{"id":"https://openalex.org/W2151357092","doi":"https://doi.org/10.1093/bib/bbv020","title":"A survey of current trends in computational drug repositioning","display_name":"A survey of current trends in computational drug repositioning","publication_year":2015,"publication_date":"2015-03-31","ids":{"openalex":"https://openalex.org/W2151357092","doi":"https://doi.org/10.1093/bib/bbv020","mag":"2151357092","pmid":"https://pubmed.ncbi.nlm.nih.gov/25832646"},"language":"en","primary_location":{"id":"doi:10.1093/bib/bbv020","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbv020","pdf_url":"https://academic.oup.com/bib/article-pdf/17/1/2/6684680/bbv020.pdf","source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://academic.oup.com/bib/article-pdf/17/1/2/6684680/bbv020.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5074284592","display_name":"Jiao Li","orcid":"https://orcid.org/0000-0001-6391-8343"},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Jiao Li","raw_affiliation_strings":["Jiao Li, PhD, is a division chief of the Institute of Medical Information, Chinese Academy of Medical Sciences. Her research interests include data modeling for drug discovery and translational bioinformatics","Institute of Medical Information, Chinese Academy of Medical Sciences, 3rd Yabao Road, Chaoyang District, Beijing 100020, China,","Institute of Medical Information, Chinese Academy of Medical Sciences"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Jiao Li, PhD, is a division chief of the Institute of Medical Information, Chinese Academy of Medical Sciences. Her research interests include data modeling for drug discovery and translational bioinformatics","institution_ids":["https://openalex.org/I200296433"]},{"raw_affiliation_string":"Institute of Medical Information, Chinese Academy of Medical Sciences, 3rd Yabao Road, Chaoyang District, Beijing 100020, China,","institution_ids":["https://openalex.org/I200296433"]},{"raw_affiliation_string":"Institute of Medical Information, Chinese Academy of Medical Sciences","institution_ids":["https://openalex.org/I200296433"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008413649","display_name":"Si Zheng","orcid":"https://orcid.org/0000-0002-9834-9774"},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]},{"id":"https://openalex.org/I4210150587","display_name":"Institute of Mining","ror":"https://ror.org/03vqakm84","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210150587","https://openalex.org/I4210163714"]}],"countries":["CN","RU"],"is_corresponding":false,"raw_author_name":"Si Zheng","raw_affiliation_strings":["Si Zheng is a faculty member of the Institute of Medical Information, Chinese Academy of Medical Sciences. Her research focuses on complex disease molecular network modeling and mining","Institute of Medical Information, Chinese Academy of Medical Sciences, 3rd Yabao Road, Chaoyang District, Beijing 100020, China,","Institute of Medical Information, Chinese Academy of Medical Sciences"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Si Zheng is a faculty member of the Institute of Medical Information, Chinese Academy of Medical Sciences. Her research focuses on complex disease molecular network modeling and mining","institution_ids":["https://openalex.org/I200296433","https://openalex.org/I4210150587"]},{"raw_affiliation_string":"Institute of Medical Information, Chinese Academy of Medical Sciences, 3rd Yabao Road, Chaoyang District, Beijing 100020, China,","institution_ids":["https://openalex.org/I200296433"]},{"raw_affiliation_string":"Institute of Medical Information, Chinese Academy of Medical Sciences","institution_ids":["https://openalex.org/I200296433"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100427284","display_name":"Bin Chen","orcid":"https://orcid.org/0000-0001-8709-2419"},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]},{"id":"https://openalex.org/I4210090117","display_name":"Courtesy Associates","ror":"https://ror.org/0099crw67","country_code":"US","type":"other","lineage":["https://openalex.org/I4210090117"]}],"countries":["CN","US"],"is_corresponding":false,"raw_author_name":"Bin Chen","raw_affiliation_strings":["Bin Chen, PhD, is a postdoctoral scholar at Stanford School of Medicine. He focuses on developing methods to leverage various