{"id":"https://openalex.org/W1880949099","doi":"https://doi.org/10.1093/bib/bbv068","title":"Advances in computational approaches for prioritizing driver mutations and significantly mutated genes in cancer genomes","display_name":"Advances in computational approaches for prioritizing driver mutations and significantly mutated genes in cancer genomes","publication_year":2015,"publication_date":"2015-08-24","ids":{"openalex":"https://openalex.org/W1880949099","doi":"https://doi.org/10.1093/bib/bbv068","mag":"1880949099","pmid":"https://pubmed.ncbi.nlm.nih.gov/26307061"},"language":"en","primary_location":{"id":"doi:10.1093/bib/bbv068","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbv068","pdf_url":"https://academic.oup.com/bib/article-pdf/17/4/642/6685954/bbv068.pdf","source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://academic.oup.com/bib/article-pdf/17/4/642/6685954/bbv068.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5021122269","display_name":"Feixiong Cheng","orcid":"https://orcid.org/0000-0002-1736-2847"},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]},{"id":"https://openalex.org/I4210089577","display_name":"Gender Studies","ror":"https://ror.org/00at2pp81","country_code":"CZ","type":"nonprofit","lineage":["https://openalex.org/I4210089577"]}],"countries":["CZ","US"],"is_corresponding":false,"raw_author_name":"Feixiong Cheng","raw_affiliation_strings":["Feixiong Cheng is a postdoctoral researcher in Dr. Zhongming Zhao\u2019s group at Vanderbilt University, USA, working mostly on next-generation sequencing data for precision cancer medicine and network-based pharmacogenomics studies","Department of Biomedical Informatics, Vanderbilt University School of Medicine, 2525 West End Avenue, Suite 600, Nashville, TN 37203, USA","Professor of Cancer Research at Vanderbilt University","Vanderbilt University, USA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Feixiong Cheng is a postdoctoral researcher in Dr. Zhongming Zhao\u2019s group at Vanderbilt University, USA, working mostly on next-generation sequencing data for precision cancer medicine and network-based pharmacogenomics studies","institution_ids":["https://openalex.org/I4210089577"]},{"raw_affiliation_string":"Department of Biomedical Informatics, Vanderbilt University School of Medicine, 2525 West End Avenue, Suite 600, Nashville, TN 37203, USA","institution_ids":["https://openalex.org/I200719446"]},{"raw_affiliation_string":"Professor of Cancer Research at Vanderbilt University","institution_ids":["https://openalex.org/I200719446"]},{"raw_affiliation_string":"Vanderbilt University, USA,","institution_ids":["https://openalex.org/I200719446"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023153659","display_name":"Junfei Zhao","orcid":"https://orcid.org/0000-0002-4569-9797"},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]},{"id":"https://openalex.org/I4210089577","display_name":"Gender Studies","ror":"https://ror.org/00at2pp81","country_code":"CZ","type":"nonprofit","lineage":["https://openalex.org/I4210089577"]}],"countries":["CZ","US"],"is_corresponding":false,"raw_author_name":"Junfei Zhao","raw_affiliation_strings":["Junfei Zhao is a postdoctoral researcher in Dr. Zhongming Zhao\u2019s group at Vanderbilt University, USA, developing statistical methods and computational approaches for identifying cancer mutations and genes from next-generation sequencing data in cancer genomes","Department of Biomedical Informatics, Vanderbilt University School of Medicine, 2525 West End Avenue, Suite 600, Nashville, TN 37203, USA","Professor of Cancer Research at Vanderbilt University","Vanderbilt University, USA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Junfei Zhao is a postdoctoral researcher in Dr. Zhongming Zhao\u2019s group at Vanderbilt University, USA, developing statistical methods and computational approaches for identifying cancer mutations and genes from next-generation sequencing data in cancer genomes","institution_ids":["https://openalex.org/I4210089577"]},{"raw_affiliation_string":"Department of Biomedical Informatics, Vanderbilt University School of Medicine, 2525 West End Avenue, Suite 600, Nashville, TN 37203, USA","institution_ids":["https://openalex.org/I200719446"]},{"raw_affiliation_string":"Professor of Cancer Research at Vanderbilt University","institution_ids":["https://openalex.org/I200719446"]},{"raw_affiliation_string":"Vanderbilt University, USA,","institution_ids":["https://openalex.org/I200719446"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5006688612","display_name":"Zhongming