{"id":"https://openalex.org/W7162242532","doi":"https://doi.org/10.1093/bib/bbag242","title":"A scalable, multi-resolution consensus clustering approach for prioritizing robust signals from high-throughput screens","display_name":"A scalable, multi-resolution consensus clustering approach for prioritizing robust signals from high-throughput screens","publication_year":2026,"publication_date":"2026-05-01","ids":{"openalex":"https://openalex.org/W7162242532","doi":"https://doi.org/10.1093/bib/bbag242","pmid":"https://pubmed.ncbi.nlm.nih.gov/42177640"},"language":"en","primary_location":{"id":"doi:10.1093/bib/bbag242","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbag242","pdf_url":null,"source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1093/bib/bbag242","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5132646346","display_name":"Shaine Chenxin Bao","orcid":null},"institutions":[{"id":"https://openalex.org/I165143802","display_name":"The University of Queensland","ror":"https://ror.org/00rqy9422","country_code":"AU","type":"education","lineage":["https://openalex.org/I165143802"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Shaine Chenxin Bao","raw_affiliation_strings":["Institute for Molecular Bioscience, The University of Queensland , 306 Carmody Road, St Lucia, Brisbane , QLD, 4072,"],"raw_orcid":"https://orcid.org/0009-0008-2085-8326","affiliations":[{"raw_affiliation_string":"Institute for Molecular Bioscience, The University of Queensland , 306 Carmody Road, St Lucia, Brisbane , QLD, 4072,","institution_ids":["https://openalex.org/I165143802"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077917060","display_name":"Kathleen I. Pishas","orcid":"https://orcid.org/0000-0001-7863-807X"},"institutions":[{"id":"https://openalex.org/I2800555584","display_name":"Peter MacCallum Cancer Centre","ror":"https://ror.org/02a8bt934","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I2800555584"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Kathleen I Pishas","raw_affiliation_strings":["Peter MacCallum Cancer Centre , 305 Grattan Street, Melbourne, VIC, 3000 ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Peter MacCallum Cancer Centre , 305 Grattan Street, Melbourne, VIC, 3000 ,","institution_ids":["https://openalex.org/I2800555584"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046079707","display_name":"Karla J. Cowley","orcid":"https://orcid.org/0000-0001-9757-2627"},"institutions":[{"id":"https://openalex.org/I2800555584","display_name":"Peter MacCallum Cancer Centre","ror":"https://ror.org/02a8bt934","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I2800555584"]},{"id":"https://openalex.org/I4405265764","display_name":"Victorian Centre for Functional Genomics","ror":"https://ror.org/05nq3sz50","country_code":"AU","type":"education","lineage":["https://openalex.org/I2800555584","https://openalex.org/I4405265764"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Karla J Cowley","raw_affiliation_strings":["Victorian Centre for Functional Genomics, Peter MacCallum Cancer Centre , 305 Grattan Street, Melbourne , VIC, 3000,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Victorian Centre for Functional Genomics, Peter MacCallum Cancer Centre , 305 Grattan Street, Melbourne , VIC, 3000,","institution_ids":["https://openalex.org/I2800555584","https://openalex.org/I4405265764"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039106985","display_name":"Qiongyi Zhao","orcid":"https://orcid.org/0000-0002-6341-0416"},"institutions":[{"id":"https://openalex.org/I165143802","display_name":"The University of Queensland","ror":"https://ror.org/00rqy9422","country_code":"AU","type":"education","lineage":["https://openalex.org/I165143802"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Qiongyi Zhao","raw_affiliation_strings":["Institute for Molecular Bioscience, The University of Queensland , 306 Carmody Road, St Lucia, Brisbane , QLD, 4072,"],"raw_orcid":"https://orcid.org/0000-0002-6341-0416","affiliations":[{"raw_affiliation_string":"Institute for Molecular Bioscience, The University of Queensland , 306 Carmody Road, St Lucia, Brisbane , QLD, 4072,","institution_ids":["https://openalex.org/I165143802"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5136883204","display_name":"Emily C A Goodall","orcid":null},"institutions":[{"id":"https://openalex.org/I165143802","display_name":"The University of