{"id":"https://openalex.org/W2171556032","doi":"https://doi.org/10.1093/bib/bbs027","title":"A statistical procedure to map high-order epistasis for complex traits","display_name":"A statistical procedure to map high-order epistasis for complex traits","publication_year":2012,"publication_date":"2012-06-20","ids":{"openalex":"https://openalex.org/W2171556032","doi":"https://doi.org/10.1093/bib/bbs027","mag":"2171556032","pmid":"https://pubmed.ncbi.nlm.nih.gov/22723459"},"language":"en","primary_location":{"id":"doi:10.1093/bib/bbs027","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbs027","pdf_url":"https://academic.oup.com/bib/article-pdf/14/3/302/706413/bbs027.pdf","source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://academic.oup.com/bib/article-pdf/14/3/302/706413/bbs027.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103137279","display_name":"Xiaoyun Pang","orcid":"https://orcid.org/0000-0002-8476-3771"},"institutions":[{"id":"https://openalex.org/I31683504","display_name":"Beijing Forestry University","ror":"https://ror.org/04xv2pc41","country_code":"CN","type":"education","lineage":["https://openalex.org/I1327237609","https://openalex.org/I31683504","https://openalex.org/I4210127390"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"X. Pang","raw_affiliation_strings":["Beijing Forestry University, Beijing 100083, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Beijing Forestry University, Beijing 100083, China","institution_ids":["https://openalex.org/I31683504"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056175467","display_name":"Zuoheng Wang","orcid":"https://orcid.org/0000-0002-7251-3687"},"institutions":[{"id":"https://openalex.org/I27357992","display_name":"Dalian University of Technology","ror":"https://ror.org/023hj5876","country_code":"CN","type":"education","lineage":["https://openalex.org/I27357992"]},{"id":"https://openalex.org/I870398029","display_name":"Center for Excellence in Education","ror":"https://ror.org/03qhz4n98","country_code":"US","type":"education","lineage":["https://openalex.org/I870398029"]}],"countries":["CN","US"],"is_corresponding":false,"raw_author_name":"Z. Wang","raw_affiliation_strings":["Zhong Wang obtained his PhD in Engineering Mechanics at Dalian University of Technology in 2000. He found and managed a software company in Japan from 2000 to 2008. He is Visiting Scholar in the Center for Computational Biology at Beijing Forestry University. He writes computer software for statistical genetic models","Dalian University of Technology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Zhong Wang obtained his PhD in Engineering Mechanics at Dalian University of Technology in 2000. He found and managed a software company in Japan from 2000 to 2008. He is Visiting Scholar in the Center for Computational Biology at Beijing Forestry University. He writes computer software for statistical genetic models","institution_ids":["https://openalex.org/I870398029"]},{"raw_affiliation_string":"Dalian University of Technology","institution_ids":["https://openalex.org/I27357992"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050986328","display_name":"John Stephen F. Yap","orcid":null},"institutions":[{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]},{"id":"https://openalex.org/I4210157790","display_name":"Statistical Research (United States)","ror":"https://ror.org/058eg8775","country_code":"US","type":"company","lineage":["https://openalex.org/I4210157790"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J. S. Yap","raw_affiliation_strings":["John S. Yap obtained his PhD in Statistics at the University of Florida in 2007. He monitors the accuracy and reasonableness of statistical approaches that are used in drug discovery, development and delivery. He also develops new statistical models for genetic mapping","University of Florida"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"John S. Yap obtained his PhD in Statistics at the University of Florida in 2007. He monitors the accuracy and reasonableness of statistical approaches that are used in drug discovery, development and delivery. He also develops new statistical models for genetic mapping","institution_ids":["https://openalex.org/I4210157790"]},{"raw_affiliation_string":"University of Florida","institution_ids":["https://openalex.org/I33213144"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100378570","display_name":"Jing Wang","orcid":"https://orcid.org/0000-0002-7120-0857"},"institutions":[{"id":"https://openalex.org/I31683504","display_name":"Beijing Forestry University","ror":"https://ror.org/04xv2pc41","country_code":"CN","type":"education","lineage":["https://openalex.org/I1327237609","https://openalex.org/I31683504","https://openalex.org/I4210127390"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"J. Wang","raw_affiliation_strings":["Jianxin Wang obtained his PhD in Computer Science at the University of Science and Technology Beijing in 2001. He is Associate Professor of Informatics at Beijing