{"id":"https://openalex.org/W1893007615","doi":"https://doi.org/10.1093/bib/bbv064","title":"Critical limitations of prognostic signatures based on risk scores summarized from gene expression levels: a case study for resected stage I non-small-cell lung cancer","display_name":"Critical limitations of prognostic signatures based on risk scores summarized from gene expression levels: a case study for resected stage I non-small-cell lung cancer","publication_year":2015,"publication_date":"2015-08-06","ids":{"openalex":"https://openalex.org/W1893007615","doi":"https://doi.org/10.1093/bib/bbv064","mag":"1893007615","pmid":"https://pubmed.ncbi.nlm.nih.gov/26254430"},"language":"en","primary_location":{"id":"doi:10.1093/bib/bbv064","is_oa":false,"landing_page_url":"https://doi.org/10.1093/bib/bbv064","pdf_url":null,"source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5032948942","display_name":"Lishuang Qi","orcid":"https://orcid.org/0000-0002-2991-6544"},"institutions":[{"id":"https://openalex.org/I156144747","display_name":"Harbin Medical University","ror":"https://ror.org/05jscf583","country_code":"CN","type":"education","lineage":["https://openalex.org/I156144747"]},{"id":"https://openalex.org/I98813999","display_name":"American College of Surgeons","ror":"https://ror.org/009mk5659","country_code":"US","type":"other","lineage":["https://openalex.org/I98813999"]}],"countries":["CN","US"],"is_corresponding":false,"raw_author_name":"Lishuang Qi","raw_affiliation_strings":["Lishuang Qi is a lecturer of Bioinformatics at Harbin Medical University, China. Her research is focused on discovering biomarkers of cancer patients for clinical application"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lishuang Qi is a lecturer of Bioinformatics at Harbin Medical University, China. Her research is focused on discovering biomarkers of cancer patients for clinical application","institution_ids":["https://openalex.org/I156144747","https://openalex.org/I98813999"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5118092715","display_name":"Libin Chen","orcid":"https://orcid.org/0009-0007-1254-1487"},"institutions":[{"id":"https://openalex.org/I156144747","display_name":"Harbin Medical University","ror":"https://ror.org/05jscf583","country_code":"CN","type":"education","lineage":["https://openalex.org/I156144747"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Libin Chen","raw_affiliation_strings":["Libin Chen is a postgraduate student in Bioinformatics at Harbin Medical University, China. His research is focused on developing algorithm using bioinformatics"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Libin Chen is a postgraduate student in Bioinformatics at Harbin Medical University, China. His research is focused on developing algorithm using bioinformatics","institution_ids":["https://openalex.org/I156144747"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100421407","display_name":"Yang Li","orcid":"https://orcid.org/0000-0002-0403-7287"},"institutions":[{"id":"https://openalex.org/I156144747","display_name":"Harbin Medical University","ror":"https://ror.org/05jscf583","country_code":"CN","type":"education","lineage":["https://openalex.org/I156144747"]},{"id":"https://openalex.org/I4210151837","display_name":"High Throughput Biology (United States)","ror":"https://ror.org/05h1bjp83","country_code":"US","type":"company","lineage":["https://openalex.org/I4210151837"]}],"countries":["CN","US"],"is_corresponding":false,"raw_author_name":"Yang Li","raw_affiliation_strings":["Yang Li is a postgraduate student in Bioinformatics at Harbin Medical University, China. His research is focused on the high-throughput omics data analysis"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Yang Li is a postgraduate student in Bioinformatics at Harbin Medical University, China. His research is focused on the high-throughput omics data analysis","institution_ids":["https://openalex.org/I156144747","https://openalex.org/I4210151837"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029934320","display_name":"Yuan Qin","orcid":"https://orcid.org/0000-0003-4713-6151"},"institutions":[{"id":"https://openalex.org/I156144747","display_name":"Harbin Medical University","ror":"https://ror.org/05jscf583","country_code":"CN","type":"education","lineage":["https://openalex.org/I156144747"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yuan Qin","raw_affiliation_strings":["Yuan Qin is a postgraduate student in Bioinformatics at Harbin Medical University, China. His research is focused on the prognosis analysis"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Yuan Qin is a postgraduate student in Bioinformatics at Harbin Medical University, China. His research is focused on the prognosis