{"id":"https://openalex.org/W2259538443","doi":"https://doi.org/10.1093/bib/bbv066","title":"Drug\u2013target interaction prediction: databases, web servers and computational models","display_name":"Drug\u2013target interaction prediction: databases, web servers and computational models","publication_year":2015,"publication_date":"2015-08-17","ids":{"openalex":"https://openalex.org/W2259538443","doi":"https://doi.org/10.1093/bib/bbv066","mag":"2259538443","pmid":"https://pubmed.ncbi.nlm.nih.gov/26283676"},"language":"en","primary_location":{"id":"doi:10.1093/bib/bbv066","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbv066","pdf_url":"https://academic.oup.com/bib/article-pdf/17/4/696/6685810/bbv066.pdf","source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},"type":"review","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://academic.oup.com/bib/article-pdf/17/4/696/6685810/bbv066.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100371774","display_name":"Xing Chen","orcid":"https://orcid.org/0000-0001-9641-3528"},"institutions":[{"id":"https://openalex.org/I4210095018","display_name":"National Center for Mathematics and Interdisciplinary Sciences","ror":"https://ror.org/00s97k668","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210095018"]},{"id":"https://openalex.org/I4210090176","display_name":"Institute of Computing Technology","ror":"https://ror.org/0090r4d87","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210090176"]},{"id":"https://openalex.org/I99065089","display_name":"Tsinghua University","ror":"https://ror.org/03cve4549","country_code":"CN","type":"education","lineage":["https://openalex.org/I99065089"]},{"id":"https://openalex.org/I154099455","display_name":"Shandong University","ror":"https://ror.org/0207yh398","country_code":"CN","type":"education","lineage":["https://openalex.org/I154099455"]},{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"funder","lineage":["https://openalex.org/I19820366"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Xing Chen","raw_affiliation_strings":["fellow of the Institute of Computing Technology, Chinese Academy of Sciences","Department of Automation, Tsinghua University","Department of Computer, Shandong University","School of Mechanical, Electrical & Information Engineering, Shandong University","National Center for Mathematics and Interdisciplinary Sciences, Chinese Academy of Sciences, Zhongguancun East Road, Haidian District, Beijing 100190, China","Institute of Computing Technology, Chinese Academy of Sciences","National Center for Mathematics and Interdisciplinary Sciences, Chinese Academy of Sciences"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"fellow of the Institute of Computing Technology, Chinese Academy of Sciences","institution_ids":[]},{"raw_affiliation_string":"Department of Automation, Tsinghua University","institution_ids":["https://openalex.org/I99065089"]},{"raw_affiliation_string":"Department of Computer, Shandong University","institution_ids":[]},{"raw_affiliation_string":"School of Mechanical, Electrical & Information Engineering, Shandong University","institution_ids":["https://openalex.org/I154099455"]},{"raw_affiliation_string":"National Center for Mathematics and Interdisciplinary Sciences, Chinese Academy of Sciences, Zhongguancun East Road, Haidian District, Beijing 100190, China","institution_ids":[]},{"raw_affiliation_string":"Institute of Computing Technology, Chinese Academy of Sciences","institution_ids":["https://openalex.org/I4210090176","https://openalex.org/I19820366"]},{"raw_affiliation_string":"National Center for Mathematics and Interdisciplinary Sciences, Chinese Academy of Sciences","institution_ids":["https://openalex.org/I4210095018"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054311881","display_name":"Chenggang Yan","orcid":"https://orcid.org/0000-0003-1204-0512"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Chenggang Clarence Yan","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037657152","display_name":"Xiaotian Zhang","orcid":"https://orcid.org/0000-0002-9533-4761"},"institutions":[{"id":"https://openalex.org/I4210095018","display_name":"National Center for Mathematics and Interdisciplinary Sciences","ror":"https://ror.org/00s97k668","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210095018"]},{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"funder","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210090176","display_name":"Institute