{"id":"https://openalex.org/W2043495046","doi":"https://doi.org/10.1093/bib/bbn025","title":"Critical technologies for bioinformatics","display_name":"Critical technologies for bioinformatics","publication_year":2008,"publication_date":"2008-03-27","ids":{"openalex":"https://openalex.org/W2043495046","doi":"https://doi.org/10.1093/bib/bbn025","mag":"2043495046","pmid":"https://pubmed.ncbi.nlm.nih.gov/18499720"},"language":"en","primary_location":{"id":"doi:10.1093/bib/bbn025","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbn025","pdf_url":"https://academic.oup.com/bib/article-pdf/9/4/261/744142/bbn025.pdf","source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://academic.oup.com/bib/article-pdf/9/4/261/744142/bbn025.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5089063979","display_name":"Vladimir Brusi\u0107","orcid":"https://orcid.org/0000-0003-0523-5266"},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"V. Brusic","raw_affiliation_strings":["Dana-Farber Cancer Institute, Boston, MA 02115, USA","Dana-Farber Cancer Institute, Boston, MA 02115 USA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dana-Farber Cancer Institute, Boston, MA 02115, USA","institution_ids":["https://openalex.org/I4210117453"]},{"raw_affiliation_string":"Dana-Farber Cancer Institute, Boston, MA 02115 USA;","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5083278600","display_name":"Shoba Ranganathan","orcid":"https://orcid.org/0000-0002-8290-813X"},"institutions":[{"id":"https://openalex.org/I99043593","display_name":"Macquarie University","ror":"https://ror.org/01sf06y89","country_code":"AU","type":"education","lineage":["https://openalex.org/I99043593"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"S. Ranganathan","raw_affiliation_strings":["Macquarie University, Sydney, NSW 2109, Australia","\u2207Macquarie University, Sydney, NSW 2109, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Macquarie University, Sydney, NSW 2109, Australia","institution_ids":["https://openalex.org/I99043593"]},{"raw_affiliation_string":"\u2207Macquarie University, Sydney, NSW 2109, Australia","institution_ids":["https://openalex.org/I99043593"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3885,"currency":"USD","value_usd":3885},"apc_paid":null,"fwci":0.2598,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.57715194,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"9","issue":"4","first_page":"261","last_page":"262"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13937","display_name":"Genetics, Bioinformatics, and Biomedical Research","score":0.9789999723434448,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T13937","display_name":"Genetics, Bioinformatics, and Biomedical Research","score":0.9789999723434448,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5942376255989075},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.49309536814689636},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.38316380977630615},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.2266724705696106}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5942376255989075},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.49309536814689636},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.38316380977630615},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2266724705696106}],"mesh":[{"descriptor_ui":"D001709","descriptor_name":"Biotechnology","qualifier_ui":"Q000639","qualifier_name":"trends","is_major_topic":false},{"descriptor_ui":"D001709","descriptor_name":"Biotechnology","qualifier_ui":"Q000639","qualifier_name":"trends","is_major_topic":false},{"descriptor_ui":"D001709","descriptor_name":"Biotechnology","qualifier_ui":"Q000639","qualifier_name":"trends","is_major_topic":false},{"descriptor_ui":"D002874","descriptor_name":"Chromosome