Queensland","ror":"https://ror.org/00rqy9422","country_code":"AU","type":"education","lineage":["https://openalex.org/I165143802"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Emily C A Goodall","raw_affiliation_strings":["Institute for Molecular Bioscience, The University of Queensland , 306 Carmody Road, St Lucia, Brisbane , QLD, 4072,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Molecular Bioscience, The University of Queensland , 306 Carmody Road, St Lucia, Brisbane , QLD, 4072,","institution_ids":["https://openalex.org/I165143802"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5136887946","display_name":"Ian R Henderson","orcid":null},"institutions":[{"id":"https://openalex.org/I165143802","display_name":"The University of Queensland","ror":"https://ror.org/00rqy9422","country_code":"AU","type":"education","lineage":["https://openalex.org/I165143802"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Ian R Henderson","raw_affiliation_strings":["Institute for Molecular Bioscience, The University of Queensland , 306 Carmody Road, St Lucia, Brisbane , QLD, 4072,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Molecular Bioscience, The University of Queensland , 306 Carmody Road, St Lucia, Brisbane , QLD, 4072,","institution_ids":["https://openalex.org/I165143802"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5136861358","display_name":"Xin Liu","orcid":null},"institutions":[{"id":"https://openalex.org/I2800555584","display_name":"Peter MacCallum Cancer Centre","ror":"https://ror.org/02a8bt934","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I2800555584"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Xin Liu","raw_affiliation_strings":["Peter MacCallum Cancer Centre , 305 Grattan Street, Melbourne, VIC, 3000 ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Peter MacCallum Cancer Centre , 305 Grattan Street, Melbourne, VIC, 3000 ,","institution_ids":["https://openalex.org/I2800555584"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5136216227","display_name":"Evanny Marinovic","orcid":"https://orcid.org/0000-0002-2047-5009"},"institutions":[{"id":"https://openalex.org/I2800555584","display_name":"Peter MacCallum Cancer Centre","ror":"https://ror.org/02a8bt934","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I2800555584"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Evanny Marinovic","raw_affiliation_strings":["Peter MacCallum Cancer Centre , 305 Grattan Street, Melbourne, VIC, 3000 ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Peter MacCallum Cancer Centre , 305 Grattan Street, Melbourne, VIC, 3000 ,","institution_ids":["https://openalex.org/I2800555584"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018264282","display_name":"Mark Carey","orcid":"https://orcid.org/0000-0002-0473-6993"},"institutions":[{"id":"https://openalex.org/I1289530486","display_name":"BC Cancer Agency","ror":"https://ror.org/03sfybe47","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1289530486"]},{"id":"https://openalex.org/I141945490","display_name":"University of British Columbia","ror":"https://ror.org/03rmrcq20","country_code":"CA","type":"education","lineage":["https://openalex.org/I141945490"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Mark S Carey","raw_affiliation_strings":["Department of Clinical Research, BC Cancer , 600 West 10th Avenue, Vancouver, BC, V5Z 4E6 ,","Division of Gynecology Oncology, Department of Obstetrics and Gynecology, University of British Columbia , 2775 Laurel St, Vancouver, BC, V5Z 1M9 ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Research, BC Cancer , 600 West 10th Avenue, Vancouver, BC, V5Z 4E6 ,","institution_ids":["https://openalex.org/I1289530486"]},{"raw_affiliation_string":"Division of Gynecology Oncology, Department of Obstetrics and Gynecology, University of British Columbia , 2775 Laurel St, Vancouver, BC, V5Z 1M9 ,","institution_ids":["https://openalex.org/I141945490"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037117618","display_name":"Ian Campbell","orcid":"https://orcid.org/0000-0002-7773-4155"},"institutions":[{"id":"https://openalex.org/I2800555584","display_name":"Peter MacCallum Cancer Centre","ror":"https://ror.org/02a8bt934","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I2800555584"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Ian G Campbell","raw_affiliation_strings":["Peter MacCallum Cancer Centre , 305 Grattan Street, Melbourne, VIC, 3000 ,","The Sir Peter MacCallum Department of Oncology, The University