Zhao","orcid":"https://orcid.org/0000-0002-3477-0914"},"institutions":[{"id":"https://openalex.org/I196764719","display_name":"Breast Cancer Research Foundation","ror":"https://ror.org/0348ff195","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I196764719"]},{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Zhongming Zhao","raw_affiliation_strings":["Zhongming Zhao is Ingram Professor of Cancer Research at Vanderbilt University and the Chief Bioinformatics Officer at Vanderbilt-Ingram Cancer Center. His recent research activity focuses on precision cancer medicine, especially identifying actionable mutations and driver genes from cancer genomes","Department of Biomedical Informatics, Vanderbilt University School of Medicine, 2525 West End Avenue, Suite 600, Nashville, TN 37203, USA","Professor of Cancer Research at Vanderbilt University","Vanderbilt University, USA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Zhongming Zhao is Ingram Professor of Cancer Research at Vanderbilt University and the Chief Bioinformatics Officer at Vanderbilt-Ingram Cancer Center. His recent research activity focuses on precision cancer medicine, especially identifying actionable mutations and driver genes from cancer genomes","institution_ids":["https://openalex.org/I196764719"]},{"raw_affiliation_string":"Department of Biomedical Informatics, Vanderbilt University School of Medicine, 2525 West End Avenue, Suite 600, Nashville, TN 37203, USA","institution_ids":["https://openalex.org/I200719446"]},{"raw_affiliation_string":"Professor of Cancer Research at Vanderbilt University","institution_ids":["https://openalex.org/I200719446"]},{"raw_affiliation_string":"Vanderbilt University, USA,","institution_ids":["https://openalex.org/I200719446"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5006688612"],"corresponding_institution_ids":["https://openalex.org/I196764719","https://openalex.org/I200719446"],"apc_list":{"value":3885,"currency":"USD","value_usd":3885},"apc_paid":null,"fwci":4.107,"has_fulltext":true,"cited_by_count":161,"citation_normalized_percentile":{"value":0.95196785,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":100},"biblio":{"volume":"17","issue":"4","first_page":"642","last_page":"656"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11642","display_name":"Genomics and Rare Diseases","score":0.9976999759674072,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10015","display_name":"Genomics and Phylogenetic Studies","score":0.9922000169754028,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.6165004968643188},{"id":"https://openalex.org/keywords/genome","display_name":"Genome","score":0.6048425436019897},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.5927289724349976},{"id":"https://openalex.org/keywords/exome","display_name":"Exome","score":0.5896012187004089},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.5367423892021179},{"id":"https://openalex.org/keywords/somatic-cell","display_name":"Somatic cell","score":0.5293999910354614},{"id":"https://openalex.org/keywords/cancer","display_name":"Cancer","score":0.5182895064353943},{"id":"https://openalex.org/keywords/exome-sequencing","display_name":"Exome sequencing","score":0.5162262916564941},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.5024697780609131},{"id":"https://openalex.org/keywords/mutation","display_name":"Mutation","score":0.488357275724411},{"id":"https://openalex.org/keywords/genomics","display_name":"Genomics","score":0.46398285031318665},{"id":"https://openalex.org/keywords/transcriptome","display_name":"Transcriptome","score":0.4474859833717346},{"id":"https://openalex.org/keywords/copy-number-variation","display_name":"Copy-number variation","score":0.44427138566970825},{"id":"https://openalex.org/keywords/dna-sequencing","display_name":"DNA sequencing","score":0.4338851869106293},{"id":"https://openalex.org/keywords/cancer-genome-sequencing","display_name":"Cancer genome sequencing","score":0.41861987113952637}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6165004968643188},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.6048425436019897},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5927289724349976},{"id":"https://openalex.org/C10590036","wikidata":"https://www.wikidata.org/wiki/Q417664","display_name":"Exome","level":5,"score":0.5896012187004089},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5367423892021179},{"id":"https://openalex.org/C134305767","wikidata":"https://www.wikidata.org/wiki/Q725508","display_name":"Somatic