{"id":"https://openalex.org/W2155985338","doi":"https://doi.org/10.1093/bib/bbm051","title":"Current trends in the bioinformatic sequence analysis of metabolic pathways in prokaryotes","display_name":"Current trends in the bioinformatic sequence analysis of metabolic pathways in prokaryotes","publication_year":2007,"publication_date":"2007-10-23","ids":{"openalex":"https://openalex.org/W2155985338","doi":"https://doi.org/10.1093/bib/bbm051","mag":"2155985338","pmid":"https://pubmed.ncbi.nlm.nih.gov/18024984"},"language":"en","primary_location":{"id":"doi:10.1093/bib/bbm051","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbm051","pdf_url":"https://academic.oup.com/bib/article-pdf/9/1/34/822609/bbm051.pdf","source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://academic.oup.com/bib/article-pdf/9/1/34/822609/bbm051.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5078202592","display_name":"Matteo Brilli","orcid":"https://orcid.org/0000-0001-9891-4617"},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]},{"id":"https://openalex.org/I45084792","display_name":"University of Florence","ror":"https://ror.org/04jr1s763","country_code":"IT","type":"education","lineage":["https://openalex.org/I45084792"]}],"countries":["GB","IT"],"is_corresponding":true,"raw_author_name":"M. Brilli","raw_affiliation_strings":["Department of Animal Biology and Genetics, University of Florence, Via Romana 17/19, 50125 Firenze, Italy. matteo.brilli@dbag.unifi.it","Department of Animal Biology and Genetics, University of Florence, Via Romana 17/19, 50125 Firenze, Italy","Laboratory of the University of Cambridge, where"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Animal Biology and Genetics, University of Florence, Via Romana 17/19, 50125 Firenze, Italy. matteo.brilli@dbag.unifi.it","institution_ids":["https://openalex.org/I45084792"]},{"raw_affiliation_string":"Department of Animal Biology and Genetics, University of Florence, Via Romana 17/19, 50125 Firenze, Italy","institution_ids":["https://openalex.org/I45084792"]},{"raw_affiliation_string":"Laboratory of the University of Cambridge, where","institution_ids":["https://openalex.org/I241749"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051013535","display_name":"Renato Fani","orcid":"https://orcid.org/0000-0001-9114-2335"},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]},{"id":"https://openalex.org/I45084792","display_name":"University of Florence","ror":"https://ror.org/04jr1s763","country_code":"IT","type":"education","lineage":["https://openalex.org/I45084792"]}],"countries":["GB","IT"],"is_corresponding":false,"raw_author_name":"R. Fani","raw_affiliation_strings":["Renato Fani is professor of Genetics at the University of Florence. In the last 20 years, he has studied the evolution of metabolic pathways both from the experimental and bioinformatics perspective","Department of Animal Biology and Genetics, University of Florence, Via Romana 17/19, 50125 Firenze, Italy","Laboratory of the University of Cambridge, where"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Renato Fani is professor of Genetics at the University of Florence. In the last 20 years, he has studied the evolution of metabolic pathways both from the experimental and bioinformatics perspective","institution_ids":["https://openalex.org/I45084792"]},{"raw_affiliation_string":"Department of Animal Biology and Genetics, University of Florence, Via Romana 17/19, 50125 Firenze, Italy","institution_ids":["https://openalex.org/I45084792"]},{"raw_affiliation_string":"Laboratory of the University of Cambridge, where","institution_ids":["https://openalex.org/I241749"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5056748708","display_name":"P\u00edetro Li\u00f3","orcid":"https://orcid.org/0000-0002-0540-5053"},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]},{"id":"https://openalex.org/I4210110041","display_name":"Systems Dynamics (United States)","ror":"https://ror.org/01z7k2z53","country_code":"US","type":"company","lineage":["https://openalex.org/I4210110041"]},{"id":"https://openalex.org/I45084792","display_name":"University of Florence","ror":"https://ror.org/04jr1s763","country_code":"IT","type":"education","lineage":["https://openalex.org/I45084792"]}],"countries":["GB","IT","US"],"is_corresponding":false,"raw_author_name":"P. Lio","raw_affiliation_strings":["Pietro Li\u00f2 is Senior