{"id":"https://openalex.org/W2148181108","doi":"https://doi.org/10.1093/bib/bbs031","title":"Taxonomic binning of metagenome samples generated by next-generation sequencing technologies","display_name":"Taxonomic binning of metagenome samples generated by next-generation sequencing technologies","publication_year":2012,"publication_date":"2012-07-31","ids":{"openalex":"https://openalex.org/W2148181108","doi":"https://doi.org/10.1093/bib/bbs031","mag":"2148181108","pmid":"https://pubmed.ncbi.nlm.nih.gov/22851513"},"language":"en","primary_location":{"id":"doi:10.1093/bib/bbs031","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbs031","pdf_url":"https://academic.oup.com/bib/article-pdf/13/6/646/479852/bbs031.pdf","source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://academic.oup.com/bib/article-pdf/13/6/646/479852/bbs031.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5089233824","display_name":"Johannes Dr\u00f6ge","orcid":"https://orcid.org/0000-0002-6752-2204"},"institutions":[{"id":"https://openalex.org/I44260953","display_name":"Heinrich Heine University D\u00fcsseldorf","ror":"https://ror.org/024z2rq82","country_code":"DE","type":"education","lineage":["https://openalex.org/I44260953"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"J. Droge","raw_affiliation_strings":["Heinrich Heine University D\u00fcsseldorf, Germany"],"affiliations":[{"raw_affiliation_string":"Heinrich Heine University D\u00fcsseldorf, Germany","institution_ids":["https://openalex.org/I44260953"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5081103408","display_name":"Alice C. McHardy","orcid":"https://orcid.org/0000-0003-2370-3430"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A. C. McHardy","raw_affiliation_strings":[],"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5089233824"],"corresponding_institution_ids":["https://openalex.org/I44260953"],"apc_list":{"value":4011,"currency":"USD","value_usd":4011},"apc_paid":null,"fwci":6.3042,"has_fulltext":false,"cited_by_count":127,"citation_normalized_percentile":{"value":0.97534098,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":94,"max":100},"biblio":{"volume":"13","issue":"6","first_page":"646","last_page":"655"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10015","display_name":"Genomics and Phylogenetic Studies","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10015","display_name":"Genomics and Phylogenetic Studies","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11791","display_name":"Microbial Community Ecology and Physiology","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2303","display_name":"Ecology"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10141","display_name":"Probiotics and Fermented Foods","score":0.9950000047683716,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/metagenomics","display_name":"Metagenomics","score":0.895652174949646},{"id":"https://openalex.org/keywords/shotgun-sequencing","display_name":"Shotgun sequencing","score":0.7869012355804443},{"id":"https://openalex.org/keywords/genome","display_name":"Genome","score":0.6654761433601379},{"id":"https://openalex.org/keywords/dna-sequencing","display_name":"DNA sequencing","score":0.6354352235794067},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.6051725745201111},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.5573648810386658},{"id":"https://openalex.org/keywords/clade","display_name":"Clade","score":0.4733983278274536},{"id":"https://openalex.org/keywords/annotation","display_name":"Annotation","score":0.4668384790420532},{"id":"https://openalex.org/keywords/sequence-assembly","display_name":"Sequence assembly","score":0.4562644958496094},{"id":"https://openalex.org/keywords/whole-genome-sequencing","display_name":"Whole genome sequencing","score":0.4447661340236664},{"id":"https://openalex.org/keywords/sequence","display_name":"Sequence (biology)","score":0.414180189371109},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.28477078676223755},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.17091411352157593},{"id":"https://openalex.org/keywords/phylogenetics","display_name":"Phylogenetics","score":0.16302752494812012}],"concepts":[{"id":"https://openalex.org/C15151743","wikidata":"https://www.wikidata.org/wiki/Q903778","display_name":"Metagenomics","level":3,"score":0.895652174949646},{"id":"https://openalex.org/C101985253","wikidata":"https://www.wikidata.org/wiki/Q1073526","display_name":"Shotgun