Forestry University and currently a visiting scholar at the Pennsylvania State University. His research interest is in computational bioinformatics in biology","Beijing Forestry Univ"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Jianxin Wang obtained his PhD in Computer Science at the University of Science and Technology Beijing in 2001. He is Associate Professor of Informatics at Beijing Forestry University and currently a visiting scholar at the Pennsylvania State University. His research interest is in computational bioinformatics in biology","institution_ids":["https://openalex.org/I31683504"]},{"raw_affiliation_string":"Beijing Forestry Univ","institution_ids":["https://openalex.org/I31683504"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101574328","display_name":"Jun Zhu","orcid":"https://orcid.org/0000-0002-9427-4517"},"institutions":[{"id":"https://openalex.org/I130769515","display_name":"Pennsylvania State University","ror":"https://ror.org/04p491231","country_code":"US","type":"education","lineage":["https://openalex.org/I130769515"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J. Zhu","raw_affiliation_strings":["Jinjia Zhu obtained his PhD in Statistics at the Pennsylvania State University in 2008. He was Assistant Professor in the Department of Mathematics and Computer Sciences at the Penn State Harrisburg from 2008 to 2010, and is currently Assistant Professor in the Division of Biostatistics in the Department of Public Health Sciences at the Pennsylvania State College of Medicine, Hershey. His research interest is in computational statistics and statistical applications, particularly in modeling human diseases","Department of Public Health Sciences"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Jinjia Zhu obtained his PhD in Statistics at the Pennsylvania State University in 2008. He was Assistant Professor in the Department of Mathematics and Computer Sciences at the Penn State Harrisburg from 2008 to 2010, and is currently Assistant Professor in the Division of Biostatistics in the Department of Public Health Sciences at the Pennsylvania State College of Medicine, Hershey. His research interest is in computational statistics and statistical applications, particularly in modeling human diseases","institution_ids":["https://openalex.org/I130769515"]},{"raw_affiliation_string":"Department of Public Health Sciences","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056989115","display_name":"Bo Wang","orcid":"https://orcid.org/0000-0003-2270-2241"},"institutions":[{"id":"https://openalex.org/I31683504","display_name":"Beijing Forestry University","ror":"https://ror.org/04xv2pc41","country_code":"CN","type":"education","lineage":["https://openalex.org/I1327237609","https://openalex.org/I31683504","https://openalex.org/I4210127390"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"W. Bo","raw_affiliation_strings":["Wenhao Bo is a PhD candidate in Forest Genetics and Tree Breeding in the Center for Computational Biology at Beijing Forestry University. His research focuses on the genetic mapping of quantitative traits in Populus","Beijing Forestry Univ"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Wenhao Bo is a PhD candidate in Forest Genetics and Tree Breeding in the Center for Computational Biology at Beijing Forestry University. His research focuses on the genetic mapping of quantitative traits in Populus","institution_ids":["https://openalex.org/I31683504"]},{"raw_affiliation_string":"Beijing Forestry Univ","institution_ids":["https://openalex.org/I31683504"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021290908","display_name":"Yang Lv","orcid":"https://orcid.org/0000-0001-9386-1210"},"institutions":[{"id":"https://openalex.org/I31683504","display_name":"Beijing Forestry University","ror":"https://ror.org/04xv2pc41","country_code":"CN","type":"education","lineage":["https://openalex.org/I1327237609","https://openalex.org/I31683504","https://openalex.org/I4210127390"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Y. Lv","raw_affiliation_strings":["Yafei Lv is a Master\u2019s student in Forest Genetics and Tree Breeding in the Center for Computational Biology at Beijing Forestry University. His research focuses on the statistical genetics of quantitative traits in forest trees","Beijing Forestry Univ"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Yafei Lv is a Master\u2019s student in Forest Genetics and Tree Breeding in the Center for Computational Biology at Beijing Forestry University. His research focuses on the statistical genetics of quantitative traits in forest trees","institution_ids":["https://openalex.org/I31683504"]},{"raw_affiliation_string":"Beijing Forestry Univ","institution_ids":["https://openalex.org/I31683504"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072519673","display_name":"Fei Xu","orcid":"https://orcid.org/0000-0002-8033-6844"},"institutions":[{"id":"https://openalex.org/I31683504","display_name":"Beijing Forestry