{"id":"https://openalex.org/W2270868069","doi":"https://doi.org/10.1093/bib/bbv065","title":"Algorithms for modeling global and context-specific functional relationship networks","display_name":"Algorithms for modeling global and context-specific functional relationship networks","publication_year":2015,"publication_date":"2015-08-06","ids":{"openalex":"https://openalex.org/W2270868069","doi":"https://doi.org/10.1093/bib/bbv065","mag":"2270868069","pmid":"https://pubmed.ncbi.nlm.nih.gov/26254431"},"language":"en","primary_location":{"id":"doi:10.1093/bib/bbv065","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbv065","pdf_url":"https://academic.oup.com/bib/article-pdf/17/4/686/6685387/bbv065.pdf","source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://academic.oup.com/bib/article-pdf/17/4/686/6685387/bbv065.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101876549","display_name":"Fan Zhu","orcid":"https://orcid.org/0009-0002-9523-3909"},"institutions":[{"id":"https://openalex.org/I199037182","display_name":"Washtenaw Community College","ror":"https://ror.org/03k77wm53","country_code":"US","type":"education","lineage":["https://openalex.org/I199037182"]},{"id":"https://openalex.org/I4210140143","display_name":"Dynamic Systems (United States)","ror":"https://ror.org/043vm9914","country_code":"US","type":"company","lineage":["https://openalex.org/I4210140143"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Fan Zhu","raw_affiliation_strings":["Fan Zhu is a research fellow at the Department of Computational Medicine and Bioinformatics, University of Michigan. His research interests include dynamic network modeling and clinical outcome prediction","2044 Palmer Commons, 100 Washtenaw Ave., Ann Arbor, MI 48109;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fan Zhu is a research fellow at the Department of Computational Medicine and Bioinformatics, University of Michigan. His research interests include dynamic network modeling and clinical outcome prediction","institution_ids":["https://openalex.org/I4210140143"]},{"raw_affiliation_string":"2044 Palmer Commons, 100 Washtenaw Ave., Ann Arbor, MI 48109;","institution_ids":["https://openalex.org/I199037182"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012832644","display_name":"Bharat Panwar","orcid":"https://orcid.org/0000-0002-4227-9615"},"institutions":[{"id":"https://openalex.org/I199037182","display_name":"Washtenaw Community College","ror":"https://ror.org/03k77wm53","country_code":"US","type":"education","lineage":["https://openalex.org/I199037182"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bharat Panwar","raw_affiliation_strings":["Bharat Panwar is a postdoctoral fellow at the Department of Computational Medicine and Bioinformatics, University of Michigan. His research interests are in the areas of functional genomics and machine learning","2044 Palmer Commons, 100 Washtenaw Ave., Ann Arbor, MI 48109;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bharat Panwar is a postdoctoral fellow at the Department of Computational Medicine and Bioinformatics, University of Michigan. His research interests are in the areas of functional genomics and machine learning","institution_ids":[]},{"raw_affiliation_string":"2044 Palmer Commons, 100 Washtenaw Ave., Ann Arbor, MI 48109;","institution_ids":["https://openalex.org/I199037182"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5011032655","display_name":"Yuanfang Guan","orcid":"https://orcid.org/0000-0001-8275-2852"},"institutions":[{"id":"https://openalex.org/I199037182","display_name":"Washtenaw Community College","ror":"https://ror.org/03k77wm53","country_code":"US","type":"education","lineage":["https://openalex.org/I199037182"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yuanfang Guan","raw_affiliation_strings":["Yuanfang Guan is an assistant professor at Department of Computational Medicine and Bioinformatics, University of Michigan. Her research interests include network biology, data integration and clinical informatics","2044 Palmer Commons, 100 Washtenaw Ave., Ann Arbor, MI 48109;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Yuanfang Guan is an assistant professor at Department of Computational Medicine and Bioinformatics, University of Michigan. Her research interests include network biology, data integration and clinical informatics","institution_ids":[]},{"raw_affiliation_string":"2044 Palmer Commons, 100 Washtenaw Ave., Ann Arbor, MI 48109;","institution_ids":["https://openalex.org/I199037182"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4011,"currency":"USD","value_usd":4011},"apc_paid":null,"fwci":0.2956,"has_fulltext":true,"cited_by_count":3,"citation_normalized_percentile":{"value":0.62582828,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":96},"biblio":{"volume":"17","issue":"4","first_page":"686","last_page":"695"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9968000054359436,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/functional-genomics","display_name":"Functional genomics","score":0.7007977962493896},{"id":"https://openalex.org/keywords/context","display_name":"Context (archaeology)","score":0.6828089952468872},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6515139937400818},{"id":"https://openalex.org/keywords/biological-network","display_name":"Biological network","score":0.5018951892852783},{"id":"https://openalex.org/keywords/data-science","display_name":"Data science","score":0.45250001549720764},{"id":"https://openalex.org/keywords/gene-regulatory-network","display_name":"Gene regulatory network","score":0.4297565221786499},{"id":"https://openalex.org/keywords/genomics","display_name":"Genomics","score":0.4239659309387207},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.38329726457595825},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.3314138352870941},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.24314332008361816},{"id":"https://openalex.org/keywords/genome","display_name":"Genome","score":0.12486106157302856},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.0947207510471344}],"concepts":[{"id":"https://openalex.org/C161078062","wikidata":"https://www.wikidata.org/wiki/Q1068690","display_name":"Functional genomics","level":5,"score":0.7007977962493896},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.6828089952468872},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6515139937400818},{"id":"https://openalex.org/C28225019","wikidata":"https://www.wikidata.org/wiki/Q4915005","display_name":"Biological network","level":2,"score":0.5018951892852783},{"id":"https://openalex.org/C2522767166","wikidata":"https://www.wikidata.org/wiki/Q2374463","display_name":"Data science","level":1,"score":0.45250001549720764},{"id":"https://openalex.org/C67339327","wikidata":"https://www.wikidata.org/wiki/Q1502576","display_name":"Gene regulatory network","level":4,"score":0.4297565221786499},{"id":"https://openalex.org/C189206191","wikidata":"https://www.wikidata.org/wiki/Q222046","display_name":"Genomics","level":4,"score":0.4239659309387207},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.38329726457595825},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.3314138352870941},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.24314332008361816},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.12486106157302856},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0947207510471344},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016678","descriptor_name":"Genome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016678","descriptor_name":"Genome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016678","descriptor_name":"Genome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1093/bib/bbv065","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbv065","pdf_url":"https://academic.oup.com/bib/article-pdf/17/4/686/6685387/bbv065.pdf","source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},{"id":"pmid:26254431","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26254431","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in bioinformatics","raw_type":null},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.891.3972","is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.891.3972","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://bib.oxfordjournals.org/content/early/2015/08/06/bib.bbv065.full.pdf","raw_type":"text"},{"id":"pmh:oai:open-archive.highwire.org:bib:17/4/686","is_oa":false,"landing_page_url":"http://bib.oxfordjournals.org/cgi/content/short/17/4/686","pdf_url":null,"source":{"id":"https://openalex.org/S4406923041","display_name":"HighWire Press Open Archive","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"TEXT"},{"id":"pmh:oai:pubmedcentral.nih.gov:4945826","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4945826","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Brief Bioinform","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1093/bib/bbv065","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbv065","pdf_url":"https://academic.oup.com/bib/article-pdf/17/4/686/6685387/bbv065.pdf","source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G4007539625","display_name":null,"funder_award_id":"R21 NS082212","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2270868069.pdf","grobid_xml":"https://content.openalex.org/works/W2270868069.grobid-xml"},"referenced_works_count":114,"referenced_works":["https://openalex.org/W1480376833","https://openalex.org/W1494413412","https://openalex.org/W1527927437","https://openalex.org/W1893022572","https://openalex.org/W1964542367","https://openalex.org/W1966327575","https://openalex.org/W1969709265","https://openalex.org/W1971061059","https://openalex.org/W1976386441","https://openalex.org/W1981457795","https://openalex.org/W1985213868","https://openalex.org/W1988263223","https://openalex.org/W1995008770","https://openalex.org/W2000567731","https://openalex.org/W2011312755","https://openalex.org/W2015538881","https://openalex.org/W2018570668","https://openalex.org/W2027762334","https://openalex.org/W2031925571","https://openalex.org/W2032065412","https://openalex.org/W2032619610","https://openalex.org/W2033642768","https://openalex.org/W2036956532","https://openalex.org/W2038012561","https://openalex.org/W2041471741","https://openalex.org/W2043083737","https://openalex.org/W2