{"id":"https://openalex.org/W2162069081","doi":"https://doi.org/10.1093/bib/bbt054","title":"A comprehensive overview of Infinium HumanMethylation450 data processing","display_name":"A comprehensive overview of Infinium HumanMethylation450 data processing","publication_year":2013,"publication_date":"2013-08-29","ids":{"openalex":"https://openalex.org/W2162069081","doi":"https://doi.org/10.1093/bib/bbt054","mag":"2162069081","pmid":"https://pubmed.ncbi.nlm.nih.gov/23990268"},"language":"en","primary_location":{"id":"doi:10.1093/bib/bbt054","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbt054","pdf_url":"https://academic.oup.com/bib/article-pdf/15/6/929/431694/bbt054.pdf","source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://academic.oup.com/bib/article-pdf/15/6/929/431694/bbt054.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5043062646","display_name":"Sarah Dedeurwaerder","orcid":null},"institutions":[{"id":"https://openalex.org/I132053463","display_name":"Universit\u00e9 Libre de Bruxelles","ror":"https://ror.org/01r9htc13","country_code":"BE","type":"education","lineage":["https://openalex.org/I132053463"]},{"id":"https://openalex.org/I196764719","display_name":"Breast Cancer Research Foundation","ror":"https://ror.org/0348ff195","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I196764719"]}],"countries":["BE","US"],"is_corresponding":false,"raw_author_name":"S. Dedeurwaerder","raw_affiliation_strings":["Sarah Dedeurwaerder is a post-doc at the Laboratory of Cancer Epigenetics, Universit\u00e9 Libre de Bruxelles. Her projects focus on the study of the DNA methylome of breast cancer samples to identify potential biomarkers for diagnosis, prognosis or response to treatment","Laboratory of Cancer Epigenetics, Universite \u00b4Libre de Bruxelles, Route de Lennik 808, 1070 Brussels, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sarah Dedeurwaerder is a post-doc at the Laboratory of Cancer Epigenetics, Universit\u00e9 Libre de Bruxelles. Her projects focus on the study of the DNA methylome of breast cancer samples to identify potential biomarkers for diagnosis, prognosis or response to treatment","institution_ids":["https://openalex.org/I196764719"]},{"raw_affiliation_string":"Laboratory of Cancer Epigenetics, Universite \u00b4Libre de Bruxelles, Route de Lennik 808, 1070 Brussels, Belgium","institution_ids":["https://openalex.org/I132053463"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067483013","display_name":"Matthieu Defrance","orcid":"https://orcid.org/0000-0002-3090-3142"},"institutions":[{"id":"https://openalex.org/I132053463","display_name":"Universit\u00e9 Libre de Bruxelles","ror":"https://ror.org/01r9htc13","country_code":"BE","type":"education","lineage":["https://openalex.org/I132053463"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"M. Defrance","raw_affiliation_strings":["Matthieu Defrance is a post-doc at the Laboratory of Cancer Epigenetics, Universit\u00e9 Libre de Bruxelles. He is a computational scientist with strong expertise in the analysis of DNA methylation arrays, ChIP-seq data and next-generation sequencing data in general","Laboratory of Cancer Epigenetics, Universite \u00b4Libre de Bruxelles, Route de Lennik 808, 1070 Brussels, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Matthieu Defrance is a post-doc at the Laboratory of Cancer Epigenetics, Universit\u00e9 Libre de Bruxelles. He is a computational scientist with strong expertise in the analysis of DNA methylation arrays, ChIP-seq data and next-generation sequencing data in general","institution_ids":["https://openalex.org/I132053463"]},{"raw_affiliation_string":"Laboratory of Cancer Epigenetics, Universite \u00b4Libre de Bruxelles, Route de Lennik 808, 1070 Brussels, Belgium","institution_ids":["https://openalex.org/I132053463"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005475425","display_name":"Martin Bizet","orcid":"https://orcid.org/0000-0001-7410-2526"},"institutions":[{"id":"https://openalex.org/I132053463","display_name":"Universit\u00e9 Libre de Bruxelles","ror":"https://ror.org/01r9htc13","country_code":"BE","type":"education","lineage":["https://openalex.org/I132053463"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"M. Bizet","raw_affiliation_strings":["Martin Bizet is a PhD student at the Laboratory of Cancer Epigenetics and the Machine Learning Group, Universit\u00e9 Libre de Bruxelles. He is a computational scientist","Laboratory of Cancer Epigenetics, Universite \u00b4Libre de