{"id":"https://openalex.org/W2097197448","doi":"https://doi.org/10.1093/bib/bbm033","title":"Modelling and simulation techniques for membrane biology","display_name":"Modelling and simulation techniques for membrane biology","publication_year":2007,"publication_date":"2007-03-29","ids":{"openalex":"https://openalex.org/W2097197448","doi":"https://doi.org/10.1093/bib/bbm033","mag":"2097197448","pmid":"https://pubmed.ncbi.nlm.nih.gov/17693422"},"language":"en","primary_location":{"id":"doi:10.1093/bib/bbm033","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbm033","pdf_url":"https://academic.oup.com/bib/article-pdf/8/4/234/591708/bbm033.pdf","source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},"type":"review","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://academic.oup.com/bib/article-pdf/8/4/234/591708/bbm033.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5003330950","display_name":"Kevin Burrage","orcid":"https://orcid.org/0000-0002-8111-1137"},"institutions":[{"id":"https://openalex.org/I165143802","display_name":"University of Queensland","ror":"https://ror.org/00rqy9422","country_code":"AU","type":"education","lineage":["https://openalex.org/I165143802"]}],"countries":["AU"],"is_corresponding":true,"raw_author_name":"K. Burrage","raw_affiliation_strings":["The Advanced Computational Modelling Centre and the ARC Centre in Bioinformatics, The University of Queensland, Brisbane 4072, Australia. kb@maths.uq.edu.au","The Advanced Computational Modelling Centre and the ARC Centre in Bioinformatics, The University of Queensland, Brisbane 4072, Australia"],"affiliations":[{"raw_affiliation_string":"The Advanced Computational Modelling Centre and the ARC Centre in Bioinformatics, The University of Queensland, Brisbane 4072, Australia. kb@maths.uq.edu.au","institution_ids":["https://openalex.org/I165143802"]},{"raw_affiliation_string":"The Advanced Computational Modelling Centre and the ARC Centre in Bioinformatics, The University of Queensland, Brisbane 4072, Australia","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082543074","display_name":"John T. Hancock","orcid":"https://orcid.org/0000-0002-0213-8850"},"institutions":[{"id":"https://openalex.org/I165143802","display_name":"University of Queensland","ror":"https://ror.org/00rqy9422","country_code":"AU","type":"education","lineage":["https://openalex.org/I165143802"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"J. Hancock","raw_affiliation_strings":["University of Queensland"],"affiliations":[{"raw_affiliation_string":"University of Queensland","institution_ids":["https://openalex.org/I165143802"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042438246","display_name":"Andr\u00e9 Leier","orcid":"https://orcid.org/0000-0002-2647-2693"},"institutions":[{"id":"https://openalex.org/I165143802","display_name":"University of Queensland","ror":"https://ror.org/00rqy9422","country_code":"AU","type":"education","lineage":["https://openalex.org/I165143802"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"A. Leier","raw_affiliation_strings":["University of Queensland"],"affiliations":[{"raw_affiliation_string":"University of Queensland","institution_ids":["https://openalex.org/I165143802"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5043698287","display_name":"Dan V. Nicolau","orcid":"https://orcid.org/0000-0002-9956-0600"},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"D. V. Nicolau","raw_affiliation_strings":["University of Oxford"],"affiliations":[{"raw_affiliation_string":"University of Oxford","institution_ids":["https://openalex.org/I40120149"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5003330950"],"corresponding_institution_ids":["https://openalex.org/I165143802"],"apc_list":{"value":4011,"currency":"USD","value_usd":4011},"apc_paid":null,"fwci":1.6132,"has_fulltext":true,"cited_by_count":41,"citation_normalized_percentile":{"value":0.82670121,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"8","issue":"4","first_page":"234","last_page":"244"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9983000159263611,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9983000159263611,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10407","display_name":"Lipid Membrane Structure and Behavior","score":0.996999979019165,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11582","display_name":"Nanopore and Nanochannel Transport Studies","score":0.9921000003814697,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.617536723613739},{"id":"https://openalex.org/keywords/systems-biology","display_name":"Systems