{"id":"https://openalex.org/W7162327140","doi":"https://doi.org/10.1093/bib/bbag251","title":"Decoding causal m6A: a bioinformatics roadmap for psychiatric disorders","display_name":"Decoding causal m6A: a bioinformatics roadmap for psychiatric disorders","publication_year":2026,"publication_date":"2026-05-01","ids":{"openalex":"https://openalex.org/W7162327140","doi":"https://doi.org/10.1093/bib/bbag251","pmid":"https://pubmed.ncbi.nlm.nih.gov/42184108"},"language":"en","primary_location":{"id":"doi:10.1093/bib/bbag251","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbag251","pdf_url":null,"source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1093/bib/bbag251","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5079803065","display_name":"Shuhe Liu","orcid":"https://orcid.org/0009-0005-7843-8429"},"institutions":[{"id":"https://openalex.org/I146655781","display_name":"University of Liverpool","ror":"https://ror.org/04xs57h96","country_code":"GB","type":"education","lineage":["https://openalex.org/I146655781"]},{"id":"https://openalex.org/I4210116071","display_name":"Suzhou Municipal Hospital","ror":"https://ror.org/02cdyrc89","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210116071"]},{"id":"https://openalex.org/I69356397","display_name":"Xi\u2019an Jiaotong-Liverpool University","ror":"https://ror.org/03zmrmn05","country_code":"CN","type":"education","lineage":["https://openalex.org/I69356397"]}],"countries":["CN","GB"],"is_corresponding":false,"raw_author_name":"Shuhe Liu","raw_affiliation_strings":["Department of Biosciences and Bioinformatics, School of Science, Xi'an Jiaotong-Liverpool University , 111 Ren'ai Road, Suzhou Industrial Park, Suzhou, Jiangsu 215123 ,","Institute of Systems, Molecular and Integrative Biology, University of Liverpool , Crown Street, L69 7BE Liverpool ,","Suzhou Municipal Key Laboratory of AI4Health , 111 Ren'ai Road, Suzhou Industrial Park, Suzhou, Jiangsu 215123 ,"],"raw_orcid":"https://orcid.org/0009-0005-7843-8429","affiliations":[{"raw_affiliation_string":"Department of Biosciences and Bioinformatics, School of Science, Xi'an Jiaotong-Liverpool University , 111 Ren'ai Road, Suzhou Industrial Park, Suzhou, Jiangsu 215123 ,","institution_ids":["https://openalex.org/I69356397"]},{"raw_affiliation_string":"Institute of Systems, Molecular and Integrative Biology, University of Liverpool , Crown Street, L69 7BE Liverpool ,","institution_ids":["https://openalex.org/I146655781"]},{"raw_affiliation_string":"Suzhou Municipal Key Laboratory of AI4Health , 111 Ren'ai Road, Suzhou Industrial Park, Suzhou, Jiangsu 215123 ,","institution_ids":["https://openalex.org/I4210116071"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078594132","display_name":"Xichen Zhao","orcid":"https://orcid.org/0000-0003-1392-917X"},"institutions":[{"id":"https://openalex.org/I146655781","display_name":"University of Liverpool","ror":"https://ror.org/04xs57h96","country_code":"GB","type":"education","lineage":["https://openalex.org/I146655781"]},{"id":"https://openalex.org/I69356397","display_name":"Xi\u2019an Jiaotong-Liverpool University","ror":"https://ror.org/03zmrmn05","country_code":"CN","type":"education","lineage":["https://openalex.org/I69356397"]}],"countries":["CN","GB"],"is_corresponding":false,"raw_author_name":"Xichen Zhao","raw_affiliation_strings":["Department of Biosciences and Bioinformatics, School of Science, Xi'an Jiaotong-Liverpool University , 111 Ren'ai Road, Suzhou Industrial Park, Suzhou, Jiangsu 215123 ,","Institute of Systems, Molecular and Integrative Biology, University of Liverpool , Crown Street, L69 7BE Liverpool ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biosciences and Bioinformatics, School of Science, Xi'an Jiaotong-Liverpool University , 111 Ren'ai Road, Suzhou Industrial Park, Suzhou, Jiangsu 215123 ,","institution_ids":["https://openalex.org/I69356397"]},{"raw_affiliation_string":"Institute of Systems, Molecular and Integrative Biology, University of Liverpool , Crown Street, L69 7BE Liverpool ,","institution_ids":["https://openalex.org/I146655781"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5136928257","display_name":"Zhen Wei","orcid":"https://orcid.org/0000-0002-1614-9614"},"institutions":[{"id":"https://openalex.org/I146655781","display_name":"University of