data in translational drug discovery to help discover new therapeutics faster","Institute of Medical Information, Chinese Academy of Medical Sciences, 3rd Yabao Road, Chaoyang District, Beijing 100020, China,","courtesy, Medicine, Pathology and Computer Science,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bin Chen, PhD, is a postdoctoral scholar at Stanford School of Medicine. He focuses on developing methods to leverage various data in translational drug discovery to help discover new therapeutics faster","institution_ids":[]},{"raw_affiliation_string":"Institute of Medical Information, Chinese Academy of Medical Sciences, 3rd Yabao Road, Chaoyang District, Beijing 100020, China,","institution_ids":["https://openalex.org/I200296433"]},{"raw_affiliation_string":"courtesy, Medicine, Pathology and Computer Science,","institution_ids":["https://openalex.org/I4210090117"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036068985","display_name":"Atul J. Butte","orcid":"https://orcid.org/0000-0002-7433-2740"},"institutions":[{"id":"https://openalex.org/I1334016132","display_name":"Lucile Packard Children's Hospital","ror":"https://ror.org/05a25vm86","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334016132","https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]}],"countries":["CN","US"],"is_corresponding":false,"raw_author_name":"Atul J. Butte","raw_affiliation_strings":["Atul Butte, MD, PhD, is an associate professor of Pediatrics and Genetics, and by courtesy, Medicine, Pathology and Computer Science, and is Chief of the Division of Systems Medicine at Stanford University and Lucile Packard Children's Hospital. He has authored nearly 200 publications","Division of Systems Medicine at Stanford University and Lucile Packard Children's Hospital","Institute of Medical Information, Chinese Academy of Medical Sciences, 3rd Yabao Road, Chaoyang District, Beijing 100020, China,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Atul Butte, MD, PhD, is an associate professor of Pediatrics and Genetics, and by courtesy, Medicine, Pathology and Computer Science, and is Chief of the Division of Systems Medicine at Stanford University and Lucile Packard Children's Hospital. He has authored nearly 200 publications","institution_ids":["https://openalex.org/I1334016132"]},{"raw_affiliation_string":"Division of Systems Medicine at Stanford University and Lucile Packard Children's Hospital","institution_ids":["https://openalex.org/I1334016132"]},{"raw_affiliation_string":"Institute of Medical Information, Chinese Academy of Medical Sciences, 3rd Yabao Road, Chaoyang District, Beijing 100020, China,","institution_ids":["https://openalex.org/I200296433"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086610385","display_name":"S. Joshua Swamidass","orcid":"https://orcid.org/0000-0003-2191-0778"},"institutions":[{"id":"https://openalex.org/I1334016132","display_name":"Lucile Packard Children's Hospital","ror":"https://ror.org/05a25vm86","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334016132","https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I196652580","display_name":"Swami Ramanand Teerth Marathwada University","ror":"https://ror.org/03nevd013","country_code":"IN","type":"education","lineage":["https://openalex.org/I196652580"]},{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]}],"countries":["CN","IN","US"],"is_corresponding":false,"raw_author_name":"S. Joshua Swamidass","raw_affiliation_strings":["S. Joshua Swamidass, MD, PhD. Both a physician and a computational scientist, Dr Swamidass is an assistant professor of Laboratory and Genomic Medicine in the Pathology and Immunology Department of Washington University in St. Louis","Division of Systems Medicine at Stanford University and Lucile Packard Children's Hospital","Institute of Medical Information, Chinese Academy of Medical Sciences, 3rd Yabao Road, Chaoyang District, Beijing 100020, China,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"S. Joshua Swamidass, MD, PhD. Both a physician and a computational scientist, Dr Swamidass is an assistant professor of Laboratory and Genomic Medicine in the Pathology and Immunology Department of Washington University in St. Louis","institution_ids":["https://openalex.org/I196652580"]},{"raw_affiliation_string":"Division