of Computing Technology","ror":"https://ror.org/0090r4d87","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210090176"]},{"id":"https://openalex.org/I99065089","display_name":"Tsinghua University","ror":"https://ror.org/03cve4549","country_code":"CN","type":"education","lineage":["https://openalex.org/I99065089"]},{"id":"https://openalex.org/I154099455","display_name":"Shandong University","ror":"https://ror.org/0207yh398","country_code":"CN","type":"education","lineage":["https://openalex.org/I154099455"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaotian Zhang","raw_affiliation_strings":["School of Mechanical, Electrical & Information Engineering, Shandong University","fellow of the Institute of Computing Technology, Chinese Academy of Sciences","National Center for Mathematics and Interdisciplinary Sciences, Chinese Academy of Sciences, Zhongguancun East Road, Haidian District, Beijing 100190, China","Department of Automation, Tsinghua University","Department of Computer, Shandong University","National Center for Mathematics and Interdisciplinary Sciences, Chinese Academy of Sciences","Institute of Computing Technology, Chinese Academy of Sciences"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Mechanical, Electrical & Information Engineering, Shandong University","institution_ids":["https://openalex.org/I154099455"]},{"raw_affiliation_string":"fellow of the Institute of Computing Technology, Chinese Academy of Sciences","institution_ids":[]},{"raw_affiliation_string":"National Center for Mathematics and Interdisciplinary Sciences, Chinese Academy of Sciences, Zhongguancun East Road, Haidian District, Beijing 100190, China","institution_ids":[]},{"raw_affiliation_string":"Department of Automation, Tsinghua University","institution_ids":["https://openalex.org/I99065089"]},{"raw_affiliation_string":"Department of Computer, Shandong University","institution_ids":[]},{"raw_affiliation_string":"National Center for Mathematics and Interdisciplinary Sciences, Chinese Academy of Sciences","institution_ids":["https://openalex.org/I4210095018"]},{"raw_affiliation_string":"Institute of Computing Technology, Chinese Academy of Sciences","institution_ids":["https://openalex.org/I4210090176","https://openalex.org/I19820366"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100437220","display_name":"Xu Zhang","orcid":"https://orcid.org/0000-0002-3313-5070"},"institutions":[{"id":"https://openalex.org/I4210095018","display_name":"National Center for Mathematics and Interdisciplinary Sciences","ror":"https://ror.org/00s97k668","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210095018"]},{"id":"https://openalex.org/I4210090176","display_name":"Institute of Computing Technology","ror":"https://ror.org/0090r4d87","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210090176"]},{"id":"https://openalex.org/I99065089","display_name":"Tsinghua University","ror":"https://ror.org/03cve4549","country_code":"CN","type":"education","lineage":["https://openalex.org/I99065089"]},{"id":"https://openalex.org/I154099455","display_name":"Shandong University","ror":"https://ror.org/0207yh398","country_code":"CN","type":"education","lineage":["https://openalex.org/I154099455"]},{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"funder","lineage":["https://openalex.org/I19820366"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xu Zhang","raw_affiliation_strings":["Department of Computer, Shandong University","Department of Automation, Tsinghua University","National Center for Mathematics and Interdisciplinary Sciences, Chinese Academy of Sciences","School of Mechanical, Electrical & Information Engineering, Shandong University","Institute of Computing Technology, Chinese Academy of Sciences","fellow of the Institute of Computing Technology, Chinese Academy of Sciences","National Center for Mathematics and Interdisciplinary Sciences, Chinese Academy of Sciences, Zhongguancun East Road, Haidian District, Beijing 100190, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Computer, Shandong University","institution_ids":[]},{"raw_affiliation_string":"Department of Automation, Tsinghua University","institution_ids":["https://openalex.org/I99065089"]},{"raw_affiliation_string":"National Center for Mathematics and Interdisciplinary