{"id":"https://openalex.org/W1826975184","doi":"https://doi.org/10.1093/bib/bbv030","title":"Individualized identification of disease-associated pathways with disrupted coordination of gene expression","display_name":"Individualized identification of disease-associated pathways with disrupted coordination of gene expression","publication_year":2015,"publication_date":"2015-05-27","ids":{"openalex":"https://openalex.org/W1826975184","doi":"https://doi.org/10.1093/bib/bbv030","mag":"1826975184","pmid":"https://pubmed.ncbi.nlm.nih.gov/26023086"},"language":"en","primary_location":{"id":"doi:10.1093/bib/bbv030","is_oa":false,"landing_page_url":"https://doi.org/10.1093/bib/bbv030","pdf_url":null,"source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100357154","display_name":"Hongwei Wang","orcid":"https://orcid.org/0000-0003-3581-8892"},"institutions":[{"id":"https://openalex.org/I4210099593","display_name":"Computer Algorithms for Medicine","ror":"https://ror.org/00zky6d38","country_code":"AT","type":"facility","lineage":["https://openalex.org/I4210099593"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Hongwei Wang","raw_affiliation_strings":["Hongwei Wang is a PhD candidate in Bioinformatics at Harbin Medical University. His research is focused on developing novel algorithms for personalized medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hongwei Wang is a PhD candidate in Bioinformatics at Harbin Medical University. His research is focused on developing novel algorithms for personalized medicine","institution_ids":["https://openalex.org/I4210099593"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101437057","display_name":"Hao Cai","orcid":"https://orcid.org/0000-0002-4937-085X"},"institutions":[{"id":"https://openalex.org/I4210151837","display_name":"High Throughput Biology (United States)","ror":"https://ror.org/05h1bjp83","country_code":"US","type":"company","lineage":["https://openalex.org/I4210151837"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hao Cai","raw_affiliation_strings":["Hao Cai is a postgraduate student in Bioinformatics at Fujian Medical University. Her research is focused on the high-throughput omics data analysis"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hao Cai is a postgraduate student in Bioinformatics at Fujian Medical University. Her research is focused on the high-throughput omics data analysis","institution_ids":["https://openalex.org/I4210151837"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059727447","display_name":"Lu Ao","orcid":"https://orcid.org/0000-0001-7378-4967"},"institutions":[{"id":"https://openalex.org/I4210151837","display_name":"High Throughput Biology (United States)","ror":"https://ror.org/05h1bjp83","country_code":"US","type":"company","lineage":["https://openalex.org/I4210151837"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lu Ao","raw_affiliation_strings":["Lu Ao is a PhD candidate in Bioinformatics at Harbin Medical University. Her research is focused on the high-throughput omics data analysis"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lu Ao is a PhD candidate in Bioinformatics at Harbin Medical University. Her research is focused on the high-throughput omics data analysis","institution_ids":["https://openalex.org/I4210151837"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066344285","display_name":"Haidan Yan","orcid":"https://orcid.org/0000-0003-0214-7471"},"institutions":[{"id":"https://openalex.org/I4210151837","display_name":"High Throughput Biology (United States)","ror":"https://ror.org/05h1bjp83","country_code":"US","type":"company","lineage":["https://openalex.org/I4210151837"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Haidan Yan","raw_affiliation_strings":["Haidan Yan, PhD, is an Assistant of Bioinformatics at Fujian Medical University. Her research is focused on the high-throughput omics data analysis"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Haidan Yan, PhD, is an Assistant of Bioinformatics at Fujian Medical University. Her research is focused on the high-throughput omics data analysis","institution_ids":["https://openalex.org/I4210151837"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043417955","display_name":"Wenyuan Zhao","orcid":"https://orcid.org/0000-0002-6477-9434"},"institutions":[{"id":"https://openalex.org/I2801316944","display_name":"Cancer Research UK","ror":"https://ror.org/054225q67","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I2801316944"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Wenyuan Zhao","raw_affiliation_strings":["Wenyuan Zhao, PhD, is a Lecturer of Bioinformatics at Harbin Medical University. Her research is focused on understanding the relationship between inflammation and cancer"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Wenyuan Zhao, PhD, is a Lecturer of Bioinformatics at Harbin Medical University. Her research is focused on understanding the relationship between inflammation and cancer","institution_ids":["https://openalex.org/I2801316944"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032948942","display_name":"Lishuang Qi","orcid":"https://orcid.org/0000-0002-2991-6544"},"institutions":[{"id":"https://openalex.org/I141596103","display_name":"University