of Systems Medicine at Stanford University and Lucile Packard Children's Hospital","institution_ids":["https://openalex.org/I1334016132"]},{"raw_affiliation_string":"Institute of Medical Information, Chinese Academy of Medical Sciences, 3rd Yabao Road, Chaoyang District, Beijing 100020, China,","institution_ids":["https://openalex.org/I200296433"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5083081872","display_name":"Zhiyong Lu","orcid":"https://orcid.org/0000-0001-9998-916X"},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]},{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]},{"id":"https://openalex.org/I4210109390","display_name":"National Center for Biotechnology Information","ror":"https://ror.org/02meqm098","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I2800548410","https://openalex.org/I4210109390"]}],"countries":["CN","US"],"is_corresponding":false,"raw_author_name":"Zhiyong Lu","raw_affiliation_strings":["Zhiyong Lu, PhD, is Earl Stadtman investigator at the National Center for Biotechnology Information (NCBI), National Institutes of Health (NIH) where he leads the biomedical text mining research group","Institute of Medical Information, Chinese Academy of Medical Sciences, 3rd Yabao Road, Chaoyang District, Beijing 100020, China,","Medicine in the Pathology and Immunology Department of Washington University in St. Louis"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Zhiyong Lu, PhD, is Earl Stadtman investigator at the National Center for Biotechnology Information (NCBI), National Institutes of Health (NIH) where he leads the biomedical text mining research group","institution_ids":["https://openalex.org/I4210109390"]},{"raw_affiliation_string":"Institute of Medical Information, Chinese Academy of Medical Sciences, 3rd Yabao Road, Chaoyang District, Beijing 100020, China,","institution_ids":["https://openalex.org/I200296433"]},{"raw_affiliation_string":"Medicine in the Pathology and Immunology Department of Washington University in St. Louis","institution_ids":["https://openalex.org/I204465549"]}]}],"institutions":[],"countries_distinct_count":4,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5074284592"],"corresponding_institution_ids":["https://openalex.org/I200296433"],"apc_list":{"value":3885,"currency":"USD","value_usd":3885},"apc_paid":{"value":3885,"currency":"USD","value_usd":3885},"fwci":48.2778,"has_fulltext":true,"cited_by_count":580,"citation_normalized_percentile":{"value":0.99879767,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"17","issue":"1","first_page":"2","last_page":"12"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9860000014305115,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12576","display_name":"vaccines and immunoinformatics approaches","score":0.98580002784729,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/drug-repositioning","display_name":"Drug repositioning","score":0.9421138763427734},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.7180753350257874},{"id":"https://openalex.org/keywords/computational-model","display_name":"Computational model","score":0.6671862006187439},{"id":"https://openalex.org/keywords/repurposing","display_name":"Repurposing","score":0.6494181752204895},{"id":"https://openalex.org/keywords/big-data","display_name":"Big data","score":0.6031769514083862},{"id":"https://openalex.org/keywords/data-science","display_name":"Data science","score":0.5699407458305359},{"id":"https://openalex.org/keywords/drug-discovery","display_name":"Drug discovery","score":0.5142107009887695},{"id":"https://openalex.org/keywords/computational-complexity-theory","display_name":"Computational complexity theory","score":0.4369739592075348},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.36765533685684204},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.35616034269332886},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.2543492317199707},{"id":"https://openalex.org/keywords/drug","display_name":"Drug","score":0.20673587918281555},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.1685146987438202},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.12383514642715454},{"id":"https://openalex.org/keywords/algorithm","display_name":"Algorithm","score":0.09991070628166199},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.08874368667602539}],"concepts":[{"id":"https://openalex.org/C103637391","wikidata":"https://www.wikidata.org/wiki/Q5308921","display_name":"Drug