Liverpool","ror":"https://ror.org/04xs57h96","country_code":"GB","type":"education","lineage":["https://openalex.org/I146655781"]},{"id":"https://openalex.org/I4210116071","display_name":"Suzhou Municipal Hospital","ror":"https://ror.org/02cdyrc89","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210116071"]},{"id":"https://openalex.org/I69356397","display_name":"Xi\u2019an Jiaotong-Liverpool University","ror":"https://ror.org/03zmrmn05","country_code":"CN","type":"education","lineage":["https://openalex.org/I69356397"]}],"countries":["CN","GB"],"is_corresponding":true,"raw_author_name":"Zhen Wei","raw_affiliation_strings":["Department of Biosciences and Bioinformatics, School of Science, Xi'an Jiaotong-Liverpool University , 111 Ren'ai Road, Suzhou Industrial Park, Suzhou, Jiangsu 215123 ,","Institute of Life Course and Medical Sciences, University of Liverpool , 6 West Derby Street, L7 8TX Liverpool,","Suzhou Municipal Key Laboratory of AI4Health , 111 Ren'ai Road, Suzhou Industrial Park, Suzhou, Jiangsu 215123 ,"],"raw_orcid":"https://orcid.org/0000-0002-1614-9614","affiliations":[{"raw_affiliation_string":"Department of Biosciences and Bioinformatics, School of Science, Xi'an Jiaotong-Liverpool University , 111 Ren'ai Road, Suzhou Industrial Park, Suzhou, Jiangsu 215123 ,","institution_ids":["https://openalex.org/I69356397"]},{"raw_affiliation_string":"Institute of Life Course and Medical Sciences, University of Liverpool , 6 West Derby Street, L7 8TX Liverpool,","institution_ids":["https://openalex.org/I146655781"]},{"raw_affiliation_string":"Suzhou Municipal Key Laboratory of AI4Health , 111 Ren'ai Road, Suzhou Industrial Park, Suzhou, Jiangsu 215123 ,","institution_ids":["https://openalex.org/I4210116071"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102748258","display_name":"Daniel F. Carr","orcid":"https://orcid.org/0000-0001-8028-4282"},"institutions":[{"id":"https://openalex.org/I146655781","display_name":"University of Liverpool","ror":"https://ror.org/04xs57h96","country_code":"GB","type":"education","lineage":["https://openalex.org/I146655781"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Daniel F Carr","raw_affiliation_strings":["Department of Pharmacology and Therapeutics, University of Liverpool , Crown Street, L69 7BE Liverpool,","Institute of Systems, Molecular and Integrative Biology, University of Liverpool , Crown Street, L69 7BE Liverpool ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Therapeutics, University of Liverpool , Crown Street, L69 7BE Liverpool,","institution_ids":["https://openalex.org/I146655781"]},{"raw_affiliation_string":"Institute of Systems, Molecular and Integrative Biology, University of Liverpool , Crown Street, L69 7BE Liverpool ,","institution_ids":["https://openalex.org/I146655781"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5136900414","display_name":"John Moraros","orcid":null},"institutions":[{"id":"https://openalex.org/I146655781","display_name":"University of Liverpool","ror":"https://ror.org/04xs57h96","country_code":"GB","type":"education","lineage":["https://openalex.org/I146655781"]},{"id":"https://openalex.org/I4210116071","display_name":"Suzhou Municipal Hospital","ror":"https://ror.org/02cdyrc89","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210116071"]},{"id":"https://openalex.org/I69356397","display_name":"Xi\u2019an Jiaotong-Liverpool University","ror":"https://ror.org/03zmrmn05","country_code":"CN","type":"education","lineage":["https://openalex.org/I69356397"]}],"countries":["CN","GB"],"is_corresponding":true,"raw_author_name":"John Moraros","raw_affiliation_strings":["Department of Biosciences and Bioinformatics, School of Science, Xi'an Jiaotong-Liverpool University , 111 Ren'ai Road, Suzhou Industrial Park, Suzhou, Jiangsu 215123 ,","Institute of Population Health, University of Liverpool , Brownlow Street, L69 3GF Liverpool ,","Suzhou Municipal Key Laboratory of AI4Health , 111 Ren'ai Road, Suzhou Industrial Park, Suzhou, Jiangsu 215123 ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biosciences and Bioinformatics, School of Science, Xi'an Jiaotong-Liverpool University , 111 Ren'ai Road, Suzhou Industrial Park, Suzhou, Jiangsu 215123 ,","institution_ids":["https://openalex.org/I69356397"]},{"raw_affiliation_string":"Institute of Population Health, University of Liverpool , Brownlow Street, L69 3GF Liverpool ,","institution_ids":["https://openalex.org/I146655781"]},{"raw_affiliation_string":"Suzhou Municipal Key Laboratory of