Wexner Medical Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Statistics, The Ohio State University","institution_ids":["https://openalex.org/I52357470"]},{"raw_affiliation_string":"Department of Statistics, The Ohio State University, 1958 Neil Avenue, Columbus, OH 43210-1247, USA","institution_ids":["https://openalex.org/I52357470"]},{"raw_affiliation_string":"The Ohio State University Wexner Medical Center","institution_ids":["https://openalex.org/I2802841970"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060959458","display_name":"Guido Marcucci","orcid":"https://orcid.org/0000-0002-3983-5908"},"institutions":[{"id":"https://openalex.org/I2802841970","display_name":"The Ohio State University Wexner Medical Center","ror":"https://ror.org/00c01js51","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2802841970"]},{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Guido Marcucci","raw_affiliation_strings":["The Ohio State University Wexner Medical Center","Department of Statistics, The Ohio State University, 1958 Neil Avenue, Columbus, OH 43210-1247, USA","Department of Statistics, The Ohio State University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Ohio State University Wexner Medical Center","institution_ids":["https://openalex.org/I2802841970"]},{"raw_affiliation_string":"Department of Statistics, The Ohio State University, 1958 Neil Avenue, Columbus, OH 43210-1247, USA","institution_ids":["https://openalex.org/I52357470"]},{"raw_affiliation_string":"Department of Statistics, The Ohio State University","institution_ids":["https://openalex.org/I52357470"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044969846","display_name":"Ralf Bundschuh","orcid":"https://orcid.org/0000-0002-6699-8614"},"institutions":[{"id":"https://openalex.org/I2802841970","display_name":"The Ohio State University Wexner Medical Center","ror":"https://ror.org/00c01js51","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2802841970"]},{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ralf Bundschuh","raw_affiliation_strings":["Department of Statistics, The Ohio State University, 1958 Neil Avenue, Columbus, OH 43210-1247, USA","Department of Statistics, The Ohio State University","The Ohio State University Wexner Medical Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Statistics, The Ohio State University, 1958 Neil Avenue, Columbus, OH 43210-1247, USA","institution_ids":["https://openalex.org/I52357470"]},{"raw_affiliation_string":"Department of Statistics, The Ohio State University","institution_ids":["https://openalex.org/I52357470"]},{"raw_affiliation_string":"The Ohio State University Wexner Medical Center","institution_ids":["https://openalex.org/I2802841970"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019710145","display_name":"Pearlly S. Yan","orcid":"https://orcid.org/0000-0003-1965-4920"},"institutions":[{"id":"https://openalex.org/I2802841970","display_name":"The Ohio State University Wexner Medical Center","ror":"https://ror.org/00c01js51","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2802841970"]},{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Pearlly Yan","raw_affiliation_strings":["Department of Statistics, The Ohio State University","The Ohio State University Wexner Medical Center","Department of Statistics, The Ohio State University, 1958 Neil Avenue, Columbus, OH 43210-1247, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Statistics, The Ohio State University","institution_ids":["https://openalex.org/I52357470"]},{"raw_affiliation_string":"The Ohio State University Wexner Medical Center","institution_ids":["https://openalex.org/I2802841970"]},{"raw_affiliation_string":"Department of Statistics, The Ohio State University, 1958 Neil Avenue, Columbus, OH 43210-1247, USA","institution_ids":["https://openalex.org/I52357470"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5091196188","display_name":"Shili Lin","orcid":"https://orcid.org/0000-0003-2467-4491"},"institutions":[{"id":"https://openalex.org/I2802841970","display_name":"The Ohio State University Wexner Medical Center","ror":"https://ror.org/00c01js51","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2802841970"]},{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shili Lin","raw_affiliation_strings":["The Ohio State University Wexner Medical Center","Department of Statistics, The Ohio State University","Department of Statistics, The Ohio State University, 1958 Neil Avenue, Columbus, OH 43210-1247, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Ohio State University Wexner Medical Center","institution_ids":["https://openalex.org/I2802841970"]},{"raw_affiliation_string":"Department of Statistics, The Ohio State