Mapping","qualifier_ui":"Q000639","qualifier_name":"trends","is_major_topic":false},{"descriptor_ui":"D002874","descriptor_name":"Chromosome Mapping","qualifier_ui":"Q000639","qualifier_name":"trends","is_major_topic":false},{"descriptor_ui":"D002874","descriptor_name":"Chromosome Mapping","qualifier_ui":"Q000639","qualifier_name":"trends","is_major_topic":false},{"descriptor_ui":"D003628","descriptor_name":"Database Management Systems","qualifier_ui":"Q000639","qualifier_name":"trends","is_major_topic":false},{"descriptor_ui":"D003628","descriptor_name":"Database Management Systems","qualifier_ui":"Q000639","qualifier_name":"trends","is_major_topic":false},{"descriptor_ui":"D003628","descriptor_name":"Database Management Systems","qualifier_ui":"Q000639","qualifier_name":"trends","is_major_topic":false},{"descriptor_ui":"D017421","descriptor_name":"Sequence Analysis","qualifier_ui":"Q000639","qualifier_name":"trends","is_major_topic":false},{"descriptor_ui":"D017421","descriptor_name":"Sequence Analysis","qualifier_ui":"Q000639","qualifier_name":"trends","is_major_topic":false},{"descriptor_ui":"D017421","descriptor_name":"Sequence Analysis","qualifier_ui":"Q000639","qualifier_name":"trends","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000639","qualifier_name":"trends","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000639","qualifier_name":"trends","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000639","qualifier_name":"trends","is_major_topic":false},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":"Q000639","qualifier_name":"trends","is_major_topic":false},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":"Q000639","qualifier_name":"trends","is_major_topic":false},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":"Q000639","qualifier_name":"trends","is_major_topic":false},{"descriptor_ui":"D030541","descriptor_name":"Databases, Genetic","qualifier_ui":"Q000639","qualifier_name":"trends","is_major_topic":false},{"descriptor_ui":"D030541","descriptor_name":"Databases, Genetic","qualifier_ui":"Q000639","qualifier_name":"trends","is_major_topic":false},{"descriptor_ui":"D030541","descriptor_name":"Databases, Genetic","qualifier_ui":"Q000639","qualifier_name":"trends","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1093/bib/bbn025","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbn025","pdf_url":"https://academic.oup.com/bib/article-pdf/9/4/261/744142/bbn025.pdf","source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},{"id":"pmid:18499720","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18499720","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in bioinformatics","raw_type":"Editorial"}],"best_oa_location":{"id":"doi:10.1093/bib/bbn025","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbn025","pdf_url":"https://academic.oup.com/bib/article-pdf/9/4/261/744142/bbn025.pdf","source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2043495046.pdf","grobid_xml":"https://content.openalex.org/works/W2043495046.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2899084033","https://openalex.org/W2748952813","https://openalex.org/W2390279801","https://openalex.org/W2358668433","https://openalex.org/W2376932109","https://openalex.org/W2001405890","https://openalex.org/W2382290278","https://openalex.org/W2350741829","https://openalex.org/W2130043461","https://openalex.org/W2530322880"],"abstract_inverted_index":{"Scientific":[0],"advances":[1,348],"over":[2,695],"the":[3,26,124,297,337,392,485,504,523,532,565,596,608,620,625,653,673,677,696,754,757,771,778,794,853,904,912,929,952,956,961,972,985,1009,1025,1029,1069,1078,1082],"last":[4],"50":[5],"years":[6],"have":[7,24,78,385,560,671,701,890,1007],"provided":[8],"a":[9,147