{"id":"https://openalex.org/W2151753004","doi":"https://doi.org/10.1093/bib/bbl034","title":"Strategies for dealing with incomplete information in the modeling of molecular interaction networks","display_name":"Strategies for dealing with incomplete information in the modeling of molecular interaction networks","publication_year":2006,"publication_date":"2006-09-26","ids":{"openalex":"https://openalex.org/W2151753004","doi":"https://doi.org/10.1093/bib/bbl034","mag":"2151753004","pmid":"https://pubmed.ncbi.nlm.nih.gov/17003073"},"language":"en","primary_location":{"id":"doi:10.1093/bib/bbl034","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbl034","pdf_url":"https://academic.oup.com/bib/article-pdf/7/4/354/447963/bbl034.pdf","source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},"type":"review","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://academic.oup.com/bib/article-pdf/7/4/354/447963/bbl034.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5054406248","display_name":"Hidde de Jong","orcid":"https://orcid.org/0000-0002-2226-650X"},"institutions":[{"id":"https://openalex.org/I1326498283","display_name":"Institut national de recherche en sciences et technologies du num\u00e9rique","ror":"https://ror.org/02kvxyf05","country_code":"FR","type":"government","lineage":["https://openalex.org/I1326498283"]},{"id":"https://openalex.org/I4210101348","display_name":"Centre Inria de l'Universit\u00e9 Grenoble Alpes","ror":"https://ror.org/00n8d6z93","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1326498283","https://openalex.org/I4210101348"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"H. de Jong","raw_affiliation_strings":["INRIA Rh\u00f4ne-Alpes, 655 avenue de l'Europe, Montbonnot, 38334 Saint Ismier Cedex, France. Hidde.de-Jong@inrialpes.fr"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"INRIA Rh\u00f4ne-Alpes, 655 avenue de l'Europe, Montbonnot, 38334 Saint Ismier Cedex, France. Hidde.de-Jong@inrialpes.fr","institution_ids":["https://openalex.org/I4210101348","https://openalex.org/I1326498283"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5062022864","display_name":"Delphine Ropers","orcid":"https://orcid.org/0000-0003-2659-3003"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D. Ropers","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4011,"currency":"USD","value_usd":4011},"apc_paid":null,"fwci":1.2273,"has_fulltext":false,"cited_by_count":26,"citation_normalized_percentile":{"value":0.77899135,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"7","issue":"4","first_page":"354","last_page":"363"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.9926999807357788,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9922000169754028,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/intuition","display_name":"Intuition","score":0.8275465965270996},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.7146853804588318},{"id":"https://openalex.org/keywords/complete-information","display_name":"Complete information","score":0.4624927341938019},{"id":"https://openalex.org/keywords/sensitivity","display_name":"Sensitivity (control systems)","score":0.45971181988716125},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.33073800802230835},{"id":"https://openalex.org/keywords/biochemical-engineering","display_name":"Biochemical engineering","score":0.3211994171142578},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.15270966291427612},{"id":"https://openalex.org/keywords/mathematical-economics","display_name":"Mathematical economics","score":0.12552356719970703}],"concepts":[{"id":"https://openalex.org/C132010649","wikidata":"https://www.wikidata.org/wiki/Q189222","display_name":"Intuition","level":2,"score":0.8275465965270996},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.7146853804588318},{"id":"https://openalex.org/C113336015","wikidata":"https://www.wikidata.org/wiki/Q574010","display_name":"Complete information","level":2,"score":0.4624927341938019},{"id":"https://openalex.org/C21200559","wikidata":"https://www.wikidata.org/wiki/Q7451068","display_name":"Sensitivity (control systems)","level":2,"score":0.45971181988716125},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.33073800802230835},{"id":"https://openalex.org/C183696295","wikidata":"https://www.wikidata.org/wiki/Q2487696","display_name":"Biochemical engineering","level":1,"score":0.3211994171142578},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.15270966291427612},{"id":"https://openalex.org/C144237770","wikidata":"https://www.wikidata.org/wiki/Q747534","display_name":"Mathematical economics","level":1,"score":0.12552356719970703},{"id":"https://openalex.org/C111472728","wikidata":"https://www.wikidata.org/wiki/Q9471","display_name":"Epistemology","level":1,"score":0.0},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0},{"id":"https://openalex.org/C24326235","wikidata":"https://www.wikidata.org/wiki/Q126095","display_name":"Electronic