Lecturer at the Computer Laboratory of the University of Cambridge, where he undertakes research and teaching in Bioinformatics, Computational Biology and System Biology with particular interests in algorithms for multiscale phenomena, networks dynamics, sequence and microarray data analysis","Department of Animal Biology and Genetics, University of Florence, Via Romana 17/19, 50125 Firenze, Italy","Laboratory of the University of Cambridge, where"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pietro Li\u00f2 is Senior Lecturer at the Computer Laboratory of the University of Cambridge, where he undertakes research and teaching in Bioinformatics, Computational Biology and System Biology with particular interests in algorithms for multiscale phenomena, networks dynamics, sequence and microarray data analysis","institution_ids":["https://openalex.org/I4210110041"]},{"raw_affiliation_string":"Department of Animal Biology and Genetics, University of Florence, Via Romana 17/19, 50125 Firenze, Italy","institution_ids":["https://openalex.org/I45084792"]},{"raw_affiliation_string":"Laboratory of the University of Cambridge, where","institution_ids":["https://openalex.org/I241749"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5078202592"],"corresponding_institution_ids":["https://openalex.org/I241749","https://openalex.org/I45084792"],"apc_list":{"value":3885,"currency":"USD","value_usd":3885},"apc_paid":null,"fwci":0.2517,"has_fulltext":true,"cited_by_count":6,"citation_normalized_percentile":{"value":0.57614095,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"9","issue":"1","first_page":"34","last_page":"45"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10015","display_name":"Genomics and Phylogenetic Studies","score":0.9995999932289124,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10015","display_name":"Genomics and Phylogenetic Studies","score":0.9995999932289124,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":0.9991999864578247,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12254","display_name":"Machine Learning in Bioinformatics","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/exploit","display_name":"Exploit","score":0.6702852249145508},{"id":"https://openalex.org/keywords/systems-biology","display_name":"Systems biology","score":0.6494008302688599},{"id":"https://openalex.org/keywords/identification","display_name":"Identification (biology)","score":0.6346642971038818},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.5958366394042969},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5898596048355103},{"id":"https://openalex.org/keywords/context","display_name":"Context (archaeology)","score":0.5672447085380554},{"id":"https://openalex.org/keywords/metabolic-pathway","display_name":"Metabolic pathway","score":0.5348984003067017},{"id":"https://openalex.org/keywords/synthetic-biology","display_name":"Synthetic biology","score":0.5313723087310791},{"id":"https://openalex.org/keywords/genomics","display_name":"Genomics","score":0.4821038544178009},{"id":"https://openalex.org/keywords/biological-pathway","display_name":"Biological pathway","score":0.43113577365875244},{"id":"https://openalex.org/keywords/metabolic-engineering","display_name":"Metabolic engineering","score":0.41706860065460205},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.3552830219268799},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.24594885110855103},{"id":"https://openalex.org/keywords/genome","display_name":"Genome","score":0.213595449924469},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.1629859209060669},{"id":"https://openalex.org/keywords/ecology","display_name":"Ecology","score":0.09290528297424316}],"concepts":[{"id":"https://openalex.org/C165696696","wikidata":"https://www.wikidata.org/wiki/Q11287","display_name":"Exploit","level":2,"score":0.6702852249145508},{"id":"https://openalex.org/C152662350","wikidata":"https://www.wikidata.org/wiki/Q815297","display_name":"Systems biology","level":2,"score":0.6494008302688599},{"id":"https://openalex.org/C116834253","wikidata":"https://www.wikidata.org/wiki/Q2039217","display_name":"Identification (biology)","level":2,"score":0.6346642971038818},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5958366394042969},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5898596048355103},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.5672447085380554},{"id":"https://openalex.org/C192989942","wikidata":"https://www.wikidata.org/wiki/Q68685","display_name":"Metabolic