{"id":"https://openalex.org/W2103570076","doi":"https://doi.org/10.1093/bib/bbs028","title":"Joint analysis of miRNA and mRNA expression data","display_name":"Joint analysis of miRNA and mRNA expression data","publication_year":2012,"publication_date":"2012-06-12","ids":{"openalex":"https://openalex.org/W2103570076","doi":"https://doi.org/10.1093/bib/bbs028","mag":"2103570076","pmid":"https://pubmed.ncbi.nlm.nih.gov/22692086"},"language":"en","primary_location":{"id":"doi:10.1093/bib/bbs028","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbs028","pdf_url":"https://academic.oup.com/bib/article-pdf/14/3/263/707910/bbs028.pdf","source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://academic.oup.com/bib/article-pdf/14/3/263/707910/bbs028.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5079766378","display_name":"Ander Muniategui","orcid":"https://orcid.org/0000-0002-7416-912X"},"institutions":[{"id":"https://openalex.org/I170828890","display_name":"Centro de Estudios e Investigaciones T\u00e9cnicas de Gipuzkoa","ror":"https://ror.org/022wqqf69","country_code":"ES","type":"nonprofit","lineage":["https://openalex.org/I170828890"]},{"id":"https://openalex.org/I88155538","display_name":"Universidad de Navarra","ror":"https://ror.org/02rxc7m23","country_code":"ES","type":"education","lineage":["https://openalex.org/I88155538"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"A. Muniategui","raw_affiliation_strings":["CEIT, University of Navarra, San Sebastian, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CEIT, University of Navarra, San Sebastian, Spain","institution_ids":["https://openalex.org/I170828890","https://openalex.org/I88155538"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046646488","display_name":"Jon Pey","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J. Pey","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010754980","display_name":"Francisco J. Planes","orcid":"https://orcid.org/0000-0003-1155-3105"},"institutions":[{"id":"https://openalex.org/I4210148697","display_name":"Institute of Bioinformatics","ror":"https://ror.org/04hqfvm50","country_code":"IN","type":"nonprofit","lineage":["https://openalex.org/I4210148697"]},{"id":"https://openalex.org/I59433898","display_name":"Brunel University of London","ror":"https://ror.org/00dn4t376","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I59433898"]}],"countries":["GB","IN"],"is_corresponding":false,"raw_author_name":"F. J. Planes","raw_affiliation_strings":["Francisco J. Planes received his PhD in Bioinformatics at Brunel University in 2008. He joined the Bioinformatics group at CEIT in 2009. His research is devoted to the development of optimization-based techniques in the area of systems biology and bioinformatics, mainly in the field of metabolic modelling"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Francisco J. Planes received his PhD in Bioinformatics at Brunel University in 2008. He joined the Bioinformatics group at CEIT in 2009. His research is devoted to the development of optimization-based techniques in the area of systems biology and bioinformatics, mainly in the field of metabolic modelling","institution_ids":["https://openalex.org/I4210148697","https://openalex.org/I59433898"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5046603247","display_name":"\u00c1ngel Rubio","orcid":"https://orcid.org/0000-0002-3274-2450"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A. Rubio","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4011,"currency":"USD","value_usd":4011},"apc_paid":null,"fwci":4.9509,"has_fulltext":false,"cited_by_count":113,"citation_normalized_percentile":{"value":0.95587682,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":96,"max":100},"biblio":{"volume":"14","issue":"3","first_page":"263","last_page":"278"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10604","display_name":"RNA Research and Splicing","score":0.9994000196456909,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11668","display_name":"interferon and immune responses","score":0.9991999864578247,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/microrna","display_name":"microRNA","score":0.7664294242858887},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.70073401927948},{"id":"https://openalex.org/keywords/messenger-rna","display_name":"Messenger RNA","score":0.5865730047225952},{"id":"https://openalex.org/keywords/complementarity","display_name":"Complementarity (molecular biology)","score":0.5745805501937866},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.5718553066253662},{"id":"https://openalex.org/keywords/translation","display_name":"Translation (biology)","score":0.5541743040084839},{"id":"https://openalex.org/keywords/sequence","display_name":"Sequence (biology)","score":0.4944295883178711},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.2857799828052521},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.26075202226638794}],"concepts":[{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.7664294242858887},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.70073401927948},{"id":"https://openalex.org/C105580179","wikidata":"https://www.wikidata.org/wiki/Q188928","display_name":"Messenger RNA","level":3,"score":0.5865730047225952},{"id":"https://openalex.org/C202269582","wikidata":"https://www.wikidata.org/wiki/Q2644277","display_name":"Complementarity (molecular biology)","level":2,"score":0.5745805501937866},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5718553066253662},{"id":"https://openalex.org/C149364088","wikidata":"https://www.wikidata.org/wiki/Q185917","display_name":"Translation (biology)","level":4,"score":0.5541743040084839},{"id":"https://openalex.org/C2778112365","wikidata":"https://www.wikidata.org/wiki/Q3511065","display_name":"Sequence (biology)","level":2,"score":0.4944295883178711},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2857799828052521},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.26075202226638794}],"mesh":[{"descriptor_ui":"D001499","descriptor_name":"Bayes Theorem","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001499","descriptor_name":"Bayes Theorem","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001499","descriptor_name":"Bayes Theorem","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008962","descriptor_name":"Models, Theoretical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008962","descriptor_name":"Models, Theoretical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008962","descriptor_name":"Models, Theoretical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016014","descriptor_name":"Linear Models","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016014","descriptor_name":"Linear Models","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016014","descriptor_name":"Linear Models","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016018","descriptor_name":"Least-Squares Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016018","descriptor_name":"Least-Squares Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016018","descriptor_name":"Least-Squares Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030541","descriptor_name":"Databases, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030541","descriptor_name":"Databases, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030541","descriptor_name":"Databases, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1093/bib/bbs028","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbs028","pdf_url":"https://academic.oup.com/bib/article-pdf/14/3/263/707910/bbs028.pdf","source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},{"id":"pmid:22692086","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22692086","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in bioinformatics","raw_type":null}],"best_oa_location":{"id":"doi:10.1093/bib/bbs028","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbs028","pdf_url":"https://academic.oup.com/bib/article-pdf/14/3/263/707910/bbs028.pdf","source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":101,"referenced_works":["https://openalex.org/W1531414226","https://openalex.org/W1967515816","https://openalex.org/W1972989638","https://openalex.org/W1975021063","https://openalex.org/W1975437957","https://openalex.org/W1976365540","https://openalex.org/W1978697868","https://openalex.org/W1982652137","https://openalex.org/W1989654707","https://openalex.org/W1989749381","https://openalex.org/W1995886334","https://openalex.org/W1996361117","https://openalex.org/W1999746960","https://openalex.org/W2000491596","https://openalex.org/W2001508508","https://openalex.org/W2002995168","https://openalex.org/W2010461414","https://openalex.org/W2011458493","https://openalex.org/W2011566302","https://openalex.org/W2012041376","https://openalex.org/W2012238149","https://openalex.org/W2014272343","https://openalex.org/W2017408113","https://openalex.org/W2017426710","https://openalex.org/W2018908310","https://openalex.org/W2026570544","https://openalex.org/W2028962637","https://openalex.org/W2029640027","https://openalex.org/W2031014255","https://openalex.org/W2032766715","https://openalex.org/W2034595398","https://openalex.org/W2037141750","https://openalex.org/W2038622868","https://openalex.org/W2040851473","https://openalex.org/W2042898046","https://openalex.org/W2044832480","https://openalex.org/W2044849026","https://openalex.org/W2049702532","https://openalex.org/W2050869737","https://openalex.org/W2053003053","https://openalex.org/W2053835153","https://openalex.org/W2057100799","https://openalex.org/W2059073003","https://openalex.org/W2063328956","https://openalex.org/W2065946853","https://openalex.org/W2067888173","https://openalex.org/W2070571588","https://openalex.org/W2073764144","https://openalex.org/W2074821116","https://openalex.org/W2080018357","https://openalex.org/W2080551186","https://openalex.org/W2083381199","https://openalex.org/W2089001345","https://openalex.org/W2090219560","https://openalex.org/W2091934374","https://openalex.org/W2094636384","https://openalex.org/W2094722357","https://openalex.org/W2096453387","https://openalex.org/W2099111195","https://openalex.org/W2099888774","https://openalex.org/W2099908487","https://openalex.org/W2101117089","https://openalex.org/W2104488717","https://openalex.org/W2104806799","https://openalex.org/W2106120562","https://openalex.org/W2107180520","https://openalex.org/W2107961632","https://openalex.org/W2111217263","https://openalex.org/W2113390076","https://openalex.org/W2115718427","https://openalex.org/W2116350082","https://openalex.org/W2116661471","https://openalex.org/W2121412124","https://openalex.org/W2123106337","https://openalex.org/W2125879257","https://openalex.org/W2126732736","https://openalex.org/W2128219894","https://openalex.org/W2130388134","https://openalex.org/W2130410032","https://openalex.org/W2130979840","https://openalex.org/W2133968430","https://openalex.org/W2133992949","https://openalex.org/W2134118500","https://openalex.org/W2134245005","https://openalex.org/W2137248444","https://openalex.org/W2137476312","https://openalex.org/W2139655181","https://openalex.org/W2140719708","https://openalex.org/W2141350766","https://openalex.org/W2146571341","https://openalex.org/W2149475084","https://openalex.org/W2149748804","https://openalex.org/W2153195747","https://openalex.org/W2155874171","https://openalex.org/W2160913143","https://openalex.org/W2161693225","https://openalex.org/W2163106706","https://openalex.org/W2170694711","https://openalex.org/W2171698535","https://openalex.org/W2431414621","https://openalex.org/W4212977345"],"related_works":["https://openalex.org/W2521519254","https://openalex.org/W3139833644","https://openalex.org/W3123110765","https://openalex.org/W4383553409","https://openalex.org/W2212953222","https://openalex.org/W2104948296","https://openalex.org/W1735800226","https://openalex.org/W4285172739","https://openalex.org/W3174925618","https://openalex.org/W2023978881"],"abstract_inverted_index":{"miRNAs":[0,37,124],"are":[1,38,61,102,110],"small":[2],"RNA":[3],"molecules":[4],"('22":[5],"nt)":[6],"that":[7,164],"interact":[8],"with":[9],"their":[10],"target":[11,18,72],"mRNAs":[12,90,126],"inhibiting":[13],"translation":[14],"or/and":[15],"cleavaging":[16],"the":[17,30,86,89,95,105,120,131,149,154],"mRNA.":[19],"This":[20],"interaction":[21],"is":[22,51,65],"guided":[23],"by":[24],"sequence":[25,83],"complentarity":[26],"and":[27,44,55,63,69,88,104,125,168],"results":[28,132],"in":[29,40],"reduction":[31],"of":[32,85,123,133,156],"mRNA":[33],"and/or":[34],"protein":[35],"levels.":[36],"involved":[39],"key":[41],"biological":[42],"processes":[43],"different":[45],"diseases.":[46],"Therefore,":[47],"deciphering":[48],"miRNA":[49,58,71,87,174],"targets":[50,136,171],"crucial":[52],"for":[53,137],"diagnostics":[54],"therapeutics.":[56],"However,":[57,94],"regulatory":[59],"mechanisms":[60],"complex":[62],"there":[64],"still":[66,111],"no":[67],"high-throughput":[68],"low-cost":[70],"screening":[73],"technique.":[74],"In":[75],"recent":[76],"years,":[77],"several":[78],"computational":[79,100],"methods":[80,101,142,163],"based":[81],"on":[82],"complementarity":[84],"have":[91,143],"been":[92,116],"developed.":[93],"predicted":[96],"interactions":[97,152],"using":[98],"these":[99,162],"inconsistent":[103],"expected":[106],"false":[107],"positive":[108],"rates":[109],"large.":[112],"Recently,":[113],"it":[114],"has":[115],"proposed":[117],"to":[118,129,145,172],"use":[119],"expression":[121,167],"values":[122],"(and/or":[127],"proteins)":[128],"refine":[130],"sequence-based":[134,169],"putative":[135,157,170],"a":[138],"particular":[139],"experiment.":[140],"These":[141],"shown":[144],"be":[146],"effective":[147],"identifying":[148],"most":[150],"prominent":[151],"from":[153],"databases":[155],"targets.":[158,175],"Here,":[159],"we":[160],"review":[161],"combine":[165],"both":[166],"predict":[173]},"counts_by_year":[{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":5},{"year":2019,"cited_by_count":14},{"year":2018,"cited_by_count":12},{"year":2017,"cited_by_count":8},{"year":2016,"cited_by_count":15},{"year":2015,"cited_by_count":13},{"year":2014,"cited_by_count":15},{"year":2013,"cited_by_count":12},{"year":2012,"cited_by_count":3}],"updated_date":"2026-06-23T06:36:01.041984","created_date":"2025-10-10T00:00:00"}