University","institution_ids":["https://openalex.org/I52357470"]},{"raw_affiliation_string":"Department of Statistics, The Ohio State University, 1958 Neil Avenue, Columbus, OH 43210-1247, USA","institution_ids":["https://openalex.org/I52357470"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4011,"currency":"USD","value_usd":4011},"apc_paid":null,"fwci":0.8263,"has_fulltext":true,"cited_by_count":15,"citation_normalized_percentile":{"value":0.72863087,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"17","issue":"6","first_page":"926","last_page":"937"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.9965000152587891,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11482","display_name":"RNA modifications and cancer","score":0.9919999837875366,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/differentially-methylated-regions","display_name":"Differentially methylated regions","score":0.7802585959434509},{"id":"https://openalex.org/keywords/dna-methylation","display_name":"DNA methylation","score":0.626785397529602},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.5942445397377014},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.5410827994346619},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.43946918845176697},{"id":"https://openalex.org/keywords/cpg-site","display_name":"CpG site","score":0.4377235174179077},{"id":"https://openalex.org/keywords/epigenetics","display_name":"Epigenetics","score":0.42704853415489197},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.3635323643684387},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.30716317892074585},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.15791535377502441}],"concepts":[{"id":"https://openalex.org/C154253233","wikidata":"https://www.wikidata.org/wiki/Q14862240","display_name":"Differentially methylated regions","level":5,"score":0.7802585959434509},{"id":"https://openalex.org/C190727270","wikidata":"https://www.wikidata.org/wiki/Q874745","display_name":"DNA methylation","level":4,"score":0.626785397529602},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5942445397377014},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5410827994346619},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.43946918845176697},{"id":"https://openalex.org/C140173407","wikidata":"https://www.wikidata.org/wiki/Q1138358","display_name":"CpG site","level":5,"score":0.4377235174179077},{"id":"https://openalex.org/C41091548","wikidata":"https://www.wikidata.org/wiki/Q26939","display_name":"Epigenetics","level":3,"score":0.42704853415489197},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3635323643684387},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.30716317892074585},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.15791535377502441}],"mesh":[{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011401","descriptor_name":"Promoter Regions, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011401","descriptor_name":"Promoter Regions, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011401","descriptor_name":"Promoter Regions, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015470","descriptor_name":"Leukemia, Myeloid, Acute","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015470","descriptor_name":"Leukemia, Myeloid, Acute","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015470","descriptor_name":"Leukemia, Myeloid, Acute","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018899","descriptor_name":"CpG Islands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018899","descriptor_name":"CpG Islands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018899","descriptor_name":"CpG Islands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019175","descriptor_name":"DNA Methylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019175","descriptor_name":"DNA Methylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019175","descriptor_name":"DNA Methylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D057890","descriptor_name":"Epigenomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057890","descriptor_name":"Epigenomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057890","descriptor_name":"Epigenomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1093/bib/bbv089","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbv089","pdf_url":"https://academic.oup.com/bib/article-pdf/17/6/926/8280081/bbv089.pdf","source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},{"id":"pmid:26454095","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26454095","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in