{"id":"https://openalex.org/W2078775934","doi":"https://doi.org/10.1093/bib/bbp011","title":"Flux balance analysis of biological systems: applications and challenges","display_name":"Flux balance analysis of biological systems: applications and challenges","publication_year":2009,"publication_date":"2009-03-15","ids":{"openalex":"https://openalex.org/W2078775934","doi":"https://doi.org/10.1093/bib/bbp011","mag":"2078775934","pmid":"https://pubmed.ncbi.nlm.nih.gov/19287049"},"language":"en","primary_location":{"id":"doi:10.1093/bib/bbp011","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbp011","pdf_url":"https://academic.oup.com/bib/article-pdf/10/4/435/841894/bbp011.pdf","source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://academic.oup.com/bib/article-pdf/10/4/435/841894/bbp011.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5011489319","display_name":"Karthik Raman","orcid":"https://orcid.org/0000-0002-9311-7093"},"institutions":[{"id":"https://openalex.org/I202697423","display_name":"University of Zurich","ror":"https://ror.org/02crff812","country_code":"CH","type":"education","lineage":["https://openalex.org/I202697423"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"K. Raman","raw_affiliation_strings":["Department of Biochemistry, University of Zurich","Department of Biochemistry, University of Z\u00fcrich;"],"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, University of Zurich","institution_ids":["https://openalex.org/I202697423"]},{"raw_affiliation_string":"Department of Biochemistry, University of Z\u00fcrich;","institution_ids":["https://openalex.org/I202697423"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5085789773","display_name":"Nagasuma Chandra","orcid":"https://orcid.org/0000-0002-9939-8439"},"institutions":[{"id":"https://openalex.org/I59270414","display_name":"Indian Institute of Science Bangalore","ror":"https://ror.org/04dese585","country_code":"IN","type":"education","lineage":["https://openalex.org/I59270414"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"N. Chandra","raw_affiliation_strings":["Bioinformatics Centre and Supercomputer Education and Research Centre, Indian Institute of Science, Bangalore 560012, India"],"affiliations":[{"raw_affiliation_string":"Bioinformatics Centre and Supercomputer Education and Research Centre, Indian Institute of Science, Bangalore 560012, India","institution_ids":["https://openalex.org/I59270414"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5085789773"],"corresponding_institution_ids":["https://openalex.org/I59270414"],"apc_list":{"value":4011,"currency":"USD","value_usd":4011},"apc_paid":null,"fwci":10.6487,"has_fulltext":true,"cited_by_count":442,"citation_normalized_percentile":{"value":0.9894692,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"10","issue":"4","first_page":"435","last_page":"449"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10404","display_name":"Enzyme Catalysis and Immobilization","score":0.995199978351593,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.994700014591217,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/flux-balance-analysis","display_name":"Flux balance analysis","score":0.8277539014816284},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6405792236328125},{"id":"https://openalex.org/keywords/constraint","display_name":"Constraint (computer-aided design)","score":0.5636627078056335},{"id":"https://openalex.org/keywords/systems-biology","display_name":"Systems biology","score":0.5503022074699402},{"id":"https://openalex.org/keywords/biological-network","display_name":"Biological network","score":0.5137041807174683},{"id":"https://openalex.org/keywords/function","display_name":"Function (biology)","score":0.4825393557548523},{"id":"https://openalex.org/keywords/in-silico","display_name":"In silico","score":0.4771154224872589},{"id":"https://openalex.org/keywords/flux","display_name":"Flux (metallurgy)","score":0.4546126127243042},{"id":"https://openalex.org/keywords/identification","display_name":"Identification (biology)","score":0.4451420307159424},{"id":"https://openalex.org/keywords/biochemical-engineering","display_name":"Biochemical engineering","score":0.4009268879890442},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.3693512976169586},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.2017526924610138},{"id":"https://openalex.org/keywords/ecology","display_name":"Ecology","score":0.1358218789100647},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.11281687021255493},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.11099648475646973},{"id":"https://openalex.org/keywords/engineering","display_name":"Engineering","score":0.10477828979492188}],"concepts":[{"id":"https://openalex.org/C167091322","wikidata":"https://www.wikidata.org/wiki/Q5463029","display_name":"Flux balance analysis","level":2,"score":0.8277539014816284},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6405792236328125},{"id":"https://openalex.org/C2776036281","wikidata":"https://www.wikidata.org/wiki/Q48769818","display_name":"Constraint (computer-aided