of Lisbon","ror":"https://ror.org/01c27hj86","country_code":"PT","type":"education","lineage":["https://openalex.org/I141596103"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Lishuang Qi","raw_affiliation_strings":["Lishuang Qi, PhD, is a Lecturer of Bioinformatics at Harbin Medical University. Her research is focused on discovering cancer biomarkers"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lishuang Qi, PhD, is a Lecturer of Bioinformatics at Harbin Medical University. Her research is focused on discovering cancer biomarkers","institution_ids":["https://openalex.org/I141596103"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069723993","display_name":"Yunyan Gu","orcid":"https://orcid.org/0000-0001-5693-4126"},"institutions":[{"id":"https://openalex.org/I87890613","display_name":"Epigenomics (Germany)","ror":"https://ror.org/0490dah44","country_code":"DE","type":"company","lineage":["https://openalex.org/I87890613"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Yunyan Gu","raw_affiliation_strings":["Yuanyan Gu, PhD, is an Associate Professor of Bioinformatics at Harbin Medical University. Her research is focused on studying the collaborative relationship between genomic/epigenomic alternations"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Yuanyan Gu, PhD, is an Associate Professor of Bioinformatics at Harbin Medical University. Her research is focused on studying the collaborative relationship between genomic/epigenomic alternations","institution_ids":["https://openalex.org/I87890613"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5087055335","display_name":"Zheng Guo","orcid":"https://orcid.org/0000-0003-4466-6026"},"institutions":[{"id":"https://openalex.org/I129708740","display_name":"Fujian Medical University","ror":"https://ror.org/050s6ns64","country_code":"CN","type":"education","lineage":["https://openalex.org/I129708740"]},{"id":"https://openalex.org/I156144747","display_name":"Harbin Medical University","ror":"https://ror.org/05jscf583","country_code":"CN","type":"education","lineage":["https://openalex.org/I156144747"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zheng Guo","raw_affiliation_strings":["Zheng Guo, PhD, is a Professor of Bioinformatics at Harbin Medical University and Fujian Medical University. His research is focused on analyzing complex diseases at the functional module level","Harbin Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Zheng Guo, PhD, is a Professor of Bioinformatics at Harbin Medical University and Fujian Medical University. His research is focused on analyzing complex diseases at the functional module level","institution_ids":["https://openalex.org/I129708740"]},{"raw_affiliation_string":"Harbin Medical University","institution_ids":["https://openalex.org/I156144747"]}]}],"institutions":[],"countries_distinct_count":6,"institutions_distinct_count":7,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4011,"currency":"USD","value_usd":4011},"apc_paid":null,"fwci":2.2169,"has_fulltext":false,"cited_by_count":29,"citation_normalized_percentile":{"value":0.87667851,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"17","issue":"1","first_page":"78","last_page":"87"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.9993000030517578,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.9958000183105469,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lung-cancer","display_name":"Lung cancer","score":0.5746008157730103},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"Breast cancer","score":0.5605912208557129},{"id":"https://openalex.org/keywords/biological-pathway","display_name":"Biological pathway","score":0.5493230819702148},{"id":"https://openalex.org/keywords/disease","display_name":"Disease","score":0.5125172138214111},{"id":"https://openalex.org/keywords/identification","display_name":"Identification (biology)","score":0.5022847652435303},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.50209641456604},{"id":"https://openalex.org/keywords/estrogen-receptor","display_name":"Estrogen receptor","score":0.4927046597003937},{"id":"https://openalex.org/keywords/cancer","display_name":"Cancer","score":0.47959840297698975},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.47947415709495544},{"id":"https://openalex.org/keywords/microarray","display_name":"Microarray","score":0.4647931456565857},{"id":"https://openalex.org/keywords/tamoxifen","display_name":"Tamoxifen","score":0.4644909203052521},{"id":"https://openalex.org/keywords/gene-expression-profiling","display_name":"Gene expression profiling","score":0.4387558400630951},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.42205607891082764},{"id":"https://openalex.org/keywords/population","display_name":"Population","score":0.4195984899997711},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.4144560396671295},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.3678648769855499},{"id":"https://openalex.org/keywords/oncology","display_name":"Oncology","score":0.32024723291397095},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.30116090178489685},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.22662949562072754},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.21155613660812378}],"concepts":[{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.5746008157730103},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.5605912208557129},{"id":"https://openalex.org/C9927688","wikidata":"https://www.wikidata.org/wiki/Q4915012","display_name":"Biological