{"id":"https://openalex.org/W2157176621","doi":"https://doi.org/10.1093/bib/bbs049","title":"Towards a comprehensive picture of the genetic landscape of complex traits","display_name":"Towards a comprehensive picture of the genetic landscape of complex traits","publication_year":2012,"publication_date":"2012-08-27","ids":{"openalex":"https://openalex.org/W2157176621","doi":"https://doi.org/10.1093/bib/bbs049","mag":"2157176621","pmid":"https://pubmed.ncbi.nlm.nih.gov/22930650"},"language":"en","primary_location":{"id":"doi:10.1093/bib/bbs049","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbs049","pdf_url":"https://academic.oup.com/bib/article-pdf/15/1/30/455449/bbs049.pdf","source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://academic.oup.com/bib/article-pdf/15/1/30/455449/bbs049.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5034711230","display_name":"Zhenning Wang","orcid":"https://orcid.org/0000-0003-0557-3097"},"institutions":[{"id":"https://openalex.org/I130769515","display_name":"Pennsylvania State University","ror":"https://ror.org/04p491231","country_code":"US","type":"education","lineage":["https://openalex.org/I130769515"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Z. Wang","raw_affiliation_strings":["Center for Statistical Genetics, The Pennsylvania State University, Hershey, PA 17033, USA. rwu@phs.psu.edu","Beijing Forestry University,; Pennsylvania State University,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Statistical Genetics, The Pennsylvania State University, Hershey, PA 17033, USA. rwu@phs.psu.edu","institution_ids":["https://openalex.org/I130769515"]},{"raw_affiliation_string":"Beijing Forestry University,; Pennsylvania State University,","institution_ids":["https://openalex.org/I130769515"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100373805","display_name":"Yujie Wang","orcid":"https://orcid.org/0000-0001-5830-2341"},"institutions":[{"id":"https://openalex.org/I130769515","display_name":"Pennsylvania State University","ror":"https://ror.org/04p491231","country_code":"US","type":"education","lineage":["https://openalex.org/I130769515"]},{"id":"https://openalex.org/I4210140143","display_name":"Dynamic Systems (United States)","ror":"https://ror.org/043vm9914","country_code":"US","type":"company","lineage":["https://openalex.org/I4210140143"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Y. Wang","raw_affiliation_strings":["Yaqun Wang is a PhD student in statistics at The Pennsylvania State University. The focus of his thesis is the dynamic modeling of Bayesian network","Pennsylvania State University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Yaqun Wang is a PhD student in statistics at The Pennsylvania State University. The focus of his thesis is the dynamic modeling of Bayesian network","institution_ids":["https://openalex.org/I4210140143"]},{"raw_affiliation_string":"Pennsylvania State University","institution_ids":["https://openalex.org/I130769515"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060599684","display_name":"N. Wang","orcid":null},"institutions":[{"id":"https://openalex.org/I1342350481","display_name":"New York State Department of State","ror":"https://ror.org/04dh87p33","country_code":"US","type":"government","lineage":["https://openalex.org/I1342350481"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"N. Wang","raw_affiliation_strings":["Ningtao Wang is a PhD student in statistics at The Pennsylvania State University. The focus of his thesis is the modeling and dissection of complex phenotypes using differential geometry"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ningtao Wang is a PhD student in statistics at The Pennsylvania State University. The focus of his thesis is the modeling and dissection of complex phenotypes using differential geometry","institution_ids":["https://openalex.org/I1342350481"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100378570","display_name":"Jing Wang","orcid":"https://orcid.org/0000-0002-7120-0857"},"institutions":[{"id":"https://openalex.org/I31683504","display_name":"Beijing Forestry University","ror":"https://ror.org/04xv2pc41","country_code":"CN","type":"education","lineage":["https://openalex.org/I1327237609","https://openalex.org/I31683504","https://openalex.org/I4210127390"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"J. Wang","raw_affiliation_strings":["Jianxin Wang is an Associate Professor in information science at Beijing Forestry University, interested in algorithmic development for complex systems","Beijing Forestry Univ"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Jianxin Wang is an Associate Professor in information science at Beijing Forestry University, interested in algorithmic development for complex systems","institution_ids":["https://openalex.org/I31683504"]},{"raw_affiliation_string":"Beijing Forestry