,319,387,425,441,634,704,730,763,835,892,920,942,977,990,999,1132],"basis":[10],"for":[11,272,413,450,460,655,661,680,706,715,733,742,948,984,1018,1129,1145],"parallel":[12],"revolutions":[13,340],"in":[14,17,20,61,180,222,341,349,378,454,526,530,647,858,1048,1056,1124,1139],"engineering":[15],"and":[16,22,43,57,68,75,84,102,106,119,138,159,168,185,197,228,232,237,248,253,267,312,328,344,346,361,394,415,435,447,457,488,493,540,554,567,649,660,669,720,722,739,747,802,823,831,841,878,910,932,966,982,987,995,1021,1044,1054,1068,1075,1103,1142,1148],"biomedicine.":[18],"Advances":[19,60,1047],"automation":[21],"miniaturization":[23],"enabled":[25],"development":[27,974,1111],"of":[28,35,41,54,65,88,99,112,126,132,144,151,173,187,200,213,217,234,256,278,296,321,354,358,363,369,376,396,402,417,444,452,466,506,534,546,569,575,579,610,637,642,651,657,676,686,709,718,724,745,749,786,796,809,837,855,874,884,906,923,934,945,963,969,992,1001,1040,1059,1062,1084,1100,1105,1112,1117,1131,1135],"modern":[29],"instrumentation":[30,350],"that":[31,289,330,406,427,612,760,766,812,898,979,1012],"supports":[32],"large-scale":[33,1118,1122],"measurement":[34],"biological":[36,94,116,127,188,201,214,218,235,418,509,602,643,710,788,846,859,876,885,908],"entities.":[37],"The":[38,72,110,171,339,356,500,516,572,639,784,1115],"burgeoning":[39],"fields":[40],"genomics":[42],"proteomics,":[44],"as":[45,47,208,210,226,410],"well":[46,209],"other":[48],"\u2018omics\u2019,":[49],"keep":[50],"generating":[51,414],"large":[52,1060],"amounts":[53,353],"molecular":[55,284,301,306,455,527,570,1020],"expression":[56],"interaction":[58,946],"data.":[59,189,202,215,355],"cytometry":[62],"enable":[63,123,548,767],"quantification":[64,1104],"cellular":[66,1022],"states":[67],"related":[69,347,497],"functional":[70,539,581,617],"properties.":[71],"latest":[73,524,674],"scanning":[74],"imaging":[76],"technologies":[77,242,259,383,412],"made":[79,386],"it":[80,250],"possible":[81,630],"to":[82,108,136,157,193,205,221,243,286,333,470,563,584,606,777,793,825,844,868,940,1024,1066,1071,1080],"scan":[83],"make":[85,761],"detailed":[86,97],"measurements":[87],"whole":[89,1032],"organisms.":[90],"Clinical":[91],"data":[92,113,145,162,166,219,245,282,360,735,789,894,901],"complement":[93,290],"data,":[95,431,645,746,1063],"enabling":[96,411],"descriptions":[98],"various":[100,115,130,254,464],"healthy":[101],"diseased":[103],"states,":[104,117],"progression":[105],"responses":[107],"therapies.":[109],"availability":[111],"representing":[114],"processes,":[118],"their":[120,494,725,752,842,879,996],"time":[121,1143],"dependencies":[122],"study":[125,826,854],"systems":[128,236,827,924],"at":[129,463,1028],"levels":[131,465,883],"organization,":[133],"from":[134,246,275,283,468,736,872],"molecule":[135,469],"organism,":[137],"even":[139],"population":[140,474],"levels.":[141],"Multiple":[142,589],"sources":[143],"support":[146,260],"rapidly":[148,694],"growing":[149],"body":[150],"biomedical":[152,397,1052,1085,1146],"knowledge;":[153],"however":[154],"our":[155],"ability":[156,1070],"analyze":[158],"interpret":[160],"these":[161,359],"lags":[163],"far":[164],"behind":[165],"generation":[167,545,574],"storage":[169],"capacity.":[170],"field":[172],"bioinformatics":[174,294,334,367,382,404,514,599,798,1049,1113],"is":[175,623,628,683,713,850,919,1089,1126],"experiencing":[176],"rapid":[177,640],"growth,":[178],"principally":[179],"three":[181],"directions:":[182],"management,":[183,195],"analysis":[184,212,433,566,708,717,744,785,905,933],"modeling":[186,1016,1036],"Data":[190],"management":[191],"refers":[192,204,220],"acquisition,":[194],"dissemination":[196],"basic":[198,308],"interpretation":[199,357,568],"Analysis":[203],"integrative":[206,863],"analysis,":[207],"complex":[211,287,429,768,787,856,907,1073],"Modeling":[216],"silico":[223,1125],"approaches":[224,368,462,804],"such":[225],"mathematical":[227,314,801],"computational":[229,268,810,838],"modeling,":[230,1042],"simulation":[231],"prediction":[233,1002],"processes.":[238],"Bioinformatics":[239,379],"uses":[240,862],"information":[241,252,342,536,965],"gather":[244],"biomedicine":[247],"translate":[249],"into":[251,511,976],"forms":[255],"knowledge.":[257,419],"Information":[258],"this":[261,478],"quest:":[262],"hardware,":[263],"networking,":[264],"databases,":[265,285,322,529],"algorithms":[266,311],"models":[269,487],"are":[270,400,594,604,773,805,1050],"used":[271,1128],"tasks":[273],"ranging":[274],"simple":[276,300,313],"retrieval":[277],"publication":[279],"abstracts":[280],"or":[281,616,1031],"simulations":[288,1076,1123],"multi-step":[291],"experimentation.":[292],"Early":[293],"infrastructure":[295,317],"1980s":[298],"comprised":[299],"databases":[302,492],"containing":[303],"several":[304],"thousand":[305],"entries,":[307],"sequence":[309,491,552,586,590,644],"comparison":[310],"models.":[315],"Current":[316],"comprises":[318],"network":[320],"web-accessible":[323],"analytical":[324,498],"tools,":[325],"computer":[326],"networks":[327,994],"supercomputers":[329],"connect":[331],"users":[332],"resources":[335],"across":[336],"world.":[338],"technology":[343,502],"biotechnology":[345],"produce":[351],"huge":[352],"extraction":[362],"new":[364,544,573],"knowledge":[365,453],"requires":[366,1037],"ever":[370],"increasing":[371],"sophistication.":[372],"This":[373,438],"special":[374],"issue":[375],"Briefings":[377],"covers":[380],"eight":[381],"which":[384],"significant":[388],"impact":[389],"on":[390,483,881,1014,1109],"both":[391,646],"theory":[393],"practice":[395],"research.":[398],"These":[399],"representative":[401],"important":[403,598],"topics":[405],"can":[407,691],"be":[408,692],"described":[409,672,702,891,1008],"sharing":[416],"Lefranc":[420],"et":[421,520,699,888,1005],"al.":[422,521,700,889,1006],"describe":[423,756],"IMGT,":[424],"system":[426,439,896,935,978],"integrates":[428,899,989],"immunogenetic":[430],"ontologies,":[432],"tools":[434,459,547,559,576,600,687,808],"web":[436,662,740],"resources.":[437],"offers":[440,480,729],"formal":[442],"description":[443],"objects,":[445],"processes":[446,1023],"relations":[448],"necessary":[449,1017],"conceptualization":[451],"immunogenetics":[456],"provides":[458,834,980],"multi-scale":[461,1015,1035],"hierarchy":[467],"organism":[471],"and,":[472],"possibly,":[473],"level.":[475],"In":[476,751],"particular,":[477],"review":[479],"an":[481,512,684,1092],"insight":[482],"merging":[484],"conceptual":[486],"ontologies":[489,983],"with":[490,496,537,807,852,960,998,1121],"combination":[495,873,1116],"tools.":[499,783,799,916,1003],"IMGT":[501],"demonstrates":[503],"conversion":[505],"precisely":[507],"defined":[508],"concepts":[510],"integrated":[513],"environment.":[515],"article":[517,927],"by":[518,550],"Standley":[519],"describes":[522,928],"developments":[525],"structure":[528,555],"particular":[531],"enhancement":[533],"structural":[535,615],"biochemical,":[538],"experimental":[541],"information.":[542],"A":[543],"querying":[549],"keywords/text,":[551],"similarity":[553,611],"similarity.":[556],"Advanced":[557],"visualization":[558,748,782,915,1043],"been":[561],"developed":[562],"assist":[564],"structures.":[571],"improves":[577],"identification":[578,656],"distant":[580,658],"relationship":[582],"relative":[583],"traditional":[585],"comparison-based":[587],"methods.":[588],"alignment":[591],"(MSA)":[592],"methods":[593,818,840],"among":[595],"most":[597],"whereby":[601],"sequences":[603],"compared":[605],"identify":[607],"regions":[609],"confer":[613],"