{"id":"https://openalex.org/W1967474090","doi":"https://doi.org/10.1093/bib/bbr065","title":"Integration of Boolean models exemplified on hepatocyte signal transduction","display_name":"Integration of Boolean models exemplified on hepatocyte signal transduction","publication_year":2011,"publication_date":"2011-10-20","ids":{"openalex":"https://openalex.org/W1967474090","doi":"https://doi.org/10.1093/bib/bbr065","mag":"1967474090","pmid":"https://pubmed.ncbi.nlm.nih.gov/22016404"},"language":"en","primary_location":{"id":"doi:10.1093/bib/bbr065","is_oa":false,"landing_page_url":"https://doi.org/10.1093/bib/bbr065","pdf_url":null,"source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5018882171","display_name":"Rebekka Schlatter","orcid":null},"institutions":[{"id":"https://openalex.org/I100066346","display_name":"University of Stuttgart","ror":"https://ror.org/04vnq7t77","country_code":"DE","type":"education","lineage":["https://openalex.org/I100066346"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"R. Schlatter","raw_affiliation_strings":["Institute for System Dynamics, University of Stuttgart, Stuttgart, Germany","Institute for System Dynamics, University of Stuttgart, Stuttgart,#N#Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for System Dynamics, University of Stuttgart, Stuttgart, Germany","institution_ids":["https://openalex.org/I100066346"]},{"raw_affiliation_string":"Institute for System Dynamics, University of Stuttgart, Stuttgart,#N#Germany","institution_ids":["https://openalex.org/I100066346"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070883027","display_name":"Nathalie Philippi","orcid":"https://orcid.org/0000-0002-6483-9222"},"institutions":[{"id":"https://openalex.org/I25974101","display_name":"University of W\u00fcrzburg","ror":"https://ror.org/00fbnyb24","country_code":"DE","type":"education","lineage":["https://openalex.org/I25974101"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"N. Philippi","raw_affiliation_strings":["Nicole Philippi spent thesis and first postdoctoral stay in bioinformatics in Department of Bioinformatics, Biocenter, Am Hubland, University of Wuerzburg, W\u00fcrzburg, combining genome-based bioinformatics with systems biological modelling and is now post-doc at the MPI for aging, Cologne"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nicole Philippi spent thesis and first postdoctoral stay in bioinformatics in Department of Bioinformatics, Biocenter, Am Hubland, University of Wuerzburg, W\u00fcrzburg, combining genome-based bioinformatics with systems biological modelling and is now post-doc at the MPI for aging, Cologne","institution_ids":["https://openalex.org/I25974101"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056948879","display_name":"Gaby Wangorsch","orcid":"https://orcid.org/0000-0003-3200-5394"},"institutions":[{"id":"https://openalex.org/I4210118410","display_name":"Institut th\u00e9matique G\u00e9n\u00e9tique, g\u00e9nomique et bioinformatique","ror":"https://ror.org/01rfstj90","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488","https://openalex.org/I4210118410"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"G. Wangorsch","raw_affiliation_strings":["Gaby Wangorsch is a doctoral student of bioinformatics in Department of Bioinformatics, Biocenter, Am Hubland, University of Wuerzburg, W\u00fcrzburg, combining genome-based bioinformatics with systems biological modelling"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gaby Wangorsch is a doctoral student of bioinformatics in Department of Bioinformatics, Biocenter, Am Hubland, University of Wuerzburg, W\u00fcrzburg, combining genome-based bioinformatics with systems biological modelling","institution_ids":["https://openalex.org/I4210118410"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066251778","display_name":"Robert Pick","orcid":"https://orcid.org/0000-0001-9785-8481"},"institutions":[{"id":"https://openalex.org/I4210143440","display_name":"Centre of Experimental Medicine of the Slovak Academy of Sciences","ror":"https://ror.org/0380mmw63","country_code":"SK","type":"facility","lineage":["https://openalex.org/I207624831","https://openalex.org/I4210143440"]},{"id":"https://openalex.org/I4405258122","display_name":"Institut f\u00fcr Chirurgische Forschung","ror":"https://ror.org/005506478","country_code":"DE","type":"facility","lineage":["https://openalex.org/I3018771216","https://openalex.org/I4405258122","https://openalex.org/I8204097"]},{"id":"https://openalex.org/I8204097","display_name":"Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen","ror":"https://ror.org/05591te55","country_code":"DE","type":"education","lineage":["https://openalex.org/I8204097"]}],"countries":["DE","SK"],"is_corresponding":false,"raw_author_name":"R. Pick","raw_affiliation_strings":["Robert