{"id":"https://openalex.org/W2169020257","doi":"https://doi.org/10.1093/bib/bbp005","title":"Computational systems biology of the cell cycle","display_name":"Computational systems biology of the cell cycle","publication_year":2009,"publication_date":"2009-03-06","ids":{"openalex":"https://openalex.org/W2169020257","doi":"https://doi.org/10.1093/bib/bbp005","mag":"2169020257","pmid":"https://pubmed.ncbi.nlm.nih.gov/19270018"},"language":"en","primary_location":{"id":"doi:10.1093/bib/bbp005","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbp005","pdf_url":"https://academic.oup.com/bib/article-pdf/10/4/424/837916/bbp005.pdf","source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},"type":"review","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://academic.oup.com/bib/article-pdf/10/4/424/837916/bbp005.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5017814227","display_name":"Attila Csik\u00e1sz\u2010Nagy","orcid":"https://orcid.org/0000-0002-2919-5601"},"institutions":[{"id":"https://openalex.org/I193223587","display_name":"University of Trento","ror":"https://ror.org/05trd4x28","country_code":"IT","type":"education","lineage":["https://openalex.org/I193223587"]},{"id":"https://openalex.org/I2802934434","display_name":"The Microsoft Research - University of Trento Centre for Computational and Systems Biology","ror":"https://ror.org/04kcgyj43","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I1290206253","https://openalex.org/I193223587","https://openalex.org/I2802934434","https://openalex.org/I4210164937"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"A. Csikasz-Nagy","raw_affiliation_strings":["The Microsoft Research - University of Trento Centre for Computational and Systems Biology, Piazza Manci 17, Povo-Trento I-38100, Italy. csikasz@cosbi.eu"],"affiliations":[{"raw_affiliation_string":"The Microsoft Research - University of Trento Centre for Computational and Systems Biology, Piazza Manci 17, Povo-Trento I-38100, Italy. csikasz@cosbi.eu","institution_ids":["https://openalex.org/I2802934434","https://openalex.org/I193223587"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5017814227"],"corresponding_institution_ids":["https://openalex.org/I193223587","https://openalex.org/I2802934434"],"apc_list":{"value":4011,"currency":"USD","value_usd":4011},"apc_paid":null,"fwci":3.3696,"has_fulltext":false,"cited_by_count":79,"citation_normalized_percentile":{"value":0.93006008,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":94,"max":99},"biblio":{"volume":"10","issue":"4","first_page":"424","last_page":"434"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10497","display_name":"Fungal and yeast genetics research","score":0.998199999332428,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9940000176429749,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/computational-model","display_name":"Computational model","score":0.7669875621795654},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6465024948120117},{"id":"https://openalex.org/keywords/systems-biology","display_name":"Systems biology","score":0.5832383632659912},{"id":"https://openalex.org/keywords/field","display_name":"Field (mathematics)","score":0.4933435022830963},{"id":"https://openalex.org/keywords/cell-cycle","display_name":"Cell cycle","score":0.45525607466697693},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.35329264402389526},{"id":"https://openalex.org/keywords/cell","display_name":"Cell","score":0.2837430238723755},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.2770252823829651},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.22064125537872314},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.09076592326164246}],"concepts":[{"id":"https://openalex.org/C66024118","wikidata":"https://www.wikidata.org/wiki/Q1122506","display_name":"Computational model","level":2,"score":0.7669875621795654},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6465024948120117},{"id":"https://openalex.org/C152662350","wikidata":"https://www.wikidata.org/wiki/Q815297","display_name":"Systems biology","level":2,"score":0.5832383632659912},{"id":"https://openalex.org/C9652623","wikidata":"https://www.wikidata.org/wiki/Q190109","display_name":"Field (mathematics)","level":2,"score":0.4933435022830963},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.45525607466697693},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.35329264402389526},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.2837430238723755},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2770252823829651},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.22064125537872314},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.09076592326164246},{"id":"https://openalex.org/C202444582","wikidata":"https://www.wikidata.org/wiki/Q837863","display_name":"Pure mathematics","level":1,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002453","descriptor_name":"Cell Cycle","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002453","descriptor_name":"Cell Cycle","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002453","descriptor_name":"Cell Cycle","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D018797","descriptor_name":"Cell Cycle Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018797","descriptor_name":"Cell Cycle Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018797","descriptor_name":"Cell Cycle Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D049490","descriptor_name":"Systems Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D049490","descriptor_name":"Systems Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D049490","descriptor_name":"Systems Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D049673","descriptor_name":"History, 20th Century","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049673","descriptor_name":"History, 20th Century","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049673","descriptor_name":"History, 20th Century","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1093/bib/bbp005","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbp005","pdf_url":"https://academic.oup.com/bib/article-pdf/10/4/424/837916/bbp005.pdf","source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},{"id":"pmid:19270018","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19270018","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in bioinformatics","raw_type":null},{"id":"pmh:oai:kclpure.kcl.ac.uk:publications/ba8967e5-17ef-4af5-83ac-9a8ce9164d8c","is_oa":false,"landing_page_url":"https://kclpure.kcl.ac.uk/portal/en/publications/ba8967e5-17ef-4af5-83ac-9a8ce9164d8c","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Csikasz-Nagy , A 2009 , ' Computational systems biology of the cell cycle ' , BRIEFINGS IN BIOINFORMATICS , vol. 10 , no. 4 , pp. 424-434 . https://doi.org/10.1093/bib/bbp005","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1093/bib/bbp005","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbp005","pdf_url":"https://academic.oup.com/bib/article-pdf/10/4/424/837916/bbp005.pdf","source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2169020257.pdf","grobid_xml":"https://content.openalex.org/works/W2169020257.grobid-xml"},"referenced_works_count":209,"referenced_works":["https://openalex.org/W19125392","https://openalex.org/W54310204","https://openalex.org/W150897306","https://openalex.org/W157111480","https://openalex.org/W193425649","https://openalex.org/W291482096","https://openalex.org/W614669698","https://openalex.org/W1500458256","https://openalex.org/W1502429591","https://openalex.org/W1524736962","https://openalex.org/W1525349614","https://openalex.org/W1560213116","https://openalex.org/W1587018940","https://openalex.org/W1590250492","https://openalex.org/W1595516773","https://openalex.org/W1599301396","https://openalex.org/W1910998188","https://openalex.org/W1964037688","https://openalex.org/W1964743469","https://openalex.org/W1964942721","https://openalex.org/W1965239527","https://openalex.org/W1968146089","https://openalex.org/W1968357038","https://openalex.org/W1969783058","https://openalex.org/W1970249028","https://openalex.org/W1970250905","https://openalex.org/W1971727132","https://openalex.org/W1972312016","https://openalex.org/W1975312467","https://openalex.org/W1975351609","https://openalex.org/W1976991065","https://openalex.org/W1980034145","https://openalex.org/W1982588549","https://openalex.org/W1985911638","https://openalex.org/W1986672344","https://openalex.org/W1988507461","https://openalex.org/W1990656423","https://openalex.org/W1991216151","https://openalex.org/W1992179397","https://openalex.org/W1993252