{"id":"https://openalex.org/W2013868755","doi":"https://doi.org/10.1093/bib/bbl035","title":"Evolving research trends in bioinformatics","display_name":"Evolving research trends in bioinformatics","publication_year":2006,"publication_date":"2006-11-01","ids":{"openalex":"https://openalex.org/W2013868755","doi":"https://doi.org/10.1093/bib/bbl035","mag":"2013868755","pmid":"https://pubmed.ncbi.nlm.nih.gov/17077138"},"language":"en","primary_location":{"id":"doi:10.1093/bib/bbl035","is_oa":false,"landing_page_url":"https://doi.org/10.1093/bib/bbl035","pdf_url":null,"source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111654428","display_name":"Carolina Perez\u2010Iratxeta","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C. Perez-Iratxeta","raw_affiliation_strings":["Ottawa Health Research Institute, Ontario, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ottawa Health Research Institute, Ontario, Canada","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010178662","display_name":"Miguel A. Andrade\u2010Navarro","orcid":"https://orcid.org/0000-0001-6650-1711"},"institutions":[{"id":"https://openalex.org/I153718931","display_name":"University of Ottawa","ror":"https://ror.org/03c4mmv16","country_code":"CA","type":"education","lineage":["https://openalex.org/I153718931"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"M. A. Andrade-Navarro","raw_affiliation_strings":["University of Ottawa"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Ottawa","institution_ids":["https://openalex.org/I153718931"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5006115537","display_name":"Jonathan D. Wren","orcid":"https://orcid.org/0000-0003-2776-3545"},"institutions":[{"id":"https://openalex.org/I4210110449","display_name":"Translational Research in Oncology","ror":"https://ror.org/01yqkfx81","country_code":"FR","type":"nonprofit","lineage":["https://openalex.org/I4210110449"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"J. D. Wren","raw_affiliation_strings":["Preclinical Translational Cancer Research"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Preclinical Translational Cancer Research","institution_ids":["https://openalex.org/I4210110449"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4011,"currency":"USD","value_usd":4011},"apc_paid":null,"fwci":1.2709,"has_fulltext":false,"cited_by_count":59,"citation_normalized_percentile":{"value":0.76999186,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"8","issue":"2","first_page":"88","last_page":"95"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13937","display_name":"Genetics, Bioinformatics, and Biomedical Research","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T13937","display_name":"Genetics, Bioinformatics, and Biomedical Research","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13280","display_name":"Biomedical and Engineering Education","score":0.9643999934196472,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.9538999795913696,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/biomedicine","display_name":"Biomedicine","score":0.6511310935020447},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5716112852096558},{"id":"https://openalex.org/keywords/data-science","display_name":"Data science","score":0.5472783446311951},{"id":"https://openalex.org/keywords/informatics","display_name":"Informatics","score":0.5196563005447388},{"id":"https://openalex.org/keywords/structural-bioinformatics","display_name":"Structural bioinformatics","score":0.4613521099090576},{"id":"https://openalex.org/keywords/the-internet","display_name":"The Internet","score":0.4411340653896332},{"id":"https://openalex.org/keywords/field","display_name":"Field (mathematics)","score":0.428228497505188},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.3641365170478821},{"id":"https://openalex.org/keywords/world-wide-web","display_name":"World Wide Web","score":0.23513224720954895},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.14122241735458374},{"id":"https://openalex.org/keywords/political-science","display_name":"Political science","score":0.12675541639328003}],"concepts":[{"id":"https://openalex.org/C66782513","wikidata":"https://www.wikidata.org/wiki/Q864601","display_name":"Biomedicine","level":2,"score":0.6511310935020447},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5716112852096558},{"id":"https://openalex.org/C2522767166","wikidata":"https://www.wikidata.org/wiki/Q2374463","display_name":"Data science","level":1,"score":0.5472783446311951},{"id":"https://openalex.org/C191630685","wikidata":"https://www.wikidata.org/wiki/Q4027615","display_name":"Informatics","level":2,"score":0.5196563005447388},{"id":"https://openalex.org/C69131567","wikidata":"https://www.wikidata.org/wiki/Q2068215","display_name":"Structural