of Melbourne , 305 Grattan Street, Parkville , VIC, 3000,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Peter MacCallum Cancer Centre , 305 Grattan Street, Melbourne, VIC, 3000 ,","institution_ids":["https://openalex.org/I2800555584"]},{"raw_affiliation_string":"The Sir Peter MacCallum Department of Oncology, The University of Melbourne , 305 Grattan Street, Parkville , VIC, 3000,","institution_ids":["https://openalex.org/I2800555584"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044516621","display_name":"Kaylene J. Simpson","orcid":"https://orcid.org/0000-0001-9136-1781"},"institutions":[{"id":"https://openalex.org/I2800555584","display_name":"Peter MacCallum Cancer Centre","ror":"https://ror.org/02a8bt934","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I2800555584"]},{"id":"https://openalex.org/I4405265764","display_name":"Victorian Centre for Functional Genomics","ror":"https://ror.org/05nq3sz50","country_code":"AU","type":"education","lineage":["https://openalex.org/I2800555584","https://openalex.org/I4405265764"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Kaylene J Simpson","raw_affiliation_strings":["The Sir Peter MacCallum Department of Oncology, The University of Melbourne , 305 Grattan Street, Parkville , VIC, 3000,","Victorian Centre for Functional Genomics, Peter MacCallum Cancer Centre , 305 Grattan Street, Melbourne , VIC, 3000,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Sir Peter MacCallum Department of Oncology, The University of Melbourne , 305 Grattan Street, Parkville , VIC, 3000,","institution_ids":["https://openalex.org/I2800555584"]},{"raw_affiliation_string":"Victorian Centre for Functional Genomics, Peter MacCallum Cancer Centre , 305 Grattan Street, Melbourne , VIC, 3000,","institution_ids":["https://openalex.org/I2800555584","https://openalex.org/I4405265764"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5136247036","display_name":"Dane Cheasley","orcid":"https://orcid.org/0000-0002-1170-4690"},"institutions":[{"id":"https://openalex.org/I2800555584","display_name":"Peter MacCallum Cancer Centre","ror":"https://ror.org/02a8bt934","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I2800555584"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Dane Cheasley","raw_affiliation_strings":["Peter MacCallum Cancer Centre , 305 Grattan Street, Melbourne, VIC, 3000 ,","The Sir Peter MacCallum Department of Oncology, The University of Melbourne , 305 Grattan Street, Parkville , VIC, 3000,"],"raw_orcid":"https://orcid.org/0000-0002-1170-4690","affiliations":[{"raw_affiliation_string":"Peter MacCallum Cancer Centre , 305 Grattan Street, Melbourne, VIC, 3000 ,","institution_ids":["https://openalex.org/I2800555584"]},{"raw_affiliation_string":"The Sir Peter MacCallum Department of Oncology, The University of Melbourne , 305 Grattan Street, Parkville , VIC, 3000,","institution_ids":["https://openalex.org/I2800555584"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041968549","display_name":"Dalia Mizikovsky","orcid":"https://orcid.org/0000-0002-8742-963X"},"institutions":[{"id":"https://openalex.org/I165143802","display_name":"The University of Queensland","ror":"https://ror.org/00rqy9422","country_code":"AU","type":"education","lineage":["https://openalex.org/I165143802"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Dalia Mizikovsky","raw_affiliation_strings":["Institute for Molecular Bioscience, The University of Queensland , 306 Carmody Road, St Lucia, Brisbane , QLD, 4072,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Molecular Bioscience, The University of Queensland , 306 Carmody Road, St Lucia, Brisbane , QLD, 4072,","institution_ids":["https://openalex.org/I165143802"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5087836581","display_name":"Nathan J. Palpant","orcid":"https://orcid.org/0000-0002-9334-8107"},"institutions":[{"id":"https://openalex.org/I165143802","display_name":"The University of Queensland","ror":"https://ror.org/00rqy9422","country_code":"AU","type":"education","lineage":["https://openalex.org/I165143802"]}],"countries":["AU"],"is_corresponding":true,"raw_author_name":"Nathan J Palpant","raw_affiliation_strings":["Institute for Molecular Bioscience, The University of Queensland , 306 Carmody Road, St Lucia, Brisbane , QLD, 4072,"],"raw_orcid":"https://orcid.org/0000-0002-9334-8107","affiliations":[{"raw_affiliation_string":"Institute for Molecular Bioscience, The University of Queensland , 