Bruxelles, Route de Lennik 808, 1070 Brussels, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Martin Bizet is a PhD student at the Laboratory of Cancer Epigenetics and the Machine Learning Group, Universit\u00e9 Libre de Bruxelles. He is a computational scientist","institution_ids":["https://openalex.org/I132053463"]},{"raw_affiliation_string":"Laboratory of Cancer Epigenetics, Universite \u00b4Libre de Bruxelles, Route de Lennik 808, 1070 Brussels, Belgium","institution_ids":["https://openalex.org/I132053463"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079802157","display_name":"Emilie Calonne","orcid":"https://orcid.org/0000-0002-3649-2129"},"institutions":[{"id":"https://openalex.org/I132053463","display_name":"Universit\u00e9 Libre de Bruxelles","ror":"https://ror.org/01r9htc13","country_code":"BE","type":"education","lineage":["https://openalex.org/I132053463"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"E. Calonne","raw_affiliation_strings":["Emilie Calonne is a lab technician at the Laboratory of Cancer Epigenetics, Universit\u00e9 Libre de Bruxelles. She performs microarray and next-generation sequencing experiments","Laboratory of Cancer Epigenetics, Universite \u00b4Libre de Bruxelles, Route de Lennik 808, 1070 Brussels, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Emilie Calonne is a lab technician at the Laboratory of Cancer Epigenetics, Universit\u00e9 Libre de Bruxelles. She performs microarray and next-generation sequencing experiments","institution_ids":["https://openalex.org/I132053463"]},{"raw_affiliation_string":"Laboratory of Cancer Epigenetics, Universite \u00b4Libre de Bruxelles, Route de Lennik 808, 1070 Brussels, Belgium","institution_ids":["https://openalex.org/I132053463"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072869049","display_name":"Gianluca Bontempi","orcid":"https://orcid.org/0000-0001-8621-316X"},"institutions":[{"id":"https://openalex.org/I132053463","display_name":"Universit\u00e9 Libre de Bruxelles","ror":"https://ror.org/01r9htc13","country_code":"BE","type":"education","lineage":["https://openalex.org/I132053463"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"G. Bontempi","raw_affiliation_strings":["Laboratory of Cancer Epigenetics, Universite Libre de Bruxelles, Route de Lennik 808, 1070 Brussels, Belgium","Laboratory of Cancer Epigenetics, Universite \u00b4Libre de Bruxelles, Route de Lennik 808, 1070 Brussels, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Cancer Epigenetics, Universite Libre de Bruxelles, Route de Lennik 808, 1070 Brussels, Belgium","institution_ids":["https://openalex.org/I132053463"]},{"raw_affiliation_string":"Laboratory of Cancer Epigenetics, Universite \u00b4Libre de Bruxelles, Route de Lennik 808, 1070 Brussels, Belgium","institution_ids":["https://openalex.org/I132053463"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5038483344","display_name":"Fran\u00e7ois Fuks","orcid":"https://orcid.org/0000-0003-4637-7287"},"institutions":[{"id":"https://openalex.org/I132053463","display_name":"Universit\u00e9 Libre de Bruxelles","ror":"https://ror.org/01r9htc13","country_code":"BE","type":"education","lineage":["https://openalex.org/I132053463"]}],"countries":["BE"],"is_corresponding":true,"raw_author_name":"F. Fuks","raw_affiliation_strings":["Fran\u00e7ois Fuks is Director of the Laboratory of Cancer Epigenetics, Universit\u00e9 Libre de Bruxelles. His research focuses on the role of epigenetic modifications, in particular DNA and histone modifications, in health and disease","Laboratory of Cancer Epigenetics, Universite \u00b4Libre de Bruxelles, Route de Lennik 808, 1070 Brussels, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fran\u00e7ois Fuks is Director of the Laboratory of Cancer Epigenetics, Universit\u00e9 Libre de Bruxelles. His research focuses on the role of epigenetic modifications, in particular DNA and histone modifications, in health and disease","institution_ids":["https://openalex.org/I132053463"]},{"raw_affiliation_string":"Laboratory of Cancer Epigenetics, Universite \u00b4Libre de Bruxelles, Route de Lennik 808, 1070 Brussels, Belgium","institution_ids":["https://openalex.org/I132053463"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5038483344"],"corresponding_institution_ids":["https://openalex.org/I132053463"],"apc_list":{"value":4011,"currency":"USD","value_usd":4011},"apc_paid":{"value":4011,"currency":"USD","value_usd":4011},"fwci":7.2931,"has_fulltext":true,"cited_by_count":245,"citation_normalized_percentile":{"value":0.98065586,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":97,"max":100},"biblio":{"volume":"15","issue":"6","first_page":"929","last_page":"941"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11482","display_name":"RNA