{"id":"https://openalex.org/W2113484804","doi":"https://doi.org/10.1093/bib/bbr043","title":"Dissection of human MiRNA regulatory influence to subpathway","display_name":"Dissection of human MiRNA regulatory influence to subpathway","publication_year":2011,"publication_date":"2011-09-10","ids":{"openalex":"https://openalex.org/W2113484804","doi":"https://doi.org/10.1093/bib/bbr043","mag":"2113484804","pmid":"https://pubmed.ncbi.nlm.nih.gov/21908864"},"language":"en","primary_location":{"id":"doi:10.1093/bib/bbr043","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbr043","pdf_url":"https://academic.oup.com/bib/article-pdf/13/2/175/705307/bbr043.pdf","source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://academic.oup.com/bib/article-pdf/13/2/175/705307/bbr043.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100353939","display_name":"Xin Li","orcid":"https://orcid.org/0000-0002-7414-5734"},"institutions":[{"id":"https://openalex.org/I156144747","display_name":"Harbin Medical University","ror":"https://ror.org/05jscf583","country_code":"CN","type":"education","lineage":["https://openalex.org/I156144747"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"X. Li","raw_affiliation_strings":["College of Bioinformatics Science and Technology and Bio-pharmaceutical Key Laboratory of Heilongjiang Province, Harbin Medical University, Harbin 150081, P. R. China. lixia@hrbmu.edu.cn","College of Bioinformatics Science and Technology and Bio-pharmaceutical Key Laboratory of Heilongjiang Province, Harbin Medical University, Harbin 150081, P. R. China"],"affiliations":[{"raw_affiliation_string":"College of Bioinformatics Science and Technology and Bio-pharmaceutical Key Laboratory of Heilongjiang Province, Harbin Medical University, Harbin 150081, P. R. China. lixia@hrbmu.edu.cn","institution_ids":["https://openalex.org/I156144747"]},{"raw_affiliation_string":"College of Bioinformatics Science and Technology and Bio-pharmaceutical Key Laboratory of Heilongjiang Province, Harbin Medical University, Harbin 150081, P. R. China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041957721","display_name":"Wei Jiang","orcid":"https://orcid.org/0000-0003-1591-4721"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"W. Jiang","raw_affiliation_strings":[],"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100317967","display_name":"Wei Li","orcid":"https://orcid.org/0000-0001-5696-4309"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"W. Li","raw_affiliation_strings":[],"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110522546","display_name":"Baofeng Lian","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"B. Lian","raw_affiliation_strings":[],"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100640301","display_name":"Shiyuan Wang","orcid":"https://orcid.org/0000-0002-5028-5839"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S. Wang","raw_affiliation_strings":[],"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081088981","display_name":"Maofu Liao","orcid":"https://orcid.org/0000-0002-3481-450X"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M. Liao","raw_affiliation_strings":[],"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5115589134","display_name":"X. Chen","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"X. Chen","raw_affiliation_strings":[],"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100322552","display_name":"Yan Wang","orcid":"https://orcid.org/0000-0001-9324-4191"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Y. Wang","raw_affiliation_strings":[],"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089159821","display_name":"Yingli Lv","orcid":"https://orcid.org/0009-0007-1290-1745"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Y. Lv","raw_affiliation_strings":[],"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100640301","display_name":"Shiyuan Wang","orcid":"https://orcid.org/0000-0002-5028-5839"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S. Wang","raw_affiliation_strings":[],"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5060926331","display_name":"Lin Yang","orcid":"https://orcid.org/0000-0003-2193-9597"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"L. Yang","raw_affiliation_strings":[],"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":11,"corresponding_author_ids":["https://openalex.org/A5100353939"],"corresponding_institution_ids":["https://openalex.org/I156144747"],"apc_list":{"value":4011,"currency":"USD","value_usd":4011},"apc_paid":null,"fwci":1.4678,"has_fulltext":false,"cited_by_count":32,"citation_normalized_percentile":{"value":0.82728237,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"13","issue":"2","first_page":"175","last_page":"186"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10604","display_name":"RNA Research and Splicing","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10207","display_name":"Advanced biosensing and bioanalysis techniques","score":0.9988999962806702,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/microrna","display_name":"microRNA","score":0.816769003868103},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.5960942506790161},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.5955026745796204},{"id":"https://openalex.org/keywords/function","display_name":"Function (biology)","score":0.5417402982711792},{"id":"https://openalex.org/keywords/disease","display_name":"Disease","score":0.45914292335510254},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.4092639088630676},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.2696627974510193},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.22109979391098022},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.1847694218158722},{"id":"https://openalex.org/keywords/pathology","display_name":"Pathology","score":0.09830525517463684}],"concepts":[{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.816769003868103},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5960942506790161},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5955026745796204},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.5417402982711792},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.45914292335510254},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.4092639088630676},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2696627974510193},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.22109979391098022},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.1847694218158722},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.09830525517463684}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D030541","descriptor_name":"Databases, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030541","descriptor_name":"Databases, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030541","descriptor_name":"Databases, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1093/bib/bbr043","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbr043","pdf_url":"https://academic.oup.com/bib/article-pdf/13/2/175/705307/bbr043.pdf","source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},{"id":"pmid:21908864","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21908864","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in bioinformatics","raw_type":null}],"best_oa_location":{"id":"doi:10.1093/bib/bbr043","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbr043","pdf_url":"https://academic.oup.com/bib/article-pdf/13/2/175/705307/bbr043.pdf","source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.44999998807907104,"display_name":"Life in Land","id":"https://metadata.un.org/sdg/15"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2113484804.pdf","grobid_xml":"https://content.openalex.org/works/W2113484804.grobid-xml"},"referenced_works_count":48,"referenced_works":["https://openalex.org/W1648301895","https://openalex.org/W1972785590","https://openalex.org/W1975377745","https://openalex.org/W1975437957","https://openalex.org/W1976180663","https://openalex.org/W1994734311","https://openalex.org/W2001782792","https://openalex.org/W2004682594","https://openalex.org/W2006079840","https://openalex.org/W2008806010","https://openalex.org/W2010688739","https://openalex.org/W2017129209","https://openalex.org/W2017358009","https://openalex.org/W2019801716","https://openalex.org/W2031780066","https://openalex.org/W2038067635","https://openalex.org/W2042881722","https://openalex.org/W2044832480","https://openalex.org/W2049660571","https://openalex.org/W2050869737","https://openalex.org/W2056126207","https://openalex.org/W2059073003","https://openalex.org/W2070765029","https://openalex.org/W2078309889","https://openalex.org/W2094722357","https://openalex.org/W2099029060","https://openalex.org/W2100236919","https://openalex.org/W2103194512","https://openalex.org/W2112192177","https://openalex.org/W2113445340","https://openalex.org/W2124486266","https://openalex.org/W2124838156","https://openalex.org/W2128219894","https://openalex.org/W2128768066","https://openalex.org/W2136943892","https://openalex.org/W2148229838","https://openalex.org/W2154085311","https://openalex.org/W2155044281","https://openalex.org/W2159482845","https://openalex.org/W2159793493","https://openalex.org/W2160968516","https://openalex.org/W2161549952","https://openalex.org/W2163480486","https://openalex.org/W2164928285","https://openalex.org/W2169404653","https://openalex.org/W2171559697","https://openalex.org/W3103971085","https://openalex.org/W4294216483"],"related_works":["https://openalex.org/W2737319532","https://openalex.org/W3151405604","https://openalex.org/W2565797512","https://openalex.org/W2057742104","https://openalex.org/W4283692078","https://openalex.org/W2025542119","https://openalex.org/W1967563157","https://openalex.org/W1143447605","https://openalex.org/W2111650087","https://openalex.org/W1995085194"],"abstract_inverted_index":{"The":[0],"global":[1,71,140],"insight":[2],"into":[3],"the":[4,32,38,56,96,117,127,130,134,143,153,175],"relationships":[5,144],"between":[6],"miRNAs":[7,49,69,83,106],"and":[8,45,50,82,113,148,159,171],"their":[9],"regulatory":[10,58],"influences":[11,59],"remains":[12],"poorly":[13],"understood.":[14],"And":[15],"most":[16],"of":[17,27,31,68,90,99,119,129,156,162],"complex":[18,163],"diseases":[19],"may":[20],"be":[21,178],"attributed":[22],"to":[23,43,60,126,168],"certain":[24],"local":[25],"areas":[26],"pathway":[28],"(subpathway)":[29],"instead":[30],"entire":[33],"pathway.":[34],"Here,":[35],"we":[36,101],"reviewed":[37],"studies":[39],"on":[40,87,142],"miRNA":[41,57,147,157],"regulations":[42,158],"pathways":[44,76],"constructed":[46],"a":[47,65,139],"bipartite":[48],"subpathways":[51,91,109,121],"network":[52],"for":[53,114,173],"systematic":[54],"analyzing":[55],"subpathways.":[61],"We":[62],"found":[63,103],"that":[64,104],"small":[66],"fraction":[67],"were":[70,77],"regulators,":[72],"environmental":[73],"information":[74],"processing":[75],"preferentially":[78],"regulated":[79,107,120],"by":[80],"miRNAs,":[81,100,112,116],"had":[84],"synergistic":[85],"effect":[86],"regulating":[88],"group":[89],"with":[92],"similar":[93],"function.":[94],"Integrating":[95],"disease":[97,105],"states":[98],"also":[102,151],"more":[108],"than":[110],"nondisease":[111],"all":[115,174],"number":[118,128],"was":[122],"not":[123,136],"in":[124],"proportion":[125],"related":[131],"diseases.":[132,164],"Therefore,":[133],"study":[135],"only":[137],"provided":[138],"view":[141],"among":[145],"disease,":[146],"subpathway,":[149],"but":[150],"uncovered":[152],"function":[154],"aspects":[155],"potential":[160],"pathogenesis":[161],"A":[165],"web":[166],"server":[167],"query,":[169],"visualize":[170],"download":[172],"data":[176],"can":[177],"freely":[179],"accessed":[180],"at":[181],"http://bioinfo.hrbmu.edu.cn/miR2Subpath.":[182]},"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":7},{"year":2012,"cited_by_count":3}],"updated_date":"2026-01-13T01:12:25.745995","created_date":"2025-10-10T00:00:00"}