{"id":"https://openalex.org/W2140964867","doi":"https://doi.org/10.1093/bib/bbn048","title":"Simulation of DNA sequence evolution under models of recent directional selection","display_name":"Simulation of DNA sequence evolution under models of recent directional selection","publication_year":2008,"publication_date":"2008-10-08","ids":{"openalex":"https://openalex.org/W2140964867","doi":"https://doi.org/10.1093/bib/bbn048","mag":"2140964867","pmid":"https://pubmed.ncbi.nlm.nih.gov/19109303"},"language":"en","primary_location":{"id":"doi:10.1093/bib/bbn048","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbn048","pdf_url":"https://academic.oup.com/bib/article-pdf/10/1/84/617808/bbn048.pdf","source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://academic.oup.com/bib/article-pdf/10/1/84/617808/bbn048.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110243479","display_name":"Y. Kim","orcid":null},"institutions":[{"id":"https://openalex.org/I180923762","display_name":"University of Cologne","ror":"https://ror.org/00rcxh774","country_code":"DE","type":"education","lineage":["https://openalex.org/I180923762"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Y. Kim","raw_affiliation_strings":["Universit\u00e4t zu K\u00f6ln, Institut f\u00fcr Genetik, Z\u00fclpicher Strasse 47, 50674 K\u00f6ln, Germany"],"affiliations":[{"raw_affiliation_string":"Universit\u00e4t zu K\u00f6ln, Institut f\u00fcr Genetik, Z\u00fclpicher Strasse 47, 50674 K\u00f6ln, Germany","institution_ids":["https://openalex.org/I180923762"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5067935909","display_name":"Thomas Wiehe","orcid":"https://orcid.org/0000-0002-8932-2772"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"T. Wiehe","raw_affiliation_strings":[],"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5110243479"],"corresponding_institution_ids":["https://openalex.org/I180923762"],"apc_list":{"value":4011,"currency":"USD","value_usd":4011},"apc_paid":null,"fwci":0.9507,"has_fulltext":true,"cited_by_count":35,"citation_normalized_percentile":{"value":0.78893393,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"10","issue":"1","first_page":"84","last_page":"96"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11764","display_name":"Evolution and Genetic Dynamics","score":0.9991000294685364,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11764","display_name":"Evolution and Genetic Dynamics","score":0.9991000294685364,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11468","display_name":"Genetic Mapping and Diversity in Plants and Animals","score":0.9976999759674072,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10012","display_name":"Genetic diversity and population structure","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/coalescent-theory","display_name":"Coalescent theory","score":0.875963032245636},{"id":"https://openalex.org/keywords/selection","display_name":"Selection (genetic algorithm)","score":0.6978732347488403},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6955701112747192},{"id":"https://openalex.org/keywords/sequence","display_name":"Sequence (biology)","score":0.6063213348388672},{"id":"https://openalex.org/keywords/population","display_name":"Population","score":0.5344820022583008},{"id":"https://openalex.org/keywords/variation","display_name":"Variation (astronomy)","score":0.44207048416137695},{"id":"https://openalex.org/keywords/algorithm","display_name":"Algorithm","score":0.37171196937561035},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.30811217427253723},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.15161001682281494},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.10274171829223633}],"concepts":[{"id":"https://openalex.org/C2554327","wikidata":"https://www.wikidata.org/wiki/Q2698599","display_name":"Coalescent theory","level":4,"score":0.875963032245636},{"id":"https://openalex.org/C81917197","wikidata":"https://www.wikidata.org/wiki/Q628760","display_name":"Selection (genetic algorithm)","level":2,"score":0.6978732347488403},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6955701112747192},{"id":"https://openalex.org/C2778112365","wikidata":"https://www.wikidata.org/wiki/Q3511065","display_name":"Sequence (biology)","level":2,"score":0.6063213348388672},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.5344820022583008},{"id":"https://openalex.org/C2778334786","wikidata":"https://www.wikidata.org/wiki/Q1586270","display_name":"Variation (astronomy)","level":2,"score":0.44207048416137695},{"id":"https://openalex.org/C11413529","wikidata":"https://www.wikidata.org/wiki/Q8366","display_name":"Algorithm","level":1,"score":0.37171196937561035},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.30811217427253723},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.15161001682281494},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.10274171829223633},{"id":"https://openalex.org/C193252679","wikidata":"https://www.wikidata.org/wiki/Q242125","display_name":"Phylogenetic tree","level":3,"score":0.0},{"id":"https://openalex.org/C149923435","wikidata":"https://www.wikidata.org/wiki/Q37732","display_name":"Demography","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C44870925","wikidata":"https://www.wikidata.org/wiki/Q37547","display_name":"Astrophysics","level":1,"score":0.0},{"id":"https://openalex.org/C144024400","wikidata":"https://www.wikidata.org/wiki/Q21201","display_name":"Sociology","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012641","descriptor_name":"Selection, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012641","descriptor_name":"Selection, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012641","descriptor_name":"Selection, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012641","descriptor_name":"Selection, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014644","descriptor_name":"Genetic Variation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014644","descriptor_name":"Genetic Variation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014644","descriptor_name":"Genetic Variation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014644","descriptor_name":"Genetic