repositioning","level":3,"score":0.9421138763427734},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.7180753350257874},{"id":"https://openalex.org/C66024118","wikidata":"https://www.wikidata.org/wiki/Q1122506","display_name":"Computational model","level":2,"score":0.6671862006187439},{"id":"https://openalex.org/C519536355","wikidata":"https://www.wikidata.org/wiki/Q21021151","display_name":"Repurposing","level":2,"score":0.6494181752204895},{"id":"https://openalex.org/C75684735","wikidata":"https://www.wikidata.org/wiki/Q858810","display_name":"Big data","level":2,"score":0.6031769514083862},{"id":"https://openalex.org/C2522767166","wikidata":"https://www.wikidata.org/wiki/Q2374463","display_name":"Data science","level":1,"score":0.5699407458305359},{"id":"https://openalex.org/C74187038","wikidata":"https://www.wikidata.org/wiki/Q1418791","display_name":"Drug discovery","level":2,"score":0.5142107009887695},{"id":"https://openalex.org/C179799912","wikidata":"https://www.wikidata.org/wiki/Q205084","display_name":"Computational complexity theory","level":2,"score":0.4369739592075348},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.36765533685684204},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.35616034269332886},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.2543492317199707},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.20673587918281555},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.1685146987438202},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.12383514642715454},{"id":"https://openalex.org/C11413529","wikidata":"https://www.wikidata.org/wiki/Q8366","display_name":"Algorithm","level":1,"score":0.09991070628166199},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.08874368667602539},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.0},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004338","descriptor_name":"Drug Combinations","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004338","descriptor_name":"Drug Combinations","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004338","descriptor_name":"Drug Combinations","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011795","descriptor_name":"Surveys and Questionnaires","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011795","descriptor_name":"Surveys and Questionnaires","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011795","descriptor_name":"Surveys and Questionnaires","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015394","descriptor_name":"Molecular Structure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015394","descriptor_name":"Molecular Structure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015394","descriptor_name":"Molecular Structure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000639","qualifier_name":"trends","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000639","qualifier_name":"trends","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000639","qualifier_name":"trends","is_major_topic":false},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057225","descriptor_name":"Data Mining","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057225","descriptor_name":"Data Mining","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057225","descriptor_name":"Data Mining","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058492","descriptor_name":"Drug Repositioning","qualifier_ui":"Q000639","qualifier_name":"trends","is_major_topic":false},{"descriptor_ui":"D058492","descriptor_name":"Drug Repositioning","qualifier_ui":"Q000639","qualifier_name":"trends","is_major_topic":false},{"descriptor_ui":"D058492","descriptor_name":"Drug Repositioning","qualifier_ui":"Q000639","qualifier_name":"trends","is_major_topic":false},{"descriptor_ui":"D058492","descriptor_name":"Drug Repositioning","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":false},{"descriptor_ui":"D058492","descriptor_name":"Drug Repositioning","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":false},{"descriptor_ui":"D058492","descriptor_name":"Drug