University","ror":"https://ror.org/04xv2pc41","country_code":"CN","type":"education","lineage":["https://openalex.org/I1327237609","https://openalex.org/I31683504","https://openalex.org/I4210127390"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"F. Xu","raw_affiliation_strings":["Fang Xu is a Master\u2019s student in Forest Genetics and Tree Breeding in the Center for Computational Biology at Beijing Forestry University. His research focuses on the genetic diversity and evolution of Populus using molecular markers","Beijing Forestry Univ"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fang Xu is a Master\u2019s student in Forest Genetics and Tree Breeding in the Center for Computational Biology at Beijing Forestry University. His research focuses on the genetic diversity and evolution of Populus using molecular markers","institution_ids":["https://openalex.org/I31683504"]},{"raw_affiliation_string":"Beijing Forestry Univ","institution_ids":["https://openalex.org/I31683504"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078246042","display_name":"Tao Zhou","orcid":"https://orcid.org/0000-0001-7702-8472"},"institutions":[{"id":"https://openalex.org/I31683504","display_name":"Beijing Forestry University","ror":"https://ror.org/04xv2pc41","country_code":"CN","type":"education","lineage":["https://openalex.org/I1327237609","https://openalex.org/I31683504","https://openalex.org/I4210127390"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"T. Zhou","raw_affiliation_strings":["Tao Zhou is a PhD candidate in Forest Genetics and Tree Breeding in the Center for Computational Biology at Beijing Forestry University. His research focuses on the study of the genetic mechanisms for adaptive response to environmental stress in Populus","Beijing Forestry Univ"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tao Zhou is a PhD candidate in Forest Genetics and Tree Breeding in the Center for Computational Biology at Beijing Forestry University. His research focuses on the study of the genetic mechanisms for adaptive response to environmental stress in Populus","institution_ids":["https://openalex.org/I31683504"]},{"raw_affiliation_string":"Beijing Forestry Univ","institution_ids":["https://openalex.org/I31683504"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064319719","display_name":"Shuai Peng","orcid":"https://orcid.org/0000-0002-8064-920X"},"institutions":[{"id":"https://openalex.org/I31683504","display_name":"Beijing Forestry University","ror":"https://ror.org/04xv2pc41","country_code":"CN","type":"education","lineage":["https://openalex.org/I1327237609","https://openalex.org/I31683504","https://openalex.org/I4210127390"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"S. Peng","raw_affiliation_strings":["Shaofeng Peng is a PhD student in Forest Genetics and Tree Breeding in the Center for Computational Biology at Beijing Forestry University. Her research focuses on the use of molecular biotechnologies to study the population genetics of forest trees","Beijing Forestry Univ"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shaofeng Peng is a PhD student in Forest Genetics and Tree Breeding in the Center for Computational Biology at Beijing Forestry University. Her research focuses on the use of molecular biotechnologies to study the population genetics of forest trees","institution_ids":["https://openalex.org/I31683504"]},{"raw_affiliation_string":"Beijing Forestry Univ","institution_ids":["https://openalex.org/I31683504"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041818639","display_name":"Danyu Shen","orcid":"https://orcid.org/0000-0002-2973-0010"},"institutions":[{"id":"https://openalex.org/I31683504","display_name":"Beijing Forestry University","ror":"https://ror.org/04xv2pc41","country_code":"CN","type":"education","lineage":["https://openalex.org/I1327237609","https://openalex.org/I31683504","https://openalex.org/I4210127390"]},{"id":"https://openalex.org/I4210132245","display_name":"Research Institute of Forestry","ror":"https://ror.org/02nmvgz47","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210128615","https://openalex.org/I4210132245","https://openalex.org/I4210134523"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"D. Shen","raw_affiliation_strings":["Dengfeng Shen is a PhD student in Forest Genetics and Tree Breeding in the Center for Computational Biology at Beijing Forestry University. Her research focuses on the study of ecological genetics and evolutionary genetics in Populus","Beijing Forestry Univ"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dengfeng Shen is a PhD student in Forest Genetics and Tree Breeding in the Center for Computational Biology at Beijing Forestry University. Her research focuses on the study of ecological genetics and evolutionary genetics in Populus","institution_ids":["https://openalex.org/I4210132245"]},{"raw_affiliation_string":"Beijing Forestry Univ","institution_ids":["https://openalex.org/I31683504"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5088306828","display_name":"Rongling