044525257","https://openalex.org/W2046618236","https://openalex.org/W2046831513","https://openalex.org/W2047632644","https://openalex.org/W2052968292","https://openalex.org/W2053673723","https://openalex.org/W2057012490","https://openalex.org/W2060705109","https://openalex.org/W2063325205","https://openalex.org/W2063354556","https://openalex.org/W2068948802","https://openalex.org/W2069898971","https://openalex.org/W2070412833","https://openalex.org/W2074506998","https://openalex.org/W2074755764","https://openalex.org/W2075496125","https://openalex.org/W2091789479","https://openalex.org/W2095956310","https://openalex.org/W2096766502","https://openalex.org/W2097698606","https://openalex.org/W2104843251","https://openalex.org/W2105129830","https://openalex.org/W2109384743","https://openalex.org/W2111823238","https://openalex.org/W2112811019","https://openalex.org/W2119043225","https://openalex.org/W2119062243","https://openalex.org/W2123699903","https://openalex.org/W2125118217","https://openalex.org/W2125631472","https://openalex.org/W2127057035","https://openalex.org/W2129293106","https://openalex.org/W2132350103","https://openalex.org/W2132582966","https://openalex.org/W2134873429","https://openalex.org/W2136988691","https://openalex.org/W2137786672","https://openalex.org/W2141577802","https://openalex.org/W2141885858","https://openalex.org/W2143076232","https://openalex.org/W2143962926","https://openalex.org/W2145448069","https://openalex.org/W2147618936","https://openalex.org/W2147714160","https://openalex.org/W2148851475","https://openalex.org/W2150646520","https://openalex.org/W2150908245","https://openalex.org/W2150926065","https://openalex.org/W2151681456","https://openalex.org/W2152482800","https://openalex.org/W2152653671","https://openalex.org/W2152896172","https://openalex.org/W2153459501","https://openalex.org/W2154061034","https://openalex.org/W2155134825","https://openalex.org/W2155142785","https://openalex.org/W2155205047","https://openalex.org/W2155331065","https://openalex.org/W2157121418","https://openalex.org/W2157697073","https://openalex.org/W2158485828","https://openalex.org/W2158825911","https://openalex.org/W2159482845","https://openalex.org/W2159585030","https://openalex.org/W2160095931","https://openalex.org/W2161920970","https://openalex.org/W2161922735","https://openalex.org/W2162142896","https://openalex.org/W2163480486","https://openalex.org/W2163485494","https://openalex.org/W2163675212","https://openalex.org/W2166347816","https://openalex.org/W2167009288","https://openalex.org/W2168104796","https://openalex.org/W2169053773","https://openalex.org/W2171157548","https://openalex.org/W2171662214","https://openalex.org/W2416075146","https://openalex.org/W2473338842","https://openalex.org/W2522041912","https://openalex.org/W2787894218","https://openalex.org/W2916288174","https://openalex.org/W2916767477","https://openalex.org/W4210623056","https://openalex.org/W4236956086","https://openalex.org/W4294216483","https://openalex.org/W4388323202","https://openalex.org/W6684142064"],"related_works":["https://openalex.org/W2360935227","https://openalex.org/W2364993072","https://openalex.org/W2115576822","https://openalex.org/W2356429006","https://openalex.org/W2380568150","https://openalex.org/W2385787406","https://openalex.org/W2155595079","https://openalex.org/W4362472570","https://openalex.org/W2411510900","https://openalex.org/W2263355832"],"abstract_inverted_index":{"Functional":[0],"genomics":[1],"has":[2],"enormous":[3],"potential":[4],"to":[5,56],"facilitate":[6],"our":[7],"understanding":[8],"of":[9,33,64],"normal":[10],"and":[11,119,123],"disease-specific":[12],"physiology.":[13],"In":[14],"the":[15,31,58,67,104,112],"past":[16],"decade,":[17],"intensive":[18],"research":[19],"efforts":[20],"have":[21,53,91],"been":[22,54,92],"focused":[23],"on":[24,42],"modeling":[25,38,109,122],"functional":[26,59,70,78,106,128],"relationship":[27,60,71,107,129],"networks,":[28,61],"which":[29],"summarize":[30],"probability":[32],"gene":[34],"co-functionality":[35],"relationships.":[36],"Such":[37],"can":[39],"be":[40],"based":[41],"either":[43],"expression":[44],"data":[45,49,117],"only":[46],"or":[47,85,96],"heterogeneous":[48,115],"integration.":[50],"Numerous":[51],"methods":[52,90],"deployed":[55],"infer":[57],"while":[62],"most":[63],"them":[65],"target":[66],"global":[68],"(non-context-specific)":[69],"networks.":[72,99,130],"However,":[73],"it":[74],"is":[75],"expected":[76],"that":[77],"relationships":[79],"consistently":[80],"reprogram":[81],"under":[82],"different":[83],"tissues":[84],"biological":[86],"processes.":[87],"Thus,":[88],"advanced":[89],"developed":[93],"targeting":[94],"tissue-specific":[95],"developmental":[97],"stage-specific":[98],"This":[100],"article":[101],"brings":[102],"together":[103],"state-of-the-art":[105],"network":[108,121],"methods,":[110],"emphasizes":[111],"need":[113],"for":[114,127],"genomic":[116],"integration":[118],"context-specific":[120],"outlines":[124],"future":[125],"directions":[126]},"counts_by_year":[{"year":2019,"cited_by_count":1},{"year":2016,"cited_by_count":2}],"updated_date":"2026-06-18T08:10:14.011955","created_date":"2025-10-10T00:00:00"}