Univ","institution_ids":["https://openalex.org/I31683504"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034711230","display_name":"Zhenning Wang","orcid":"https://orcid.org/0000-0003-0557-3097"},"institutions":[{"id":"https://openalex.org/I130769515","display_name":"Pennsylvania State University","ror":"https://ror.org/04p491231","country_code":"US","type":"education","lineage":["https://openalex.org/I130769515"]},{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Z. Wang","raw_affiliation_strings":["Center for Statistical Genetics, The Pennsylvania State University, Hershey, PA 17033, USA. rwu@phs.psu.edu","Yale University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Statistical Genetics, The Pennsylvania State University, Hershey, PA 17033, USA. rwu@phs.psu.edu","institution_ids":["https://openalex.org/I130769515"]},{"raw_affiliation_string":"Yale University","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088975843","display_name":"C. Eduardo Vallejos","orcid":"https://orcid.org/0000-0001-8936-7885"},"institutions":[{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]},{"id":"https://openalex.org/I4210131892","display_name":"Institute of Molecular Genetics","ror":"https://ror.org/03apz2q12","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210129690","https://openalex.org/I4210131892"]}],"countries":["RU","US"],"is_corresponding":false,"raw_author_name":"C. E. Vallejos","raw_affiliation_strings":["C. E. Vallejos is an Associate Professor in plant genetics at the University of Florida. His research interest centers on the molecular genetics of disease resistance in crops, such as Phaseolus vulgaris","University of Florida"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"C. E. Vallejos is an Associate Professor in plant genetics at the University of Florida. His research interest centers on the molecular genetics of disease resistance in crops, such as Phaseolus vulgaris","institution_ids":["https://openalex.org/I4210131892"]},{"raw_affiliation_string":"University of Florida","institution_ids":["https://openalex.org/I33213144"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5031422180","display_name":"Rongling Wu","orcid":"https://orcid.org/0000-0001-8350-7779"},"institutions":[{"id":"https://openalex.org/I4210152479","display_name":"Statistical Service","ror":"https://ror.org/05vydvf11","country_code":"CY","type":"government","lineage":["https://openalex.org/I4210152479"]}],"countries":["CY"],"is_corresponding":false,"raw_author_name":"R. Wu","raw_affiliation_strings":["Rongling Wu is a Professor in biostatistics and bioinformatics and the Director of the Center for Statistical Genetics at The Pennsylvania State University. He founded the Center for Computational Biology at Beijing Forestry University. He is interested in quantitative and statistical genetics","Department of Public Health Sciences"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rongling Wu is a Professor in biostatistics and bioinformatics and the Director of the Center for Statistical Genetics at The Pennsylvania State University. He founded the Center for Computational Biology at Beijing Forestry University. He is interested in quantitative and statistical genetics","institution_ids":["https://openalex.org/I4210152479"]},{"raw_affiliation_string":"Department of Public Health Sciences","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":4,"institutions_distinct_count":8,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4011,"currency":"USD","value_usd":4011},"apc_paid":null,"fwci":1.6046,"has_fulltext":false,"cited_by_count":11,"citation_normalized_percentile":{"value":0.8474299,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"15","issue":"1","first_page":"30","last_page":"42"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11468","display_name":"Genetic Mapping and Diversity in Plants and Animals","score":0.9988999962806702,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11468","display_name":"Genetic Mapping and Diversity in Plants and Animals","score":0.9988999962806702,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9800000190734863,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.9772999882698059,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/evolutionary-biology","display_name":"Evolutionary biology","score":0.45961707830429077},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.4580610394477844},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.38359981775283813},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.3342116177082062}],"concepts":[{"id":"https://openalex.org/C78458016","wikidata":"https://www.wikidata.org/wiki/Q840400","display_name":"Evolutionary biology","level":1,"score":0.45961707830429077},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4580610394477844},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.38359981775283813},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3342116177082062}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002874","descriptor_name":"Chromosome