Sciences, Chinese Academy of Sciences","institution_ids":["https://openalex.org/I4210095018"]},{"raw_affiliation_string":"School of Mechanical, Electrical & Information Engineering, Shandong University","institution_ids":["https://openalex.org/I154099455"]},{"raw_affiliation_string":"Institute of Computing Technology, Chinese Academy of Sciences","institution_ids":["https://openalex.org/I4210090176","https://openalex.org/I19820366"]},{"raw_affiliation_string":"fellow of the Institute of Computing Technology, Chinese Academy of Sciences","institution_ids":[]},{"raw_affiliation_string":"National Center for Mathematics and Interdisciplinary Sciences, Chinese Academy of Sciences, Zhongguancun East Road, Haidian District, Beijing 100190, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103354467","display_name":"Feng Dai","orcid":null},"institutions":[{"id":"https://openalex.org/I4210090176","display_name":"Institute of Computing Technology","ror":"https://ror.org/0090r4d87","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210090176"]},{"id":"https://openalex.org/I4210095018","display_name":"National Center for Mathematics and Interdisciplinary Sciences","ror":"https://ror.org/00s97k668","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210095018"]},{"id":"https://openalex.org/I154099455","display_name":"Shandong University","ror":"https://ror.org/0207yh398","country_code":"CN","type":"education","lineage":["https://openalex.org/I154099455"]},{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"funder","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I99065089","display_name":"Tsinghua University","ror":"https://ror.org/03cve4549","country_code":"CN","type":"education","lineage":["https://openalex.org/I99065089"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Feng Dai","raw_affiliation_strings":["National Center for Mathematics and Interdisciplinary Sciences, Chinese Academy of Sciences","Department of Automation, Tsinghua University","Institute of Computing Technology, Chinese Academy of Sciences","National Center for Mathematics and Interdisciplinary Sciences, Chinese Academy of Sciences, Zhongguancun East Road, Haidian District, Beijing 100190, China","fellow of the Institute of Computing Technology, Chinese Academy of Sciences","School of Mechanical, Electrical & Information Engineering, Shandong University","Department of Computer, Shandong University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Center for Mathematics and Interdisciplinary Sciences, Chinese Academy of Sciences","institution_ids":["https://openalex.org/I4210095018"]},{"raw_affiliation_string":"Department of Automation, Tsinghua University","institution_ids":["https://openalex.org/I99065089"]},{"raw_affiliation_string":"Institute of Computing Technology, Chinese Academy of Sciences","institution_ids":["https://openalex.org/I4210090176","https://openalex.org/I19820366"]},{"raw_affiliation_string":"National Center for Mathematics and Interdisciplinary Sciences, Chinese Academy of Sciences, Zhongguancun East Road, Haidian District, Beijing 100190, China","institution_ids":[]},{"raw_affiliation_string":"fellow of the Institute of Computing Technology, Chinese Academy of Sciences","institution_ids":[]},{"raw_affiliation_string":"School of Mechanical, Electrical & Information Engineering, Shandong University","institution_ids":["https://openalex.org/I154099455"]},{"raw_affiliation_string":"Department of Computer, Shandong University","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101847664","display_name":"Jian Yin","orcid":"https://orcid.org/0000-0001-7832-7482"},"institutions":[{"id":"https://openalex.org/I99065089","display_name":"Tsinghua University","ror":"https://ror.org/03cve4549","country_code":"CN","type":"education","lineage":["https://openalex.org/I99065089"]},{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"funder","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I154099455","display_name":"Shandong University","ror":"https://ror.org/0207yh398","country_code":"CN","type":"education","lineage":["https://openalex.org/I154099455"]},{"id":"https://openalex.org/I4210090176","display_name":"Institute of Computing Technology","ror":"https://ror.org/0090r4d87","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210090176"]},{"id":"https://openalex.org/I4210095018","display_name":"National Center for Mathematics and