{"id":"https://openalex.org/W7163695050","doi":"https://doi.org/10.1093/bib/bbag285","title":"CryoFSL: an annotation-efficient, few-shot learning framework for robust protein particle picking in cryo-electron microscopy micrographs","display_name":"CryoFSL: an annotation-efficient, few-shot learning framework for robust protein particle picking in cryo-electron microscopy micrographs","publication_year":2026,"publication_date":"2026-05-01","ids":{"openalex":"https://openalex.org/W7163695050","doi":"https://doi.org/10.1093/bib/bbag285","pmid":"https://pubmed.ncbi.nlm.nih.gov/42248583"},"language":"en","primary_location":{"id":"doi:10.1093/bib/bbag285","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbag285","pdf_url":null,"source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1093/bib/bbag285","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5093382204","display_name":"Biplab Poudel","orcid":null},"institutions":[{"id":"https://openalex.org/I196679149","display_name":"Lander University","ror":"https://ror.org/05eq86m59","country_code":"US","type":"education","lineage":["https://openalex.org/I196679149"]},{"id":"https://openalex.org/I2800649613","display_name":"University of Missouri Health System","ror":"https://ror.org/03yp8z857","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800649613"]},{"id":"https://openalex.org/I76835614","display_name":"University of Missouri","ror":"https://ror.org/02ymw8z06","country_code":"US","type":"education","lineage":["https://openalex.org/I76835614"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Biplab Poudel","raw_affiliation_strings":["Bond Life Sciences Center, University of Missouri , 1201 Rollins Street, Columbia, MO 65211 ,","Department of Applied Computing, Lander University , 320 Stanley Avenue, Greenwood, SC 29649 ,","Department of Electrical Engineering and Computer Science, NextGen Precision Health, University of Missouri , 416 South 6th Street, Columbia, MO 65211 ,"],"raw_orcid":"https://orcid.org/0009-0006-8636-1449","affiliations":[{"raw_affiliation_string":"Bond Life Sciences Center, University of Missouri , 1201 Rollins Street, Columbia, MO 65211 ,","institution_ids":["https://openalex.org/I76835614"]},{"raw_affiliation_string":"Department of Applied Computing, Lander University , 320 Stanley Avenue, Greenwood, SC 29649 ,","institution_ids":["https://openalex.org/I196679149"]},{"raw_affiliation_string":"Department of Electrical Engineering and Computer Science, NextGen Precision Health, University of Missouri , 416 South 6th Street, Columbia, MO 65211 ,","institution_ids":["https://openalex.org/I2800649613"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075943283","display_name":"Rajan Gyawali","orcid":"https://orcid.org/0000-0002-7052-4964"},"institutions":[{"id":"https://openalex.org/I2800649613","display_name":"University of Missouri Health System","ror":"https://ror.org/03yp8z857","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800649613"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rajan Gyawali","raw_affiliation_strings":["Department of Electrical Engineering and Computer Science, NextGen Precision Health, University of Missouri , 416 South 6th Street, Columbia, MO 65211 ,"],"raw_orcid":"https://orcid.org/0000-0002-7052-4964","affiliations":[{"raw_affiliation_string":"Department of Electrical Engineering and Computer Science, NextGen Precision Health, University of Missouri , 416 South 6th Street, Columbia, MO 65211 ,","institution_ids":["https://openalex.org/I2800649613"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046490180","display_name":"Ashwin Dhakal","orcid":"https://orcid.org/0000-0002-4047-9947"},"institutions":[{"id":"https://openalex.org/I2800649613","display_name":"University of Missouri Health System","ror":"https://ror.org/03yp8z857","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800649613"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ashwin Dhakal","raw_affiliation_strings":["Department of Electrical Engineering and Computer Science, NextGen Precision Health, University of Missouri , 416 South 6th Street, Columbia, MO 65211 ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Electrical Engineering and Computer Science, NextGen Precision Health, University of Missouri , 416 South 6th Street, Columbia, MO 65211 ,","institution_ids":["https://openalex.org/I2800649613"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5137967218","display_name":"Jianlin Cheng","orcid":"https://orcid.org/0000-0003-0305-2853"},"institutions":[{"id":"https://openalex.org/I2800649613","display_name":"University of Missouri Health System","ror":"https://ror.org/03yp8z857","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800649613"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Jianlin Cheng","raw_affiliation_strings":["Department of Electrical Engineering and Computer Science, NextGen Precision Health, University of Missouri , 416 South 6th Street, Columbia, MO 65211 ,"],"raw_orcid":"https://orcid.org/0000-0003-0305-2853","affiliations":[{"raw_affiliation_string":"Department