769","https://openalex.org/W1994306321","https://openalex.org/W1994500037","https://openalex.org/W1994927524","https://openalex.org/W1995428640","https://openalex.org/W1995738916","https://openalex.org/W1996195324","https://openalex.org/W1997577150","https://openalex.org/W1998303008","https://openalex.org/W2000618709","https://openalex.org/W2000619385","https://openalex.org/W2000645646","https://openalex.org/W2000692739","https://openalex.org/W2000815456","https://openalex.org/W2002735482","https://openalex.org/W2003512951","https://openalex.org/W2004008931","https://openalex.org/W2005282179","https://openalex.org/W2007269038","https://openalex.org/W2010325522","https://openalex.org/W2010683612","https://openalex.org/W2010900077","https://openalex.org/W2014419453","https://openalex.org/W2014765011","https://openalex.org/W2015188565","https://openalex.org/W2015869454","https://openalex.org/W2019463927","https://openalex.org/W2020651752","https://openalex.org/W2022333738","https://openalex.org/W2026237039","https://openalex.org/W2027464230","https://openalex.org/W2028648662","https://openalex.org/W2029217862","https://openalex.org/W2029361184","https://openalex.org/W2029627816","https://openalex.org/W2030877568","https://openalex.org/W2034108028","https://openalex.org/W2034269086","https://openalex.org/W2034271226","https://openalex.org/W2037036397","https://openalex.org/W2037992356","https://openalex.org/W2041140376","https://openalex.org/W2041518110","https://openalex.org/W2044852019","https://openalex.org/W2045478141","https://openalex.org/W2047631217","https://openalex.org/W2047674748","https://openalex.org/W2048165911","https://openalex.org/W2049058758","https://openalex.org/W2052561372","https://openalex.org/W2053019692","https://openalex.org/W2053961182","https://openalex.org/W2054887782","https://openalex.org/W2056076198","https://openalex.org/W2062029454","https://openalex.org/W2064633630","https://openalex.org/W2064702160","https://openalex.org/W2064974862","https://openalex.org/W2065258087","https://openalex.org/W2067077009","https://openalex.org/W2067655540","https://openalex.org/W2068311060","https://openalex.org/W2069076431","https://openalex.org/W2069217711","https://openalex.org/W2069328603","https://openalex.org/W2069941324","https://openalex.org/W2070005695","https://openalex.org/W2071026449","https://openalex.org/W2071413187","https://openalex.org/W2072720547","https://openalex.org/W2073506826","https://openalex.org/W2073957864","https://openalex.org/W2074304510","https://openalex.org/W2075161553","https://openalex.org/W2076650991","https://openalex.org/W2077326330","https://openalex.org/W2078757619","https://openalex.org/W2079725937","https://openalex.org/W2081298797","https://openalex.org/W2081873623","https://openalex.org/W2081927965","https://openalex.org/W2083337908","https://openalex.org/W2086038326","https://openalex.org/W2086056969","https://openalex.org/W2087834482","https://openalex.org/W2088003984","https://openalex.org/W2090806203","https://openalex.org/W2097520363","https://openalex.org/W2098057270","https://openalex.org/W2098229509","https://openalex.org/W2099020540","https://openalex.org/W2102055689","https://openalex.org/W2102486637","https://openalex.org/W2102653059","https://openalex.org/W2103453943","https://openalex.org/W2103853212","https://openalex.org/W2105841205","https://openalex.org/W2106647330","https://openalex.org/W2107062718","https://openalex.org/W2109125373","https://openalex.org/W2109453611","https://openalex.org/W2111308694","https://openalex.org/W2111663010","https://openalex.org/W2112651905","https://openalex.org/W2113397956","https://openalex.org/W2115343689","https://openalex.org/W2116566535","https://openalex.org/W2117392072","https://openalex.org/W2117822125","https://openalex.org/W2117949454","https://openalex.org/W2118039525","https://openalex.org/W2118515271","https://openalex.org/W2119445257","https://openalex.org/W2119510512","https://openalex.org/W2120713344","https://openalex.org/W2123500593","https://openalex.org/W2127073167","https://openalex.org/W2128214239","https://openalex.org/W2128626625","https://openalex.org/W2128782793","https://openalex.org/W2129260097","https://openalex.org/W2129569342","https://openalex.org/W2129641019","https://openalex.org/W2131740293","https://openalex.org/W2132