Interdisciplinary Sciences","ror":"https://ror.org/00s97k668","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210095018"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jian Yin","raw_affiliation_strings":["Institute of Computing Technology, Chinese Academy of Sciences","National Center for Mathematics and Interdisciplinary Sciences, Chinese Academy of Sciences","Department of Computer, Shandong University","fellow of the Institute of Computing Technology, Chinese Academy of Sciences","Department of Automation, Tsinghua University","National Center for Mathematics and Interdisciplinary Sciences, Chinese Academy of Sciences, Zhongguancun East Road, Haidian District, Beijing 100190, China","School of Mechanical, Electrical & Information Engineering, Shandong University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Computing Technology, Chinese Academy of Sciences","institution_ids":["https://openalex.org/I4210090176","https://openalex.org/I19820366"]},{"raw_affiliation_string":"National Center for Mathematics and Interdisciplinary Sciences, Chinese Academy of Sciences","institution_ids":["https://openalex.org/I4210095018"]},{"raw_affiliation_string":"Department of Computer, Shandong University","institution_ids":[]},{"raw_affiliation_string":"fellow of the Institute of Computing Technology, Chinese Academy of Sciences","institution_ids":[]},{"raw_affiliation_string":"Department of Automation, Tsinghua University","institution_ids":["https://openalex.org/I99065089"]},{"raw_affiliation_string":"National Center for Mathematics and Interdisciplinary Sciences, Chinese Academy of Sciences, Zhongguancun East Road, Haidian District, Beijing 100190, China","institution_ids":[]},{"raw_affiliation_string":"School of Mechanical, Electrical & Information Engineering, Shandong University","institution_ids":["https://openalex.org/I154099455"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5046305086","display_name":"Yongdong Zhang","orcid":"https://orcid.org/0000-0002-1151-1792"},"institutions":[{"id":"https://openalex.org/I154099455","display_name":"Shandong University","ror":"https://ror.org/0207yh398","country_code":"CN","type":"education","lineage":["https://openalex.org/I154099455"]},{"id":"https://openalex.org/I4210095018","display_name":"National Center for Mathematics and Interdisciplinary Sciences","ror":"https://ror.org/00s97k668","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210095018"]},{"id":"https://openalex.org/I4210090176","display_name":"Institute of Computing Technology","ror":"https://ror.org/0090r4d87","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210090176"]},{"id":"https://openalex.org/I99065089","display_name":"Tsinghua University","ror":"https://ror.org/03cve4549","country_code":"CN","type":"education","lineage":["https://openalex.org/I99065089"]},{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"funder","lineage":["https://openalex.org/I19820366"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yongdong Zhang","raw_affiliation_strings":["fellow of the Institute of Computing Technology, Chinese Academy of Sciences","School of Mechanical, Electrical & Information Engineering, Shandong University","National Center for Mathematics and Interdisciplinary Sciences, Chinese Academy of Sciences, Zhongguancun East Road, Haidian District, Beijing 100190, China","Department of Automation, Tsinghua University","National Center for Mathematics and Interdisciplinary Sciences, Chinese Academy of Sciences","Department of Computer, Shandong University","Institute of Computing Technology, Chinese Academy of Sciences"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"fellow of the Institute of Computing Technology, Chinese Academy of Sciences","institution_ids":[]},{"raw_affiliation_string":"School of Mechanical, Electrical & Information Engineering, Shandong University","institution_ids":["https://openalex.org/I154099455"]},{"raw_affiliation_string":"National Center for Mathematics and Interdisciplinary Sciences, Chinese Academy of Sciences, Zhongguancun East Road, Haidian District, Beijing 100190, China","institution_ids":[]},{"raw_affiliation_string":"Department of Automation, Tsinghua University","institution_ids":["https://openalex.org/I99065089"]},{"raw_affiliation_string":"National Center for Mathematics and Interdisciplinary Sciences, Chinese Academy of