of Electrical Engineering and Computer Science, NextGen Precision Health, University of Missouri , 416 South 6th Street, Columbia, MO 65211 ,","institution_ids":["https://openalex.org/I2800649613"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5137991483","display_name":"Dong Xu","orcid":"https://orcid.org/0000-0002-4809-0514"},"institutions":[{"id":"https://openalex.org/I2613432","display_name":"University of South Florida","ror":"https://ror.org/032db5x82","country_code":"US","type":"education","lineage":["https://openalex.org/I2613432"]},{"id":"https://openalex.org/I2800649613","display_name":"University of Missouri Health System","ror":"https://ror.org/03yp8z857","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800649613"]},{"id":"https://openalex.org/I76835614","display_name":"University of Missouri","ror":"https://ror.org/02ymw8z06","country_code":"US","type":"education","lineage":["https://openalex.org/I76835614"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Dong Xu","raw_affiliation_strings":["Bond Life Sciences Center, University of Missouri , 1201 Rollins Street, Columbia, MO 65211 ,","Department of Electrical Engineering and Computer Science, NextGen Precision Health, University of Missouri , 416 South 6th Street, Columbia, MO 65211 ,","Health Informatics Institute, Morsani College of Medicine, University of South Florida , 3650 Spectrum Boulevard, Tampa, FL 33612 ,"],"raw_orcid":"https://orcid.org/0000-0002-4809-0514","affiliations":[{"raw_affiliation_string":"Bond Life Sciences Center, University of Missouri , 1201 Rollins Street, Columbia, MO 65211 ,","institution_ids":["https://openalex.org/I76835614"]},{"raw_affiliation_string":"Department of Electrical Engineering and Computer Science, NextGen Precision Health, University of Missouri , 416 South 6th Street, Columbia, MO 65211 ,","institution_ids":["https://openalex.org/I2800649613"]},{"raw_affiliation_string":"Health Informatics Institute, Morsani College of Medicine, University of South Florida , 3650 Spectrum Boulevard, Tampa, FL 33612 ,","institution_ids":["https://openalex.org/I2613432"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5137967218","https://openalex.org/A5137991483"],"corresponding_institution_ids":["https://openalex.org/I2613432","https://openalex.org/I2800649613","https://openalex.org/I76835614"],"apc_list":{"value":3885,"currency":"USD","value_usd":3885},"apc_paid":{"value":3885,"currency":"USD","value_usd":3885},"fwci":4.5556,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.94831299,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":94,"max":97},"biblio":{"volume":"27","issue":"3","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10857","display_name":"Advanced Electron Microscopy Techniques and Applications","score":0.9853000044822693,"subfield":{"id":"https://openalex.org/subfields/1315","display_name":"Structural Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10857","display_name":"Advanced Electron Microscopy Techniques and Applications","score":0.9853000044822693,"subfield":{"id":"https://openalex.org/subfields/1315","display_name":"Structural Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12254","display_name":"Machine Learning in Bioinformatics","score":0.002099999925121665,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12859","display_name":"Cell Image Analysis Techniques","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/robustness","display_name":"Robustness (evolution)","score":0.6575999855995178},{"id":"https://openalex.org/keywords/annotation","display_name":"Annotation","score":0.42980000376701355},{"id":"https://openalex.org/keywords/electron-micrographs","display_name":"Electron micrographs","score":0.41019999980926514},{"id":"https://openalex.org/keywords/pattern-recognition","display_name":"Pattern recognition (psychology)","score":0.400299996137619},{"id":"https://openalex.org/keywords/microscopy","display_name":"Microscopy","score":0.3889000117778778},{"id":"https://openalex.org/keywords/micrograph","display_name":"Micrograph","score":0.3465000092983246},{"id":"https://openalex.org/keywords/feature","display_name":"Feature (linguistics)","score":0.3449999988079071},{"id":"https://openalex.org/keywords/generalization","display_name":"Generalization","score":0.34130001068115234}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6636000275611877},{"id":"https://openalex.org/C63479239","wikidata":"https://www.wikidata.org/wiki/Q7353546","display_name":"Robustness (evolution)","level":3,"score":0.6575999855995178},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.63919997215271},{"id":"https://openalex.org/C2776321320","wikidata":"https://www.wikidata.org/wiki/Q857525","display_name":"Annotation","level":2,"score":0.42980000376701355},{"id":"https://openalex.org/C3018767501","wikidata":"https://www.wikidata.org/wiki/Q130416","display_name":"Electron micrographs","level":3,"score":0.41019999980926514},{"id":"https://openalex.org/C153180895","wikidata":"https://www.wikidata.org/wiki/Q7148389","display_name":"Pattern