AI4Health , 111 Ren'ai Road, Suzhou Industrial Park, Suzhou, Jiangsu 215123 ,","institution_ids":["https://openalex.org/I4210116071"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5136900414","https://openalex.org/A5136928257"],"corresponding_institution_ids":["https://openalex.org/I146655781","https://openalex.org/I4210116071","https://openalex.org/I69356397"],"apc_list":{"value":3885,"currency":"USD","value_usd":3885},"apc_paid":{"value":3885,"currency":"USD","value_usd":3885},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.45937746,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"27","issue":"3","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11482","display_name":"RNA modifications and cancer","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11482","display_name":"RNA modifications and cancer","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13157","display_name":"Cancer-related gene regulation","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/causal-inference","display_name":"Causal inference","score":0.6934999823570251},{"id":"https://openalex.org/keywords/inference","display_name":"Inference","score":0.5687999725341797},{"id":"https://openalex.org/keywords/psychological-intervention","display_name":"Psychological intervention","score":0.48019999265670776},{"id":"https://openalex.org/keywords/key","display_name":"Key (lock)","score":0.42969998717308044},{"id":"https://openalex.org/keywords/regulator","display_name":"Regulator","score":0.41839998960494995},{"id":"https://openalex.org/keywords/clinical-trial","display_name":"Clinical trial","score":0.37439998984336853},{"id":"https://openalex.org/keywords/major-depressive-disorder","display_name":"Major depressive disorder","score":0.33329999446868896},{"id":"https://openalex.org/keywords/causal-model","display_name":"Causal model","score":0.3222000002861023}],"concepts":[{"id":"https://openalex.org/C158600405","wikidata":"https://www.wikidata.org/wiki/Q5054566","display_name":"Causal inference","level":2,"score":0.6934999823570251},{"id":"https://openalex.org/C2776214188","wikidata":"https://www.wikidata.org/wiki/Q408386","display_name":"Inference","level":2,"score":0.5687999725341797},{"id":"https://openalex.org/C27415008","wikidata":"https://www.wikidata.org/wiki/Q7256382","display_name":"Psychological intervention","level":2,"score":0.48019999265670776},{"id":"https://openalex.org/C26517878","wikidata":"https://www.wikidata.org/wiki/Q228039","display_name":"Key (lock)","level":2,"score":0.42969998717308044},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.423799991607666},{"id":"https://openalex.org/C6929976","wikidata":"https://www.wikidata.org/wiki/Q3771881","display_name":"Regulator","level":3,"score":0.41839998960494995},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.40230000019073486},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.376800000667572},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.37439998984336853},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3741999864578247},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.37290000915527344},{"id":"https://openalex.org/C2522767166","wikidata":"https://www.wikidata.org/wiki/Q2374463","display_name":"Data science","level":1,"score":0.3537999987602234},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.3483999967575073},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3481999933719635},{"id":"https://openalex.org/C2780051608","wikidata":"https://www.wikidata.org/wiki/Q42844","display_name":"Major depressive disorder","level":3,"score":0.33329999446868896},{"id":"https://openalex.org/C11671645","wikidata":"https://www.wikidata.org/wiki/Q5054567","display_name":"Causal model","level":2,"score":0.3222000002861023},{"id":"https://openalex.org/C57273362","wikidata":"https://www.wikidata.org/wiki/Q576722","display_name":"Decoding methods","level":2,"score":0.3100999891757965},{"id":"https://openalex.org/C67339327","wikidata":"https://www.wikidata.org/wiki/Q1502576","display_name":"Gene regulatory network","level":4,"score":0.30970001220703125},{"id":"https://openalex.org/C12713177","wikidata":"https://www.wikidata.org/wiki/Q1900281","display_name":"Perspective (graphical)","level":2,"score":0.29170000553131104},{"id":"https://openalex.org/C2776867660","wikidata":"https://www.wikidata.org/wiki/Q1814941","display_name":"Depression (economics)","level":2,"score":0.28450000286102295},{"id":"https://openalex.org/C2779473830","wikidata":"https://www.wikidata.org/wiki/Q1540899","display_name":"MEDLINE","level":2,"score":0.28130000829696655},{"id":"https://openalex.org/C2908876842","wikidata":"https://www.wikidata.org/wiki/Q12135","display_name":"Psychiatric Disease","level":3,"score":0.2802000045776367},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.272599995136261},{"id":"https://openalex.org/C84201533","wikidata":"https://www.wikidata.org/wiki/Q7256235","display_name":"Psychiatric genetics","level":3,"score":0.25929999351501465},{"id":"https://openalex.org/C134261354","wikidata":"https://www.wikidata.org/wiki/Q938438","display_name":"Statistical inference","level":2,"score":0.2515999972820282},{"id":"https://openalex.org/C70410870","wikidata":"https://www.wikidata.org/wiki/Q199906","display_name":"Clinical psychology","level":1,"score":0.25119999051094055}],"mesh":[{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000097906","descriptor_name":"RNA Methylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000097906","descriptor_name":"RNA Methylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000099123","descriptor_name":"Epitranscriptome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000099123","descriptor_name":"Epitranscriptome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000099129","descriptor_name":"Epitranscriptomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000099129","descriptor_name":"Epitranscriptomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000241","descriptor_name":"Adenosine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D000241","descriptor_name":"Adenosine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D000241","descriptor_name":"Adenosine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D000241","descriptor_name":"Adenosine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D000241","descriptor_name":"Adenosine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D000241","descriptor_name":"Adenosine","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000241","descriptor_name":"Adenosine","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000241","descriptor_name":"Adenosine","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000241","descriptor_name":"Adenosine","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000241","descriptor_name":"Adenosine","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000241","descriptor_name":"Adenosine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000241","descriptor_name":"Adenosine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000241","descriptor_name":"Adenosine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000241","descriptor_name":"Adenosine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000241","descriptor_name":"Adenosine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001523","descriptor_name":"Mental Disorders","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D001523","descriptor_name":"Mental Disorders","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D001523","descriptor_name":"Mental Disorders","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D001523","descriptor_name":"Mental Disorders","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D001523","descriptor_name":"Mental Disorders","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D001523","descriptor_name":"Mental Disorders","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001523","descriptor_name":"Mental Disorders","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001523","descriptor_name":"Mental Disorders","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001523","descriptor_name":"Mental Disorders","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001523","descriptor_name":"Mental Disorders","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D003865","descriptor_name":"Major Depressive Disorder","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D003865","descriptor_name":"Major Depressive Disorder","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D003865","descriptor_name":"Major Depressive Disorder","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D003865","descriptor_name":"Major Depressive Disorder","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D003865","descriptor_name":"Major Depressive