design)","level":2,"score":0.5636627078056335},{"id":"https://openalex.org/C152662350","wikidata":"https://www.wikidata.org/wiki/Q815297","display_name":"Systems biology","level":2,"score":0.5503022074699402},{"id":"https://openalex.org/C28225019","wikidata":"https://www.wikidata.org/wiki/Q4915005","display_name":"Biological network","level":2,"score":0.5137041807174683},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.4825393557548523},{"id":"https://openalex.org/C2775905019","wikidata":"https://www.wikidata.org/wiki/Q192572","display_name":"In silico","level":3,"score":0.4771154224872589},{"id":"https://openalex.org/C68709404","wikidata":"https://www.wikidata.org/wiki/Q1134475","display_name":"Flux (metallurgy)","level":2,"score":0.4546126127243042},{"id":"https://openalex.org/C116834253","wikidata":"https://www.wikidata.org/wiki/Q2039217","display_name":"Identification (biology)","level":2,"score":0.4451420307159424},{"id":"https://openalex.org/C183696295","wikidata":"https://www.wikidata.org/wiki/Q2487696","display_name":"Biochemical engineering","level":1,"score":0.4009268879890442},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3693512976169586},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2017526924610138},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.1358218789100647},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.11281687021255493},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.11099648475646973},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.10477828979492188},{"id":"https://openalex.org/C78458016","wikidata":"https://www.wikidata.org/wiki/Q840400","display_name":"Evolutionary biology","level":1,"score":0.0},{"id":"https://openalex.org/C2524010","wikidata":"https://www.wikidata.org/wiki/Q8087","display_name":"Geometry","level":1,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004734","descriptor_name":"Energy Metabolism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004734","descriptor_name":"Energy Metabolism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004734","descriptor_name":"Energy Metabolism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013816","descriptor_name":"Thermodynamics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013816","descriptor_name":"Thermodynamics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013816","descriptor_name":"Thermodynamics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D053858","descriptor_name":"Metabolic Networks and Pathways","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D053858","descriptor_name":"Metabolic Networks and Pathways","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D053858","descriptor_name":"Metabolic Networks and Pathways","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1093/bib/bbp011","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbp011","pdf_url":"https://academic.oup.com/bib/article-pdf/10/4/435/841894/bbp011.pdf","source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},{"id":"pmid:19287049","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19287049","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in bioinformatics","raw_type":null},{"id":"pmh:oai:eprints.iisc.ac.in:21140","is_oa":false,"landing_page_url":null,"pdf_url":null,"source":{"id":"https://openalex.org/S4377196309","display_name":"NOT FOUND REPOSITORY (Indian Institute of Science Bangalore)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I59270414","host_organization_name":"Indian Institute of Science Bangalore","host_organization_lineage":["https://openalex.org/I59270414"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1093/bib/bbp011","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbp011","pdf_url":"https://academic.oup.com/bib/article-pdf/10/4/435/841894/bbp011.pdf","source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Life in Land","score":0.6200000047683716,"id":"https://metadata.un.org/sdg/15"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2078775934.pdf","grobid_xml":"https://content.openalex.org/works/W2078775934.grobid-xml"},"referenced_works_count":83,"referenced_works":["https://openalex.org/W59031459","https://openalex.org/W1529898704","https://openalex.org/W1543388089","https://openalex.org/W1597762351","https://openalex.org/W1966394322","https://openalex.org/W1982309495","https://openalex.org/W1982346730","https://openalex.org/W1990969593","https://openalex.org/W1994134392","https://openalex.org/W1995804838","https://openalex.org/W1996529795","https://openalex.org/W1996791690","https://openalex.org/W1996912752","https://openalex.org/W1998777096","https://openalex.org/W2002880495","https://openalex.org/W2006672203","https://openalex.org/W2009940763","https://openalex.org/W2010579377","https://openalex.org/W2013171416","https://openalex.org/W2018591360","https://openalex.org/W2022012525","https://openalex.org/W2024236807","https://openalex.org/W2025663053","https://openalex.org/W2026089579","https://openalex.org/W2037248648","https://openalex.org/W2037614307","https://openalex.org/W2037718952","https://openalex.org/W2039419058","https://openalex.org/W2043440339","https://openalex.org/W2046254395","https://openalex.org/W2048214825","https://openalex.org/W2051