{"id":"https://openalex.org/W2106576546","doi":"https://doi.org/10.1093/bib/bbl007","title":"Flux balance analysis in the era of metabolomics","display_name":"Flux balance analysis in the era of metabolomics","publication_year":2006,"publication_date":"2006-03-07","ids":{"openalex":"https://openalex.org/W2106576546","doi":"https://doi.org/10.1093/bib/bbl007","mag":"2106576546","pmid":"https://pubmed.ncbi.nlm.nih.gov/16772264"},"language":"en","primary_location":{"id":"doi:10.1093/bib/bbl007","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbl007","pdf_url":"https://academic.oup.com/bib/article-pdf/7/2/140/866765/bbl007.pdf","source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},"type":"review","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://academic.oup.com/bib/article-pdf/7/2/140/866765/bbl007.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100382860","display_name":"Jong Min Lee","orcid":"https://orcid.org/0000-0001-5395-0067"},"institutions":[{"id":"https://openalex.org/I51556381","display_name":"University of Virginia","ror":"https://ror.org/0153tk833","country_code":"US","type":"education","lineage":["https://openalex.org/I51556381"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"J. M. Lee","raw_affiliation_strings":["Department of Biomedical Engineering, University of Virginia, PO Box 800759, Charlottesville, VA 22908, USA","Department of Biomedical Engineering, University of Virginia, PO Box 800759, Charlottesville, VA, 22908, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, University of Virginia, PO Box 800759, Charlottesville, VA 22908, USA","institution_ids":["https://openalex.org/I51556381"]},{"raw_affiliation_string":"Department of Biomedical Engineering, University of Virginia, PO Box 800759, Charlottesville, VA, 22908, USA","institution_ids":["https://openalex.org/I51556381"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5100382860"],"corresponding_institution_ids":["https://openalex.org/I51556381"],"apc_list":{"value":4011,"currency":"USD","value_usd":4011},"apc_paid":null,"fwci":8.042,"has_fulltext":false,"cited_by_count":282,"citation_normalized_percentile":{"value":0.98310499,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":97,"max":100},"biblio":{"volume":"7","issue":"2","first_page":"140","last_page":"150"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10836","display_name":"Metabolomics and Mass Spectrometry Studies","score":0.9980999827384949,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/flux-balance-analysis","display_name":"Flux balance analysis","score":0.8083081841468811},{"id":"https://openalex.org/keywords/complement","display_name":"Complement (music)","score":0.6959336996078491},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6376274824142456},{"id":"https://openalex.org/keywords/a-priori-and-a-posteriori","display_name":"A priori and a posteriori","score":0.5998031497001648},{"id":"https://openalex.org/keywords/metabolomics","display_name":"Metabolomics","score":0.5623443126678467},{"id":"https://openalex.org/keywords/set","display_name":"Set (abstract data type)","score":0.4935530424118042},{"id":"https://openalex.org/keywords/data-science","display_name":"Data science","score":0.4472556412220001},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.3946050703525543},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.22782129049301147},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.15356379747390747},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.15234258770942688}],"concepts":[{"id":"https://openalex.org/C167091322","wikidata":"https://www.wikidata.org/wiki/Q5463029","display_name":"Flux balance analysis","level":2,"score":0.8083081841468811},{"id":"https://openalex.org/C112313634","wikidata":"https://www.wikidata.org/wiki/Q7886648","display_name":"Complement (music)","level":5,"score":0.6959336996078491},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6376274824142456},{"id":"https://openalex.org/C75553542","wikidata":"https://www.wikidata.org/wiki/Q178161","display_name":"A priori and a posteriori","level":2,"score":0.5998031497001648},{"id":"https://openalex.org/C21565614","wikidata":"https://www.wikidata.org/wiki/Q12149006","display_name":"Metabolomics","level":2,"score":0.5623443126678467},{"id":"https://openalex.org/C177264268","wikidata":"https://www.wikidata.org/wiki/Q1514741","display_name":"Set (abstract data type)","level":2,"score":0.4935530424118042},{"id":"https://openalex.org/C2522767166","wikidata":"https://www.wikidata.org/wiki/Q2374463","display_name":"Data