bioinformatics","level":3,"score":0.4613521099090576},{"id":"https://openalex.org/C110875604","wikidata":"https://www.wikidata.org/wiki/Q75","display_name":"The Internet","level":2,"score":0.4411340653896332},{"id":"https://openalex.org/C9652623","wikidata":"https://www.wikidata.org/wiki/Q190109","display_name":"Field (mathematics)","level":2,"score":0.428228497505188},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3641365170478821},{"id":"https://openalex.org/C136764020","wikidata":"https://www.wikidata.org/wiki/Q466","display_name":"World Wide Web","level":1,"score":0.23513224720954895},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.14122241735458374},{"id":"https://openalex.org/C17744445","wikidata":"https://www.wikidata.org/wiki/Q36442","display_name":"Political science","level":0,"score":0.12675541639328003},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.0},{"id":"https://openalex.org/C199539241","wikidata":"https://www.wikidata.org/wiki/Q7748","display_name":"Law","level":1,"score":0.0},{"id":"https://openalex.org/C47701112","wikidata":"https://www.wikidata.org/wiki/Q735188","display_name":"Protein structure","level":2,"score":0.0},{"id":"https://openalex.org/C202444582","wikidata":"https://www.wikidata.org/wiki/Q837863","display_name":"Pure mathematics","level":1,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D005544","descriptor_name":"Forecasting","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005544","descriptor_name":"Forecasting","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005544","descriptor_name":"Forecasting","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005544","descriptor_name":"Forecasting","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010506","descriptor_name":"Periodicals as Topic","qualifier_ui":"Q000639","qualifier_name":"trends","is_major_topic":false},{"descriptor_ui":"D010506","descriptor_name":"Periodicals as Topic","qualifier_ui":"Q000639","qualifier_name":"trends","is_major_topic":false},{"descriptor_ui":"D010506","descriptor_name":"Periodicals as Topic","qualifier_ui":"Q000639","qualifier_name":"trends","is_major_topic":false},{"descriptor_ui":"D010506","descriptor_name":"Periodicals as Topic","qualifier_ui":"Q000639","qualifier_name":"trends","is_major_topic":false},{"descriptor_ui":"D010506","descriptor_name":"Periodicals as Topic","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":false},{"descriptor_ui":"D010506","descriptor_name":"Periodicals as Topic","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":false},{"descriptor_ui":"D010506","descriptor_name":"Periodicals as Topic","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":false},{"descriptor_ui":"D010506","descriptor_name":"Periodicals as Topic","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":false},{"descriptor_ui":"D012106","descriptor_name":"Research","qualifier_ui":"Q000639","qualifier_name":"trends","is_major_topic":false},{"descriptor_ui":"D012106","descriptor_name":"Research","qualifier_ui":"Q000639","qualifier_name":"trends","is_major_topic":false},{"descriptor_ui":"D012106","descriptor_name":"Research","qualifier_ui":"Q000639","qualifier_name":"trends","is_major_topic":false},{"descriptor_ui":"D012106","descriptor_name":"Research","qualifier_ui":"Q000639","qualifier_name":"trends","is_major_topic":false},{"descriptor_ui":"D012106","descriptor_name":"Research","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":false},{"descriptor_ui":"D012106","descriptor_name":"Research","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":false},{"descriptor_ui":"D012106","descriptor_name":"Research","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":false},{"descriptor_ui":"D012106","descriptor_name":"Research","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":false},{"descriptor_ui":"D016239","descriptor_name":"MEDLINE","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016239","descriptor_name":"MEDLINE","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016239","descriptor_name":"MEDLINE","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016239","descriptor_name":"MEDLINE","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000639","qualifier_name":"trends","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000639","qualifier_name":"trends","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000639","qualifier_name":"trends","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000639","qualifier_name":"trends","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":false},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":"Q000639","qualifier_name":"trends","is_major_topic":false},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":"Q000639","qualifier_name":"trends","is_major_topic":false},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":"Q000639","qualifier_name":"trends","is_major_topic":false},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":"Q000639","qualifier_name":"trends","is_major_topic":false},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":false},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":false},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":false},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1093/bib/bbl035","is_oa":false,"landing_page_url":"https://doi.org/10.1093/bib/bbl035","pdf_url":null,"source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},{"id":"pmid:17077138","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17077138","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in