306 Carmody Road, St Lucia, Brisbane , QLD, 4072,","institution_ids":["https://openalex.org/I165143802"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5087836581"],"corresponding_institution_ids":["https://openalex.org/I165143802"],"apc_list":{"value":4011,"currency":"USD","value_usd":4011},"apc_paid":{"value":4011,"currency":"USD","value_usd":4011},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.57644345,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"27","issue":"3","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.7623999714851379,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.7623999714851379,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12859","display_name":"Cell Image Analysis Techniques","score":0.03929999843239784,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10015","display_name":"Genomics and Phylogenetic Studies","score":0.03920000046491623,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cluster-analysis","display_name":"Cluster analysis","score":0.7831000089645386},{"id":"https://openalex.org/keywords/benchmarking","display_name":"Benchmarking","score":0.7766000032424927},{"id":"https://openalex.org/keywords/scalability","display_name":"Scalability","score":0.5824000239372253},{"id":"https://openalex.org/keywords/construct","display_name":"Construct (python library)","score":0.5791000127792358},{"id":"https://openalex.org/keywords/cluster","display_name":"Cluster (spacecraft)","score":0.5504999756813049},{"id":"https://openalex.org/keywords/ground-truth","display_name":"Ground truth","score":0.4927999973297119},{"id":"https://openalex.org/keywords/hierarchical-clustering","display_name":"Hierarchical clustering","score":0.4684000015258789}],"concepts":[{"id":"https://openalex.org/C73555534","wikidata":"https://www.wikidata.org/wiki/Q622825","display_name":"Cluster analysis","level":2,"score":0.7831000089645386},{"id":"https://openalex.org/C86251818","wikidata":"https://www.wikidata.org/wiki/Q816754","display_name":"Benchmarking","level":2,"score":0.7766000032424927},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.7436000108718872},{"id":"https://openalex.org/C48044578","wikidata":"https://www.wikidata.org/wiki/Q727490","display_name":"Scalability","level":2,"score":0.5824000239372253},{"id":"https://openalex.org/C2780801425","wikidata":"https://www.wikidata.org/wiki/Q5164392","display_name":"Construct (python library)","level":2,"score":0.5791000127792358},{"id":"https://openalex.org/C164866538","wikidata":"https://www.wikidata.org/wiki/Q367351","display_name":"Cluster (spacecraft)","level":2,"score":0.5504999756813049},{"id":"https://openalex.org/C146849305","wikidata":"https://www.wikidata.org/wiki/Q370766","display_name":"Ground truth","level":2,"score":0.4927999973297119},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.48829999566078186},{"id":"https://openalex.org/C92835128","wikidata":"https://www.wikidata.org/wiki/Q1277447","display_name":"Hierarchical clustering","level":3,"score":0.4684000015258789},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.44429999589920044},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.4097000062465668},{"id":"https://openalex.org/C185798385","wikidata":"https://www.wikidata.org/wiki/Q1161707","display_name":"Benchmark (surveying)","level":2,"score":0.3840000033378601},{"id":"https://openalex.org/C186767784","wikidata":"https://www.wikidata.org/wiki/Q5162841","display_name":"Consensus clustering","level":5,"score":0.3625999987125397},{"id":"https://openalex.org/C99498987","wikidata":"https://www.wikidata.org/wiki/Q2210247","display_name":"Noise (video)","level":3,"score":0.33390000462532043},{"id":"https://openalex.org/C184509293","wikidata":"https://www.wikidata.org/wiki/Q5136711","display_name":"Clustering high-dimensional data","level":3,"score":0.2985000014305115},{"id":"https://openalex.org/C67226441","wikidata":"https://www.wikidata.org/wiki/Q1665389","display_name":"Robust statistics","level":3,"score":0.2976999878883362},{"id":"https://openalex.org/C201797286","wikidata":"https://www.wikidata.org/wiki/Q4914986","display_name":"Biological data","level":2,"score":0.2897999882698059},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.2831999957561493},{"id":"https://openalex.org/C63882131","wikidata":"https://www.wikidata.org/wiki/Q17122954","display_name":"Strengths and weaknesses","level":2,"score":0.2815999984741211},{"id":"https://openalex.org/C152662350","wikidata":"https://www.wikidata.org/wiki/Q815297","display_name":"Systems