{"id":"https://openalex.org/W2254904118","doi":"https://doi.org/10.1093/bib/bbv047","title":"Critical evaluation of<i>in silico</i>methods for prediction of coiled-coil domains in proteins","display_name":"Critical evaluation of<i>in silico</i>methods for prediction of coiled-coil domains in proteins","publication_year":2015,"publication_date":"2015-07-15","ids":{"openalex":"https://openalex.org/W2254904118","doi":"https://doi.org/10.1093/bib/bbv047","mag":"2254904118","pmid":"https://pubmed.ncbi.nlm.nih.gov/26177815"},"language":"en","primary_location":{"id":"doi:10.1093/bib/bbv047","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbv047","pdf_url":"https://academic.oup.com/bib/article-pdf/17/2/270/25416651/bbv047.pdf","source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},"type":"review","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://academic.oup.com/bib/article-pdf/17/2/270/25416651/bbv047.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100369818","display_name":"Chen Li","orcid":"https://orcid.org/0000-0002-1847-754X"},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Chen Li","raw_affiliation_strings":["Biochemistry & Molecular Biology"],"affiliations":[{"raw_affiliation_string":"Biochemistry & Molecular Biology","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060643624","display_name":"Catherine Ching Han Chang","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Catherine Ching Han Chang","raw_affiliation_strings":[],"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021219848","display_name":"Jeremy Nagel","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jeremy Nagel","raw_affiliation_strings":["Biochemistry & Molecular Biology"],"affiliations":[{"raw_affiliation_string":"Biochemistry & Molecular Biology","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042881187","display_name":"Benjamin T. Porebski","orcid":"https://orcid.org/0000-0003-1398-0442"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Benjamin T. Porebski","raw_affiliation_strings":["Biochemistry & Molecular Biology"],"affiliations":[{"raw_affiliation_string":"Biochemistry & Molecular Biology","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039138118","display_name":"Morihiro Hayashida","orcid":"https://orcid.org/0000-0001-7961-0175"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Morihiro Hayashida","raw_affiliation_strings":[],"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016330265","display_name":"Tatsuya Akutsu","orcid":"https://orcid.org/0000-0001-9763-797X"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tatsuya Akutsu","raw_affiliation_strings":[],"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012709797","display_name":"Jiangning Song","orcid":"https://orcid.org/0000-0001-8031-9086"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jiangning Song","raw_affiliation_strings":["Biochemistry & Molecular Biology"],"affiliations":[{"raw_affiliation_string":"Biochemistry & Molecular Biology","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5031275115","display_name":"Ashley M. Buckle","orcid":"https://orcid.org/0000-0003-2943-9044"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ashley M. Buckle","raw_affiliation_strings":["Biochemistry & Molecular Biology"],"affiliations":[{"raw_affiliation_string":"Biochemistry & Molecular Biology","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":8,"corresponding_author_ids":["https://openalex.org/A5100369818"],"corresponding_institution_ids":[],"apc_list":{"value":4011,"currency":"USD","value_usd":4011},"apc_paid":null,"fwci":1.205,"has_fulltext":false,"cited_by_count":28,"citation_normalized_percentile":{"value":0.79413825,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":99},"biblio":{"volume":"17","issue":"2","first_page":"270","last_page":"282"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.9993000030517578,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.9993000030517578,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10604","display_name":"RNA Research and Splicing","score":0.9986000061035156,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10949","display_name":"Genetic Neurodegenerative Diseases","score":0.9980999827384949,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/coiled-coil","display_name":"Coiled coil","score":0.8342622518539429},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.6006187200546265},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5854272842407227},{"id":"https://openalex.org/keywords/uniprot","display_name":"UniProt","score":0.5509138703346252},{"id":"https://openalex.org/keywords/in-silico","display_name":"In silico","score":0.47899100184440613},{"id":"https://openalex.org/keywords/protein-structure-prediction","display_name":"Protein structure prediction","score":0.46247923374176025},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.4286336898803711},{"id":"https://openalex.org/keywords/structural-bioinformatics","display_name":"Structural bioinformatics","score":0.4231695830821991},{"id":"https://openalex.org/keywords/protein-structure","display_name":"Protein