modifications and cancer","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.9944999814033508,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/normalization","display_name":"Normalization (sociology)","score":0.6408786177635193},{"id":"https://openalex.org/keywords/data-science","display_name":"Data science","score":0.5717920660972595},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5709743499755859},{"id":"https://openalex.org/keywords/dna-methylation","display_name":"DNA methylation","score":0.43068578839302063},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.1595543920993805},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.10566076636314392},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.102688729763031},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.09123426675796509}],"concepts":[{"id":"https://openalex.org/C136886441","wikidata":"https://www.wikidata.org/wiki/Q926129","display_name":"Normalization (sociology)","level":2,"score":0.6408786177635193},{"id":"https://openalex.org/C2522767166","wikidata":"https://www.wikidata.org/wiki/Q2374463","display_name":"Data science","level":1,"score":0.5717920660972595},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5709743499755859},{"id":"https://openalex.org/C190727270","wikidata":"https://www.wikidata.org/wiki/Q874745","display_name":"DNA methylation","level":4,"score":0.43068578839302063},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1595543920993805},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.10566076636314392},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.102688729763031},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.09123426675796509},{"id":"https://openalex.org/C144024400","wikidata":"https://www.wikidata.org/wiki/Q21201","display_name":"Sociology","level":0,"score":0.0},{"id":"https://openalex.org/C19165224","wikidata":"https://www.wikidata.org/wiki/Q23404","display_name":"Anthropology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D003627","descriptor_name":"Data Interpretation, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003627","descriptor_name":"Data Interpretation, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003627","descriptor_name":"Data Interpretation, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015345","descriptor_name":"Oligonucleotide Probes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015345","descriptor_name":"Oligonucleotide Probes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015345","descriptor_name":"Oligonucleotide Probes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015894","descriptor_name":"Genome, Human","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015894","descriptor_name":"Genome, Human","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015894","descriptor_name":"Genome, Human","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018899","descriptor_name":"CpG Islands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018899","descriptor_name":"CpG Islands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018899","descriptor_name":"CpG Islands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019175","descriptor_name":"DNA Methylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019175","descriptor_name":"DNA Methylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019175","descriptor_name":"DNA Methylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":false},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":false},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":false},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1093/bib/bbt054","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbt054","pdf_url":"https://academic.oup.com/bib/article-pdf/15/6/929/431694/bbt054.pdf","source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},{"id":"pmid:23990268","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23990268","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in bioinformatics","raw_type":null},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.784.4007","is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.784.4007","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/01/4a/bbt054.PMC4239800.pdf","raw_type":"text"},{"id":"pmh:oai:dipot.ulb.ac.be:2013/186990","is_oa":true,"landing_page_url":"http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/186990","pdf_url":null,"source":{"id":"https://openalex.org/S4306401063","display_name":"D\u00e9p\u00f4t