cell","level":3,"score":0.5293999910354614},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5182895064353943},{"id":"https://openalex.org/C16671776","wikidata":"https://www.wikidata.org/wiki/Q5420592","display_name":"Exome sequencing","level":4,"score":0.5162262916564941},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.5024697780609131},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.488357275724411},{"id":"https://openalex.org/C189206191","wikidata":"https://www.wikidata.org/wiki/Q222046","display_name":"Genomics","level":4,"score":0.46398285031318665},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.4474859833717346},{"id":"https://openalex.org/C120821319","wikidata":"https://www.wikidata.org/wiki/Q1501491","display_name":"Copy-number variation","level":4,"score":0.44427138566970825},{"id":"https://openalex.org/C51679486","wikidata":"https://www.wikidata.org/wiki/Q380546","display_name":"DNA sequencing","level":3,"score":0.4338851869106293},{"id":"https://openalex.org/C205270622","wikidata":"https://www.wikidata.org/wiki/Q17082639","display_name":"Cancer genome sequencing","level":5,"score":0.41861987113952637},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059014","descriptor_name":"High-Throughput Nucleotide Sequencing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059014","descriptor_name":"High-Throughput Nucleotide Sequencing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059014","descriptor_name":"High-Throughput Nucleotide Sequencing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059472","descriptor_name":"Exome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059472","descriptor_name":"Exome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059472","descriptor_name":"Exome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1093/bib/bbv068","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbv068","pdf_url":"https://academic.oup.com/bib/article-pdf/17/4/642/6685954/bbv068.pdf","source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},{"id":"pmid:26307061","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26307061","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in bioinformatics","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4945827","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4945827","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Brief Bioinform","raw_type":"Text"},{"id":"pmh:oai:open-archive.highwire.org:bib:17/4/642","is_oa":false,"landing_page_url":"http://bib.oxfordjournals.org/cgi/content/short/17/4/642","pdf_url":null,"source":{"id":"https://openalex.org/S4406923041","display_name":"HighWire Press Open Archive","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"TEXT"}],"best_oa_location":{"id":"doi:10.1093/bib/bbv068","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbv068","pdf_url":"https://academic.oup.com/bib/article-pdf/17/4/642/6685954/bbv068.pdf","source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.46000000834465027,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"awards":[{"id":"https://openalex.org/G1417463056","display_name":"Targeting antigen presentation to improve immunotherapy responses in breast cancer","funder_award_id":"3p50ca098131-21s1","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G2947732366","display_name":"Mapping the Genetic Architecture of Complex Disease via RNA-seq and GWAS Data","funder_award_id":"5r01lm011177-03","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G426684539","display_name":"Genome Editing Shared Resource","funder_award_id":"5p30ca068485-27","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G4841106333","display_name":"SPORE in GI Cancer","funder_award_id":"6p50ca095103-15","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G725763919","display_name":null,"funder_award_id":"P30 CA 068485","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G771694649","display_name":null,"funder_award_id":"R01 LM011177","funder_id":"https://openalex.org/F4320337372","funder_display_name":"U.S. National Library of Medicine"},{"id":"https://openalex.org/G996870926","display_name":null,"funder_award_id":"P50CA095103","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320313505","display_name":"Robert J. Kleberg, Jr. and Helen C. Kleberg Foundation","ror":"https://ror.org/05r5zfp34"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337372","display_name":"U.S. National Library of