817950","https://openalex.org/W2132935366","https://openalex.org/W2133401281","https://openalex.org/W2136445042","https://openalex.org/W2136559804","https://openalex.org/W2136834693","https://openalex.org/W2136977672","https://openalex.org/W2137531873","https://openalex.org/W2137913331","https://openalex.org/W2138675401","https://openalex.org/W2139047628","https://openalex.org/W2139349129","https://openalex.org/W2142206257","https://openalex.org/W2142460132","https://openalex.org/W2142659266","https://openalex.org/W2142676005","https://openalex.org/W2142895432","https://openalex.org/W2143784594","https://openalex.org/W2144702196","https://openalex.org/W2147054306","https://openalex.org/W2150114634","https://openalex.org/W2150375898","https://openalex.org/W2150750144","https://openalex.org/W2150767223","https://openalex.org/W2150908245","https://openalex.org/W2152071488","https://openalex.org/W2152293062","https://openalex.org/W2152604899","https://openalex.org/W2153100796","https://openalex.org/W2157989234","https://openalex.org/W2158388529","https://openalex.org/W2159084624","https://openalex.org/W2159460045","https://openalex.org/W2160751597","https://openalex.org/W2163175770","https://openalex.org/W2163300538","https://openalex.org/W2164568756","https://openalex.org/W2167154952","https://openalex.org/W2168258419","https://openalex.org/W2172102555","https://openalex.org/W2326127975","https://openalex.org/W2404903241","https://openalex.org/W2609701453","https://openalex.org/W2917431650","https://openalex.org/W4254388167","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W2106422137","https://openalex.org/W4253786108","https://openalex.org/W2094440667","https://openalex.org/W2406383220","https://openalex.org/W3022642502","https://openalex.org/W2057769265","https://openalex.org/W4245853730","https://openalex.org/W2119000371","https://openalex.org/W207829213","https://openalex.org/W2315680351"],"abstract_inverted_index":{"One":[0],"of":[1,6,21,35,55,99,114,142,167,179,182,190],"the":[2,11,33,44,56,77,94,139,191],"early":[3],"success":[4],"stories":[5],"computational":[7,29,106,152,180],"systems":[8],"biology":[9],"was":[10],"work":[12],"done":[13],"on":[14,65],"cell-cycle":[15,22,79,168,183],"regulation.":[16],"The":[17],"earliest":[18],"mathematical":[19],"descriptions":[20],"control":[23],"evolved":[24],"into":[25],"very":[26],"complex,":[27],"detailed":[28],"models":[30,47,166],"that":[31,58],"describe":[32],"regulation":[34,169],"cell":[36,41,134],"division":[37],"in":[38,89,93,121,170],"many":[39,105],"different":[40],"types.":[42],"On":[43],"way":[45],"these":[46,158],"predicted":[48],"several":[49],"dynamical":[50],"properties":[51],"and":[52,85,92,154,160,177,185],"unknown":[53],"components":[54],"system":[57],"were":[59],"later":[60],"experimentally":[61],"verified/identified.":[62],"Still,":[63],"research":[64],"this":[66],"field":[67],"is":[68,81],"far":[69],"from":[70,145],"over.":[71],"We":[72,124,149],"need":[73,150],"to":[74,118,126,156],"understand":[75],"how":[76],"core":[78],"machinery":[80],"controlled":[82],"by":[83,132],"internal":[84],"external":[86],"signals,":[87],"also":[88],"yeast":[90],"cells":[91],"more":[95,162,164],"complex":[96],"regulatory":[97],"networks":[98],"higher":[100],"eukaryotes.":[101],"Furthermore,":[102],"there":[103],"are":[104],"challenges":[107],"what":[108],"we":[109,174],"face":[110],"as":[111,136,138],"new":[112,151],"types":[113],"data":[115,143,159],"appear":[116],"thanks":[117],"continuing":[119],"advances":[120],"experimental":[122],"techniques.":[123],"have":[125],"deal":[127],"with":[128],"cell-to-cell":[129],"variations,":[130],"revealed":[131],"single":[133],"measurements,":[135],"well":[137],"tremendous":[140],"amount":[141],"flowing":[144],"high":[146],"throughput":[147],"machines.":[148],"concepts":[153],"tools":[155],"handle":[157],"develop":[161],"detailed,":[163],"precise":[165],"various":[171],"organisms.":[172],"Here":[173],"review":[175],"past":[176],"present":[178],"modeling":[181],"regulation,":[184],"discuss":[186],"possible":[187],"future":[188],"directions":[189],"field.":[192]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":6},{"year":2013,"cited_by_count":7},{"year":2012,"cited_by_count":11}],"updated_date":"2026-04-04T16:13:02.066488","created_date":"2025-10-10T00:00:00"}