bioinformatics","raw_type":null},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.116.1741","is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.116.1741","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://www.cs.uga.edu/~shravya/papers/EvolvingResearchTrends.pdf","raw_type":"text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.495.6034","is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.495.6034","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://bib.oxfordjournals.org/content/8/2/88.full.pdf","raw_type":"text"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.6100000143051147,"display_name":"Industry, innovation and infrastructure","id":"https://metadata.un.org/sdg/9"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320320994","display_name":"Canada Research Chairs","ror":"https://ror.org/0517h6h17"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":12,"referenced_works":["https://openalex.org/W19996625","https://openalex.org/W1525672751","https://openalex.org/W1583905206","https://openalex.org/W1588488206","https://openalex.org/W1590248655","https://openalex.org/W1981221473","https://openalex.org/W2039675847","https://openalex.org/W2063286618","https://openalex.org/W2092511577","https://openalex.org/W2129421709","https://openalex.org/W2165646960","https://openalex.org/W2396787206"],"related_works":["https://openalex.org/W1585658352","https://openalex.org/W2952723686","https://openalex.org/W103890959","https://openalex.org/W2744706861","https://openalex.org/W2018220225","https://openalex.org/W4238016125","https://openalex.org/W4234825420","https://openalex.org/W2625471714","https://openalex.org/W2969122352","https://openalex.org/W2905207649"],"abstract_inverted_index":{"The":[0],"cross-disciplinary":[1],"nature":[2],"of":[3,28,39,51,56,66,75,91,117,134,156,175,183,202,208,216],"bioinformatics":[4,13,30,68,157,191],"entails":[5],"co-evolution":[6],"with":[7],"other":[8],"biomedical":[9,44,77,92,107,125],"disciplines,":[10],"whereby":[11],"some":[12],"applications":[14],"become":[15,121],"popular":[16],"in":[17,21,87,95,153,170,205,212],"certain":[18],"disciplines":[19,24,45,126],"and,":[20],"turn,":[22],"these":[23],"influence":[25],"the":[26,37,59,64,73,76,83,88,106,115,128,137,144,150,154,173,184,190,206],"focus":[27],"future":[29],"development":[31,215],"efforts.":[32],"We":[33,80,159],"observe":[34,160],"here":[35],"that":[36,114,161,178],"growth":[38,204],"computational":[40,118,217],"approaches":[41],"within":[42],"various":[43],"is":[46,181],"not":[47],"merely":[48],"a":[49,52,110,166],"reflection":[50],"general":[53],"extended":[54],"usage":[55],"computers":[57],"and":[58,70,94,112,136,177,219,224],"Internet,":[60],"but":[61],"due":[62],"to":[63,99,199,210],"production":[65],"useful":[67],"databases":[69,135,164],"methods":[71,119],"for":[72,221],"rest":[74],"scientific":[78],"community.":[79,192],"have":[81,139],"used":[82],"abstracts":[84],"stored":[85],"both":[86],"MEDLINE":[89],"database":[90],"literature":[93,108],"NIH-funded":[96],"project":[97],"grants,":[98],"quantify":[100],"two":[101],"effects.":[102],"First,":[103],"we":[104,148,196],"examine":[105],"as":[109],"whole":[111],"find":[113],"use":[116,133,155,207],"has":[120],"increasingly":[122],"prevalent":[123],"across":[124],"over":[127,143],"past":[129,145],"three":[130],"decades,":[131],"while":[132],"Internet":[138],"been":[140],"rapidly":[141],"increasing":[142],"decade.":[146],"Second,":[147],"study":[149],"recent":[151],"trends":[152],"topics.":[158],"molecular":[162],"sequence":[163],"are":[165],"widely":[167],"adopted":[168],"contribution":[169],"biomedicine":[171],"from":[172],"field":[174],"bioinformatics,":[176],"microarray":[179],"analysis":[180],"one":[182],"major":[185],"new":[186],"topics":[187],"engaged":[188],"by":[189],"Via":[193],"this":[194],"analysis,":[195],"were":[197],"able":[198],"identify":[200],"areas":[201],"rapid":[203],"informatics":[209],"aid":[211],"curriculum":[213],"planning,":[214],"infrastructure":[218],"strategies":[220],"workforce":[222],"education":[223],"funding.":[225]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":6}],"updated_date":"2026-07-23T08:03:31.855105","created_date":"2025-10-10T00:00:00"}