pathway","level":4,"score":0.5493230819702148},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5125172138214111},{"id":"https://openalex.org/C116834253","wikidata":"https://www.wikidata.org/wiki/Q2039217","display_name":"Identification (biology)","level":2,"score":0.5022847652435303},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.50209641456604},{"id":"https://openalex.org/C84606932","wikidata":"https://www.wikidata.org/wiki/Q416496","display_name":"Estrogen receptor","level":4,"score":0.4927046597003937},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.47959840297698975},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.47947415709495544},{"id":"https://openalex.org/C186836561","wikidata":"https://www.wikidata.org/wiki/Q1931516","display_name":"Microarray","level":4,"score":0.4647931456565857},{"id":"https://openalex.org/C2777176818","wikidata":"https://www.wikidata.org/wiki/Q412178","display_name":"Tamoxifen","level":4,"score":0.4644909203052521},{"id":"https://openalex.org/C18431079","wikidata":"https://www.wikidata.org/wiki/Q1502169","display_name":"Gene expression profiling","level":4,"score":0.4387558400630951},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.42205607891082764},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.4195984899997711},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4144560396671295},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3678648769855499},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.32024723291397095},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.30116090178489685},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.22662949562072754},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.21155613660812378},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.0},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000077192","descriptor_name":"Adenocarcinoma of Lung","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000077192","descriptor_name":"Adenocarcinoma of Lung","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000077192","descriptor_name":"Adenocarcinoma of Lung","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009376","descriptor_name":"Neoplasms, Hormone-Dependent","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D009376","descriptor_name":"Neoplasms, Hormone-Dependent","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D009376","descriptor_name":"Neoplasms, Hormone-Dependent","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D009376","descriptor_name":"Neoplasms, Hormone-Dependent","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009376","descriptor_name":"Neoplasms, Hormone-Dependent","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009376","descriptor_name":"Neoplasms, Hormone-Dependent","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009376","descriptor_name":"Neoplasms, Hormone-Dependent","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D009376","descriptor_name":"Neoplasms, Hormone-Dependent","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D009376","descriptor_name":"Neoplasms, Hormone-Dependent","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013629","descriptor_name":"Tamoxifen","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D013629","descriptor_name":"Tamoxifen","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D013629","descriptor_name":"Tamoxifen","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018572","descriptor_name":"Disease-Free Survival","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018572","descriptor_name":"Disease-Free Survival","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018572","descriptor_name":"Disease-Free Survival","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018931","descriptor_name":"Antineoplastic Agents, Hormonal","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D018931","descriptor_name":"Antineoplastic Agents, Hormonal","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D018931","descriptor_name":"Antineoplastic Agents, Hormonal","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":false},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":false},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":false},{"descriptor_ui":"D030541","descriptor_name":"Databases, Genetic","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":false},{"descriptor_ui":"D030541","descriptor_name":"Databases, Genetic","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":false},{"descriptor_ui":"D030541","descriptor_name":"Databases, Genetic","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":false},{"descriptor_ui":"D053208","descriptor_name":"Kaplan-Meier Estimate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053208","descriptor_name":"Kaplan-Meier