Repositioning","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1093/bib/bbv020","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbv020","pdf_url":"https://academic.oup.com/bib/article-pdf/17/1/2/6684680/bbv020.pdf","source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},{"id":"pmid:25832646","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25832646","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in bioinformatics","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:4102681","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4719067","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:ark:/13030/qt20c7s731","is_oa":false,"landing_page_url":null,"pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},{"id":"pmh:oai:escholarship.org:ark:/13030/qt20c7s731","is_oa":false,"landing_page_url":"https://escholarship.org/uc/item/20c7s731","pdf_url":null,"source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Briefings in Bioinformatics, vol 17, iss 1","raw_type":"article"},{"id":"pmh:oai:open-archive.highwire.org:bib:17/1/2","is_oa":false,"landing_page_url":"http://bib.oxfordjournals.org/cgi/content/short/17/1/2","pdf_url":null,"source":{"id":"https://openalex.org/S4406923041","display_name":"HighWire Press Open Archive","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"TEXT"}],"best_oa_location":{"id":"doi:10.1093/bib/bbv020","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbv020","pdf_url":"https://academic.oup.com/bib/article-pdf/17/1/2/6684680/bbv020.pdf","source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.5699999928474426,"id":"https://metadata.un.org/sdg/3"}],"awards":[{"id":"https://openalex.org/G512486010","display_name":null,"funder_award_id":"R01GM079719","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337372","display_name":"U.S. National Library of Medicine","ror":"https://ror.org/0060t0j89"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2151357092.pdf","grobid_xml":"https://content.openalex.org/works/W2151357092.grobid-xml"},"referenced_works_count":110,"referenced_works":["https://openalex.org/W343738323","https://openalex.org/W1540810425","https://openalex.org/W1541232310","https://openalex.org/W1544009106","https://openalex.org/W1894955529","https://openalex.org/W1964670939","https://openalex.org/W1966527984","https://openalex.org/W1969208427","https://openalex.org/W1974475138","https://openalex.org/W1975441976","https://openalex.org/W1982945330","https://openalex.org/W1983183415","https://openalex.org/W1984054151","https://openalex.org/W1989590412","https://openalex.org/W1991646180","https://openalex.org/W1992407562","https://openalex.org/W1995708259","https://openalex.org/W1997338647","https://openalex.org/W1998056319","https://openalex.org/W2009081245","https://openalex.org/W2012486622","https://openalex.org/W2012978238","https://openalex.org/W2013130010","https://openalex.org/W2014878562","https://openalex.org/W2016914833","https://openalex.org/W2020132970","https://openalex.org/W2020274161","https://openalex.org/W2021348977","https://openalex.org/W2021570230","https://openalex.org/W2023947478","https://openalex.org/W2025130434","https://openalex.org/W2044874589","https://openalex.org/W2047031939","https://openalex.org/W2049825704","https://openalex.org/W2050078980","https://openalex.org/W2054768549","https://openalex.org/W2063149926","https://openalex.org/W2068153368","https://openalex.org/W2072262468","https://openalex.org/W2073872665","https://openalex.org/W2076604395","https://openalex.org/W2078720156","https://openalex.org/W2087911044","https://openalex.org/W2088122814","https://openalex.org/W2088632292","https://openalex.org/W2091155135","https://openalex.org/W2094791588","https://openalex.org/W2097834966","https://openalex.org/W2098318720","https://openalex.org/W2098653818","https://openalex.org/W2100929382","https://openalex.org/W2102370461","https://openalex.org/W2105050951","https://openalex.org/W2106210472","https://openalex.org/W2109120098","https://openalex.org/W2111213181","https://openalex.org/W2112946624","https://openalex.org/W2113072832","https://openalex.org/W2115517051","https://openalex.org/W2116700442","https://openalex.org/W2119091936","https://openalex.org/W2121604817","https://openalex.org/W2122683221","https://openalex.org/W2124538722","https://openalex.org/W2124846732","https://openalex.org/W2125789330","https