analysis","institution_ids":["https://openalex.org/I156144747"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013982453","display_name":"Rufei Pan","orcid":null},"institutions":[{"id":"https://openalex.org/I156144747","display_name":"Harbin Medical University","ror":"https://ror.org/05jscf583","country_code":"CN","type":"education","lineage":["https://openalex.org/I156144747"]},{"id":"https://openalex.org/I4210151837","display_name":"High Throughput Biology (United States)","ror":"https://ror.org/05h1bjp83","country_code":"US","type":"company","lineage":["https://openalex.org/I4210151837"]}],"countries":["CN","US"],"is_corresponding":false,"raw_author_name":"Rufei Pan","raw_affiliation_strings":["Rufei Pan is an undergraduate student in Bioinformatics at Harbin Medical University, China. His research is focused on the high-throughput omics data analysis"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rufei Pan is an undergraduate student in Bioinformatics at Harbin Medical University, China. His research is focused on the high-throughput omics data analysis","institution_ids":["https://openalex.org/I156144747","https://openalex.org/I4210151837"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043417955","display_name":"Wenyuan Zhao","orcid":"https://orcid.org/0000-0002-6477-9434"},"institutions":[{"id":"https://openalex.org/I156144747","display_name":"Harbin Medical University","ror":"https://ror.org/05jscf583","country_code":"CN","type":"education","lineage":["https://openalex.org/I156144747"]},{"id":"https://openalex.org/I2801316944","display_name":"Cancer Research UK","ror":"https://ror.org/054225q67","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I2801316944"]}],"countries":["CN","GB"],"is_corresponding":false,"raw_author_name":"Wenyuan Zhao","raw_affiliation_strings":["Wenyuan Zhao, PhD, is a lecturer of Bioinformatics at Harbin Medical University, China. Her research is focused on understanding the relationship between inflammation and cancer"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Wenyuan Zhao, PhD, is a lecturer of Bioinformatics at Harbin Medical University, China. Her research is focused on understanding the relationship between inflammation and cancer","institution_ids":["https://openalex.org/I156144747","https://openalex.org/I2801316944"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069723993","display_name":"Yunyan Gu","orcid":"https://orcid.org/0000-0001-5693-4126"},"institutions":[{"id":"https://openalex.org/I87890613","display_name":"Epigenomics (Germany)","ror":"https://ror.org/0490dah44","country_code":"DE","type":"company","lineage":["https://openalex.org/I87890613"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Yunyan Gu","raw_affiliation_strings":["Yuanyan Gu, PhD, is an associate Professor of Bioinformatics at Harbin Medical University. Her research is focused on studying the collaborative relationship between genomic/epigenomic alternations"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Yuanyan Gu, PhD, is an associate Professor of Bioinformatics at Harbin Medical University. Her research is focused on studying the collaborative relationship between genomic/epigenomic alternations","institution_ids":["https://openalex.org/I87890613"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100357154","display_name":"Hongwei Wang","orcid":"https://orcid.org/0000-0003-3581-8892"},"institutions":[{"id":"https://openalex.org/I4210099593","display_name":"Computer Algorithms for Medicine","ror":"https://ror.org/00zky6d38","country_code":"AT","type":"facility","lineage":["https://openalex.org/I4210099593"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Hongwei Wang","raw_affiliation_strings":["Hongwei Wang is a PhD candidate in Bioinformatics at Harbin Medical University. His research is focused on developing novel algorithms for personalized identification"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hongwei Wang is a PhD candidate in Bioinformatics at Harbin Medical University. His research is focused on developing novel algorithms for personalized identification","institution_ids":["https://openalex.org/I4210099593"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108140113","display_name":"Ruiping Wang","orcid":"https://orcid.org/0000-0001-9380-0266"},"institutions":[{"id":"https://openalex.org/I4210151837","display_name":"High Throughput Biology (United States)","ror":"https://ror.org/05h1bjp83","country_code":"US","type":"company","lineage":["https://openalex.org/I4210151837"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ruiping Wang","raw_affiliation_strings":["Ruiping Wang is a PhD candidate in Bioinformatics at Harbin Medical University. Her research is focused on the high-throughput omics data analysis"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ruiping Wang is a PhD candidate