pathway","level":3,"score":0.5348984003067017},{"id":"https://openalex.org/C191908910","wikidata":"https://www.wikidata.org/wiki/Q862838","display_name":"Synthetic biology","level":2,"score":0.5313723087310791},{"id":"https://openalex.org/C189206191","wikidata":"https://www.wikidata.org/wiki/Q222046","display_name":"Genomics","level":4,"score":0.4821038544178009},{"id":"https://openalex.org/C9927688","wikidata":"https://www.wikidata.org/wiki/Q4915012","display_name":"Biological pathway","level":4,"score":0.43113577365875244},{"id":"https://openalex.org/C6350086","wikidata":"https://www.wikidata.org/wiki/Q6822347","display_name":"Metabolic engineering","level":3,"score":0.41706860065460205},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3552830219268799},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.24594885110855103},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.213595449924469},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1629859209060669},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.09290528297424316},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.0},{"id":"https://openalex.org/C38652104","wikidata":"https://www.wikidata.org/wiki/Q3510521","display_name":"Computer security","level":1,"score":0.0},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005544","descriptor_name":"Forecasting","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005544","descriptor_name":"Forecasting","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005544","descriptor_name":"Forecasting","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D017421","descriptor_name":"Sequence Analysis","qualifier_ui":"Q000639","qualifier_name":"trends","is_major_topic":false},{"descriptor_ui":"D017421","descriptor_name":"Sequence Analysis","qualifier_ui":"Q000639","qualifier_name":"trends","is_major_topic":false},{"descriptor_ui":"D017421","descriptor_name":"Sequence Analysis","qualifier_ui":"Q000639","qualifier_name":"trends","is_major_topic":false},{"descriptor_ui":"D018407","descriptor_name":"Bacterial Physiological Phenomena","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018407","descriptor_name":"Bacterial Physiological Phenomena","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018407","descriptor_name":"Bacterial Physiological Phenomena","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000639","qualifier_name":"trends","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000639","qualifier_name":"trends","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000639","qualifier_name":"trends","is_major_topic":false},{"descriptor_ui":"D025941","descriptor_name":"Protein Interaction Mapping","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D025941","descriptor_name":"Protein Interaction Mapping","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D025941","descriptor_name":"Protein Interaction Mapping","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D025941","descriptor_name":"Protein Interaction Mapping","qualifier_ui":"Q000639","qualifier_name":"trends","is_major_topic":false},{"descriptor_ui":"D025941","descriptor_name":"Protein Interaction Mapping","qualifier_ui":"Q000639","qualifier_name":"trends","is_major_topic":false},{"descriptor_ui":"D025941","descriptor_name":"Protein Interaction Mapping","qualifier_ui":"Q000639","qualifier_name":"trends","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1093/bib/bbm051","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbm051","pdf_url":"https://academic.oup.com/bib/article-pdf/9/1/34/822609/bbm051.pdf","source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},{"id":"pmid:18024984","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18024984","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in bioinformatics","raw_type":"Journal Article"},{"id":"pmh:oai:air.unimi.it:2434/621324","is_oa":true,"landing_page_url":"http://hdl.handle.net/2434/621324","pdf_url":null,"source":{"id":"https://openalex.org/S4306400516","display_name":"Archivio Istituzionale della Ricerca (Universita Degli Studi Di Milano)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I189158943","host_organization_name":"University of