Pick worked experimentally on cellular regulation including apoptosis and proliferation with Borner in Freiburg, is now postdoctoral at Walter Brendel Centre of Experimental Medicine, Ludwig-Maximilians-University Munich"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Robert Pick worked experimentally on cellular regulation including apoptosis and proliferation with Borner in Freiburg, is now postdoctoral at Walter Brendel Centre of Experimental Medicine, Ludwig-Maximilians-University Munich","institution_ids":["https://openalex.org/I4210143440","https://openalex.org/I4405258122","https://openalex.org/I8204097"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054507125","display_name":"Oliver Sawodny","orcid":"https://orcid.org/0000-0002-6910-2473"},"institutions":[{"id":"https://openalex.org/I100066346","display_name":"University of Stuttgart","ror":"https://ror.org/04vnq7t77","country_code":"DE","type":"education","lineage":["https://openalex.org/I100066346"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"O. Sawodny","raw_affiliation_strings":["Oliver Sawodny is professor and chair at the institute for systems dynamics in University of Stuttgart, Pfaffenwaldring Stuttgart"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oliver Sawodny is professor and chair at the institute for systems dynamics in University of Stuttgart, Pfaffenwaldring Stuttgart","institution_ids":["https://openalex.org/I100066346"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090130012","display_name":"Christoph Borner","orcid":"https://orcid.org/0000-0001-5127-7630"},"institutions":[{"id":"https://openalex.org/I161046081","display_name":"University of Freiburg","ror":"https://ror.org/0245cg223","country_code":"DE","type":"education","lineage":["https://openalex.org/I161046081"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"C. Borner","raw_affiliation_strings":["Christoph Borner is a professor and chair at Institute of Molecular Medicine and Cell Research (ZBMZ), as well as BIOSS Centre for Biological Signalling Studies, Albert Ludwigs University Freiburg, Freiburg"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Christoph Borner is a professor and chair at Institute of Molecular Medicine and Cell Research (ZBMZ), as well as BIOSS Centre for Biological Signalling Studies, Albert Ludwigs University Freiburg, Freiburg","institution_ids":["https://openalex.org/I161046081"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052831097","display_name":"Jens Timmer","orcid":"https://orcid.org/0000-0003-4517-1383"},"institutions":[{"id":"https://openalex.org/I161046081","display_name":"University of Freiburg","ror":"https://ror.org/0245cg223","country_code":"DE","type":"education","lineage":["https://openalex.org/I161046081"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"J. Timmer","raw_affiliation_strings":["Jens Timmer directs the Centre for Data Analysis and Modelling, works further at BIOSS Centre for Biological Signalling Studies and is professor for theoretical physics in Institute of Physics and Freiburg Institute for Advanced Studies (FRIAS), University of Freiburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Jens Timmer directs the Centre for Data Analysis and Modelling, works further at BIOSS Centre for Biological Signalling Studies and is professor for theoretical physics in Institute of Physics and Freiburg Institute for Advanced Studies (FRIAS), University of Freiburg, Germany","institution_ids":["https://openalex.org/I161046081"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060161549","display_name":"Michael Ederer","orcid":"https://orcid.org/0000-0002-9871-0216"},"institutions":[{"id":"https://openalex.org/I100066346","display_name":"University of Stuttgart","ror":"https://ror.org/04vnq7t77","country_code":"DE","type":"education","lineage":["https://openalex.org/I100066346"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"M. Ederer","raw_affiliation_strings":["Michael Ederer is a group leader of the institute for systems dynamics in Institute for System Dynamics, University of Stuttgart, Pfaffenwaldring, Stuttgart"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Michael Ederer is a group leader of the institute for systems dynamics in Institute for System Dynamics, University of Stuttgart, Pfaffenwaldring, Stuttgart","institution_ids":["https://openalex.org/I100066346"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5086202312","display_name":"Thomas Dandekar","orcid":"https://orcid.org/0000-0003-1886-7625"},"institutions":[{"id":"https://openalex.org/I25974101","display_name":"University of