in Bioinformatics at Harbin Medical University. Her research is focused on the high-throughput omics data analysis","institution_ids":["https://openalex.org/I4210151837"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081750308","display_name":"Xiangqi Chen","orcid":"https://orcid.org/0000-0003-3367-6261"},"institutions":[{"id":"https://openalex.org/I129708740","display_name":"Fujian Medical University","ror":"https://ror.org/050s6ns64","country_code":"CN","type":"education","lineage":["https://openalex.org/I129708740"]},{"id":"https://openalex.org/I4210153515","display_name":"Union Hospital","ror":"https://ror.org/0516c4k86","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210153515"]}],"countries":["CN","US"],"is_corresponding":false,"raw_author_name":"Xiangqi Chen","raw_affiliation_strings":["Xiangqi Chen, PhD, is an associate chief physician in Department of Respiratory, Fujian Medical University Union Hospital, China. Her research is focused on clinical diagnosis and treatment of respiratory system disease"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Xiangqi Chen, PhD, is an associate chief physician in Department of Respiratory, Fujian Medical University Union Hospital, China. Her research is focused on clinical diagnosis and treatment of respiratory system disease","institution_ids":["https://openalex.org/I129708740","https://openalex.org/I4210153515"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5087055335","display_name":"Zheng Guo","orcid":"https://orcid.org/0000-0003-4466-6026"},"institutions":[{"id":"https://openalex.org/I129708740","display_name":"Fujian Medical University","ror":"https://ror.org/050s6ns64","country_code":"CN","type":"education","lineage":["https://openalex.org/I129708740"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zheng Guo","raw_affiliation_strings":["Zheng Guo, PhD, is a Professor of Bioinformatics at Harbin Medical University and Fujian Medical University. His research is focused on analyzing complex diseases at the functional module level and translational medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Zheng Guo, PhD, is a Professor of Bioinformatics at Harbin Medical University and Fujian Medical University. His research is focused on analyzing complex diseases at the functional module level and translational medicine","institution_ids":["https://openalex.org/I129708740"]}]}],"institutions":[],"countries_distinct_count":5,"institutions_distinct_count":8,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4011,"currency":"USD","value_usd":4011},"apc_paid":null,"fwci":4.1323,"has_fulltext":false,"cited_by_count":139,"citation_normalized_percentile":{"value":0.94760928,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":90,"max":100},"biblio":{"volume":"17","issue":"2","first_page":"233","last_page":"242"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11970","display_name":"Molecular Biology Techniques and Applications","score":0.996999979019165,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9944999814033508,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/normalization","display_name":"Normalization (sociology)","score":0.7380708456039429},{"id":"https://openalex.org/keywords/gene-signature","display_name":"Gene signature","score":0.606471836566925},{"id":"https://openalex.org/keywords/spurious-relationship","display_name":"Spurious relationship","score":0.5582171678543091},{"id":"https://openalex.org/keywords/lung-cancer","display_name":"Lung cancer","score":0.5276317000389099},{"id":"https://openalex.org/keywords/gene-expression-profiling","display_name":"Gene expression profiling","score":0.4967814087867737},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.47966650128364563},{"id":"https://openalex.org/keywords/oncology","display_name":"Oncology","score":0.4780878722667694},{"id":"https://openalex.org/keywords/microarray-analysis-techniques","display_name":"Microarray analysis techniques","score":0.4529312252998352},{"id":"https://openalex.org/keywords/stage","display_name":"Stage (stratigraphy)","score":0.4409805238246918},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.4390804171562195},{"id":"https://openalex.org/keywords/signature","display_name":"Signature (topology)","score":0.41202133893966675},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.40392225980758667},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.3889915347099304},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.3576505780220032},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.32919374108314514},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.3167315721511841},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.15890169143676758},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.14392179250717163},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.11057183146476746}],"concepts":[{"id":"https://openalex.org/C136886441","wikidata":"https://www.wikidata.org/wiki/Q926129","display_name":"Normalization (sociology)","level":2,"score":0.7380708456039429},{"id":"https://openalex.org/C2779733811","wikidata":"https://www.wikidata.org/wiki/Q5531562","display_name":"Gene signature","level":4,"score":0.606471836566925},{"id":"https://openalex.org/C97256817","wikidata":"https://www.wikidata.org/wiki/Q1462316","display_name":"Spurious relationship","level":2,"score":0.5582171678543091},{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.5276317000389099},{"id":"https://openalex.org/C18431079","wikidata":"https://www.wikidata.org/wiki/Q1502169","display_name":"Gene expression profiling","level":4,"score":0.4967814087867737},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.47966650128364563},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.4780878722667694},{"id":"https://openalex.org/C8415881","wikidata":"https://www.wikidata.org/wiki/Q6839217","display_name":"Microarray analysis techniques","level":4,"score":0.4529312252998352},{"id":"https://openalex.org/C146357865","wikidata":"https://www.wikidata.org/wiki/Q1123245","display_name":"Stage (stratigraphy)","level":2,"score":0.4409805238246918},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.4390804171562195},{"id":"https://openalex.org/C2779696439","wikidata":"https://www.wikidata.org/wiki/Q7512811","display_name":"Signature (topology)","level":2,"score":0.41202133893966675},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.40392225980758667},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3889915347099304},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3576505780220032},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.32919374108314514},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3167315721511841},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.15890169143676758},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.14392179250717163},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.11057183146476746},{"id":"https://openalex.org/C144024400","wikidata":"https://www.wikidata.org/wiki/Q21201","display_name":"Sociology","level":0,"score":0.0},{"id":"https://openalex.org/C19165224","wikidata":"https://www.wikidata.org/wiki/Q23404","display_name":"Anthropology","level":1,"score":0.0},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0},{"id":"https://openalex.org/C2524010","wikidata":"https://www.wikidata.org/wiki/Q8087","display_name":"Geometry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":false},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":false},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":false},{"descriptor_ui":"D009367","descriptor_name":"Neoplasm Staging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009367","descriptor_name":"Neoplasm Staging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009367","descriptor_name":"Neoplasm Staging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012680","descriptor_name":"Sensitivity and Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012680","descriptor_name":"Sensitivity and Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012680","descriptor_name":"Sensitivity and Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015995","descriptor_name":"Prevalence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015995","descriptor_name":"Prevalence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015995","descriptor_name":"Prevalence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016019","descriptor_name":"Survival Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016019","descriptor_name":"Survival Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016019","descriptor_name":"Survival Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018570","descriptor_name":"Risk Assessment","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D018570","descriptor_name":"Risk Assessment","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D018570","descriptor_name":"Risk Assessment","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1093/bib/bbv064","is_oa":false,"landing_page_url":"https://doi.org/10.1093/bib/bbv064","pdf_url":null,"source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},{"id":"pmid:26254430","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26254430","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in bioinformatics","raw_type":null},{"id":"pmh:oai:open-archive.highwire.org:bib:17/2/233","is_oa":false,"landing_page_url":"http://bib.oxfordjournals.org/cgi/content/short/17/2/233","pdf_url":null,"source":{"id":"https://openalex.org/S4406923041","display_name":"HighWire Press Open