Disorder","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D003865","descriptor_name":"Major Depressive Disorder","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D003865","descriptor_name":"Major Depressive Disorder","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D044127","descriptor_name":"Epigenesis, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D044127","descriptor_name":"Epigenesis, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1093/bib/bbag251","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbag251","pdf_url":null,"source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},{"id":"pmid:42184108","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42184108","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in bioinformatics","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13200537","is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13200537/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Brief Bioinform","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1093/bib/bbag251","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbag251","pdf_url":null,"source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.4955978989601135,"display_name":"Good health and well-being"}],"awards":[{"id":"https://openalex.org/G1143551653","display_name":null,"funder_award_id":"61971422","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G244978865","display_name":null,"funder_award_id":"31\u2009671\u2009373","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":154,"referenced_works":["https://openalex.org/W40770424","https://openalex.org/W776567260","https://openalex.org/W1576934797","https://openalex.org/W1629202041","https://openalex.org/W1885991053","https://openalex.org/W1963717171","https://openalex.org/W1983719168","https://openalex.org/W1986988560","https://openalex.org/W1991807334","https://openalex.org/W2044676948","https://openalex.org/W2054101905","https://openalex.org/W2060541352","https://openalex.org/W2065847836","https://openalex.org/W2071930821","https://openalex.org/W2072386767","https://openalex.org/W2078964320","https://openalex.org/W2079849867","https://openalex.org/W2085106808","https://openalex.org/W2105855535","https://openalex.org/W2116778476","https://openalex.org/W2134469465","https://openalex.org/W2142063448","https://openalex.org/W2156540265","https://openalex.org/W2173304983","https://openalex.org/W2241686927","https://openalex.org/W2259938310","https://openalex.org/W2328393125","https://openalex.org/W2548359027","https://openalex.org/W2599186967","https://openalex.org/W2608560932","https://openalex.org/W2614566443","https://openalex.org/W2757528734","https://openalex.org/W2760498857","https://openalex.org/W2762515171","https://openalex.org/W2765639695","https://openalex.org/W2768991694","https://openalex.org/W2803154276","https://openalex.org/W2856435359","https://openalex.org/W2886609621","https://openalex.org/W2904763455","https://openalex.org/W2934861239","https://openalex.org/W2945570991","https://openalex.org/W2945976633","https://openalex.org/W2946217053","https://openalex.org/W2952723565","https://openalex.org/W2969469813","https://openalex.org/W2972933339","https://openalex.org/W2992866845","https://openalex.org/W3006906459","https://openalex.org/W3016950990","https://openalex.org/W3023127603","https://openalex.org/W3037791176","https://openalex.org/W3045696640","https://openalex.org/W3048545728","https://openalex.org/W3081143873","https://openalex.org/W3099368959","https://openalex.org/W3111771007","https://openalex.org/W3118379951","https://openalex.org/W3124446529","https://openalex.org/W3133117790","https://openalex.org/W3135799194","https://openalex.org/W3139236016","https://openalex.org/W3157971051","https://openalex.org/W3160358327","https://openalex.org/W3161779320","https://openalex.org/W3174760894","https://openalex.org/W3175527099","https://openalex.org/W3182032140","https://openalex.org/W3191796027","https://openalex.org/W3202212354","https://openalex.org/W3206071443","https://openalex.org/W3208315309","https://openalex.org/W3213175427","https://openalex.org/W3216913785","https://openalex.org/W4205844234","https://openalex.org/W4211103501","https://openalex.org/W4214525197","https://openalex.org/W4220686844","https://openalex.org/W4223447673","https://openalex.org/W4224299153","https://openalex.org/W4229007227","https://openalex.org/W4229528478","https://openalex.org