Mapping","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":false},{"descriptor_ui":"D002874","descriptor_name":"Chromosome Mapping","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":false},{"descriptor_ui":"D002874","descriptor_name":"Chromosome Mapping","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":false},{"descriptor_ui":"D002874","descriptor_name":"Chromosome Mapping","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":false},{"descriptor_ui":"D004843","descriptor_name":"Epistasis, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004843","descriptor_name":"Epistasis, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004843","descriptor_name":"Epistasis, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004843","descriptor_name":"Epistasis, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018507","descriptor_name":"Gene Expression Regulation, Developmental","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018507","descriptor_name":"Gene Expression Regulation, Developmental","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018507","descriptor_name":"Gene Expression Regulation, Developmental","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018507","descriptor_name":"Gene Expression Regulation, Developmental","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D040641","descriptor_name":"Quantitative Trait Loci","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D040641","descriptor_name":"Quantitative Trait Loci","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D040641","descriptor_name":"Quantitative Trait Loci","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D040641","descriptor_name":"Quantitative Trait Loci","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049490","descriptor_name":"Systems Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049490","descriptor_name":"Systems Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049490","descriptor_name":"Systems Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049490","descriptor_name":"Systems Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056726","descriptor_name":"Genetic Association Studies","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":false},{"descriptor_ui":"D056726","descriptor_name":"Genetic Association Studies","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":false},{"descriptor_ui":"D056726","descriptor_name":"Genetic Association Studies","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":false},{"descriptor_ui":"D056726","descriptor_name":"Genetic Association Studies","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1093/bib/bbs049","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbs049","pdf_url":"https://academic.oup.com/bib/article-pdf/15/1/30/455449/bbs049.pdf","source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},{"id":"pmid:22930650","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22930650","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in bioinformatics","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:3896925","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3896925","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Brief Bioinform","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1093/bib/bbs049","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbs049","pdf_url":"https://academic.oup.com/bib/article-pdf/15/1/30/455449/bbs049.pdf","source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G8252663693","display_name":null,"funder_award_id":"UL1RR0330184","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"}],"funders":[{"id":"https://openalex.org/F4320337375","display_name":"National Center for Research Resources","ror":"https://ror.org/04pw6fb54"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":77,"referenced_works":["https://openalex.org/W250626939","https://openalex.org/W1561461159","https://openalex.org/W1572692634","https://openalex.org/W1821797507","https://openalex.org/W1902536864","https://openalex.org/W1914121885","https://openalex.org/W1936555975","https://openalex.org/W1944381374","https://openalex.org/W1957111431","https://openalex.org/W1965350320","https://openalex.org/W1966194800","https://openalex.org/W1967731019","https://openalex.org/W1972029972","https://openalex.org/W1972130972","https://openalex.org/W1972764318","https://openalex.org/W1975797445","https://openalex.org/W1978486653","https://openalex.org/W1985416968","https://openalex.org/W1985467296","https://openalex.org/W1991150279","https://openalex.org/W1992967587","https://openalex.org/W1996952375","https://openalex.org/W1997667014","https://openalex.org/W2000902397","https://openalex.org/W2010437889","https://openalex.org/W2011222373","https://openalex.org/W2030456687","https://openalex.org/W2033249060","https://openalex.org/W2033477461","https://openalex.org/W2