Milan","host_organization_lineage":["https://openalex.org/I189158943"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:flore.unifi.it:2158/387364","is_oa":false,"landing_page_url":"http://hdl.handle.net/2158/387364","pdf_url":null,"source":{"id":"https://openalex.org/S4306402033","display_name":"Florence Research (University of Florence)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I45084792","host_organization_name":"University of Florence","host_organization_lineage":["https://openalex.org/I45084792"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1093/bib/bbm051","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbm051","pdf_url":"https://academic.oup.com/bib/article-pdf/9/1/34/822609/bbm051.pdf","source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2155985338.pdf","grobid_xml":"https://content.openalex.org/works/W2155985338.grobid-xml"},"referenced_works_count":173,"referenced_works":["https://openalex.org/W131950025","https://openalex.org/W1501664771","https://openalex.org/W1542595575","https://openalex.org/W1598176384","https://openalex.org/W1670466145","https://openalex.org/W1713210353","https://openalex.org/W1815199292","https://openalex.org/W1913187248","https://openalex.org/W1958476169","https://openalex.org/W1962555837","https://openalex.org/W1964086051","https://openalex.org/W1970476129","https://openalex.org/W1971268821","https://openalex.org/W1971425971","https://openalex.org/W1974614108","https://openalex.org/W1974748393","https://openalex.org/W1975348430","https://openalex.org/W1977027195","https://openalex.org/W1977922844","https://openalex.org/W1984053739","https://openalex.org/W1988496202","https://openalex.org/W1988891235","https://openalex.org/W1991670061","https://openalex.org/W1993589803","https://openalex.org/W1993908486","https://openalex.org/W1996642589","https://openalex.org/W1996852546","https://openalex.org/W1997460472","https://openalex.org/W1997554676","https://openalex.org/W1997839385","https://openalex.org/W1997870387","https://openalex.org/W2000535151","https://openalex.org/W2004674004","https://openalex.org/W2006607348","https://openalex.org/W2008856488","https://openalex.org/W2015281347","https://openalex.org/W2018590530","https://openalex.org/W2025853251","https://openalex.org/W2026199611","https://openalex.org/W2026856794","https://openalex.org/W2029112298","https://openalex.org/W2029553118","https://openalex.org/W2037442572","https://openalex.org/W2039700732","https://openalex.org/W2041862730","https://openalex.org/W2043305797","https://openalex.org/W2045604000","https://openalex.org/W2057015734","https://openalex.org/W2057885377","https://openalex.org/W2065410795","https://openalex.org/W2065915143","https://openalex.org/W2066398814","https://openalex.org/W2069663555","https://openalex.org/W2074944035","https://openalex.org/W2075672090","https://openalex.org/W2079493886","https://openalex.org/W2080021452","https://openalex.org/W2083488851","https://openalex.org/W2084908610","https://openalex.org/W2087885007","https://openalex.org/W2088321573","https://openalex.org/W2092414509","https://openalex.org/W2096139934","https://openalex.org/W2096358531","https://openalex.org/W2096731969","https://openalex.org/W2098419010","https://openalex.org/W2099102792","https://openalex.org/W2100018338","https://openalex.org/W2100648873","https://openalex.org/W2100990314","https://openalex.org/W2101330776","https://openalex.org/W2102498314","https://openalex.org/W2103017472","https://openalex.org/W2103726835","https://openalex.org/W2105100203","https://openalex.org/W2105356147","https://openalex.org/W2105792118","https://openalex.org/W2106044656","https://openalex.org/W2106116715","https://openalex.org/W2106913956","https://openalex.org/W2107424557","https://openalex.org/W2107717979","https://openalex.org/W2108758729","https://openalex.org/W2109715166","https://openalex.org/W2111468050","https://openalex.org/W2112884978","https://openalex.org/W2113654464","https://openalex.org/W2114886480","https://openalex.org/W2116099439","https://openalex.org/W2119464316","https://openalex.org/W2119632499","https://openalex.org/W2120096705","https://openalex.org/W2121356022","https://openalex.org/W2121564430","https://openalex.org/W2122851202","https://openalex.org/W2124166542","https://openalex.org/W2124285343","https://openalex.org/W2124354935","https://openalex.org/W2124681451","https://openalex.org/W2124786890","https://openalex.org/W2124908487","https://openalex.org/W2125121305