sequencing","level":4,"score":0.7869012355804443},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.6654761433601379},{"id":"https://openalex.org/C51679486","wikidata":"https://www.wikidata.org/wiki/Q380546","display_name":"DNA sequencing","level":3,"score":0.6354352235794067},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.6051725745201111},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5573648810386658},{"id":"https://openalex.org/C44465124","wikidata":"https://www.wikidata.org/wiki/Q713623","display_name":"Clade","level":4,"score":0.4733983278274536},{"id":"https://openalex.org/C2776321320","wikidata":"https://www.wikidata.org/wiki/Q857525","display_name":"Annotation","level":2,"score":0.4668384790420532},{"id":"https://openalex.org/C18949551","wikidata":"https://www.wikidata.org/wiki/Q740578","display_name":"Sequence assembly","level":5,"score":0.4562644958496094},{"id":"https://openalex.org/C24432333","wikidata":"https://www.wikidata.org/wiki/Q2068526","display_name":"Whole genome sequencing","level":4,"score":0.4447661340236664},{"id":"https://openalex.org/C2778112365","wikidata":"https://www.wikidata.org/wiki/Q3511065","display_name":"Sequence (biology)","level":2,"score":0.414180189371109},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.28477078676223755},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.17091411352157593},{"id":"https://openalex.org/C90132467","wikidata":"https://www.wikidata.org/wiki/Q171184","display_name":"Phylogenetics","level":3,"score":0.16302752494812012},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.0},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.0}],"mesh":[{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016000","descriptor_name":"Cluster Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016000","descriptor_name":"Cluster Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016000","descriptor_name":"Cluster Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017422","descriptor_name":"Sequence Analysis, DNA","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D017422","descriptor_name":"Sequence Analysis, DNA","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D017422","descriptor_name":"Sequence Analysis, DNA","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D054892","descriptor_name":"Metagenome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D054892","descriptor_name":"Metagenome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D054892","descriptor_name":"Metagenome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D056186","descriptor_name":"Metagenomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056186","descriptor_name":"Metagenomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056186","descriptor_name":"Metagenomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1093/bib/bbs031","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbs031","pdf_url":"https://academic.oup.com/bib/article-pdf/13/6/646/479852/bbs031.pdf","source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},{"id":"pmid:22851513","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22851513","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in bioinformatics","raw_type":null}],"best_oa_location":{"id":"doi:10.1093/bib/bbs031","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbs031","pdf_url":"https://academic.oup.com/bib/article-pdf/13/6/646/479852/bbs031.pdf","source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2148181108.pdf","grobid_xml":"https://content.openalex.org/works/W2148181108.grobid-xml"},"referenced_works_count":70,"referenced_works":["https://openalex.org/W29941083","https://openalex.org/W1539550196","https://openalex.org/W1562379206","https://openalex.org/W1577577364","https://openalex.org/W1603910045","https://openalex.org/W1964106002","https://openalex.org/W1966952999","https://openalex.org/W1969346416","https://openalex.org/W1972924519","https://openalex.org/W1979006961","https://openalex.org/W1988925586","https://openalex.org/W1989348205","https://openalex.org/W2000072710","https://openalex.org/W2017425843","https://openalex.org/W2023046869","https://openalex.org/W2023829651","https://openalex.org/W2024471867","https://openalex.org/W2027496182","https://