Sciences","institution_ids":["https://openalex.org/I4210095018"]},{"raw_affiliation_string":"Department of Computer, Shandong University","institution_ids":[]},{"raw_affiliation_string":"Institute of Computing Technology, Chinese Academy of Sciences","institution_ids":["https://openalex.org/I4210090176","https://openalex.org/I19820366"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5100371774"],"corresponding_institution_ids":["https://openalex.org/I154099455","https://openalex.org/I19820366","https://openalex.org/I4210090176","https://openalex.org/I4210095018","https://openalex.org/I99065089"],"apc_list":{"value":4011,"currency":"USD","value_usd":4011},"apc_paid":null,"fwci":42.7026,"has_fulltext":true,"cited_by_count":670,"citation_normalized_percentile":{"value":0.99879049,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"17","issue":"4","first_page":"696","last_page":"712"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.982200026512146,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.7520415186882019},{"id":"https://openalex.org/keywords/drug-discovery","display_name":"Drug discovery","score":0.6972041726112366},{"id":"https://openalex.org/keywords/identification","display_name":"Identification (biology)","score":0.6920967698097229},{"id":"https://openalex.org/keywords/drug-target","display_name":"Drug target","score":0.6463875770568848},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.6439691185951233},{"id":"https://openalex.org/keywords/web-server","display_name":"Web server","score":0.6002771258354187},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.5280319452285767},{"id":"https://openalex.org/keywords/computational-model","display_name":"Computational model","score":0.5173765420913696},{"id":"https://openalex.org/keywords/web-application","display_name":"Web application","score":0.4697461724281311},{"id":"https://openalex.org/keywords/interaction-network","display_name":"Interaction network","score":0.45005983114242554},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.3621378540992737},{"id":"https://openalex.org/keywords/the-internet","display_name":"The Internet","score":0.21539553999900818},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.20932257175445557}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.7520415186882019},{"id":"https://openalex.org/C74187038","wikidata":"https://www.wikidata.org/wiki/Q1418791","display_name":"Drug discovery","level":2,"score":0.6972041726112366},{"id":"https://openalex.org/C116834253","wikidata":"https://www.wikidata.org/wiki/Q2039217","display_name":"Identification (biology)","level":2,"score":0.6920967698097229},{"id":"https://openalex.org/C2989108626","wikidata":"https://www.wikidata.org/wiki/Q904407","display_name":"Drug target","level":2,"score":0.6463875770568848},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.6439691185951233},{"id":"https://openalex.org/C11392498","wikidata":"https://www.wikidata.org/wiki/Q11288","display_name":"Web server","level":3,"score":0.6002771258354187},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.5280319452285767},{"id":"https://openalex.org/C66024118","wikidata":"https://www.wikidata.org/wiki/Q1122506","display_name":"Computational model","level":2,"score":0.5173765420913696},{"id":"https://openalex.org/C118643609","wikidata":"https://www.wikidata.org/wiki/Q189210","display_name":"Web application","level":2,"score":0.4697461724281311},{"id":"https://openalex.org/C55105296","wikidata":"https://www.wikidata.org/wiki/Q841382","display_name":"Interaction network","level":3,"score":0.45005983114242554},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.3621378540992737},{"id":"https://openalex.org/C110875604","wikidata":"https://www.wikidata.org/wiki/Q75","display_name":"The Internet","level":2,"score":0.21539553999900818},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.20932257175445557},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.0},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.0},{"id":"https://openalex.org/C136764020","wikidata":"https://www.wikidata.org/wiki/Q466","display_name":"World Wide Web","level":1,"score":0.0},{"id":"https://openalex.org/C111919701","wikidata":"https://www.wikidata.org/wiki/Q9135","display_name":"Operating