biology","score":0.4344833493232727},{"id":"https://openalex.org/keywords/computational-model","display_name":"Computational model","score":0.421263724565506},{"id":"https://openalex.org/keywords/statistical-physics","display_name":"Statistical physics","score":0.32160109281539917},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.2075495421886444},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.19850778579711914},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.17283359169960022},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.16087067127227783}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.617536723613739},{"id":"https://openalex.org/C152662350","wikidata":"https://www.wikidata.org/wiki/Q815297","display_name":"Systems biology","level":2,"score":0.4344833493232727},{"id":"https://openalex.org/C66024118","wikidata":"https://www.wikidata.org/wiki/Q1122506","display_name":"Computational model","level":2,"score":0.421263724565506},{"id":"https://openalex.org/C121864883","wikidata":"https://www.wikidata.org/wiki/Q677916","display_name":"Statistical physics","level":1,"score":0.32160109281539917},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.2075495421886444},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.19850778579711914},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.17283359169960022},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.16087067127227783}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008956","descriptor_name":"Models, Chemical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008956","descriptor_name":"Models, Chemical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008956","descriptor_name":"Models, Chemical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009010","descriptor_name":"Monte Carlo Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009010","descriptor_name":"Monte Carlo Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009010","descriptor_name":"Monte Carlo Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015233","descriptor_name":"Models, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015233","descriptor_name":"Models, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015233","descriptor_name":"Models, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D021962","descriptor_name":"Membrane Microdomains","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D021962","descriptor_name":"Membrane Microdomains","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D021962","descriptor_name":"Membrane Microdomains","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D021962","descriptor_name":"Membrane Microdomains","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D021962","descriptor_name":"Membrane Microdomains","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D021962","descriptor_name":"Membrane Microdomains","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D021962","descriptor_name":"Membrane Microdomains","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D021962","descriptor_name":"Membrane Microdomains","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D021962","descriptor_name":"Membrane Microdomains","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1093/bib/bbm033","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbm033","pdf_url":"https://academic.oup.com/bib/article-pdf/8/4/234/591708/bbm033.pdf","source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},{"id":"pmid:17693422","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17693422","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in bioinformatics","raw_type":null},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.563.3002","is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.563.3002","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://bib.oxfordjournals.org/content/early/2007/08/09/bib.bbm033.full.pdf","raw_type":"text"},{"id":"pmh:oai:espace.library.uq.edu.au:UQ:130532","is_oa":false,"landing_page_url":null,"pdf_url":null,"source":{"id":"https://openalex.org/S4306402388","display_name":"Queensland's institutional digital repository (The University of Queensland)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I165143802","host_organization_name":"The University of