structure","score":0.40500950813293457},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.37500816583633423},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.36758682131767273},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.3626953959465027},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.357472687959671},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.24479857087135315},{"id":"https://openalex.org/keywords/biophysics","display_name":"Biophysics","score":0.18617510795593262},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.1499461531639099}],"concepts":[{"id":"https://openalex.org/C55988834","wikidata":"https://www.wikidata.org/wiki/Q903650","display_name":"Coiled coil","level":2,"score":0.8342622518539429},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.6006187200546265},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5854272842407227},{"id":"https://openalex.org/C202264299","wikidata":"https://www.wikidata.org/wiki/Q905695","display_name":"UniProt","level":3,"score":0.5509138703346252},{"id":"https://openalex.org/C2775905019","wikidata":"https://www.wikidata.org/wiki/Q192572","display_name":"In silico","level":3,"score":0.47899100184440613},{"id":"https://openalex.org/C18051474","wikidata":"https://www.wikidata.org/wiki/Q899656","display_name":"Protein structure prediction","level":3,"score":0.46247923374176025},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.4286336898803711},{"id":"https://openalex.org/C69131567","wikidata":"https://www.wikidata.org/wiki/Q2068215","display_name":"Structural bioinformatics","level":3,"score":0.4231695830821991},{"id":"https://openalex.org/C47701112","wikidata":"https://www.wikidata.org/wiki/Q735188","display_name":"Protein structure","level":2,"score":0.40500950813293457},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.37500816583633423},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.36758682131767273},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3626953959465027},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.357472687959671},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.24479857087135315},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.18617510795593262},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1499461531639099}],"mesh":[{"descriptor_ui":"D000072417","descriptor_name":"Protein Domains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000072417","descriptor_name":"Protein Domains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000072417","descriptor_name":"Protein Domains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008956","descriptor_name":"Models, Chemical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008956","descriptor_name":"Models, Chemical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008956","descriptor_name":"Models, Chemical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019281","descriptor_name":"Dimerization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019281","descriptor_name":"Dimerization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019281","descriptor_name":"Dimerization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020539","descriptor_name":"Sequence Analysis, Protein","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020539","descriptor_name":"Sequence Analysis, Protein","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020539","descriptor_name":"Sequence Analysis, Protein","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1093/bib/bbv047","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbv047","pdf_url":"https://academic.oup.com/bib/article-pdf/17/2/270/25416651/bbv047.pdf","source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},{"id":"pmid:26177815","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26177815","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in bioinformatics","raw_type":null},{"id":"pmh:oai:europepmc.org:5032797","is_oa":false,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6078162","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:open-archive.highwire.org:bib:17/2/270","is_oa":false,"landing_page_url":"http://bib.oxfordjournals.org/cgi/content/short/17/2/270","pdf_url":null,"source":{"id":"https://openalex.org/S4406923041","display_name":"HighWire Press Open Archive","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"TEXT"}],"best_oa_location":{"id":"doi:10.1093/bib/bbv047","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbv047","pdf_url":"https://academic.oup.com/bib/article-pdf/17/2/270/25416651/bbv047.pdf","source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Industry, innovation and infrastructure","id":"https://metadata.un.org/sdg/9","score":0.6200000047683716}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2254904118.pdf","grobid_xml":"https://content.openalex.org/works/W2254904118.grobid-xml"},"referenced_works_count":87,"referenced_works":["https://openalex.org/W341336861","https://openalex.org/W1577024459","https://openalex.org/W1766594731","https://openalex.org/W1965231243","https://openalex.org/W1967302489","https://openalex.org/W1971047357","https://openalex.org/W1978763290","https://openalex.org/W1982005006","https://openalex.org/W1982251004","https://openalex.org/W1983869242","https://openalex.org/W1984711666","https://openalex.org/W1985514943","https://openalex.org/W1987584191","https://openalex.org/W1989619236","https://openalex.org/W1993061512","https://openalex.org/W1994947657","https://openalex.org/W1998130142","https://openalex.org/W1998377570","https://openalex.org/W2002844124","https://openalex.org/W2006617902","https://openalex.org/W2010822247","https://openalex.org/W2015546050","https://openalex.org/W2016332