evolutionary,":[614],"relatedness.":[618],"Because":[619],"MSA":[621,632],"problem":[622],"NP-hard,":[624],"optimal":[626],"solution":[627],"not":[629],"unless":[631],"involves":[633],"small":[635],"number":[636,650,1134],"sequences.":[638,711],"growth":[641,962],"length":[648],"sequences,":[652],"need":[654],"homologs":[659],"accessibility":[663],"require":[664],"increasingly":[665,1090],"sophisticated":[666],"algorithms.":[667,815],"Katoh":[668],"Toh":[670],"version":[675],"MAFFT":[678,682],"program":[679],"MSA.":[681],"example":[685],"where":[688,770],"high-quality":[689],"MSAs":[690],"performed":[693],"Internet.":[697],"Kumar":[698],"MEGA,":[703],"tool":[705],"evolutionary":[707,726],"MEGA":[712,762],"designed":[714],"comparative":[716],"genes":[719],"proteins":[721],"investigation":[723],"relationships.":[727],"It":[728,861],"convenient":[731],"means":[732],"managing":[734],"local":[737],"files":[738],"repositories,":[741],"statistical":[743,803],"results.":[750],"article,":[753],"authors":[755],"design":[758],"features":[759],"biologist-centric":[764],"tool,":[765],"analyses":[769,1074],"results":[772,913,1083],"clearly,":[774],"unambiguously":[775],"presented":[776],"user":[779],"through":[780,914],"advanced":[781,797,1038],"brings":[790],"formidable":[791],"challenges":[792],"developers":[795],"Formal":[800],"complemented":[806],"intelligence":[811,817,839],"employ":[813,819],"heuristic":[814],"Computational":[816],"fuzzy":[820],"logic,":[821],"search":[822],"classification":[824],"than":[828,865],"learn,":[829],"evolve":[830],"adapt.":[832],"Fogel":[833],"primer":[836],"application":[843],"selected":[845],"problems.":[847],"Systems":[848],"biology":[849],"concerned":[851],"interactions":[857,1106],"systems.":[860],"rather":[864],"reductionist":[866],"approach":[867],"discover":[869],"properties":[870],"arising":[871],"multiple":[875,882,900],"entities":[877],"effects":[880],"organization.":[886],"Hu":[887],"visual":[893],"mining":[895],"VisANT":[897],"types,":[902],"performs":[903],"networks,":[909],"displays":[911],"Transcriptional":[917],"regulation":[918],"key":[921,1136],"area":[922],"biology.":[925],"Wingender's":[926],"TRANSFAC":[930,954],"database":[931],"whose":[936],"original":[937,973],"aim":[938],"was":[939],"provide":[941,1077],"genome-wide":[943],"map":[944],"sites":[947],"transcription":[949,993],"factors.":[950],"Over":[951],"years,":[953],"became":[955],"industry":[957],"standard.":[958],"However,":[959],"genomic":[964],"genome":[967],"mapping":[968],"model":[970],"organisms,":[971,1102],"evolved":[975],"classifications":[981],"domain,":[986],"also":[988],"catalog":[991],"parts":[997],"set":[1000],"Hunter":[1004],"Physiome":[1010],"project":[1011],"focuses":[1013],"relating":[1019],"events":[1026],"observed":[1027],"organ":[1030],"organism.":[1033],"Such":[1034],"techniques":[1039],"mechanistic":[1041],"numerical":[1045],"techniques.":[1046],"reshaping":[1051],"research":[1053,1086,1147],"applications":[1055],"biotechnology.":[1057],"Integration":[1058],"quantities":[1061],"instant":[1064],"access":[1065],"information,":[1067],"perform":[1072],"capacity":[1079],"amplify":[1081],"many-fold.":[1087],"Biomedicine":[1088],"becoming":[1091],"information-rich":[1093],"field.":[1094],"Deciphering":[1095],"qualitative":[1096],"relationships":[1097],"between":[1098],"components":[1099],"living":[1101],"will":[1107],"depend":[1108],"further":[1110],"technologies.":[1114],"screening":[1119],"experiments":[1120],"already":[1127],"selection":[1130],"limited":[1133],"experiments,":[1137],"resulting":[1138],"decreased":[1140],"cost":[1141],"required":[1144],"discovery.":[1149]},"counts_by_year":[{"year":2020,"cited_by_count":1}],"updated_date":"2026-08-21T09:56:20.448147","created_date":"2025-10-10T00:00:00"}