openalex.org/W2029437806","https://openalex.org/W2033900229","https://openalex.org/W2045382640","https://openalex.org/W2047927409","https://openalex.org/W2055503200","https://openalex.org/W2068187483","https://openalex.org/W2068308871","https://openalex.org/W2082464084","https://openalex.org/W2083395367","https://openalex.org/W2091232725","https://openalex.org/W2091693057","https://openalex.org/W2091922579","https://openalex.org/W2096406964","https://openalex.org/W2096525273","https://openalex.org/W2105796601","https://openalex.org/W2111662966","https://openalex.org/W2112419798","https://openalex.org/W2113601822","https://openalex.org/W2113915152","https://openalex.org/W2117582473","https://openalex.org/W2118526609","https://openalex.org/W2120365168","https://openalex.org/W2124637227","https://openalex.org/W2125230147","https://openalex.org/W2125826054","https://openalex.org/W2126809954","https://openalex.org/W2128124531","https://openalex.org/W2131988453","https://openalex.org/W2134800079","https://openalex.org/W2135621733","https://openalex.org/W2135947999","https://openalex.org/W2140059069","https://openalex.org/W2140211206","https://openalex.org/W2142678478","https://openalex.org/W2143842034","https://openalex.org/W2150337627","https://openalex.org/W2150484441","https://openalex.org/W2152469342","https://openalex.org/W2153990926","https://openalex.org/W2154969423","https://openalex.org/W2155066423","https://openalex.org/W2155545841","https://openalex.org/W2156965197","https://openalex.org/W2163830511","https://openalex.org/W2170089054","https://openalex.org/W2171309014","https://openalex.org/W2172296101","https://openalex.org/W2616754551","https://openalex.org/W2914037595","https://openalex.org/W3033390461","https://openalex.org/W4235333019","https://openalex.org/W4250297812"],"related_works":["https://openalex.org/W3043668926","https://openalex.org/W3036436206","https://openalex.org/W4238948313","https://openalex.org/W4389452281","https://openalex.org/W3111832393","https://openalex.org/W3000916974","https://openalex.org/W3183189600","https://openalex.org/W3134948850","https://openalex.org/W2573498001","https://openalex.org/W2987572536"],"abstract_inverted_index":{"Metagenome":[0],"research":[1],"uses":[2],"random":[3],"shotgun":[4],"sequencing":[5,29,34,117],"of":[6,15,44,54,58,67,72,76,89,133,140,148],"microbial":[7,143],"community":[8,74],"DNA":[9],"to":[10,86,94],"study":[11],"the":[12,59,87],"genetic":[13],"sequences":[14],"its":[16],"members":[17],"without":[18],"cultivation.":[19],"This":[20,109],"development":[21],"has":[22],"been":[23],"strongly":[24],"supported":[25],"by":[26],"improvements":[27],"in":[28,62],"technologies,":[30],"which":[31],"have":[32],"rendered":[33],"cheaper":[35],"than":[36],"before.":[37],"As":[38],"a":[39,73,91,137],"consequence,":[40],"downstream":[41],"computational":[42],"analysis":[43,64,139],"metagenome":[45,63],"sequence":[46,95,102,104],"samples":[47],"is":[48,65,110,119],"now":[49],"faced":[50],"with":[51],"large":[52],"amounts":[53],"complex":[55],"data.":[56],"One":[57],"essential":[60],"steps":[61],"reconstruction":[66,122],"draft":[68,77,113,134],"genomes":[69,135],"for":[70,79,112,121],"populations":[71],"or":[75,106],"'pan-genomes'":[78],"higher":[80],"level":[81],"clades.":[82],"'Taxonomic":[83],"binning'":[84],"corresponds":[85],"process":[88],"assigning":[90],"taxonomic":[92],"identifier":[93],"fragments,":[96],"based":[97,123],"on":[98,124],"information":[99,126],"such":[100],"as":[101],"similarity,":[103],"composition":[105],"read":[107],"coverage.":[108],"used":[111],"genome":[114],"reconstruction,":[115],"if":[116],"coverage":[118],"insufficient":[120],"assembly":[125],"alone.":[127],"Subsequent":[128],"functional":[129],"and":[130,145],"metabolic":[131],"annotation":[132],"allows":[136],"genome-level":[138],"novel":[141],"uncultured":[142],"species":[144],"even":[146],"inference":[147],"their":[149],"cultivation":[150],"requirements.":[151]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":9},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":7},{"year":2018,"cited_by_count":8},{"year":2017,"cited_by_count":17},{"year":2016,"cited_by_count":17},{"year":2015,"cited_by_count":7},{"year":2014,"cited_by_count":26},{"year":2013,"cited_by_count":15}],"updated_date":"2026-01-13T01:12:25.745995","created_date":"2025-10-10T00:00:00"}