W\u00fcrzburg","ror":"https://ror.org/00fbnyb24","country_code":"DE","type":"education","lineage":["https://openalex.org/I25974101"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"T. Dandekar","raw_affiliation_strings":["Thomas Dandekar is the head of the department of bioinformatics, Biocenter, Am Hubland, University of Wuerzburg W\u00fcrzburg, combining genome-based bioinformatics with systems biological modelling"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Thomas Dandekar is the head of the department of bioinformatics, Biocenter, Am Hubland, University of Wuerzburg W\u00fcrzburg, combining genome-based bioinformatics with systems biological modelling","institution_ids":["https://openalex.org/I25974101"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":7,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4011,"currency":"USD","value_usd":4011},"apc_paid":null,"fwci":1.4598,"has_fulltext":false,"cited_by_count":35,"citation_normalized_percentile":{"value":0.8026875,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"13","issue":"3","first_page":"365","last_page":"376"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9940000176429749,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.7227758765220642},{"id":"https://openalex.org/keywords/boolean-network","display_name":"Boolean network","score":0.5835067629814148},{"id":"https://openalex.org/keywords/boolean-function","display_name":"Boolean function","score":0.5572237372398376},{"id":"https://openalex.org/keywords/theoretical-computer-science","display_name":"Theoretical computer science","score":0.5292115807533264},{"id":"https://openalex.org/keywords/systems-biology","display_name":"Systems biology","score":0.4997527599334717},{"id":"https://openalex.org/keywords/biological-network","display_name":"Biological network","score":0.48384371399879456},{"id":"https://openalex.org/keywords/and-inverter-graph","display_name":"And-inverter graph","score":0.47166216373443604},{"id":"https://openalex.org/keywords/network-model","display_name":"Network model","score":0.4274597465991974},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.304057240486145},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.2978990375995636},{"id":"https://openalex.org/keywords/boolean-expression","display_name":"Boolean expression","score":0.28607964515686035},{"id":"https://openalex.org/keywords/algorithm","display_name":"Algorithm","score":0.18915998935699463},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.17063358426094055}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.7227758765220642},{"id":"https://openalex.org/C134444547","wikidata":"https://www.wikidata.org/wiki/Q585230","display_name":"Boolean network","level":3,"score":0.5835067629814148},{"id":"https://openalex.org/C187455244","wikidata":"https://www.wikidata.org/wiki/Q942353","display_name":"Boolean function","level":2,"score":0.5572237372398376},{"id":"https://openalex.org/C80444323","wikidata":"https://www.wikidata.org/wiki/Q2878974","display_name":"Theoretical computer science","level":1,"score":0.5292115807533264},{"id":"https://openalex.org/C152662350","wikidata":"https://www.wikidata.org/wiki/Q815297","display_name":"Systems biology","level":2,"score":0.4997527599334717},{"id":"https://openalex.org/C28225019","wikidata":"https://www.wikidata.org/wiki/Q4915005","display_name":"Biological network","level":2,"score":0.48384371399879456},{"id":"https://openalex.org/C196836630","wikidata":"https://www.wikidata.org/wiki/Q4753279","display_name":"And-inverter graph","level":4,"score":0.47166216373443604},{"id":"https://openalex.org/C104122410","wikidata":"https://www.wikidata.org/wiki/Q1416406","display_name":"Network model","level":2,"score":0.4274597465991974},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.304057240486145},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.2978990375995636},{"id":"https://openalex.org/C158465420","wikidata":"https://www.wikidata.org/wiki/Q1979515","display_name":"Boolean expression","level":3,"score":0.28607964515686035},{"id":"https://openalex.org/C11413529","wikidata":"https://www.wikidata.org/wiki/Q8366","display_name":"Algorithm","level":1,"score":0.18915998935699463},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.17063358426094055}],"mesh":[{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008962","descriptor_name":"Models, Theoretical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008962","descriptor_name":"Models, Theoretical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008962","descriptor_name":"Models, Theoretical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D022781","descriptor_name":"Hepatocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D022781","descriptor_name":"Hepatocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D022781","descriptor_name":"Hepatocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D049490","descriptor_name":"Systems Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049490","descriptor_name":"Systems Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049490","descriptor_name":"Systems Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1093/bib/bbr065","is_oa":false,"landing_page_url":"https://doi.org/10.1093/bib/bbr065","pdf_url":null,"source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},{"id":"pmid:22016404","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22016404","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in