","https://openalex.org/W2126217507","https://openalex.org/W2126975650","https://openalex.org/W2129422961","https://openalex.org/W2129448726","https://openalex.org/W2129621613","https://openalex.org/W2130150648","https://openalex.org/W2130281874","https://openalex.org/W2130687290","https://openalex.org/W2133579817","https://openalex.org/W2133666768","https://openalex.org/W2135221645","https://openalex.org/W2135805255","https://openalex.org/W2136280642","https://openalex.org/W2137137210","https://openalex.org/W2137464714","https://openalex.org/W2141157874","https://openalex.org/W2141408320","https://openalex.org/W2141595482","https://openalex.org/W2141885858","https://openalex.org/W2142967149","https://openalex.org/W2145661401","https://openalex.org/W2146108849","https://openalex.org/W2146312020","https://openalex.org/W2148973980","https://openalex.org/W2150444353","https://openalex.org/W2150550043","https://openalex.org/W2151487377","https://openalex.org/W2155836971","https://openalex.org/W2156007463","https://openalex.org/W2156536014","https://openalex.org/W2157076973","https://openalex.org/W2157657843","https://openalex.org/W2157865313","https://openalex.org/W2160471420","https://openalex.org/W2161746138","https://openalex.org/W2161858322","https://openalex.org/W2163352757","https://openalex.org/W2163480486","https://openalex.org/W2163941254","https://openalex.org/W2165106082","https://openalex.org/W2165674132","https://openalex.org/W2168208027","https://openalex.org/W2169929748","https://openalex.org/W2171080001","https://openalex.org/W3095583226","https://openalex.org/W3142026388","https://openalex.org/W4231264298","https://openalex.org/W4236653809","https://openalex.org/W4249652851","https://openalex.org/W4251391134","https://openalex.org/W4252706339","https://openalex.org/W4298039863","https://openalex.org/W6642723664","https://openalex.org/W6643992038","https://openalex.org/W6649998153","https://openalex.org/W6656967546","https://openalex.org/W6659793138","https://openalex.org/W6674492325","https://openalex.org/W6674960884","https://openalex.org/W6678558321","https://openalex.org/W6678595789","https://openalex.org/W6678917750","https://openalex.org/W6679248178","https://openalex.org/W6680093329","https://openalex.org/W6680848828","https://openalex.org/W6683919048","https://openalex.org/W6684292109","https://openalex.org/W7073599666","https://openalex.org/W7073949363","https://openalex.org/W7075678862","https://openalex.org/W7075701783"],"related_works":["https://openalex.org/W3047447888","https://openalex.org/W2053717739","https://openalex.org/W2626617466","https://openalex.org/W1999457307","https://openalex.org/W2059128096","https://openalex.org/W2032408161","https://openalex.org/W2792366154","https://openalex.org/W2126646394","https://openalex.org/W2338895903","https://openalex.org/W3044523069"],"abstract_inverted_index":{"The":[0],"study":[1],"of":[2,28,43,50,78,87,103],"metabolic":[3,33,57,104],"pathways":[4,58,80,105],"is":[5,37],"becoming":[6],"increasingly":[7],"important":[8],"to":[9,68],"exploit":[10],"an":[11],"integrated,":[12],"systems-level":[13],"approach":[14],"for":[15],"optimizing":[16],"a":[17],"desired":[18],"cellular":[19],"property":[20],"or":[21,59],"phenotype.":[22],"In":[23,90],"this":[24,91],"context,":[25],"the":[26,40,48,85,95],"integration":[27],"genomics":[29],"data":[30],"with":[31],"genetic,":[32],"and":[34,66],"regulatory":[35],"models":[36],"essential":[38],"because":[39],"systematic":[41],"design":[42],"artificial,":[44],"biological":[45],"systems":[46],"requires":[47],"identification":[49],"robust":[51],"building":[52],"blocks":[53],"like":[54],"gene":[55],"promoters,":[56],"genetic":[60],"circuits":[61],"taken":[62],"from":[63,108],"natural":[64,79],"organisms,":[65],"manipulated":[67],"develop":[69],"ad":[70],"hoc":[71],"features.":[72],"Computational":[73],"tools":[74,99],"allowing":[75],"precise":[76],"descriptions":[77],"might":[81],"thus":[82],"allow":[83],"improving":[84],"performance":[86],"artificial":[88],"routes.":[89],"review,":[92],"we":[93],"introduce":[94],"most":[96],"recent":[97],"bioinformatics":[98],"enabling":[100],"detailed":[101],"characterizations":[102],"in":[106],"bacteria":[107],"different":[109],"perspectives.":[110]},"counts_by_year":[{"year":2020,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-08-21T09:56:20.448147","created_date":"2025-10-10T00:00:00"}