040912377","https://openalex.org/W2041237913","https://openalex.org/W2042827641","https://openalex.org/W2044972684","https://openalex.org/W2046247026","https://openalex.org/W2050180108","https://openalex.org/W2055085859","https://openalex.org/W2055380365","https://openalex.org/W2056961883","https://openalex.org/W2062029454","https://openalex.org/W2062533676","https://openalex.org/W2066483624","https://openalex.org/W2066775313","https://openalex.org/W2071937330","https://openalex.org/W2076372398","https://openalex.org/W2076382102","https://openalex.org/W2078140686","https://openalex.org/W2080183225","https://openalex.org/W2080843536","https://openalex.org/W2082066439","https://openalex.org/W2094829151","https://openalex.org/W2102770120","https://openalex.org/W2103975152","https://openalex.org/W2107491970","https://openalex.org/W2108723074","https://openalex.org/W2108864800","https://openalex.org/W2121344045","https://openalex.org/W2121825082","https://openalex.org/W2124911220","https://openalex.org/W2129265801","https://openalex.org/W2130499440","https://openalex.org/W2133467365","https://openalex.org/W2139839130","https://openalex.org/W2141484921","https://openalex.org/W2142260323","https://openalex.org/W2145221987","https://openalex.org/W2148860875","https://openalex.org/W2153453282","https://openalex.org/W2163285329","https://openalex.org/W2166106382","https://openalex.org/W2168558754","https://openalex.org/W2168846334","https://openalex.org/W2171538603","https://openalex.org/W2401047372","https://openalex.org/W2784504176","https://openalex.org/W2914618148","https://openalex.org/W4241639017","https://openalex.org/W4252140292"],"related_works":["https://openalex.org/W2748952813","https://openalex.org/W2082860237","https://openalex.org/W2119695867","https://openalex.org/W2130076355","https://openalex.org/W1990804418","https://openalex.org/W1993764875","https://openalex.org/W2046158694","https://openalex.org/W2788277189","https://openalex.org/W1971568933","https://openalex.org/W2061542922"],"abstract_inverted_index":{"The":[0,212],"formation":[1,83],"of":[2,31,43,76,108,116,168,185,188,214,231,235],"phenotypic":[3,52,82,121],"traits,":[4],"such":[5],"as":[6,84],"biomass":[7],"production,":[8],"tumor":[9],"volume":[10],"and":[11,23,100,147,199,219,241],"viral":[12],"abundance,":[13],"undergoes":[14],"a":[15,85,91,106,131,157,178,186,209,223,228],"complex":[16,169,236],"process":[17,149],"in":[18,78,135,144],"which":[19,196],"interactions":[20,109],"between":[21],"genes":[22,44,59,77,103],"developmental":[24,62],"stimuli":[25],"take":[26],"place":[27],"at":[28],"each":[29,204],"level":[30],"biological":[32],"organization":[33],"from":[34,150],"cells":[35],"to":[36,57,152,163,191,206,226],"organisms.":[37],"Traditional":[38],"studies":[39],"emphasize":[40],"the":[41,74,95,117,137,142,145,165,173,193,232],"impact":[42],"by":[45,140,171,195],"directly":[46],"linking":[47],"DNA-based":[48],"markers":[49],"with":[50,203],"static":[51],"values.":[53],"Functional":[54],"mapping,":[55,162,216],"derived":[56],"detect":[58],"that":[60,104,126,176,238],"control":[61],"processes":[63],"using":[64,88],"growth":[65],"equations,":[66,90],"has":[67],"proven":[68],"powerful":[69],"for":[70,120],"addressing":[71],"questions":[72],"about":[73],"roles":[75],"development.":[79,122],"By":[80],"treating":[81],"cohesive":[86],"system":[87,96,187],"differential":[89,189],"different":[92],"approach-systems":[93],"mapping-dissects":[94],"into":[97,208],"interconnected":[98],"elements":[99],"then":[101],"map":[102],"determine":[105],"web":[107],"among":[110],"these":[111],"elements,":[112],"facilitating":[113],"our":[114],"understanding":[115],"genetic":[118,127,166,233],"machineries":[119],"Here,":[123],"we":[124],"argue":[125],"mapping":[128,182,218,221],"can":[129],"play":[130],"more":[132],"important":[133,243],"role":[134],"studying":[136],"genotype-phenotype":[138],"relationship":[139],"filling":[141],"gaps":[143],"biochemical":[146],"regulatory":[148,174],"DNA":[151],"end-point":[153],"phenotype.":[154,180],"We":[155],"describe":[156],"new":[158],"framework,":[159],"named":[160],"network":[161,220],"study":[164],"architecture":[167],"traits":[170],"integrating":[172],"networks":[175],"cause":[177],"high-order":[179],"Network":[181],"makes":[183],"use":[184],"equations":[190],"quantify":[192],"rule":[194],"transcriptional,":[197],"proteomic":[198],"metabolomic":[200],"components":[201],"interact":[202],"other":[205],"organize":[207],"functional":[210,215],"whole.":[211],"synthesis":[213],"systems":[217],"provides":[222],"novel":[224],"avenue":[225],"decipher":[227],"comprehensive":[229],"picture":[230],"landscape":[234],"phenotypes":[237],"underlie":[239],"economically":[240],"biomedically":[242],"traits.":[244]},"counts_by_year":[{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":1}],"updated_date":"2026-06-17T06:14:20.161405","created_date":"2025-10-10T00:00:00"}