recognition (psychology)","level":2,"score":0.400299996137619},{"id":"https://openalex.org/C147080431","wikidata":"https://www.wikidata.org/wiki/Q1074953","display_name":"Microscopy","level":2,"score":0.3889000117778778},{"id":"https://openalex.org/C31972630","wikidata":"https://www.wikidata.org/wiki/Q844240","display_name":"Computer vision","level":1,"score":0.37779998779296875},{"id":"https://openalex.org/C185891055","wikidata":"https://www.wikidata.org/wiki/Q130416","display_name":"Micrograph","level":3,"score":0.3465000092983246},{"id":"https://openalex.org/C2776401178","wikidata":"https://www.wikidata.org/wiki/Q12050496","display_name":"Feature (linguistics)","level":2,"score":0.3449999988079071},{"id":"https://openalex.org/C177148314","wikidata":"https://www.wikidata.org/wiki/Q170084","display_name":"Generalization","level":2,"score":0.34130001068115234},{"id":"https://openalex.org/C83248878","wikidata":"https://www.wikidata.org/wiki/Q344000","display_name":"Active appearance model","level":3,"score":0.3310000002384186},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.31709998846054077},{"id":"https://openalex.org/C2778517922","wikidata":"https://www.wikidata.org/wiki/Q7140482","display_name":"Particle (ecology)","level":2,"score":0.31040000915527344},{"id":"https://openalex.org/C108583219","wikidata":"https://www.wikidata.org/wiki/Q197536","display_name":"Deep learning","level":2,"score":0.3052000105381012},{"id":"https://openalex.org/C136389625","wikidata":"https://www.wikidata.org/wiki/Q334384","display_name":"Supervised learning","level":3,"score":0.3019999861717224},{"id":"https://openalex.org/C138268822","wikidata":"https://www.wikidata.org/wiki/Q1051925","display_name":"Resolution (logic)","level":2,"score":0.2842000126838684},{"id":"https://openalex.org/C186060115","wikidata":"https://www.wikidata.org/wiki/Q30336093","display_name":"Biological system","level":1,"score":0.2802000045776367},{"id":"https://openalex.org/C2778160393","wikidata":"https://www.wikidata.org/wiki/Q18670161","display_name":"Mascot","level":2,"score":0.27399998903274536},{"id":"https://openalex.org/C2776760102","wikidata":"https://www.wikidata.org/wiki/Q5139990","display_name":"Code (set theory)","level":3,"score":0.25920000672340393},{"id":"https://openalex.org/C177284502","wikidata":"https://www.wikidata.org/wiki/Q1005390","display_name":"Adapter (computing)","level":2,"score":0.2572000026702881},{"id":"https://openalex.org/C112972136","wikidata":"https://www.wikidata.org/wiki/Q7595718","display_name":"Stability (learning theory)","level":2,"score":0.2567000091075897}],"mesh":[{"descriptor_ui":"D000077321","descriptor_name":"Deep Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000077321","descriptor_name":"Deep Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000077321","descriptor_name":"Deep Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007091","descriptor_name":"Image Processing, Computer-Assisted","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D007091","descriptor_name":"Image Processing, Computer-Assisted","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D007091","descriptor_name":"Image Processing, Computer-Assisted","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":true},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":true},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":true},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020285","descriptor_name":"Cryoelectron Microscopy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D020285","descriptor_name":"Cryoelectron Microscopy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D020285","descriptor_name":"Cryoelectron Microscopy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D059629","descriptor_name":"Signal-To-Noise Ratio","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059629","descriptor_name":"Signal-To-Noise Ratio","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059629","descriptor_name":"Signal-To-Noise Ratio","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1093/bib/bbag285","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbag285","pdf_url":null,"source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},{"id":"pmid:42248583","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42248583","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in bioinformatics","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13240594","is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13240594/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Brief Bioinform","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1093/bib/bbag285","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbag285","pdf_url":null,"source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.49904054403305054,"display_name":"No poverty","id":"https://metadata.un.org/sdg/1"}],"awards":[{"id":"https://openalex.org/G1812338942","display_name":"Multi-view self-supervised deep learning for biological sequences and