{"id":"https://openalex.org/W1817412134","doi":"https://doi.org/10.1093/bib/bbv040","title":"Untangling the complexity of blood coagulation network: use of computational modelling in pharmacology and diagnostics","display_name":"Untangling the complexity of blood coagulation network: use of computational modelling in pharmacology and diagnostics","publication_year":2015,"publication_date":"2015-06-27","ids":{"openalex":"https://openalex.org/W1817412134","doi":"https://doi.org/10.1093/bib/bbv040","mag":"1817412134","pmid":"https://pubmed.ncbi.nlm.nih.gov/26116831"},"language":"en","primary_location":{"id":"doi:10.1093/bib/bbv040","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbv040","pdf_url":"https://academic.oup.com/bib/article-pdf/17/3/429/6685491/bbv040.pdf","source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://academic.oup.com/bib/article-pdf/17/3/429/6685491/bbv040.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5029278386","display_name":"A. M. Shibeko","orcid":"https://orcid.org/0000-0003-1494-3125"},"institutions":[{"id":"https://openalex.org/I4210122842","display_name":"Center for Theoretical Problems of Physicochemical Pharmacology","ror":"https://ror.org/02ncvqp37","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210115279","https://openalex.org/I4210122842"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Alexey M. Shibeko","raw_affiliation_strings":["Alexey Shibeko is a Senior Scientist in the Laboratory of Cell Biophysics at the Center for Theoretical Problems of Physicochemical Pharmacology. He studies processes of blood coagulation activation and blood clot lysis in vitro and in silico"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Alexey Shibeko is a Senior Scientist in the Laboratory of Cell Biophysics at the Center for Theoretical Problems of Physicochemical Pharmacology. He studies processes of blood coagulation activation and blood clot lysis in vitro and in silico","institution_ids":["https://openalex.org/I4210122842"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5058001042","display_name":"Mikhail A. Panteleev","orcid":"https://orcid.org/0000-0002-8128-7757"},"institutions":[{"id":"https://openalex.org/I153845743","display_name":"Moscow Institute of Physics and Technology","ror":"https://ror.org/00v0z9322","country_code":"RU","type":"education","lineage":["https://openalex.org/I153845743"]},{"id":"https://openalex.org/I19880235","display_name":"Lomonosov Moscow State University","ror":"https://ror.org/010pmpe69","country_code":"RU","type":"education","lineage":["https://openalex.org/I19880235"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Mikhail A. Panteleev","raw_affiliation_strings":["Mikhail Panteleev is a head of the Laboratory of Cellular Haemostasis and Thrombosis at the Federal Center for Children's Haematology, a professor of Physics Faculty at the M.V.Lomonosov Moscow State University (Moscow, Russia), and a professor of the Faculty of Biological and Medical Physics at the Moscow Institute of Physics and Technology (Dolgoprudnyi, Russia). He works in experimental biophysics and computational systems biology with focus on the regulation of blood coagulation, platelet signal transduction, diagnostics and drug development in haematology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mikhail Panteleev is a head of the Laboratory of Cellular Haemostasis and Thrombosis at the Federal Center for Children's Haematology, a professor of Physics Faculty at the M.V.Lomonosov Moscow State University (Moscow, Russia), and a professor of the Faculty of Biological and Medical Physics at the Moscow Institute of Physics and Technology (Dolgoprudnyi, Russia). He works in experimental biophysics and computational systems biology with focus on the regulation of blood coagulation, platelet signal transduction, diagnostics and drug development in haematology","institution_ids":["https://openalex.org/I153845743","https://openalex.org/I19880235"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3885,"currency":"USD","value_usd":3885},"apc_paid":null,"fwci":1.5853,"has_fulltext":false,"cited_by_count":26,"citation_normalized_percentile":{"value":0.82864691,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"17","issue":"3","first_page":"429","last_page":"439"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11280","display_name":"Hemophilia Treatment and Research","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11280","display_name":"Hemophilia Treatment and Research","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11917","display_name":"Coagulation, Bradykinin, Polyphosphates, and Angioedema","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":0.9994000196456909,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/coagulation","display_name":"Coagulation","score":0.658897340297699},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6138038635253906},{"id":"https://openalex.org/keywords/computational-model","display_name":"Computational model","score":0.595363199710846},{"id":"https://openalex.org/keywords/risk-analysis","display_name":"Risk analysis (engineering)","score":0.49677520990371704},{"id":"https://openalex.org/keywords/coagulation-system","display_name":"Coagulation system","score":0.49139443039894104},{"id":"https://openalex.org/keywords/pharmacodynamics","display_name":"Pharmacodynamics","score":0.4286056458950043},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.3491666316986084},{"id":"https://openalex.org/keywords/management-science","display_name":"Management