Queensland","host_organization_lineage":["https://openalex.org/I165143802"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1093/bib/bbm033","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbm033","pdf_url":"https://academic.oup.com/bib/article-pdf/8/4/234/591708/bbm033.pdf","source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2097197448.pdf","grobid_xml":"https://content.openalex.org/works/W2097197448.grobid-xml"},"referenced_works_count":72,"referenced_works":["https://openalex.org/W11463020","https://openalex.org/W82875452","https://openalex.org/W1564861448","https://openalex.org/W1575104486","https://openalex.org/W1583154040","https://openalex.org/W1938835738","https://openalex.org/W1971327350","https://openalex.org/W1981277012","https://openalex.org/W1982903250","https://openalex.org/W1985556515","https://openalex.org/W1986606329","https://openalex.org/W1987129107","https://openalex.org/W1987317750","https://openalex.org/W1989307095","https://openalex.org/W1991381358","https://openalex.org/W1991655565","https://openalex.org/W2000638372","https://openalex.org/W2004413809","https://openalex.org/W2015884353","https://openalex.org/W2017038627","https://openalex.org/W2021211941","https://openalex.org/W2021578350","https://openalex.org/W2025646685","https://openalex.org/W2027351414","https://openalex.org/W2034401440","https://openalex.org/W2038467979","https://openalex.org/W2040101943","https://openalex.org/W2041745210","https://openalex.org/W2042289689","https://openalex.org/W2055862760","https://openalex.org/W2057303937","https://openalex.org/W2057788561","https://openalex.org/W2059719532","https://openalex.org/W2062404235","https://openalex.org/W2065105320","https://openalex.org/W2065232395","https://openalex.org/W2066594542","https://openalex.org/W2068237765","https://openalex.org/W2069500900","https://openalex.org/W2070658593","https://openalex.org/W2074097004","https://openalex.org/W2075161553","https://openalex.org/W2083636453","https://openalex.org/W2084924279","https://openalex.org/W2088925327","https://openalex.org/W2098048003","https://openalex.org/W2107251417","https://openalex.org/W2107885482","https://openalex.org/W2111271983","https://openalex.org/W2114656957","https://openalex.org/W2122882997","https://openalex.org/W2124391925","https://openalex.org/W2130727150","https://openalex.org/W2131821335","https://openalex.org/W2132898564","https://openalex.org/W2134358521","https://openalex.org/W2135371328","https://openalex.org/W2143016004","https://openalex.org/W2148303154","https://openalex.org/W2153034921","https://openalex.org/W2155418451","https://openalex.org/W2156458781","https://openalex.org/W2170103257","https://openalex.org/W2172159758","https://openalex.org/W2528399248","https://openalex.org/W4231021340","https://openalex.org/W4298287958","https://openalex.org/W4299506498","https://openalex.org/W6648138588","https://openalex.org/W6654506559","https://openalex.org/W6657458672","https://openalex.org/W7075630590"],"related_works":["https://openalex.org/W2899084033","https://openalex.org/W2748952813","https://openalex.org/W2390279801","https://openalex.org/W2358668433","https://openalex.org/W2376932109","https://openalex.org/W2382290278","https://openalex.org/W2350741829","https://openalex.org/W2130043461","https://openalex.org/W207829213","https://openalex.org/W2315680351"],"abstract_inverted_index":{"One":[0],"of":[1,6,13,57],"the":[2,11,14,38,41,84],"most":[3],"important":[4],"aspects":[5],"Computational":[7],"Cell":[8],"Biology":[9],"is":[10],"understanding":[12],"complicated":[15,29],"dynamical":[16],"processes":[17,25],"that":[18,30],"take":[19],"place":[20],"on":[21,80],"plasma":[22],"membranes.":[23],"These":[24],"are":[26],"often":[27],"so":[28],"purely":[31],"temporal":[32],"models":[33,45],"cannot":[34],"always":[35],"adequately":[36],"capture":[37],"dynamics.":[39],"On":[40],"other":[42],"hand,":[43],"spatial":[44,93],"can":[46],"have":[47],"large":[48],"computational":[49],"overheads.":[50],"In":[51],"this":[52],"article,":[53],"we":[54],"review":[55],"some":[56,81],"these":[58],"issues":[59],"with":[60],"respect":[61],"to":[62,72],"chemistry,":[63],"membrane":[64],"microdomains":[65],"and":[66,69,76,91],"anomalous":[67],"diffusion":[68],"discuss":[70],"how":[71],"select":[73],"appropriate":[74],"modelling":[75],"simulation":[77],"paradigms":[78],"based":[79],"or":[82],"all":[83],"following":[85],"aspects:":[86],"discrete,":[87],"continuous,":[88],"stochastic,":[89],"delayed":[90],"complex":[92],"processes.":[94]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":3},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":7}],"updated_date":"2026-04-04T16:13:02.066488","created_date":"2025-10-10T00:00:00"}