beyond","funder_award_id":"5r35gm126985-07","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G2934804753","display_name":"Acquiring a GPU server to accelerate developing deep learning methods to reconstruct protein structures from cryo-EM data","funder_award_id":"3r01gm146340-02s1","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":55,"referenced_works":["https://openalex.org/W6877422","https://openalex.org/W177317313","https://openalex.org/W1982295411","https://openalex.org/W2017508876","https://openalex.org/W2028470175","https://openalex.org/W2047902460","https://openalex.org/W2072404529","https://openalex.org/W2077586257","https://openalex.org/W2100455255","https://openalex.org/W2104234755","https://openalex.org/W2110065044","https://openalex.org/W2138390185","https://openalex.org/W2161661741","https://openalex.org/W2168745915","https://openalex.org/W2340685884","https://openalex.org/W2576780822","https://openalex.org/W2587625522","https://openalex.org/W2614431660","https://openalex.org/W2684441367","https://openalex.org/W2793402357","https://openalex.org/W2950003311","https://openalex.org/W2952729952","https://openalex.org/W2963364133","https://openalex.org/W2963568497","https://openalex.org/W2964121744","https://openalex.org/W2977933365","https://openalex.org/W2999597532","https://openalex.org/W3005800881","https://openalex.org/W3009153763","https://openalex.org/W3131342469","https://openalex.org/W4210742541","https://openalex.org/W4229041984","https://openalex.org/W4252684946","https://openalex.org/W4280560666","https://openalex.org/W4283790249","https://openalex.org/W4292567336","https://openalex.org/W4310035804","https://openalex.org/W4381686770","https://openalex.org/W4390874575","https://openalex.org/W4392157400","https://openalex.org/W4399512708","https://openalex.org/W4401307635","https://openalex.org/W4402385927","https://openalex.org/W4402501200","https://openalex.org/W4403587641","https://openalex.org/W4405219469","https://openalex.org/W4405786657","https://openalex.org/W4406709427","https://openalex.org/W4409112594","https://openalex.org/W4411297653","https://openalex.org/W4412087773","https://openalex.org/W4412487264","https://openalex.org/W4412779165","https://openalex.org/W4413129391","https://openalex.org/W7125122432"],"related_works":[],"abstract_inverted_index":{"Accurate":[0],"identification":[1],"of":[2,31,169],"protein":[3,51],"particles":[4,152,171],"in":[5,126,161,180],"cryo-electron":[6],"microscopy":[7],"(cryo-EM)":[8],"micrographs":[9,83,147],"is":[10,197],"crucial":[11],"for":[12,99,188],"high-resolution":[13],"structure":[14],"determination,":[15],"but":[16],"remains":[17],"challenging":[18],"due":[19],"to":[20,49],"the":[21,29,87,105,127,170,186],"heavy":[22],"reliance":[23],"on":[24,65],"extensive":[25],"annotated":[26],"datasets":[27],"and":[28,45,84,101,110,118,135,148,178,191],"difficulty":[30],"ensuring":[32],"robustness":[33],"under":[34],"low":[35],"signal-to-noise":[36],"ratio":[37],"(SNR)":[38],"conditions.":[39],"Current":[40],"approaches":[41],"require":[42],"large":[43],"annotations":[44],"exhibit":[46],"poor":[47],"generalization":[48],"new":[50],"targets.":[52],"We":[53],"present":[54],"CryoFSL":[55,112,157],"(Cryo-EM":[56],"Few":[57],"Shot-Learning),":[58],"a":[59,167],"novel":[60],"few-shot":[61,128],"learning":[62,121,129],"framework":[63],"built":[64],"Segment":[66],"Anything":[67],"Model":[68],"2":[69],"with":[70,77,139,153,165],"lightweight":[71],"adapters,":[72],"enabling":[73],"robust":[74],"particle":[75],"picking":[76],"as":[78,80],"few":[79],"five":[81],"labeled":[82],"significantly":[85],"reducing":[86],"annotation":[88,108],"burden.":[89],"The":[90,195],"framework's":[91],"hierarchical":[92],"adapter":[93],"design":[94],"supports":[95],"dynamic":[96],"feature":[97],"modulation":[98],"low-SNR":[100],"heterogeneous":[102,146],"conditions,":[103],"resolving":[104],"trade-off":[106],"between":[107],"burden":[109],"performance.":[111],"surpasses":[113],"both":[114],"traditional":[115],"template-based":[116],"methods":[117],"state-of-the-art":[119],"deep":[120],"models":[122],"across":[123,145],"diverse":[124],"proteins":[125],"setting,":[130],"achieving":[131],"superior":[132],"recall,":[133],"precision,":[134],"3D":[136],"reconstruction":[137,164],"resolution":[138,160],"minimal":[140],"supervision.":[141],"It":[142],"maintains":[143],"stability":[144],"consistently":[149],"detects":[150],"high-quality":[151],"fewer":[154],"false-positives.":[155],"Notably,":[156],"achieves":[158],"competitive":[159],"density":[162],"map":[163],"just":[166],"fraction":[168],"picked":[172],"by":[173],"other":[174],"methods,":[175],"redefining":[176],"efficiency":[177],"quality":[179],"cryo-EM":[181],"analysis.":[182],"This":[183],"work":[184],"paves":[185],"way":[187],"scalable,":[189],"generalizable,":[190],"annotation-efficient":[192],"particle-picking":[193],"pipelines.":[194],"code":[196],"available":[198],"at":[199],"https://github.com/biplabpoudel25/CryoFSL.":[200]},"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-08-21T09:56:20.448147","created_date":"2026-06-06T00:00:00"}