Medicine","ror":"https://ror.org/0060t0j89"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1880949099.pdf","grobid_xml":"https://content.openalex.org/works/W1880949099.grobid-xml"},"referenced_works_count":159,"referenced_works":["https://openalex.org/W1525676863","https://openalex.org/W1533942137","https://openalex.org/W1565378970","https://openalex.org/W1943756471","https://openalex.org/W1965379872","https://openalex.org/W1965856472","https://openalex.org/W1966331733","https://openalex.org/W1967220865","https://openalex.org/W1967940883","https://openalex.org/W1968667083","https://openalex.org/W1973489592","https://openalex.org/W1976196984","https://openalex.org/W1976815080","https://openalex.org/W1980740976","https://openalex.org/W1982564236","https://openalex.org/W1983466841","https://openalex.org/W1984675437","https://openalex.org/W1987507232","https://openalex.org/W1987605205","https://openalex.org/W1989277387","https://openalex.org/W1990139627","https://openalex.org/W1993482839","https://openalex.org/W1993591356","https://openalex.org/W1995837988","https://openalex.org/W2003516452","https://openalex.org/W2009720434","https://openalex.org/W2012673284","https://openalex.org/W2015845481","https://openalex.org/W2018838463","https://openalex.org/W2019925980","https://openalex.org/W2022714591","https://openalex.org/W2025884426","https://openalex.org/W2027667376","https://openalex.org/W2028433016","https://openalex.org/W2031616673","https://openalex.org/W2031942960","https://openalex.org/W2032518018","https://openalex.org/W2033430197","https://openalex.org/W2033546354","https://openalex.org/W2033751993","https://openalex.org/W2036325840","https://openalex.org/W2039877945","https://openalex.org/W2040676413","https://openalex.org/W2042210471","https://openalex.org/W2042386784","https://openalex.org/W2044433401","https://openalex.org/W2048500586","https://openalex.org/W2049141611","https://openalex.org/W2049553585","https://openalex.org/W2056086199","https://openalex.org/W2056782561","https://openalex.org/W2059069581","https://openalex.org/W2059145105","https://openalex.org/W2060427373","https://openalex.org/W2062263714","https://openalex.org/W2062375641","https://openalex.org/W2063384194","https://openalex.org/W2064990035","https://openalex.org/W2066104717","https://openalex.org/W2072572998","https://openalex.org/W2075661710","https://openalex.org/W2076154138","https://openalex.org/W2076357933","https://openalex.org/W2077098920","https://openalex.org/W2079018735","https://openalex.org/W2081375228","https://openalex.org/W2081781433","https://openalex.org/W2082020673","https://openalex.org/W2085963386","https://openalex.org/W2088891952","https://openalex.org/W2089335658","https://openalex.org/W2089350319","https://openalex.org/W2092180333","https://openalex.org/W2095319945","https://openalex.org/W2095867585","https://openalex.org/W2095926488","https://openalex.org/W2096460732","https://openalex.org/W2096766502","https://openalex.org/W2099382478","https://openalex.org/W2100714130","https://openalex.org/W2101924219","https://openalex.org/W2104885590","https://openalex.org/W2105924489","https://openalex.org/W2107680358","https://openalex.org/W2107782176","https://openalex.org/W2111326065","https://openalex.org/W2114031931","https://openalex.org/W2114843025","https://openalex.org/W2117098110","https://openalex.org/W2117307067","https://openalex.org/W2118037512","https://openalex.org/W2118151336","https://openalex.org/W2119097398","https://openalex.org/W2119109240","https://openalex.org/W2119180969","https://openalex.org/W2120227082","https://openalex.org/W2121906867","https://openalex.org/W2122863289","https://openalex.org/W2124465358","https://openalex.org/W2124789022","https://openalex.org/W2126450377","https://openalex.org/W2127230663","https://openalex.org/W2127611185","https://openalex.org/W2127862779","https://openalex.org/W2128327828","https://openalex.org/W2129148650","https://openalex.org/W2129973040","https://openalex.org/W2130430382","https://openalex.org/W2130479394","https://openalex.org/W2131256900","https://openalex.org/W2131848047","https://openalex.org/W2132623845","https://openalex.org/W2134508297","https://openalex.org/W2136410424","https://openalex.org/W2137886330","https://openalex.org/W2138601221","https://openalex.org/W2139227366","https://openalex.org/W2139648620","https://openalex.org/W2139994096","https://openalex.org/W2140349867","https://openalex.org/W2140575188","https://openalex.org/W2141014201","https://openalex.org/W2141663748","https://openalex.org/W2141783822","