bioinformatics","raw_type":null},{"id":"pmh:oai:open-archive.highwire.org:bib:17/6/926","is_oa":false,"landing_page_url":"http://bib.oxfordjournals.org/cgi/content/short/17/6/926","pdf_url":null,"source":{"id":"https://openalex.org/S4406923041","display_name":"HighWire Press Open Archive","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"TEXT"},{"id":"pmh:oai:pubmedcentral.nih.gov:5142008","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5142008","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Brief Bioinform","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1093/bib/bbv089","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbv089","pdf_url":"https://academic.oup.com/bib/article-pdf/17/6/926/8280081/bbv089.pdf","source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/14","display_name":"Life below water","score":0.6399999856948853}],"awards":[{"id":"https://openalex.org/G1964313893","display_name":"Collaborative Research: ATD: Statistical and Computational Methods for the Analysis of Metagenomic Count Data","funder_award_id":"1220772","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G2410345525","display_name":null,"funder_award_id":"DMS-1220772","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G5641734660","display_name":null,"funder_award_id":"T32 GM068412","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2218713587.pdf","grobid_xml":"https://content.openalex.org/works/W2218713587.grobid-xml"},"referenced_works_count":23,"referenced_works":["https://openalex.org/W1965019479","https://openalex.org/W1978351838","https://openalex.org/W1979273476","https://openalex.org/W1981898318","https://openalex.org/W2011196554","https://openalex.org/W2029671524","https://openalex.org/W2036282108","https://openalex.org/W2038926354","https://openalex.org/W2055551894","https://openalex.org/W2059099579","https://openalex.org/W2072202929","https://openalex.org/W2077248943","https://openalex.org/W2081874429","https://openalex.org/W2101259235","https://openalex.org/W2106340111","https://openalex.org/W2117675660","https://openalex.org/W2123174009","https://openalex.org/W2126434569","https://openalex.org/W2136629470","https://openalex.org/W2150936392","https://openalex.org/W2155461556","https://openalex.org/W2156165856","https://openalex.org/W2163518607"],"related_works":["https://openalex.org/W2214376880","https://openalex.org/W3212149434","https://openalex.org/W2073893804","https://openalex.org/W2291484187","https://openalex.org/W4233664389","https://openalex.org/W2921336251","https://openalex.org/W2054523001","https://openalex.org/W2046384469","https://openalex.org/W2127540087","https://openalex.org/W4286742095"],"abstract_inverted_index":{"DNA":[0],"methylation":[1,35,49],"is":[2],"a":[3,23,26],"well-established":[4],"epigenetic":[5],"mark,":[6],"whose":[7],"pattern":[8],"throughout":[9],"the":[10,14,112,128,135],"genome,":[11],"especially":[12],"in":[13,22,57,60,141],"promoter":[15],"or":[16],"CpG":[17],"islands,":[18],"may":[19],"be":[20],"modified":[21],"cell":[24],"at":[25,37],"disease":[27],"stage.":[28],"Recently":[29],"developed":[30],"probabilistic":[31],"approaches":[32],"allow":[33],"distributing":[34],"signals":[36,67],"nucleotide":[38],"resolution":[39],"from":[40,51],"MethylCap-seq":[41],"data.":[42],"Standard":[43],"statistical":[44],"methods":[45,101],"for":[46,86,102,151],"detecting":[47,103,142],"differential":[48],"suffer":[50],"'curse":[52],"of":[53,66,81,88,114,137],"dimensionality'":[54],"and":[55,93,95,155],"sparsity":[56],"signals,":[58],"resulting":[59],"high":[61],"false-positive":[62],"rates.":[63],"Strong":[64],"correlation":[65],"between":[68],"CG":[69],"sites":[70],"also":[71],"yields":[72],"spurious":[73],"results.":[74],"In":[75],"this":[76],"article,":[77],"we":[78,124],"review":[79],"applicability":[80],"high-dimensional":[82],"mean":[83,138],"vector":[84,139],"tests":[85,98,116,140],"detection":[87],"differentially":[89],"methylated":[90],"regions":[91],"(DMRs)":[92],"compare":[94],"contrast":[96],"such":[97],"with":[99],"other":[100],"DMRs.":[104],"Comprehensive":[105],"simulation":[106],"studies":[107],"are":[108,148],"conducted":[109],"to":[110,131],"highlight":[111],"performance":[113],"these":[115],"under":[117],"different":[118],"settings.":[119],"Based":[120],"on":[121,127],"our":[122],"observation,":[123],"make":[125],"recommendations":[126],"optimal":[129],"test":[130],"use.":[132],"We":[133],"illustrate":[134],"superiority":[136],"cancer-related":[143],"canonical":[144],"gene":[145],"pathways,":[146],"which":[147],"significantly":[149],"enriched":[150],"acute":[152],"myeloid":[153],"leukemia":[154],"ovarian":[156],"cancer.":[157]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":3}],"updated_date":"2026-07-15T18:14:33.161393","created_date":"2025-10-10T00:00:00"}