science","level":1,"score":0.4472556412220001},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.3946050703525543},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.22782129049301147},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.15356379747390747},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.15234258770942688},{"id":"https://openalex.org/C188082640","wikidata":"https://www.wikidata.org/wiki/Q1780899","display_name":"Complementation","level":4,"score":0.0},{"id":"https://openalex.org/C111472728","wikidata":"https://www.wikidata.org/wiki/Q9471","display_name":"Epistemology","level":1,"score":0.0},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001709","descriptor_name":"Biotechnology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D001709","descriptor_name":"Biotechnology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D001709","descriptor_name":"Biotechnology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D001709","descriptor_name":"Biotechnology","qualifier_ui":"Q000639","qualifier_name":"trends","is_major_topic":false},{"descriptor_ui":"D001709","descriptor_name":"Biotechnology","qualifier_ui":"Q000639","qualifier_name":"trends","is_major_topic":false},{"descriptor_ui":"D001709","descriptor_name":"Biotechnology","qualifier_ui":"Q000639","qualifier_name":"trends","is_major_topic":false},{"descriptor_ui":"D002468","descriptor_name":"Cell Physiological Phenomena","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002468","descriptor_name":"Cell Physiological Phenomena","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002468","descriptor_name":"Cell Physiological Phenomena","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004734","descriptor_name":"Energy Metabolism","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D004734","descriptor_name":"Energy Metabolism","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D004734","descriptor_name":"Energy Metabolism","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000639","qualifier_name":"trends","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000639","qualifier_name":"trends","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000639","qualifier_name":"trends","is_major_topic":false},{"descriptor_ui":"D020543","descriptor_name":"Proteome","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020543","descriptor_name":"Proteome","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020543","descriptor_name":"Proteome","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000639","qualifier_name":"trends","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000639","qualifier_name":"trends","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000639","qualifier_name":"trends","is_major_topic":false},{"descriptor_ui":"D040901","descriptor_name":"Proteomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D040901","descriptor_name":"Proteomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D040901","descriptor_name":"Proteomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D040901","descriptor_name":"Proteomics","qualifier_ui":"Q000639","qualifier_name":"trends","is_major_topic":false},{"descriptor_ui":"D040901","descriptor_name":"Proteomics","qualifier_ui":"Q000639","qualifier_name":"trends","is_major_topic":false},{"descriptor_ui":"D040901","descriptor_name":"Proteomics","qualifier_ui":"Q000639","qualifier_name":"trends","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1093/bib/bbl007","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbl007","pdf_url":"https://academic.oup.com/bib/article-pdf/7/2/140/866765/bbl007.pdf","source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},{"id":"pmid:16772264","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16772264","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in bioinformatics","raw_type":null},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.584.9565","is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.584.9565","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://bib.oxfordjournals.org/content/7/2/140.full.pdf","raw_type":"text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.597.598","is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.597.598","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://www.math.uga.edu/~caner/08vigre/fba_metabolic_06.pdf","raw_type":"text"}],"best_oa_location":{"id":"doi:10.1093/bib/bbl007","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbl007","pdf_url":"https://academic.oup.com/bib/article-pdf/7/2/140/866765/bbl007.pdf","source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":false},"content_urls":{"pdf":"https://content.openalex.org/works/W2106576546.pdf"},"referenced_works_count":61,"referenced_works":["https://openalex