institutionnel de l'Universit\u00e9 libre de Bruxelles (Universit\u00e9 Libre de Bruxelles)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I132053463","host_organization_name":"Universit\u00e9 Libre de Bruxelles","host_organization_lineage":["https://openalex.org/I132053463"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Briefings in bioinformatics, 15 (6","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4239800","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4239800","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Brief Bioinform","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1093/bib/bbt054","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbt054","pdf_url":"https://academic.oup.com/bib/article-pdf/15/6/929/431694/bbt054.pdf","source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2162069081.pdf","grobid_xml":"https://content.openalex.org/works/W2162069081.grobid-xml"},"referenced_works_count":31,"referenced_works":["https://openalex.org/W1975528145","https://openalex.org/W1998781826","https://openalex.org/W2017502278","https://openalex.org/W2020598441","https://openalex.org/W2026682494","https://openalex.org/W2029033394","https://openalex.org/W2050112556","https://openalex.org/W2056040742","https://openalex.org/W2066501895","https://openalex.org/W2081182312","https://openalex.org/W2081502106","https://openalex.org/W2096099115","https://openalex.org/W2096192437","https://openalex.org/W2097998761","https://openalex.org/W2106608030","https://openalex.org/W2107665951","https://openalex.org/W2108947463","https://openalex.org/W2119883345","https://openalex.org/W2123032740","https://openalex.org/W2124317383","https://openalex.org/W2125154191","https://openalex.org/W2127431419","https://openalex.org/W2128130893","https://openalex.org/W2134345937","https://openalex.org/W2141105144","https://openalex.org/W2150936392","https://openalex.org/W2157795344","https://openalex.org/W2159243840","https://openalex.org/W2163125553","https://openalex.org/W2169556367","https://openalex.org/W4294107304"],"related_works":["https://openalex.org/W2748952813","https://openalex.org/W2591697403","https://openalex.org/W2953716828","https://openalex.org/W2904857019","https://openalex.org/W2944728705","https://openalex.org/W3011538607","https://openalex.org/W2904022177","https://openalex.org/W4321441197","https://openalex.org/W2359348847","https://openalex.org/W4294432981"],"abstract_inverted_index":{"Infinium":[0,35],"HumanMethylation450":[1],"beadarray":[2],"is":[3,17],"a":[4,18],"popular":[5],"technology":[6],"to":[7,58,99,101],"explore":[8],"DNA":[9],"methylomes":[10],"in":[11,21,106],"health":[12],"and":[13,15,44,79,90,109],"disease,":[14],"there":[16],"current":[19],"explosion":[20],"the":[22,76,85,94,103],"use":[23],"of":[24,84,93],"this":[25],"technique.":[26],"Despite":[27],"experience":[28],"acquired":[29],"from":[30],"gene":[31],"expression":[32],"microarrays,":[33],"analyzing":[34],"Methylation":[36],"arrays":[37,52],"appeared":[38],"more":[39],"complex":[40],"than":[41],"initially":[42],"thought":[43],"several":[45,69],"difficulties":[46],"have":[47,72],"been":[48,73],"encountered,":[49],"as":[50],"those":[51],"display":[53],"specific":[54],"features":[55],"that":[56,71],"need":[57],"be":[59],"taken":[60],"into":[61],"consideration":[62],"during":[63],"data":[64,87,110],"processing.":[65],"Here,":[66],"we":[67,80],"review":[68],"issues":[70],"highlighted":[74],"by":[75],"scientific":[77],"community,":[78],"present":[81],"an":[82,91],"overview":[83],"general":[86],"processing":[88],"scheme":[89],"evaluation":[92],"different":[95],"normalization":[96],"methods":[97],"available":[98],"date":[100],"guide":[102],"450K":[104],"users":[105],"their":[107],"analysis":[108],"interpretation.":[111]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":11},{"year":2024,"cited_by_count":20},{"year":2023,"cited_by_count":17},{"year":2022,"cited_by_count":36},{"year":2021,"cited_by_count":25},{"year":2020,"cited_by_count":30},{"year":2019,"cited_by_count":10},{"year":2018,"cited_by_count":19},{"year":2017,"cited_by_count":22},{"year":2016,"cited_by_count":23},{"year":2015,"cited_by_count":17},{"year":2014,"cited_by_count":13}],"updated_date":"2026-07-30T17:31:21.811387","created_date":"2025-10-10T00:00:00"}