{"id":"https://openalex.org/W2116215156","doi":"https://doi.org/10.1093/bib/bbk004","title":"Studying statistical properties of regulatory DNA sequences, and their use in predicting regulatory regions in the eukaryotic genomes","display_name":"Studying statistical properties of regulatory DNA sequences, and their use in predicting regulatory regions in the eukaryotic genomes","publication_year":2006,"publication_date":"2006-02-04","ids":{"openalex":"https://openalex.org/W2116215156","doi":"https://doi.org/10.1093/bib/bbk004","mag":"2116215156","pmid":"https://pubmed.ncbi.nlm.nih.gov/16761364"},"language":"en","primary_location":{"id":"doi:10.1093/bib/bbk004","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbk004","pdf_url":"https://academic.oup.com/bib/article-pdf/7/1/48/23992540/bbk004.pdf","source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},"type":"review","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://academic.oup.com/bib/article-pdf/7/1/48/23992540/bbk004.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5032702053","display_name":"Irina Abnizova","orcid":"https://orcid.org/0000-0002-8460-8210"},"institutions":[{"id":"https://openalex.org/I4210134973","display_name":"MRC Biostatistics Unit","ror":"https://ror.org/046vje122","country_code":"GB","type":"facility","lineage":["https://openalex.org/I241749","https://openalex.org/I4210087105","https://openalex.org/I4210134973","https://openalex.org/I90344618"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Irina Abnizova","raw_affiliation_strings":["Irina Abnizova is a Research Scientist in MRC Biostatistics Unit. Her current research interests are the development of computational statistics and software focusing on regulatory regions and elements"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Irina Abnizova is a Research Scientist in MRC Biostatistics Unit. Her current research interests are the development of computational statistics and software focusing on regulatory regions and elements","institution_ids":["https://openalex.org/I4210134973"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111634829","display_name":"Walter R. Gilks","orcid":null},"institutions":[{"id":"https://openalex.org/I4210163794","display_name":"Data Management (Italy)","ror":"https://ror.org/017j5za44","country_code":"IT","type":"company","lineage":["https://openalex.org/I4210163794"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Walter R. Gilks","raw_affiliation_strings":["Walter Gilks is Programme Leader at MRC Biostatistics Unit. His interests are in the development of statistical methods for the analysis of genomic data"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Walter Gilks is Programme Leader at MRC Biostatistics Unit. His interests are in the development of statistical methods for the analysis of genomic data","institution_ids":["https://openalex.org/I4210163794"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4011,"currency":"USD","value_usd":4011},"apc_paid":null,"fwci":0.5455,"has_fulltext":false,"cited_by_count":9,"citation_normalized_percentile":{"value":0.65605478,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":96},"biblio":{"volume":"7","issue":"1","first_page":"48","last_page":"54"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.9979000091552734,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12254","display_name":"Machine Learning in Bioinformatics","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/genome","display_name":"Genome","score":0.7382010221481323},{"id":"https://openalex.org/keywords/regulatory-sequence","display_name":"Regulatory sequence","score":0.7072011232376099},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.6181696653366089},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.47920092940330505},{"id":"https://openalex.org/keywords/noncoding-dna","display_name":"Noncoding DNA","score":0.47785279154777527},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.4290284514427185},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.40271276235580444},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.3334258794784546},{"id":"https://openalex.org/keywords/regulation-of-gene-expression","display_name":"Regulation of gene expression","score":0.31482434272766113}],"concepts":[{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.7382010221481323},{"id":"https://openalex.org/C21592294","wikidata":"https://www.wikidata.org/wiki/Q3238407","display_name":"Regulatory sequence","level":4,"score":0.7072011232376099},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.6181696653366089},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.47920092940330505},{"id":"https://openalex.org/C64554109","wikidata":"https://www.wikidata.org/wiki/Q1458444","display_name":"Noncoding DNA","level":4,"score":0.47785279154777527},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.4290284514427185},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.40271276235580444},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.3334258794784546},{"id":"https://openalex.org/C165864922","wikidata":"https://www.wikidata.org/wiki/Q411391","display_name":"Regulation of gene expression","level":3,"score":0.31482434272766113}],"mesh":[{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D011237","descriptor_name":"Predictive Value of Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011237","descriptor_name":"Predictive Value of Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011237","descriptor_name":"Predictive Value of Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012045","descriptor_name":"Regulatory Sequences, Nucleic Acid","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012045","descriptor_name":"Regulatory Sequences, Nucleic Acid","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012045","descriptor_name":"Regulatory