.org/W152301725","https://openalex.org/W178243563","https://openalex.org/W1487827847","https://openalex.org/W1489720547","https://openalex.org/W1504699676","https://openalex.org/W1543388089","https://openalex.org/W1549912426","https://openalex.org/W1694182793","https://openalex.org/W1873506857","https://openalex.org/W1965073999","https://openalex.org/W1978781045","https://openalex.org/W1979955019","https://openalex.org/W1990969593","https://openalex.org/W1992170087","https://openalex.org/W1994031252","https://openalex.org/W1994134392","https://openalex.org/W1996529795","https://openalex.org/W2004964623","https://openalex.org/W2006672203","https://openalex.org/W2008875008","https://openalex.org/W2018591360","https://openalex.org/W2022012525","https://openalex.org/W2026089579","https://openalex.org/W2030098073","https://openalex.org/W2031681107","https://openalex.org/W2032535841","https://openalex.org/W2037248648","https://openalex.org/W2039419058","https://openalex.org/W2043440339","https://openalex.org/W2046254395","https://openalex.org/W2048596643","https://openalex.org/W2049508687","https://openalex.org/W2055840758","https://openalex.org/W2056305771","https://openalex.org/W2065669781","https://openalex.org/W2073881372","https://openalex.org/W2073951385","https://openalex.org/W2079619772","https://openalex.org/W2087969278","https://openalex.org/W2098087167","https://openalex.org/W2101155309","https://openalex.org/W2102164505","https://openalex.org/W2102177537","https://openalex.org/W2105525072","https://openalex.org/W2107333582","https://openalex.org/W2113706446","https://openalex.org/W2114430159","https://openalex.org/W2126130288","https://openalex.org/W2127359939","https://openalex.org/W2128572161","https://openalex.org/W2130364940","https://openalex.org/W2134981469","https://openalex.org/W2136568972","https://openalex.org/W2137474062","https://openalex.org/W2143861551","https://openalex.org/W2146892804","https://openalex.org/W2148190806","https://openalex.org/W2148750928","https://openalex.org/W2153373497","https://openalex.org/W2166430819","https://openalex.org/W4211085285"],"related_works":["https://openalex.org/W42525420","https://openalex.org/W4283390424","https://openalex.org/W2137270828","https://openalex.org/W1976072307","https://openalex.org/W4205440119","https://openalex.org/W4210616727","https://openalex.org/W2096576371","https://openalex.org/W1561393703","https://openalex.org/W2032555174","https://openalex.org/W4292104203"],"abstract_inverted_index":{"Flux":[0],"balance":[1],"analysis":[2],"(FBA)":[3],"has":[4,20],"emerged":[5],"as":[6,53,126,135],"an":[7,67],"effective":[8],"means":[9],"to":[10,28,92,116,129],"analyse":[11],"biological":[12,32],"networks":[13],"in":[14,66,114],"a":[15,30,54,89,127,136],"quantitative":[16,94],"manner.":[17,69],"Much":[18],"progress":[19],"been":[21],"made":[22],"on":[23],"the":[24,44,101,106,122,132],"extension":[25],"of":[26,38,46,56,64,100,124,138],"FBA":[27,115,125],"incorporate":[29],"priori":[31],"knowledge,":[33],"provide":[34],"more":[35],"practical":[36],"descriptions":[37],"observed":[39],"cell":[40],"behaviours,":[41],"and":[42,104,120,131],"predict":[43],"outcome":[45],"network":[47],"perturbations.":[48],"Metabolomics":[49],"is":[50,88],"independently":[51],"advancing":[52],"set":[55],"high-throughput":[57],"data":[58,71,103],"acquisition":[59],"tools":[60],"providing":[61],"dynamic":[62],"profiles":[63],"metabolites":[65],"unbiased":[68],"These":[70],"sets":[72],"are":[73],"neither":[74],"yet":[75],"sufficiently":[76],"comprehensive":[77],"nor":[78],"accurate":[79],"enough":[80],"for":[81],"generating":[82],"large-scale":[83],"kinetic":[84],"models.":[85],"Thus,":[86],"there":[87],"pressing":[90],"need":[91,119],"develop":[93],"techniques":[95],"that":[96],"can":[97],"make":[98],"use":[99],"emerging":[102],"embrace":[105],"associated":[107],"uncertainties.":[108],"This":[109],"article":[110],"reviews":[111],"recent":[112],"advances":[113],"meet":[117],"this":[118],"discusses":[121],"utility":[123],"complement":[128],"metabolomics":[130],"expected":[133],"synergy":[134],"result":[137],"combining":[139],"these":[140],"two":[141],"techniques.":[142]},"counts_by_year":[{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":9},{"year":2021,"cited_by_count":7},{"year":2020,"cited_by_count":9},{"year":2019,"cited_by_count":7},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":13},{"year":2016,"cited_by_count":13},{"year":2015,"cited_by_count":16},{"year":2014,"cited_by_count":14},{"year":2013,"cited_by_count":22},{"year":2012,"cited_by_count":29}],"updated_date":"2026-05-22T06:13:13.366637","created_date":"2025-10-10T00:00:00"}