://openalex.org/W2127132032","https://openalex.org/W2128054164","https://openalex.org/W2129860849","https://openalex.org/W2130007124","https://openalex.org/W2130410032","https://openalex.org/W2130479394","https://openalex.org/W2131614043","https://openalex.org/W2134954733","https://openalex.org/W2136181737","https://openalex.org/W2138050607","https://openalex.org/W2138427043","https://openalex.org/W2138512826","https://openalex.org/W2142016317","https://openalex.org/W2142572836","https://openalex.org/W2144267044","https://openalex.org/W2144866553","https://openalex.org/W2153301032","https://openalex.org/W2155157373","https://openalex.org/W2160026116","https://openalex.org/W2161771297","https://openalex.org/W2162723974","https://openalex.org/W2162965868","https://openalex.org/W2163086529","https://openalex.org/W2163303745","https://openalex.org/W2165276227","https://openalex.org/W2166458281","https://openalex.org/W2166550586","https://openalex.org/W2167980479","https://openalex.org/W2168048632","https://openalex.org/W2169491861","https://openalex.org/W2171789864","https://openalex.org/W2208662536","https://openalex.org/W2279949369","https://openalex.org/W2318545722","https://openalex.org/W2401609757","https://openalex.org/W2402674527","https://openalex.org/W2413655681","https://openalex.org/W2432328780","https://openalex.org/W3149695318","https://openalex.org/W4237581068","https://openalex.org/W6611761343","https://openalex.org/W6646129266","https://openalex.org/W6655665166","https://openalex.org/W6694985117"],"related_works":["https://openalex.org/W2899096130","https://openalex.org/W3190782215","https://openalex.org/W2902729297","https://openalex.org/W3110500039","https://openalex.org/W4255531208","https://openalex.org/W4320009247","https://openalex.org/W4206422705","https://openalex.org/W3186872001","https://openalex.org/W3174741986","https://openalex.org/W4389861022"],"abstract_inverted_index":{"Computational":[0],"drug":[1,67,98,164],"repositioning":[2,99,113,129],"or":[3],"repurposing":[4],"is":[5,53],"a":[6,145,155],"promising":[7],"and":[8,18,38,72,109,134,142],"efficient":[9],"tool":[10],"for":[11,23,57,77,128],"discovering":[12],"new":[13,55,66],"uses":[14],"from":[15,100],"existing":[16],"drugs":[17],"holds":[19],"the":[20,27,62,93,110,118,159],"great":[21],"potential":[22,140],"precision":[24],"medicine":[25],"in":[26,92,162],"age":[28],"of":[29,35,45,80,96,158],"big":[30],"data.":[31],"The":[32],"explosive":[33],"growth":[34],"large-scale":[36],"genomic":[37],"phenotypic":[39],"data,":[40],"as":[41,43,150],"well":[42],"data":[44,70,107],"small":[46],"molecular":[47,83],"compounds":[48],"with":[49,154],"granted":[50],"regulatory":[51],"approval,":[52],"enabling":[54],"developments":[56],"computational":[58,97,112,121,133,163],"repositioning.":[59,165],"To":[60],"achieve":[61],"shortest":[63],"path":[64],"toward":[65],"indications,":[68],"advanced":[69],"processing":[71],"analysis":[73],"strategies":[74,127],"are":[75],"critical":[76,94],"making":[78],"sense":[79],"these":[81],"heterogeneous":[82],"measurements.":[84],"In":[85],"this":[86],"review,":[87],"we":[88,104,116,124,138],"show":[89],"recent":[90],"advancements":[91],"areas":[95,148],"multiple":[101],"aspects.":[102],"First,":[103],"summarize":[105],"available":[106],"sources":[108],"corresponding":[111],"strategies.":[114],"Second,":[115],"characterize":[117],"commonly":[119],"used":[120],"techniques.":[122],"Third,":[123],"discuss":[125],"validation":[126],"studies,":[130],"including":[131,144],"both":[132],"experimental":[135],"methods.":[136],"Finally,":[137],"highlight":[139],"opportunities":[141],"use-cases,":[143],"few":[146],"target":[147],"such":[149],"cancers.":[151],"We":[152],"conclude":[153],"brief":[156],"discussion":[157],"remaining":[160],"challenges":[161]},"counts_by_year":[{"year":2026,"cited_by_count":12},{"year":2025,"cited_by_count":37},{"year":2024,"cited_by_count":44},{"year":2023,"cited_by_count":47},{"year":2022,"cited_by_count":72},{"year":2021,"cited_by_count":73},{"year":2020,"cited_by_count":79},{"year":2019,"cited_by_count":73},{"year":2018,"cited_by_count":55},{"year":2017,"cited_by_count":48},{"year":2016,"cited_by_count":32},{"year":2015,"cited_by_count":7}],"updated_date":"2026-08-30T07:30:35.949966","created_date":"2025-10-10T00:00:00"}