bioinformatics","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":37,"referenced_works":["https://openalex.org/W1807981783","https://openalex.org/W1964037688","https://openalex.org/W1995866342","https://openalex.org/W2008633581","https://openalex.org/W2018953646","https://openalex.org/W2022379082","https://openalex.org/W2032811716","https://openalex.org/W2060155054","https://openalex.org/W2062855494","https://openalex.org/W2065016221","https://openalex.org/W2065332736","https://openalex.org/W2068805767","https://openalex.org/W2069233518","https://openalex.org/W2069728939","https://openalex.org/W2070446721","https://openalex.org/W2074236978","https://openalex.org/W2075941967","https://openalex.org/W2079632329","https://openalex.org/W2081466838","https://openalex.org/W2082612102","https://openalex.org/W2087332832","https://openalex.org/W2088259098","https://openalex.org/W2103454055","https://openalex.org/W2103723044","https://openalex.org/W2121490181","https://openalex.org/W2122902176","https://openalex.org/W2125886217","https://openalex.org/W2128810557","https://openalex.org/W2129388048","https://openalex.org/W2132935366","https://openalex.org/W2145899141","https://openalex.org/W2146009166","https://openalex.org/W2161636210","https://openalex.org/W2166071821","https://openalex.org/W2166615014","https://openalex.org/W2167909734","https://openalex.org/W2417673423"],"related_works":["https://openalex.org/W2737808843","https://openalex.org/W4388918086","https://openalex.org/W2402814600","https://openalex.org/W2770822254","https://openalex.org/W2158714033","https://openalex.org/W2509092654","https://openalex.org/W847550529","https://openalex.org/W2120947607","https://openalex.org/W1971144865","https://openalex.org/W1750078949"],"abstract_inverted_index":{"The":[0,200],"number":[1],"of":[2,34,46,49,51,124,146,150,168,174,177,183,198,202],"mathematical":[3],"models":[4,48,58,87,94,109,127,149,170,185,189,204],"for":[5,66,91,107,113,213],"biological":[6],"pathways":[7],"is":[8,27,59,71,209],"rapidly":[9],"growing.":[10],"In":[11,37,138,160],"particular,":[12],"Boolean":[13,67,69,108,148],"modelling":[14,70,105,207],"proved":[15],"to":[16,19,31,39,101,156,194],"be":[17],"suited":[18],"describe":[20,157],"large":[21],"cellular":[22,52,133],"signalling":[23],"networks.":[24,36],"Systems":[25],"biology":[26,193],"at":[28],"the":[29,122,136,139,144,161,166,175,195,214],"threshold":[30],"holistic":[32],"understanding":[33],"comprehensive":[35,56,187],"order":[38,155],"reach":[40],"this":[41,218],"goal,":[42],"connection":[43],"and":[44,76,95],"integration":[45,145],"existing":[47],"parts":[50,173],"networks":[53],"into":[54,186],"more":[55],"network":[57,176,188],"necessary.":[60],"We":[61,83,103],"discuss":[62],"model":[63,115],"combination":[64,167,201],"approaches":[65],"models.":[68],"qualitative":[72],"rather":[73],"than":[74],"quantitative":[75,93],"does":[77],"not":[78],"require":[79],"detailed":[80],"kinetic":[81],"information.":[82],"show":[84,143],"that":[85,96],"these":[86,118],"are":[88,98],"useful":[89],"precursors":[90],"large-scale":[92],"they":[97],"comparatively":[99],"easy":[100],"combine.":[102],"propose":[104],"standards":[106,208],"as":[110],"a":[111,178,210],"prerequisite":[112],"smooth":[114],"integration.":[116],"Using":[117],"standards,":[119],"we":[120,142,164],"demonstrate":[121,165],"coupling":[123],"two":[125,129,147,151,169],"logical":[126,203],"on":[128],"different":[130,172],"examples":[131],"concerning":[132],"interactions":[134],"in":[135,154],"liver.":[137],"first":[140],"example,":[141,163],"cell":[152,180],"types":[153],"their":[158],"interaction.":[159],"second":[162],"describing":[171],"single":[179],"type.":[181],"Combination":[182],"partial":[184],"will":[190],"take":[191],"systems":[192],"next":[196,215],"level":[197],"understanding.":[199],"facilitated":[205],"by":[206],"valuable":[211],"example":[212],"step":[216],"towards":[217],"goal.":[219]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":6},{"year":2012,"cited_by_count":3}],"updated_date":"2026-07-22T07:51:19.307946","created_date":"2025-10-10T00:00:00"}