Estimate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053208","descriptor_name":"Kaplan-Meier Estimate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057285","descriptor_name":"Precision Medicine","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D057285","descriptor_name":"Precision Medicine","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D057285","descriptor_name":"Precision Medicine","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D057285","descriptor_name":"Precision Medicine","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":false},{"descriptor_ui":"D057285","descriptor_name":"Precision Medicine","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":false},{"descriptor_ui":"D057285","descriptor_name":"Precision Medicine","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1093/bib/bbv030","is_oa":false,"landing_page_url":"https://doi.org/10.1093/bib/bbv030","pdf_url":null,"source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},{"id":"pmid:26023086","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26023086","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in bioinformatics","raw_type":null},{"id":"pmh:oai:open-archive.highwire.org:bib:17/1/78","is_oa":false,"landing_page_url":"http://bib.oxfordjournals.org/cgi/content/short/17/1/78","pdf_url":null,"source":{"id":"https://openalex.org/S4406923041","display_name":"HighWire Press Open Archive","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"TEXT"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8199999928474426,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":35,"referenced_works":["https://openalex.org/W1580788756","https://openalex.org/W1969325859","https://openalex.org/W1979300931","https://openalex.org/W1999895438","https://openalex.org/W2003605385","https://openalex.org/W2007615926","https://openalex.org/W2011417152","https://openalex.org/W2016707708","https://openalex.org/W2020541351","https://openalex.org/W2073140442","https://openalex.org/W2078216990","https://openalex.org/W2096192437","https://openalex.org/W2096766502","https://openalex.org/W2100714130","https://openalex.org/W2100980426","https://openalex.org/W2108103968","https://openalex.org/W2110065044","https://openalex.org/W2110687686","https://openalex.org/W2110723933","https://openalex.org/W2112023890","https://openalex.org/W2120558414","https://openalex.org/W2130410032","https://openalex.org/W2142295792","https://openalex.org/W2146997276","https://openalex.org/W2147013674","https://openalex.org/W2158217645","https://openalex.org/W2159482845","https://openalex.org/W2170989872","https://openalex.org/W2171179595","https://openalex.org/W2171528238","https://openalex.org/W2325343629","https://openalex.org/W3016230452","https://openalex.org/W3041047318","https://openalex.org/W3147894994","https://openalex.org/W6668869196"],"related_works":["https://openalex.org/W4232528775","https://openalex.org/W2183420549","https://openalex.org/W1996185163","https://openalex.org/W2001866087","https://openalex.org/W2081127504","https://openalex.org/W2464148788","https://openalex.org/W1995735659","https://openalex.org/W2159792805","https://openalex.org/W2411830100","https://openalex.org/W3084530541"],"abstract_inverted_index":{"Current":[0],"pathway":[1,19,98],"analysis":[2,64],"approaches":[3],"are":[4],"primarily":[5],"dedicated":[6],"to":[7,33,124,136],"capturing":[8],"deregulated":[9],"pathways":[10,35,83],"at":[11,89],"the":[12,25,49,63,75,90,95,116],"population":[13],"level":[14,92],"and":[15,72,93,134],"cannot":[16],"provide":[17],"patient-specific":[18],"deregulation":[20,99],"information.":[21],"In":[22],"this":[23,107],"article,":[24],"authors":[26,76],"present":[27],"a":[28],"simple":[29,108],"approach,":[30],"called":[31],"individPath,":[32],"detect":[34],"with":[36,48,84],"significantly":[37],"disrupted":[38,85],"intra-pathway":[39,52,120],"relative":[40,53,86],"expression":[41,54,87],"orderings":[42,55,88],"for":[43,70,80],"each":[44],"disease":[45],"sample":[46],"compared":[47],"stable,":[50],"normal":[51,60],"pre-determined":[56],"in":[57,110],"previously":[58],"accumulated":[59],"samples.":[61],"Through":[62],"of":[65,97,106,118,128,140],"multiple":[66],"microarray":[67],"data":[68],"sets":[69],"lung":[71,131],"breast":[73,143],"cancer,":[74],"demonstrate":[77],"individPath's":[78],"effectiveness":[79],"detecting":[81],"cancer-associated":[82],"individual":[91],"dissecting":[94],"heterogeneity":[96],"among":[100],"different":[101],"patients.":[102],"The":[103],"portable":[104],"use":[105],"approach":[109],"clinical":[111],"contexts":[112],"is":[113],"exemplified":[114],"by":[115],"identification":[117],"prognostic":[119],"gene":[121],"pair":[122],"signatures":[123,135],"predict":[125,137],"overall":[126],"survival":[127,139],"resected":[129],"early-stage":[130],"adenocarcinoma":[132],"patients":[133,145],"relapse-free":[138],"estrogen":[141],"receptor-positive":[142],"cancer":[144],"after":[146],"tamoxifen":[147],"treatment.":[148]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":5},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":9},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":2}],"updated_date":"2026-06-16T07:32:37.131356","created_date":"2025-10-10T00:00:00"}