Wu","orcid":"https://orcid.org/0000-0002-2334-6421"},"institutions":[{"id":"https://openalex.org/I2252096349","display_name":"Fujitsu (Japan)","ror":"https://ror.org/038e2g226","country_code":"JP","type":"company","lineage":["https://openalex.org/I2252096349"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"R. Wu","raw_affiliation_strings":["Rongling Wu obtained his PhD in Quantitative Genetics at the University of Washington in 1995. He is Changjiang Scholars Professor of Genetics and the Director of the Center for Computational Biology at Beijing Forestry University. His interest is to unravel the genetic roots for the outcome of biological traits by dissecting the traits into their biochemical and developmental pathways","Department of Public Health Sciences"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rongling Wu obtained his PhD in Quantitative Genetics at the University of Washington in 1995. He is Changjiang Scholars Professor of Genetics and the Director of the Center for Computational Biology at Beijing Forestry University. His interest is to unravel the genetic roots for the outcome of biological traits by dissecting the traits into their biochemical and developmental pathways","institution_ids":["https://openalex.org/I2252096349"]},{"raw_affiliation_string":"Department of Public Health Sciences","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":12,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4011,"currency":"USD","value_usd":4011},"apc_paid":null,"fwci":0.6133,"has_fulltext":false,"cited_by_count":16,"citation_normalized_percentile":{"value":0.74122793,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":98},"biblio":{"volume":"14","issue":"3","first_page":"302","last_page":"314"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11468","display_name":"Genetic Mapping and Diversity in Plants and Animals","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11468","display_name":"Genetic Mapping and Diversity in Plants and Animals","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9977999925613403,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10594","display_name":"Genetic and phenotypic traits in livestock","score":0.991100013256073,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/epistasis","display_name":"Epistasis","score":0.9711827635765076},{"id":"https://openalex.org/keywords/quantitative-trait-locus","display_name":"Quantitative trait locus","score":0.7241256237030029},{"id":"https://openalex.org/keywords/trait","display_name":"Trait","score":0.659898042678833},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.46540290117263794},{"id":"https://openalex.org/keywords/genetic-architecture","display_name":"Genetic architecture","score":0.454303115606308},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.43106839060783386},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.401991069316864},{"id":"https://openalex.org/keywords/evolutionary-biology","display_name":"Evolutionary biology","score":0.3639755845069885},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.3517841100692749},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.3313041925430298},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.2947325110435486}],"concepts":[{"id":"https://openalex.org/C61727976","wikidata":"https://www.wikidata.org/wiki/Q751748","display_name":"Epistasis","level":3,"score":0.9711827635765076},{"id":"https://openalex.org/C81941488","wikidata":"https://www.wikidata.org/wiki/Q853421","display_name":"Quantitative trait locus","level":3,"score":0.7241256237030029},{"id":"https://openalex.org/C106934330","wikidata":"https://www.wikidata.org/wiki/Q1971873","display_name":"Trait","level":2,"score":0.659898042678833},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.46540290117263794},{"id":"https://openalex.org/C9287583","wikidata":"https://www.wikidata.org/wiki/Q5532883","display_name":"Genetic architecture","level":4,"score":0.454303115606308},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.43106839060783386},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.401991069316864},{"id":"https://openalex.org/C78458016","wikidata":"https://www.wikidata.org/wiki/Q840400","display_name":"Evolutionary biology","level":1,"score":0.3639755845069885},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3517841100692749},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.3313041925430298},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2947325110435486},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004843","descriptor_name":"Epistasis, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004843","descriptor_name":"Epistasis, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004843","descriptor_name":"Epistasis, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D040641","descriptor_name":"Quantitative Trait Loci","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D040641","descriptor_name":"Quantitative Trait Loci","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D040641","descriptor_name":"Quantitative