Archive","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"TEXT"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.6899999976158142,"display_name":"Good health and well-being"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":53,"referenced_works":["https://openalex.org/W1612719023","https://openalex.org/W1988541647","https://openalex.org/W1991897855","https://openalex.org/W1997269372","https://openalex.org/W2007615926","https://openalex.org/W2009398566","https://openalex.org/W2013654014","https://openalex.org/W2019711853","https://openalex.org/W2021173510","https://openalex.org/W2031330193","https://openalex.org/W2049226857","https://openalex.org/W2058997632","https://openalex.org/W2061481386","https://openalex.org/W2062346641","https://openalex.org/W2069764898","https://openalex.org/W2084001490","https://openalex.org/W2089689049","https://openalex.org/W2091596054","https://openalex.org/W2096192437","https://openalex.org/W2097554668","https://openalex.org/W2097805950","https://openalex.org/W2099755355","https://openalex.org/W2101606272","https://openalex.org/W2102633041","https://openalex.org/W2109570218","https://openalex.org/W2110065044","https://openalex.org/W2111501574","https://openalex.org/W2113451780","https://openalex.org/W2115157373","https://openalex.org/W2116277157","https://openalex.org/W2116343100","https://openalex.org/W2118423420","https://openalex.org/W2123035720","https://openalex.org/W2128053140","https://openalex.org/W2129925362","https://openalex.org/W2132165198","https://openalex.org/W2133585870","https://openalex.org/W2134095688","https://openalex.org/W2134770445","https://openalex.org/W2134785517","https://openalex.org/W2138778951","https://openalex.org/W2142295792","https://openalex.org/W2146728395","https://openalex.org/W2149496508","https://openalex.org/W2150688669","https://openalex.org/W2152667098","https://openalex.org/W2154941270","https://openalex.org/W2155354546","https://openalex.org/W2158402998","https://openalex.org/W2162342992","https://openalex.org/W2167736999","https://openalex.org/W2169961966","https://openalex.org/W2170989872"],"related_works":["https://openalex.org/W2183420549","https://openalex.org/W2042571415","https://openalex.org/W2012175027","https://openalex.org/W2081507994","https://openalex.org/W2077582941","https://openalex.org/W2061000157","https://openalex.org/W2055417018","https://openalex.org/W308751227","https://openalex.org/W1972696957","https://openalex.org/W2096022647"],"abstract_inverted_index":{"Most":[0],"of":[1,19,22,44,47,53,81,111,144],"current":[2],"gene":[3,105,119,152],"expression":[4,20,153],"signatures":[5,48,145,157],"for":[6,108],"cancer":[7],"prognosis":[8],"are":[9,60,84],"based":[10,146],"on":[11,147],"risk":[12,30,51,70,79,148],"scores,":[13],"usually":[14],"calculated":[15],"as":[16],"some":[17],"summaries":[18],"levels":[21],"the":[23,41,50,78,142,155,163],"signature":[24,107,121],"genes,":[25],"whose":[26],"applications":[27],"require":[28],"presetting":[29],"score":[31],"thresholds":[32],"and":[33,72,77],"data":[34,87,127],"normalization.":[35],"In":[36],"this":[37],"study,":[38],"we":[39,96],"demonstrate":[40],"critical":[42],"limitations":[43],"such":[45],"type":[46,143],"that":[49],"scores":[52,80,149],"samples":[54,83,169],"will":[55],"change":[56],"greatly":[57],"when":[58],"they":[59],"normalized":[61],"together":[62],"with":[63,133],"different":[64,131,134,140,172],"samples,":[65],"which":[66],"would":[67],"induce":[68],"spurious":[69],"classification":[71],"difficulty":[73],"in":[74,124,171],"clinical":[75,168],"settings,":[76],"independent":[82,167],"incomparable":[85],"if":[86],"normalization":[88],"is":[89,122],"not":[90],"adopted.":[91],"To":[92],"overcome":[93],"these":[94],"limitations,":[95],"propose":[97],"a":[98,103],"rank-based":[99,156],"method":[100],"to":[101,166],"extract":[102],"prognostic":[104,118],"pair":[106,120],"overall":[109],"survival":[110],"stage":[112],"I":[113],"non-small-cell":[114],"lung":[115],"cancer.":[116],"The":[117],"verified":[123],"three":[125],"integrated":[126],"sets":[128],"detected":[129],"by":[130],"laboratories":[132],"microarray":[135],"platforms.":[136],"We":[137],"conclude":[138],"that,":[139],"from":[141,151],"summarized":[150],"levels,":[154],"could":[158],"be":[159],"robustly":[160],"applied":[161],"at":[162],"individualized":[164],"level":[165],"assessed":[170],"laboratories.":[173]},"counts_by_year":[{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":13},{"year":2023,"cited_by_count":11},{"year":2022,"cited_by_count":12},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":38},{"year":2019,"cited_by_count":22},{"year":2018,"cited_by_count":8},{"year":2017,"cited_by_count":12},{"year":2016,"cited_by_count":9},{"year":2015,"cited_by_count":1}],"updated_date":"2026-07-22T07:51:19.307946","created_date":"2025-10-10T00:00:00"}