engineering","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1093/bib/bbl034","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbl034","pdf_url":"https://academic.oup.com/bib/article-pdf/7/4/354/447963/bbl034.pdf","source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},{"id":"pmid:17003073","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17003073","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in bioinformatics","raw_type":null}],"best_oa_location":{"id":"doi:10.1093/bib/bbl034","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbl034","pdf_url":"https://academic.oup.com/bib/article-pdf/7/4/354/447963/bbl034.pdf","source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320320300","display_name":"European Commission","ror":"https://ror.org/00k4n6c32"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":60,"referenced_works":["https://openalex.org/W72928827","https://openalex.org/W1482637285","https://openalex.org/W1484198052","https://openalex.org/W1486453207","https://openalex.org/W1512810258","https://openalex.org/W1543292456","https://openalex.org/W1543750907","https://openalex.org/W1601977376","https://openalex.org/W1623155147","https://openalex.org/W1637936532","https://openalex.org/W1677575702","https://openalex.org/W1970321745","https://openalex.org/W1971224531","https://openalex.org/W1971727132","https://openalex.org/W1973110798","https://openalex.org/W1974258649","https://openalex.org/W1978486653","https://openalex.org/W1983230237","https://openalex.org/W1986040959","https://openalex.org/W1988383139","https://openalex.org/W1989284002","https://openalex.org/W1996264210","https://openalex.org/W2000163865","https://openalex.org/W2007447294","https://openalex.org/W2008855387","https://openalex.org/W2018011810","https://openalex.org/W2018151888","https://openalex.org/W2031369606","https://openalex.org/W2035278103","https://openalex.org/W2046314965","https://openalex.org/W2046538693","https://openalex.org/W2047279254","https://openalex.org/W2072159031","https://openalex.org/W2076372398","https://openalex.org/W2090628795","https://openalex.org/W2092309107","https://openalex.org/W2092488734","https://openalex.org/W2094273895","https://openalex.org/W2101546531","https://openalex.org/W2105057212","https://openalex.org/W2108210068","https://openalex.org/W2114518254","https://openalex.org/W2117056464","https://openalex.org/W2122055675","https://openalex.org/W2124082948","https://openalex.org/W2129388048","https://openalex.org/W2131178894","https://openalex.org/W2133254839","https://openalex.org/W2133310238","https://openalex.org/W2134759932","https://openalex.org/W2140894160","https://openalex.org/W2142072523","https://openalex.org/W2155418451","https://openalex.org/W2160145365","https://openalex.org/W2163641552","https://openalex.org/W2167238904","https://openalex.org/W2327883350","https://openalex.org/W2500507869","https://openalex.org/W2501848746","https://openalex.org/W2605543710"],"related_works":["https://openalex.org/W2364252372","https://openalex.org/W4234066492","https://openalex.org/W1998063895","https://openalex.org/W1967044713","https://openalex.org/W2133470120","https://openalex.org/W1994286895","https://openalex.org/W2747625183","https://openalex.org/W1970592395","https://openalex.org/W2378393413","https://openalex.org/W2802922463"],"abstract_inverted_index":{"Modelers":[0],"of":[1,13,26,43,77,99,111,134,156,159],"molecular":[2,78],"interaction":[3,79],"networks":[4],"encounter":[5],"the":[6,22,30,37,75,92,100,109,117,121,132,140,160],"paradoxical":[7],"situation":[8],"that":[9,65,96],"while":[10],"large":[11],"amounts":[12],"data":[14],"are":[15,18,46,89,103],"available,":[16],"these":[17],"often":[19],"insufficient":[20],"for":[21,50,69],"formulation":[23],"and":[24,40,84],"analysis":[25,83],"mathematical":[27],"models":[28],"describing":[29,120],"network":[31,161],"dynamics.":[32,162],"In":[33,58],"particular,":[34],"information":[35,73,136],"on":[36,91],"reaction":[38],"mechanisms":[39],"numerical":[41],"values":[42],"kinetic":[44,112],"parameters":[45,113],"usually":[47],"not":[48],"available":[49],"all":[51],"but":[52],"a":[53],"few":[54],"well-studied":[55],"model":[56,85],"systems.":[57],"this":[59,144],"article":[60,145],"we":[61],"review":[62],"two":[63],"strategies":[64,88,141],"have":[66],"been":[67],"proposed":[68],"dealing":[70],"with":[71],"incomplete":[72,135],"in":[74,108,116,143],"study":[76],"networks:":[80],"parameter":[81],"sensitivity":[82],"simplification.":[86],"These":[87],"based":[90],"biologically":[93],"justified":[94],"intuition":[95],"essential":[97,157],"properties":[98,158],"system":[101],"dynamics":[102],"robust":[104],"against":[105],"moderate":[106],"changes":[107],"value":[110],"or":[114],"even":[115],"rate":[118],"laws":[119],"interactions.":[122],"Although":[123],"advanced":[124],"measurement":[125],"techniques":[126],"can":[127],"be":[128],"expected":[129],"to":[130,137],"relieve":[131],"problem":[133],"some":[138],"extent,":[139],"discussed":[142],"will":[146],"retain":[147],"their":[148],"interest":[149],"as":[150],"tools":[151],"providing":[152],"an":[153],"initial":[154],"characterization":[155]},"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":3}],"updated_date":"2026-06-11T09:08:48.828518","created_date":"2025-10-10T00:00:00"}