Trait Loci","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1093/bib/bbs027","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbs027","pdf_url":"https://academic.oup.com/bib/article-pdf/14/3/302/706413/bbs027.pdf","source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},{"id":"pmid:22723459","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22723459","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in bioinformatics","raw_type":null}],"best_oa_location":{"id":"doi:10.1093/bib/bbs027","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbs027","pdf_url":"https://academic.oup.com/bib/article-pdf/14/3/302/706413/bbs027.pdf","source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320322927","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":60,"referenced_works":["https://openalex.org/W1535800685","https://openalex.org/W1542772707","https://openalex.org/W1554403518","https://openalex.org/W1561461159","https://openalex.org/W1662965333","https://openalex.org/W1864995317","https://openalex.org/W1931205632","https://openalex.org/W1935267426","https://openalex.org/W1936555975","https://openalex.org/W1939671230","https://openalex.org/W1962833931","https://openalex.org/W1972130972","https://openalex.org/W1973413549","https://openalex.org/W1976632102","https://openalex.org/W1980175560","https://openalex.org/W1981585162","https://openalex.org/W1990139289","https://openalex.org/W2003161266","https://openalex.org/W2007571712","https://openalex.org/W2015321220","https://openalex.org/W2025596147","https://openalex.org/W2051453551","https://openalex.org/W2053868777","https://openalex.org/W2054279875","https://openalex.org/W2057473493","https://openalex.org/W2057566283","https://openalex.org/W2058321555","https://openalex.org/W2060136250","https://openalex.org/W2061530118","https://openalex.org/W2073670601","https://openalex.org/W2078771087","https://openalex.org/W2080797580","https://openalex.org/W2084006403","https://openalex.org/W2094189284","https://openalex.org/W2094831175","https://openalex.org/W2096928595","https://openalex.org/W2106441503","https://openalex.org/W2117418906","https://openalex.org/W2121825082","https://openalex.org/W2122281040","https://openalex.org/W2125860227","https://openalex.org/W2128292906","https://openalex.org/W2129133658","https://openalex.org/W2130856032","https://openalex.org/W2139030037","https://openalex.org/W2139983653","https://openalex.org/W2140091781","https://openalex.org/W2147272585","https://openalex.org/W2152955459","https://openalex.org/W2154572047","https://openalex.org/W2155781289","https://openalex.org/W2157221703","https://openalex.org/W2158620919","https://openalex.org/W2160381008","https://openalex.org/W2163285329","https://openalex.org/W2168710850","https://openalex.org/W2272268794","https://openalex.org/W2303043072","https://openalex.org/W2477748847","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W2016626084","https://openalex.org/W192057273","https://openalex.org/W2013333645","https://openalex.org/W4234256339","https://openalex.org/W1988072872","https://openalex.org/W1981674799","https://openalex.org/W3150638776","https://openalex.org/W2402496592","https://openalex.org/W2113244577","https://openalex.org/W2030319575"],"abstract_inverted_index":{"Genetic":[0],"interactions":[1,26,44],"or":[2,63],"epistasis":[3,57],"have":[4],"been":[5],"thought":[6],"to":[7,37],"play":[8],"a":[9,28,39,51,70,76,118,123],"pivotal":[10],"role":[11],"in":[12,111],"shaping":[13],"the":[14,86,102,106,127,132],"formation,":[15],"development":[16],"and":[17,45,49,84,88,97,108],"evolution":[18],"of":[19,30,42,78,90,105,126,135],"life.":[20],"Previous":[21],"work":[22],"focused":[23],"on":[24],"lower-order":[25],"between":[27],"pair":[29],"genes,":[31],"but":[32],"it":[33],"is":[34],"obviously":[35],"inadequate":[36],"explain":[38],"complex":[40,71,136],"network":[41],"genetic":[43,128],"pathways.":[46],"We":[47],"review":[48],"assess":[50],"statistical":[52,103],"model":[53,74,107],"for":[54,82,121],"characterizing":[55],"high-order":[56],"among":[58],"more":[59],"than":[60],"two":[61],"genes":[62],"quantitative":[64],"trait":[65],"loci":[66],"(QTLs)":[67],"that":[68],"control":[69],"trait.":[72],"The":[73],"includes":[75],"series":[77],"start-of-the-art":[79],"standard":[80],"procedures":[81],"estimating":[83],"testing":[85],"nature":[87],"magnitude":[89],"QTL":[91],"interactions.":[92],"Results":[93],"from":[94],"simulation":[95],"studies":[96],"real":[98],"data":[99],"analysis":[100],"warrant":[101],"properties":[104],"its":[109],"usefulness":[110],"practice.":[112],"High-order":[113],"epistatic":[114],"mapping":[115],"will":[116],"provide":[117],"routine":[119],"procedure":[120],"charting":[122],"detailed":[124],"picture":[125],"regulation":[129],"mechanisms":[130],"underlying":[131],"phenotypic":[133],"variation":[134],"traits.":[137]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-06-23T06:36:01.041984","created_date":"2025-10-10T00:00:00"}