292707","https://openalex.org/W2054475777","https://openalex.org/W2056305771","https://openalex.org/W2058991361","https://openalex.org/W2059546521","https://openalex.org/W2060007674","https://openalex.org/W2063475537","https://openalex.org/W2068065441","https://openalex.org/W2079531107","https://openalex.org/W2082948758","https://openalex.org/W2085236271","https://openalex.org/W2096245011","https://openalex.org/W2097189192","https://openalex.org/W2099039198","https://openalex.org/W2101155309","https://openalex.org/W2101501829","https://openalex.org/W2102164505","https://openalex.org/W2102461551","https://openalex.org/W2103328552","https://openalex.org/W2104108767","https://openalex.org/W2104810358","https://openalex.org/W2106374727","https://openalex.org/W2106576546","https://openalex.org/W2107333582","https://openalex.org/W2107459209","https://openalex.org/W2111421616","https://openalex.org/W2111905282","https://openalex.org/W2112933558","https://openalex.org/W2114761250","https://openalex.org/W2121277457","https://openalex.org/W2126175129","https://openalex.org/W2126176298","https://openalex.org/W2127257007","https://openalex.org/W2128572161","https://openalex.org/W2129536243","https://openalex.org/W2130364940","https://openalex.org/W2131178894","https://openalex.org/W2132757418","https://openalex.org/W2138672920","https://openalex.org/W2143517204","https://openalex.org/W2147472054","https://openalex.org/W2148190806","https://openalex.org/W2148750928","https://openalex.org/W2150583791","https://openalex.org/W2153373497","https://openalex.org/W2157635835","https://openalex.org/W2160079005","https://openalex.org/W2162237022","https://openalex.org/W2163823651","https://openalex.org/W2163841023","https://openalex.org/W2170427655","https://openalex.org/W4238101851"],"related_works":["https://openalex.org/W1995733425","https://openalex.org/W2148190806","https://openalex.org/W2158714033","https://openalex.org/W2162471251","https://openalex.org/W2020641517","https://openalex.org/W2170249521","https://openalex.org/W4386628104","https://openalex.org/W1576707484","https://openalex.org/W78967844","https://openalex.org/W2133150343"],"abstract_inverted_index":{"Systems":[0],"level":[1],"modelling":[2],"and":[3,17,82,147,150,161,167,174,190],"simulations":[4,53],"of":[5,20,23,30,41,70,72,102,114,130,144],"biological":[6,137,162],"processes":[7],"are":[8,61,178],"proving":[9],"to":[10,88,98,110,196],"be":[11],"invaluable":[12],"in":[13,74,123,140,169],"obtaining":[14],"a":[15,75,83,133],"quantitative":[16],"dynamic":[18],"perspective":[19],"various":[21],"aspects":[22],"cellular":[24,39],"function.":[25],"In":[26],"particular,":[27],"constraint-based":[28,182],"analyses":[29],"metabolic":[31,172],"networks":[32],"have":[33,184],"gained":[34],"considerable":[35],"popularity":[36],"for":[37,135,188],"simulating":[38],"metabolism,":[40],"which":[42,60,77],"flux":[43,92],"balance":[44],"analysis":[45],"(FBA),":[46],"is":[47,65],"most":[48],"widely":[49],"used.":[50],"Unlike":[51],"mechanistic":[52],"that":[54,155],"depend":[55],"on":[56,67],"accurate":[57],"kinetic":[58],"data,":[59],"scarcely":[62],"available,":[63],"FBA":[64,94,131],"based":[66],"the":[68,79,112,128,153],"principle":[69],"conservation":[71],"mass":[73],"network,":[76],"utilizes":[78],"stoichiometric":[80],"matrix":[81],"biologically":[84],"relevant":[85],"objective":[86],"function":[87],"identify":[89],"optimal":[90],"reaction":[91],"distributions.":[93],"has":[95,106],"been":[96,108],"used":[97,109],"analyse":[99,111],"genome-scale":[100],"reconstructions":[101],"several":[103],"organisms;":[104],"it":[105],"also":[107,179],"effect":[113],"perturbations,":[115],"such":[116,171],"as":[117,132,193,195],"gene":[118],"deletions":[119],"or":[120],"drug":[121,175],"inhibitions":[122],"silico.":[124],"This":[125],"article":[126],"reviews":[127],"usefulness":[129],"tool":[134],"gaining":[136],"insights,":[138],"advances":[139],"methodology":[141],"enabling":[142],"integration":[143],"regulatory":[145],"information":[146],"thermodynamic":[148],"constraints,":[149],"finally":[151],"addresses":[152],"challenges":[154],"lie":[156],"ahead.":[157],"Various":[158],"use":[159],"scenarios":[160],"insights":[163],"obtained":[164],"from":[165],"FBA,":[166],"applications":[168],"fields":[170],"engineering":[173],"target":[176],"identification,":[177],"discussed.":[180],"Genome-scale":[181],"models":[183],"an":[185],"immense":[186],"potential":[187],"building":[189],"testing":[191],"hypotheses,":[192],"well":[194],"guide":[197],"experimentation.":[198]},"counts_by_year":[{"year":2026,"cited_by_count":10},{"year":2025,"cited_by_count":24},{"year":2024,"cited_by_count":32},{"year":2023,"cited_by_count":29},{"year":2022,"cited_by_count":17},{"year":2021,"cited_by_count":34},{"year":2020,"cited_by_count":28},{"year":2019,"cited_by_count":21},{"year":2018,"cited_by_count":32},{"year":2017,"cited_by_count":25},{"year":2016,"cited_by_count":28},{"year":2015,"cited_by_count":28},{"year":2014,"cited_by_count":22},{"year":2013,"cited_by_count":30},{"year":2012,"cited_by_count":30}],"updated_date":"2026-04-05T17:49:38.594831","created_date":"2025-10-10T00:00:00"}