Sequences, Nucleic Acid","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016678","descriptor_name":"Genome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016678","descriptor_name":"Genome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016678","descriptor_name":"Genome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017422","descriptor_name":"Sequence Analysis, DNA","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":false},{"descriptor_ui":"D017422","descriptor_name":"Sequence Analysis, DNA","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":false},{"descriptor_ui":"D017422","descriptor_name":"Sequence Analysis, DNA","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1093/bib/bbk004","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbk004","pdf_url":"https://academic.oup.com/bib/article-pdf/7/1/48/23992540/bbk004.pdf","source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},{"id":"pmid:16761364","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16761364","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in bioinformatics","raw_type":null}],"best_oa_location":{"id":"doi:10.1093/bib/bbk004","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbk004","pdf_url":"https://academic.oup.com/bib/article-pdf/7/1/48/23992540/bbk004.pdf","source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":89,"referenced_works":["https://openalex.org/W1571471008","https://openalex.org/W1600524753","https://openalex.org/W1965267927","https://openalex.org/W1965696530","https://openalex.org/W1983658501","https://openalex.org/W1988981743","https://openalex.org/W1989080074","https://openalex.org/W1998300401","https://openalex.org/W2003967338","https://openalex.org/W2005244073","https://openalex.org/W2007969038","https://openalex.org/W2008900336","https://openalex.org/W2013213258","https://openalex.org/W2015502807","https://openalex.org/W2026882865","https://openalex.org/W2030823670","https://openalex.org/W2031762818","https://openalex.org/W2032231928","https://openalex.org/W2033785622","https://openalex.org/W2034206030","https://openalex.org/W2034719432","https://openalex.org/W2037940015","https://openalex.org/W2041726559","https://openalex.org/W2046222637","https://openalex.org/W2046374070","https://openalex.org/W2048241051","https://openalex.org/W2049809163","https://openalex.org/W2051333589","https://openalex.org/W2054984882","https://openalex.org/W2056002855","https://openalex.org/W2057829817","https://openalex.org/W2066099672","https://openalex.org/W2067007345","https://openalex.org/W2076313473","https://openalex.org/W2085442947","https://openalex.org/W2087892194","https://openalex.org/W2088803989","https://openalex.org/W2089995728","https://openalex.org/W2091230759","https://openalex.org/W2092006839","https://openalex.org/W2098024690","https://openalex.org/W2100990361","https://openalex.org/W2101913589","https://openalex.org/W2109314645","https://openalex.org/W2111365614","https://openalex.org/W2113689543","https://openalex.org/W2115772919","https://openalex.org/W2117549173","https://openalex.org/W2118304741","https://openalex.org/W2118628540","https://openalex.org/W2119022656","https://openalex.org/W2122707830","https://openalex.org/W2123490534","https://openalex.org/W2124025352","https://openalex.org/W2124195715","https://openalex.org/W2125126554","https://openalex.org/W2127325366","https://openalex.org/W2129765989","https://openalex.org/W2133147430","https://openalex.org/W2135000328","https://openalex.org/W2135951244","https://openalex.org/W2136725005","https://openalex.org/W2137502130","https://openalex.org/W2138922826","https://openalex.org/W2139516179","https://openalex.org/W2140538490","https://openalex.org/W2140921549","https://openalex.org/W2142946358","https://openalex.org/W2144575079","https://openalex.org/W2144857133","https://openalex.org/W2147055980","https://openalex.org/W2151625863","https://openalex.org/W2152893838","https://openalex.org/W2153800196","https://openalex.org/W2156525687","https://openalex.org/W2157523980","https://openalex.org/W2158314946","https://openalex.org/W2160035767","https://openalex.org/W2161536174","https://openalex.org/W2165228646","https://openalex.org/W2165735666","https://openalex.org/W2171985093","https://openalex.org/W2323183276","https://openalex.org/W2798823272","https://openalex.org/W4248318091","https://openalex.org/W4298849694","https://openalex.org/W6659004458","https://openalex.org/W6659963394","https://openalex.org/W6681245414"],"related_works":["https://openalex.org/W2013558642","https://openalex.org/W1965754165","https://openalex.org/W2167557676","https://openalex.org/W3156986925","https://openalex.org/W1981374009","https://openalex.org/W2551607548","https://openalex.org/W2112221859","https://openalex.org/W1518829314","https://openalex.org/W4255132758","https://openalex.org/W20265226"],"abstract_inverted_index":{"There":[0],"are":[1,24,29],"no":[2,30],"well-known":[3],"properties":[4],"in":[5,11,49,61],"regulatory":[6,22,42,54],"DNA":[7],"analogous":[8],"to":[9,40],"those":[10],"coding":[12],"sequences;":[13],"their":[14,34,59],"spatial":[15],"location":[16],"is":[17],"not":[18],"regular,":[19],"the":[20,50],"consensus":[21],"elements":[23],"often":[25],"degenerate":[26],"and":[27,56],"there":[28],"understandable":[31],"rules":[32],"governing":[33],"evolution.":[35],"This":[36],"makes":[37],"it":[38],"difficult":[39],"recognize":[41],"regions":[43,55],"within":[44],"genome.":[45],"We":[46],"review":[47],"developments":[48],"statistical":[51],"characterization":[52],"of":[53,58],"methods":[57],"recognition":[60],"eukaryotic":[62],"genomes.":[63]},"counts_by_year":[{"year":2016,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-06-11T09:08:48.828518","created_date":"2025-10-10T00:00:00"}