science","score":0.3304072618484497},{"id":"https://openalex.org/keywords/intensive-care-medicine","display_name":"Intensive care medicine","score":0.3301438093185425},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.30244219303131104},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.28989169001579285},{"id":"https://openalex.org/keywords/pharmacology","display_name":"Pharmacology","score":0.21678891777992249},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.14679306745529175},{"id":"https://openalex.org/keywords/engineering","display_name":"Engineering","score":0.11474403738975525},{"id":"https://openalex.org/keywords/pharmacokinetics","display_name":"Pharmacokinetics","score":0.11093518137931824}],"concepts":[{"id":"https://openalex.org/C2778382381","wikidata":"https://www.wikidata.org/wiki/Q179217","display_name":"Coagulation","level":2,"score":0.658897340297699},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6138038635253906},{"id":"https://openalex.org/C66024118","wikidata":"https://www.wikidata.org/wiki/Q1122506","display_name":"Computational model","level":2,"score":0.595363199710846},{"id":"https://openalex.org/C112930515","wikidata":"https://www.wikidata.org/wiki/Q4389547","display_name":"Risk analysis (engineering)","level":1,"score":0.49677520990371704},{"id":"https://openalex.org/C3020712002","wikidata":"https://www.wikidata.org/wiki/Q179217","display_name":"Coagulation system","level":3,"score":0.49139443039894104},{"id":"https://openalex.org/C111113717","wikidata":"https://www.wikidata.org/wiki/Q725307","display_name":"Pharmacodynamics","level":3,"score":0.4286056458950043},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3491666316986084},{"id":"https://openalex.org/C539667460","wikidata":"https://www.wikidata.org/wiki/Q2414942","display_name":"Management science","level":1,"score":0.3304072618484497},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.3301438093185425},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.30244219303131104},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.28989169001579285},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.21678891777992249},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.14679306745529175},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.11474403738975525},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.11093518137931824},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D001777","descriptor_name":"Blood Coagulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001777","descriptor_name":"Blood Coagulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001777","descriptor_name":"Blood Coagulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013927","descriptor_name":"Thrombosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013927","descriptor_name":"Thrombosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013927","descriptor_name":"Thrombosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015536","descriptor_name":"Down-Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015536","descriptor_name":"Down-Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015536","descriptor_name":"Down-Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1093/bib/bbv040","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbv040","pdf_url":"https://academic.oup.com/bib/article-pdf/17/3/429/6685491/bbv040.pdf","source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},{"id":"pmid:26116831","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26116831","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in bioinformatics","raw_type":"Journal Article"},{"id":"pmh:oai:open-archive.highwire.org:bib:17/3/429","is_oa":false,"landing_page_url":"http://bib.oxfordjournals.org/cgi/content/short/17/3/429","pdf_url":null,"source":{"id":"https://openalex.org/S4406923041","display_name":"HighWire Press Open Archive","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"TEXT"}],"best_oa_location":{"id":"doi:10.1093/bib/bbv040","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbv040","pdf_url":"https://academic.oup.com/bib/article-pdf/17/3/429/6685491/bbv040.pdf","source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.7599999904632568,"id":"https://metadata.un.org/sdg/3"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320329591","display_name":"Lomonosov Moscow State University","ror":"https://ror.org/010pmpe69"}],"has_content":{"pdf":true,"grobid_xml":false},"content_urls":{"pdf":"https://content.openalex.org/works/W1817412134.pdf"},"referenced_works_count":79,"referenced_works":["https://openalex.org/W74008669","https://openalex.org/W295511661","https://openalex.org/W1503079959","https://openalex.org/W1511802802","https://openalex.org/W1525674540","https://openalex.org/W1532726112","https://openalex.org/W1582819347","https://openalex.org/W1860833529","https://openalex.org/W1887163995","https://openalex.org/W1966768006","https://openalex.org/W1966792216","https://openalex.org/W1967085308","https://openalex.org/W1969121644","https://openalex.org/W1979997504","https://openalex.org/W1982442692","https://openalex.org/W1990115156","https://openalex.org/W1993627870","https://openalex.org/W1999694715","https://openalex.org/W2000600286","https://openalex.org/W2005668158","https://openalex.org/W2014482592","https://openalex.org/W2016582914","https://openalex.org/W2016886055","https://openalex.org/W2018089823","https://openalex.org/W2018510530","https://openalex.org/W2019451187","https://openalex.org/W2023122926","https://openalex.org/W2023858668","https://openalex.org/W2028718651","https://openalex.org/W2031515989","https://openalex.org/W2031677121","https://openalex.org/W2036503834","https://openalex.org/W2036682033","https://openalex.org/W2044204506","https://openalex.org/W2045609960","https://openalex.org/W2045891112","https://openalex.org/W2046936517","https://openalex.org/W2048599158","https://openalex.org/W2051676709","https://openalex.org/W2058161894","https://openalex.org/W2058191799","https://openalex.org/W2058279507","https://openalex.org/W2058297756","https://openalex.org/W2060494982","https://openalex.org/W2061254250","https://openalex.org/W2063141627","https://openalex.org/W2065789283","https://openalex.org/W2078267457","https://openalex.org/W2081647823","https://openalex.org/W2083194928","https://openalex.org/W2084769889","https://openalex.org/W2086544626","https://openalex.org/W2087350779","https://openalex.org/W2089327110","https://openalex.org/W2091823070","https://openalex.org/W2100307511","https://openalex.org/W2102115640","https://openalex.org/W2104849069","https://openalex.org/W2116400438","https://openalex.org/W2120722937","https://openalex.org/W2124464570","https://openalex.org/W2126513998","https://openalex.org/W2127414127","https://openalex.org/W2127946991","https://openalex.org/W2128042853","https://openalex.org/W2132984496","https://openalex.org/W2138147135","https://openalex.org/W2141465303","https://openalex.org/W2144009916","https://openalex.org/W2149570924","https://openalex.org/W2153132173","https://openalex.org/W2154779020","https://openalex.org/W2155892324","https://openalex.org/W2156682654","https://openalex.org/W2162671203","https://openalex.org/W2162803208","https://openalex.org/W2171640810","https://openalex.org/W6602986760","https://openalex.org/W6654747093"],"related_works":["https://openalex.org/W2512300554","https://openalex.org/W2216212565","https://openalex.org/W2358631718","https://openalex.org/W2413944392","https://openalex.org/W2021540990","https://openalex.org/W16560577","https://openalex.org/W2537496457","https://openalex.org/W2380608274","https://openalex.org/W2424979023","https://openalex.org/W2358300717"],"abstract_inverted_index":{"Blood":[0],"coagulation":[1,31,62,108,162,221],"is":[2,54],"a":[3,33,70,79,118],"complex":[4,198],"biochemical":[5],"network":[6],"that":[7,16,173],"plays":[8],"critical":[9],"roles":[10],"in":[11,103,222],"haemostasis":[12,45],"(a":[13],"physiological":[14],"process":[15],"stops":[17],"bleeding":[18],"on":[19],"injury)":[20],"and":[21,28,49,64,75,77,129,146,159,195,210],"thrombosis":[22,48],"(pathological":[23],"vessel":[24],"occlusion).":[25],"Both":[26],"up-":[27],"down-regulation":[29],"of":[30,73,100,106,117,123,141,155,161,170,191,197,220],"remain":[32],"major":[34],"challenge":[35],"for":[36,59,109,149],"modern":[37],"medicine,":[38],"with":[39],"the":[40,101,104,114,165,192,217],"ultimate":[41],"goal":[42],"to":[43,112,120,126,132,138,203],"correct":[44],"without":[46],"causing":[47],"vice":[50],"versa.":[51],"Mathematical/computational":[52],"modelling":[53,105,172,182,219],"potentially":[55],"an":[56],"important":[57],"tool":[58],"understanding":[60],"blood":[61,107],"disorders":[63],"their":[65],"treatment.":[66],"It":[67],"can":[68,207,213],"save":[69],"huge":[71],"amount":[72],"time":[74],"resources,":[76],"provide":[78],"valuable":[80],"alternative":[81],"or":[82,89,92,137],"supplement":[83],"when":[84],"clinical":[85],"studies":[86],"are":[87,151],"limited,":[88],"not":[90],"ethical,":[91],"technically":[93],"impossible.":[94],"This":[95],"article":[96],"reviews":[97],"contemporary":[98],"state":[99],"art":[102],"practical":[110],"purposes:":[111],"reveal":[113],"molecular":[115],"basis":[116],"disease,":[119],"understand":[121],"mechanisms":[122,154],"drug":[124,135],"action,":[125],"predict":[127],"pharmacodynamics":[128],"drug-drug":[130],"interactions,":[131],"suggest":[133],"potential":[134],"targets":[136],"improve":[139],"quality":[140],"diagnostics.":[142],"Different":[143],"model":[144],"types":[145],"designs":[147],"used":[148],"this":[150,206],"discussed.":[152],"Functional":[153],"procoagulant":[156],"bypassing":[157],"agents":[158],"investigations":[160],"inhibitors":[163],"were":[164],"two":[166],"particularly":[167],"popular":[168],"applications":[169],"computational":[171],"gave":[174],"non-trivial":[175],"results.":[176],"Yet,":[177],"like":[178],"any":[179],"other":[180],"tool,":[181],"has":[183],"its":[184],"limitations,":[185],"mainly":[186],"determined":[187],"by":[188],"insufficient":[189],"knowledge":[190],"system,":[193],"uncertainty":[194],"unreliability":[196],"models.":[199],"We":[200],"show":[201],"how":[202],"some":[204],"extent":[205],"be":[208,214],"overcome":[209],"discuss":[211],"what":[212],"expected":[215],"from":[216],"mathematical":[218],"not-so-far":[223],"future.":[224]},"counts_by_year":[{"year":2024,"cited_by_count":7},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":2},{"year":2020,"cited_by_count":6},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":3},{"year":2015,"cited_by_count":1}],"updated_date":"2026-08-26T07:47:46.906454","created_date":"2025-10-10T00:00:00"}