/W4280638829","https://openalex.org/W4281617200","https://openalex.org/W4281704530","https://openalex.org/W4283720201","https://openalex.org/W4290660615","https://openalex.org/W4296281088","https://openalex.org/W4310058940","https://openalex.org/W4310062882","https://openalex.org/W4315641887","https://openalex.org/W4319722070","https://openalex.org/W4321112082","https://openalex.org/W4322490796","https://openalex.org/W4323865263","https://openalex.org/W4361007538","https://openalex.org/W4378217890","https://openalex.org/W4380577133","https://openalex.org/W4380680754","https://openalex.org/W4380793095","https://openalex.org/W4382516982","https://openalex.org/W4385289339","https://openalex.org/W4385897926","https://openalex.org/W4386089664","https://openalex.org/W4386334036","https://openalex.org/W4386623843","https://openalex.org/W4386988843","https://openalex.org/W4390941101","https://openalex.org/W4390946851","https://openalex.org/W4391258086","https://openalex.org/W4391843784","https://openalex.org/W4392562632","https://openalex.org/W4392592451","https://openalex.org/W4393111197","https://openalex.org/W4393161407","https://openalex.org/W4394919305","https://openalex.org/W4396213987","https://openalex.org/W4396912882","https://openalex.org/W4398163277","https://openalex.org/W4400415645","https://openalex.org/W4400891606","https://openalex.org/W4401921233","https://openalex.org/W4402769636","https://openalex.org/W4402847467","https://openalex.org/W4403455994","https://openalex.org/W4404033539","https://openalex.org/W4404534210","https://openalex.org/W4404733180","https://openalex.org/W4404797727","https://openalex.org/W4406346981","https://openalex.org/W4406514071","https://openalex.org/W4406518889","https://openalex.org/W4406665104","https://openalex.org/W4407051264","https://openalex.org/W4407603717","https://openalex.org/W4407776912","https://openalex.org/W4408987639","https://openalex.org/W4410013168","https://openalex.org/W4410417907","https://openalex.org/W4410533985","https://openalex.org/W4410817654","https://openalex.org/W4411799147","https://openalex.org/W4411846502","https://openalex.org/W4412084581","https://openalex.org/W4412630802","https://openalex.org/W4413107335","https://openalex.org/W4413115434","https://openalex.org/W4413681411","https://openalex.org/W4414346695","https://openalex.org/W4414358530","https://openalex.org/W4416336757","https://openalex.org/W4416975445","https://openalex.org/W6966829470","https://openalex.org/W7133560634"],"related_works":[],"abstract_inverted_index":{"N":[0],"6-methyladenosine":[1],"(m6A),":[2],"the":[3,18,32,64,77,85],"most":[4],"prevalent":[5],"internal":[6],"RNA":[7],"modification,":[8],"is":[9,25],"an":[10],"emerging":[11],"key":[12],"regulator":[13],"of":[14,50,67,79,87],"gene":[15],"expression":[16],"in":[17,103,132],"central":[19],"nervous":[20],"system,":[21],"and":[22,39,83],"its":[23],"dysregulation":[24],"connected":[26],"to":[27,54,90],"psychiatric":[28,113,133],"disorders.":[29,134],"However,":[30],"disentangling":[31],"causal":[33,71],"links":[34],"between":[35],"specific":[36],"m6A":[37,110],"sites":[38],"diseases":[40],"phenotypes":[41],"remain":[42],"challenging.":[43],"This":[44],"review":[45,58],"presents":[46],"a":[47,100,122],"comprehensive":[48],"survey":[49],"practical":[51],"bioinformatics":[52],"strategies":[53,98],"address":[55],"it.":[56],"Our":[57],"outlines":[59],"four":[60],"analytical":[61,97],"themes:":[62],"(i)":[63],"reliable":[65],"calibration":[66],"false-positive":[68],"signals,":[69],"(ii)":[70],"inference":[72],"via":[73],"statistical":[74],"genetics,":[75],"(iii)":[76],"acquisition":[78],"cell-type-specific":[80],"functional":[81],"insights,":[82],"(iv)":[84],"application":[86],"machine":[88],"learning":[89],"predict":[91],"clinical":[92],"biomarkers.":[93],"We":[94],"validate":[95],"these":[96,118],"through":[99],"case":[101],"study":[102],"major":[104],"depressive":[105],"disorder,":[106],"specifically":[107],"by":[108],"intersecting":[109],"effects":[111],"with":[112],"genetic":[114],"risk.":[115],"By":[116],"streamlining":[117],"workflows,":[119],"we":[120],"provide":[121],"roadmap":[123],"for":[124],"formulating":[125],"testable":[126],"hypotheses":[127],"regarding":[128],"epitranscriptome-targeted":[129],"therapeutic":[130],"interventions":[131]},"counts_by_year":[],"updated_date":"2026-08-24T07:32:12.397491","created_date":"2026-05-26T00:00:00"}