Variation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019143","descriptor_name":"Evolution, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019143","descriptor_name":"Evolution, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019143","descriptor_name":"Evolution, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019143","descriptor_name":"Evolution, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1093/bib/bbn048","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbn048","pdf_url":"https://academic.oup.com/bib/article-pdf/10/1/84/617808/bbn048.pdf","source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},{"id":"pmid:19109303","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19109303","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in bioinformatics","raw_type":null},{"id":"pmh:oai:europepmc.org:1941266","is_oa":false,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2638626","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1093/bib/bbn048","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbn048","pdf_url":"https://academic.oup.com/bib/article-pdf/10/1/84/617808/bbn048.pdf","source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2140964867.pdf","grobid_xml":"https://content.openalex.org/works/W2140964867.grobid-xml"},"referenced_works_count":84,"referenced_works":["https://openalex.org/W31325649","https://openalex.org/W1503883746","https://openalex.org/W1546828436","https://openalex.org/W1547520239","https://openalex.org/W1847861803","https://openalex.org/W1848063220","https://openalex.org/W1861098396","https://openalex.org/W1900500601","https://openalex.org/W1932538605","https://openalex.org/W1947714123","https://openalex.org/W1963885281","https://openalex.org/W1978224130","https://openalex.org/W1979900996","https://openalex.org/W1980658629","https://openalex.org/W1985425161","https://openalex.org/W1990442358","https://openalex.org/W2001776361","https://openalex.org/W2004552562","https://openalex.org/W2010131461","https://openalex.org/W2013753628","https://openalex.org/W2025253353","https://openalex.org/W2025777882","https://openalex.org/W2035082999","https://openalex.org/W2040164651","https://openalex.org/W2054968962","https://openalex.org/W2064947972","https://openalex.org/W2065794571","https://openalex.org/W2076050649","https://openalex.org/W2084991066","https://openalex.org/W2092483466","https://openalex.org/W2094057369","https://openalex.org/W2094700388","https://openalex.org/W2095182829","https://openalex.org/W2096929518","https://openalex.org/W2097935448","https://openalex.org/W2098615058","https://openalex.org/W2098667422","https://openalex.org/W2100915101","https://openalex.org/W2104481553","https://openalex.org/W2104690544","https://openalex.org/W2108218451","https://openalex.org/W2109183238","https://openalex.org/W2109195195","https://openalex.org/W2111232620","https://openalex.org/W2111374582","https://openalex.org/W2112294153","https://openalex.org/W2113065784","https://openalex.org/W2114028825","https://openalex.org/W2116346080","https://openalex.org/W2116416291","https://openalex.org/W2118055782","https://openalex.org/W2120289437","https://openalex.org/W2120296271","https://openalex.org/W2121856031","https://openalex.org/W2124653005","https://openalex.org/W2125553407","https://openalex.org/W2126334905","https://openalex.org/W2127864194","https://openalex.org/W2127924905","https://openalex.org/W2129174519","https://openalex.org/W2129602016","https://openalex.org/W2133258562","https://openalex.org/W2134599124","https://openalex.org/W2141476192","https://openalex.org/W2147911093","https://openalex.org/W2151773637","https://openalex.org/W2155670634","https://openalex.org/W2157009743","https://openalex.org/W2157149092","https://openalex.org/W2160160618","https://openalex.org/W2161499761","https://openalex.org/W2163031152","https://openalex.org/W2163344662","https://openalex.org/W2167309398","https://openalex.org/W2168460688","https://openalex.org/W2169197527","https://openalex.org/W2172260290","https://openalex.org/W2177000155","https://openalex.org/W2319462502","https://openalex.org/W2326574757","https://openalex.org/W4236353080","https://openalex.org/W4241443362","https://openalex.org/W4251304755","https://openalex.org/W4253414868"],"related_works":["https://openalex.org/W2952954362","https://openalex.org/W3093602888","https://openalex.org/W3156045358","https://openalex.org/W2921578049","https://openalex.org/W2581424563","https://openalex.org/W2020599444","https://openalex.org/W2762052495","https://openalex.org/W1495737144","https://openalex.org/W4300801083","https://openalex.org/W2949794339"],"abstract_inverted_index":{"Computer":[0],"simulation":[1,24,107],"is":[2,46,52],"an":[3],"essential":[4],"tool":[5],"in":[6,20,34,44,80],"the":[7,21,30,64,91,97,106],"analysis":[8],"of":[9,16,32,57,76,93,100],"DNA":[10],"sequence":[11,35],"variation":[12],"for":[13,69],"mapping":[14],"events":[15],"recent":[17],"adaptive":[18],"evolution":[19],"genome.":[22],"Various":[23],"methods":[25],"are":[26,63],"employed":[27],"to":[28,54,66,105],"predict":[29],"signature":[31],"selection":[33],"variation.":[36],"The":[37,73],"most":[38],"informative":[39],"and":[40],"efficient":[41],"method":[42,51],"currently":[43],"use":[45],"coalescent":[47,67],"simulation.":[48],"However,":[49],"this":[50],"limited":[53],"simple":[55],"models":[56],"directional":[58],"selection.":[59],"Whole-population":[60],"forward-in-time":[61,81],"simulations":[62,68,82,94],"alternative":[65],"more":[70],"complex":[71],"models.":[72],"notorious":[74],"problem":[75],"excessive":[77],"computational":[78],"cost":[79],"can":[83],"be":[84],"overcome":[85],"by":[86],"various":[87],"simplifying":[88],"amendments.":[89],"Overall,":[90],"success":[92],"depends":[95],"on":[96],"creative":[98],"application":[99],"some":[101],"population":[102],"genetic":[103],"theory":[104],"algorithm.":[108]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":8},{"year":2024,"cited_by_count":4},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":2}],"updated_date":"2026-03-08T08:50:53.379069","created_date":"2025-10-10T00:00:00"}