933","https://openalex.org/W2017780934","https://openalex.org/W2017976446","https://openalex.org/W2023555945","https://openalex.org/W2027594237","https://openalex.org/W2032155561","https://openalex.org/W2034930832","https://openalex.org/W2037169923","https://openalex.org/W2040818153","https://openalex.org/W2046132401","https://openalex.org/W2046371018","https://openalex.org/W2051370951","https://openalex.org/W2051503991","https://openalex.org/W2052883021","https://openalex.org/W2053224153","https://openalex.org/W2058062660","https://openalex.org/W2059179327","https://openalex.org/W2064551580","https://openalex.org/W2069470894","https://openalex.org/W2070121169","https://openalex.org/W2072591681","https://openalex.org/W2073012734","https://openalex.org/W2075644998","https://openalex.org/W2076089035","https://openalex.org/W2083774304","https://openalex.org/W2092954353","https://openalex.org/W2098742973","https://openalex.org/W2102687634","https://openalex.org/W2103964575","https://openalex.org/W2109354682","https://openalex.org/W2113120594","https://openalex.org/W2115114820","https://openalex.org/W2115396351","https://openalex.org/W2117709367","https://openalex.org/W2117996955","https://openalex.org/W2118372625","https://openalex.org/W2119336981","https://openalex.org/W2119821739","https://openalex.org/W2122210511","https://openalex.org/W2125358782","https://openalex.org/W2125531604","https://openalex.org/W2128653811","https://openalex.org/W2129507204","https://openalex.org/W2129508689","https://openalex.org/W2130471829","https://openalex.org/W2137924550","https://openalex.org/W2138906106","https://openalex.org/W2140112946","https://openalex.org/W2152911717","https://openalex.org/W2153420734","https://openalex.org/W2158714788","https://openalex.org/W2161072217","https://openalex.org/W2162085776","https://openalex.org/W2162993917","https://openalex.org/W2169482727","https://openalex.org/W2170456357","https://openalex.org/W2170747616","https://openalex.org/W2172219847","https://openalex.org/W2328496340","https://openalex.org/W2911964244","https://openalex.org/W4239510810","https://openalex.org/W4243228481","https://openalex.org/W6611553314","https://openalex.org/W6665065844","https://openalex.org/W6684830297"],"related_works":["https://openalex.org/W4214882023","https://openalex.org/W4383473016","https://openalex.org/W2039679484","https://openalex.org/W1564749278","https://openalex.org/W1433532214","https://openalex.org/W1885320193","https://openalex.org/W2136856901","https://openalex.org/W2557251634","https://openalex.org/W2181530468","https://openalex.org/W3177828909"],"abstract_inverted_index":{"Coiled-coils":[0],"refer":[1],"to":[2,60,172,182],"a":[3,12,37,135],"bundle":[4],"of":[5,11,21,24,46,52,67,110,138],"helices":[6],"coiled":[7],"together":[8],"like":[9],"strands":[10],"rope.":[13],"It":[14],"has":[15],"been":[16,58],"estimated":[17],"that":[18,34,192],"nearly":[19],"3%":[20],"protein-encoding":[22],"regions":[23],"genes":[25],"harbour":[26],"coiled-coil":[27,85,95,98,222],"domains":[28,179],"(CCDs).":[29],"Experimental":[30],"studies":[31],"have":[32,57],"confirmed":[33,171],"CCDs":[35,68,147,157,174],"play":[36],"fundamental":[38],"role":[39],"in":[40,69,108,208,217],"subcellular":[41],"infrastructure":[42],"and":[43,64,76,82,97,104,118,145,148,211,223],"controlling":[44],"trafficking":[45],"eukaryotic":[47],"cells.":[48],"Given":[49],"the":[50,62,122],"importance":[51],"coiled-coils,":[53],"multiple":[54],"bioinformatics":[55,80,209],"tools":[56,83],"developed":[59],"facilitate":[61],"systematic":[63],"high-throughput":[65],"prediction":[66,114],"proteins.":[70],"In":[71,131],"this":[72,193],"article,":[73],"we":[74,133],"review":[75],"compare":[77],"12":[78],"sequence-based":[79],"approaches":[81,88,220],"for":[84,156,201,212,221],"prediction.":[86,101,189,227],"These":[87],"can":[89],"be":[90,173,197],"categorized":[91],"into":[92],"two":[93,165,168],"classes:":[94],"detection":[96],"oligomeric":[99,149,187,225],"state":[100,188,226],"We":[102,190],"evaluated":[103],"compared":[105],"these":[106],"methods":[107,117],"terms":[109],"their":[111],"input/output,":[112],"algorithm,":[113],"performance,":[115],"validation":[116],"software":[119],"utility.":[120],"All":[121],"independent":[123],"testing":[124],"data":[125],"sets":[126],"are":[127,215],"available":[128],"at":[129],"http://lightning.med.monash.edu/coiledcoil/.":[130],"addition,":[132],"conducted":[134],"case":[136],"study":[137],"nine":[139],"human":[140],"polyglutamine":[141],"(PolyQ)":[142],"disease-related":[143],"proteins":[144,169],"predicted":[146,181],"states":[150],"using":[151,186],"various":[152],"predictors.":[153,163],"Prediction":[154],"results":[155],"were":[158,170,180],"highly":[159],"variable":[160],"among":[161],"different":[162],"Only":[164],"peptides":[166],"from":[167],"by":[175],"majority":[176],"voting.":[177],"Both":[178],"form":[183],"dimeric":[184],"coiled-coils":[185],"anticipate":[191],"comprehensive":[194],"analysis":[195],"will":[196],"an":[198],"insightful":[199],"resource":[200],"structural":[202],"biologists":[203],"with":[204],"limited":[205],"prior":[206],"experience":[207],"tools,":[210],"bioinformaticians":[213],"who":[214],"interested":[216],"designing":[218],"novel":[219],"its":[224]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":1}],"updated_date":"2026-03-20T23:20:44.827607","created_date":"2016-06-24T00:00:00"}