https://openalex.org/W2145702571","https://openalex.org/W2146973661","https://openalex.org/W2149082178","https://openalex.org/W2150575159","https://openalex.org/W2151684398","https://openalex.org/W2152176732","https://openalex.org/W2152416668","https://openalex.org/W2153010521","https://openalex.org/W2155320075","https://openalex.org/W2157123927","https://openalex.org/W2157658519","https://openalex.org/W2158394019","https://openalex.org/W2158485828","https://openalex.org/W2158529347","https://openalex.org/W2159522138","https://openalex.org/W2159987716","https://openalex.org/W2161162779","https://openalex.org/W2162116127","https://openalex.org/W2162212014","https://openalex.org/W2164298117","https://openalex.org/W2165253681","https://openalex.org/W2165460636","https://openalex.org/W2166884712","https://openalex.org/W2167031279","https://openalex.org/W2168708357","https://openalex.org/W2171777347","https://openalex.org/W2195653324","https://openalex.org/W2259938310","https://openalex.org/W2485087331","https://openalex.org/W2560367415","https://openalex.org/W2885727518","https://openalex.org/W3098528364","https://openalex.org/W4230962320","https://openalex.org/W4237335579","https://openalex.org/W6722840805"],"related_works":["https://openalex.org/W782086276","https://openalex.org/W3024198590","https://openalex.org/W1995063759","https://openalex.org/W2149387942","https://openalex.org/W2104595023","https://openalex.org/W1992112438","https://openalex.org/W2907425113","https://openalex.org/W3149718685","https://openalex.org/W2001657129","https://openalex.org/W2415856862"],"abstract_inverted_index":{"Cancer":[0],"is":[1,112],"often":[2],"driven":[3],"by":[4],"the":[5,55,101,119],"accumulation":[6],"of":[7,38,61,78,109,122,147,153,169],"genetic":[8],"alterations,":[9],"including":[10],"single":[11],"nucleotide":[12],"variants,":[13],"small":[14],"insertions":[15],"or":[16,194],"deletions,":[17],"gene":[18],"fusions,":[19],"copy-number":[20],"variations,":[21],"and":[22,42,49,59,73,94,125,130,145,173],"large":[23],"chromosomal":[24],"rearrangements.":[25],"Recent":[26],"advances":[27,111],"in":[28,46,150,157,165,179,197],"next-generation":[29],"sequencing":[30,132],"technologies":[31],"have":[32,66,97],"helped":[33],"investigators":[34,185],"generate":[35],"massive":[36],"amounts":[37],"cancer":[39,51,64,74,80,201],"genomic":[40],"data":[41],"catalog":[43],"somatic":[44,56,81,171],"mutations":[45,72,82,149,172,196],"both":[47],"common":[48],"rare":[50],"types.":[52],"So":[53],"far,":[54],"mutation":[57],"landscapes":[58],"signatures":[60],">10":[62],"major":[63,137],"types":[65],"been":[67,98],"reported;":[68],"however,":[69],"pinpointing":[70],"driver":[71,193],"genes":[75],"from":[76],"millions":[77],"available":[79],"remains":[83],"a":[84,107],"monumental":[85],"challenge.":[86],"To":[87],"tackle":[88],"this":[89],"important":[90],"task,":[91],"many":[92],"methods":[93,124],"computational":[95],"tools":[96,126],"developed":[99],"during":[100],"past":[102],"several":[103],"years":[104],"and,":[105],"thus,":[106],"review":[108,182],"its":[110],"urgently":[113],"needed.":[114],"Here,":[115],"we":[116,135,161],"first":[117],"summarize":[118],"main":[120],"features":[121],"these":[123],"for":[127,190],"whole-exome,":[128],"whole-genome":[129],"whole-transcriptome":[131],"data.":[133],"Then,":[134],"discuss":[136],"challenges":[138],"like":[139],"tumor":[140,142,177],"intra-heterogeneity,":[141],"sample":[143],"saturation":[144],"functionality":[146],"synonymous":[148],"cancer,":[151],"all":[152],"which":[154],"may":[155,183],"result":[156],"false-positive":[158],"discoveries.":[159],"Finally,":[160],"highlight":[162],"new":[163],"directions":[164],"studying":[166],"regulatory":[167],"roles":[168],"noncoding":[170],"quantitatively":[174],"measuring":[175],"circulating":[176],"DNA":[178],"cancer.":[180],"This":[181],"help":[184],"find":[186],"an":[187],"appropriate":[188],"tool":[189],"detecting":[191],"potential":[192],"actionable":[195],"rapidly":[198],"emerging":[199],"precision":[200],"medicine.":[202]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":14},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":15},{"year":2022,"cited_by_count":22},{"year":2021,"cited_by_count":27},{"year":2020,"cited_by_count":18},{"year":2019,"cited_by_count":18},{"year":2018,"cited_by_count":12},{"year":2017,"cited_by_count":15},{"year":2016,"cited_by_count":12},{"year":2015,"cited_by_count":1}],"updated_date":"2026-08-26T07:47:46.906454","created_date":"2025-10-10T00:00:00"}