system","level":1,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016208","descriptor_name":"Databases, Factual","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016208","descriptor_name":"Databases, Factual","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016208","descriptor_name":"Databases, Factual","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016503","descriptor_name":"Drug Delivery Systems","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016503","descriptor_name":"Drug Delivery Systems","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016503","descriptor_name":"Drug Delivery Systems","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055808","descriptor_name":"Drug Discovery","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055808","descriptor_name":"Drug Discovery","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055808","descriptor_name":"Drug Discovery","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1093/bib/bbv066","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbv066","pdf_url":"https://academic.oup.com/bib/article-pdf/17/4/696/6685810/bbv066.pdf","source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},{"id":"pmid:26283676","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26283676","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in bioinformatics","raw_type":null},{"id":"pmh:oai:open-archive.highwire.org:bib:17/4/696","is_oa":false,"landing_page_url":"http://bib.oxfordjournals.org/cgi/content/short/17/4/696","pdf_url":null,"source":{"id":"https://openalex.org/S4406923041","display_name":"HighWire Press Open Archive","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"TEXT"}],"best_oa_location":{"id":"doi:10.1093/bib/bbv066","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbv066","pdf_url":"https://academic.oup.com/bib/article-pdf/17/4/696/6685810/bbv066.pdf","source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.4399999976158142,"display_name":"Good health and well-being"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320323110","display_name":"Beijing Institute of Technology","ror":"https://ror.org/01skt4w74"},{"id":"https://openalex.org/F4320336876","display_name":"National Center for Mathematics and Interdisciplinary Sciences, Chinese Academy of Sciences","ror":"https://ror.org/00s97k668"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2259538443.pdf","grobid_xml":"https://content.openalex.org/works/W2259538443.grobid-xml"},"referenced_works_count":93,"referenced_works":["https://openalex.org/W1466286227","https://openalex.org/W1540649941","https://openalex.org/W1541232310","https://openalex.org/W1813117265","https://openalex.org/W1895993106","https://openalex.org/W1966751442","https://openalex.org/W1967032556","https://openalex.org/W1968682237","https://openalex.org/W1971106435","https://openalex.org/W1971387816","https://openalex.org/W1971825415","https://openalex.org/W1974884542","https://openalex.org/W1975426150","https://openalex.org/W1978370150","https://openalex.org/W1979537657","https://openalex.org/W1984084871","https://openalex.org/W1995089537","https://openalex.org/W1995905328","https://openalex.org/W1997813612","https://openalex.org/W2002221644","https://openalex.org/W2004364785","https://openalex.org/W2008840001","https://openalex.org/W2010750139","https://openalex.org/W2015393683","https://openalex.org/W2015604457","https://openalex.org/W2018408116","https://openalex.org/W2018518196","https://openalex.org/W2027482274","https://openalex.org/W2029152175","https://openalex.org/W2029197596","https://openalex.org/W2033591223","https://openalex.org/W2035753075","https://openalex.org/W2042933379","https://openalex.org/W2044002635","https://openalex.org/W2044424923","https://openalex.org/W2048565304","https://openalex.org/W2057635677","https://openalex.org/W2060145168","https://openalex.org/W2062941476","https://openalex.org/W2064264167","https://openalex.org/W2066201825","https://openalex.org/W2068351024","https://openalex.org/W2069898171","https://openalex.org/W2070171305","https://openalex.org/W2074370114","https://openalex.org/W2080770317","https://openalex.org/W2085034490","https://openalex.org/W2086286404","https://openalex.org/W2087064593","https://openalex.org/W2096021562","https://openalex.org/W2096525273","https://openalex.org/W2096541451","https://openalex.org/W2096864392","https://openalex.org/W2099754222","https://openalex.org/W2100811683","https://openalex.org/W2105668062","https://openalex.org/W2108069034","https://openalex.org/W2109991441","https://openalex.org/W2112189758","https://openalex.org/W2113951828","https://openalex.org/W2126671570","https://openalex.org/W2128137143","https://openalex.org/W2128966273","https://openalex.org/W2131773109","https://openalex.org/W2138427043","https://openalex.org/W2138512826","https://openalex.org/W2139516171","https://openalex.org/W2139736926","https://openalex.org/W2140595402","https://openalex.org/W2142572836","https://openalex.org/W2144563439","https://openalex.org/W2152970345","https://openalex.org/W2153838454","https://openalex.org/W2154896031","https://openalex.org/W2156012049","https://openalex.org/W2160203886","https://openalex.org/W2161607603","https://openalex.org/W2165188181","https://openalex.org/W2165240999","https://openalex.org/W2165674132","https://openalex.org/W2166550586","https://openalex.org/W2167212630","https://openalex.org/W2168938595","https://openalex.org/W2169815691","https://openalex.org/W2171482501","https://openalex.org/W2335298376","https://openalex.org/W2412949524","https://openalex.org/W3101634756","https://openalex.org/W4232866872","https://openalex.org/W4244606935","https://openalex.org/W4245543257","https://openalex.org/W6703115218","https://openalex.org/W6715547131"],"related_works":["https://openalex.org/W2509838516","https://openalex.org/W1971106435","https://openalex.org/W2623587811","https://openalex.org/W2343879804","https://openalex.org/W2008235780","https://openalex.org/W2148679377","https://openalex.org/W2133776184","https://openalex.org/W2177411254","https://openalex.org/W1598853836","https://openalex.org/W2106029302"],"abstract_inverted_index":{"Identification":[0],"of":[1,113,147,183],"drug-target":[2,24,47,62,79,120,184],"interactions":[3,80,185],"is":[4],"an":[5],"important":[6],"process":[7],"in":[8,61,110],"drug":[9,65,150,157],"discovery.":[10],"Although":[11,116],"high-throughput":[12],"screening":[13],"and":[14,33,57,64,88,103,133,152,168,180],"other":[15],"biological":[16],"assays":[17],"are":[18,67],"becoming":[19],"available,":[20],"experimental":[21],"methods":[22,136],"for":[23,78,92,119,155],"interaction":[25,121],"identification":[26,63],"remain":[27],"to":[28,44,101],"be":[29],"extremely":[30],"costly,":[31],"time-consuming":[32],"challenging":[34],"even":[35],"nowadays.":[36],"Therefore,":[37],"various":[38],"computational":[39,76,129],"models":[40,77],"have":[41,107,123,137],"been":[42,124],"developed":[43],"predict":[45],"potential":[46],"associations":[48],"on":[49,160,194],"a":[50],"large":[51],"scale.":[52],"In":[53,69],"this":[54],"review,":[55],"databases":[56],"web":[58],"servers":[59],"involved":[60],"discovery":[66,151,158],"summarized.":[68],"addition,":[70],"we":[71,142,173],"mainly":[72],"introduced":[73],"some":[74],"state-of-the-art":[75],"prediction,":[81],"including":[82],"network-based":[83,132,149],"method,":[84,96],"machine":[85,94,134],"learning-based":[86,95,135],"method":[87],"so":[89],"on.":[90],"Specially,":[91],"the":[93,111,144,148,175,181],"much":[97],"attention":[98],"was":[99],"paid":[100],"supervised":[102],"semi-supervised":[104],"models,":[105,130],"which":[106],"essential":[108],"difference":[109],"adoption":[112],"negative":[114],"samples.":[115],"significant":[117],"improvements":[118],"prediction":[122,186],"obtained":[125],"by":[126,188],"many":[127],"effective":[128],"both":[131],"their":[138],"disadvantages,":[139],"respectively.":[140],"Furthermore,":[141],"discuss":[143],"future":[145],"directions":[146],"network":[153,167],"approach":[154],"personalized":[156,161],"based":[159,193],"medicine,":[162],"genome":[163],"sequencing,":[164],"tumor":[165],"clone-based":[166],"cancer":[169],"hallmark-based":[170],"network.":[171],"Finally,":[172],"discussed":[174],"new":[176],"evaluation":[177],"validation":[178],"framework":[179],"formulation":[182,192],"problem":[187],"more":[189],"realistic":[190],"regression":[191],"quantitative":[195],"bioactivity":[196],"data.":[197]},"counts_by_year":[{"year":2026,"cited_by_count":18},{"year":2025,"cited_by_count":70},{"year":2024,"cited_by_count":74},{"year":2023,"cited_by_count":70},{"year":2022,"cited_by_count":86},{"year":2021,"cited_by_count":71},{"year":2020,"cited_by_count":82},{"year":2019,"cited_by_count":78},{"year":2018,"cited_by_count":62},{"year":2017,"cited_by_count":43},{"year":2016,"cited_by_count":16}],"updated_date":"2026-07-05T07:55:05.734416","created_date":"2025-10-10T00:00:00"}