biology","level":2,"score":0.25029999017715454}],"mesh":[{"descriptor_ui":"D000098430","descriptor_name":"Clustering Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000098430","descriptor_name":"Clustering Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016000","descriptor_name":"Cluster Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016000","descriptor_name":"Cluster Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016000","descriptor_name":"Cluster Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016000","descriptor_name":"Cluster Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D057166","descriptor_name":"High-Throughput Screening Assays","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D057166","descriptor_name":"High-Throughput Screening Assays","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D057166","descriptor_name":"High-Throughput Screening Assays","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D057166","descriptor_name":"High-Throughput Screening Assays","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1093/bib/bbag242","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbag242","pdf_url":null,"source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},{"id":"pmid:42177640","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42177640","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in bioinformatics","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13198723","is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13198723/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Brief Bioinform","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1093/bib/bbag242","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbag242","pdf_url":null,"source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":29,"referenced_works":["https://openalex.org/W1521411817","https://openalex.org/W1548779692","https://openalex.org/W1644749979","https://openalex.org/W2018045523","https://openalex.org/W2048593866","https://openalex.org/W2050910224","https://openalex.org/W2083501474","https://openalex.org/W2103017472","https://openalex.org/W2115462905","https://openalex.org/W2139280638","https://openalex.org/W2598326928","https://openalex.org/W2612467560","https://openalex.org/W2653933210","https://openalex.org/W2884197618","https://openalex.org/W2949329924","https://openalex.org/W2951337536","https://openalex.org/W2952100718","https://openalex.org/W2983549323","https://openalex.org/W2997470228","https://openalex.org/W3015444296","https://openalex.org/W3040048011","https://openalex.org/W3044109215","https://openalex.org/W3115208483","https://openalex.org/W3120238974","https://openalex.org/W3175719984","https://openalex.org/W4283123298","https://openalex.org/W4381851495","https://openalex.org/W4385949246","https://openalex.org/W4402644711"],"related_works":[],"abstract_inverted_index":{"Modern":[0],"biology":[1],"increasingly":[2],"relies":[3],"on":[4,79],"large-scale":[5],"screening":[6,88],"to":[7,14,25,60,131],"generate":[8],"high":[9,37],"dimensional":[10,38],"datasets":[11,21,84],"with":[12,108],"potential":[13],"accelerate":[15],"discovery.":[16],"However,":[17],"analysing":[18],"these":[19],"complex":[20],"remains":[22],"challenging,":[23],"due":[24],"hierarchical":[26],"biological":[27,43,110,138],"structure,":[28],"uncertainty":[29],"in":[30],"the":[31],"true":[32],"number":[33,68],"of":[34,73],"groups,":[35],"and":[36,70,85,102,112],"noise":[39],"that":[40,54,92],"confounds":[41],"genuine":[42],"signal.":[44],"Here":[45],"we":[46,90],"present":[47],"an":[48],"unsupervised":[49],"consensus":[50],"clustering":[51,56,118],"tool,":[52],"Untangled,":[53],"aggregates":[55],"solutions":[57],"across":[58],"granularities":[59],"construct":[61],"a":[62,125],"stability-based":[63],"representation,":[64],"followed":[65],"by":[66],"cluster":[67,74,129],"optimization":[69],"systematic":[71],"evaluation":[72],"robustness.":[75],"Through":[76],"extensive":[77],"benchmarking":[78],"simulated":[80],"datasets,":[81],"ground":[82],"truth":[83],"diverse":[86],"high-dimensional":[87,137],"applications,":[89],"demonstrate":[91],"Untangled":[93,123],"reliably":[94],"recovers":[95],"underlying":[96],"relationships,":[97],"resolves":[98],"stable":[99],"meaningful":[100],"substructure,":[101],"more":[103],"effectively":[104],"prioritizes":[105],"robust":[106],"clusters":[107],"shared":[109],"mechanisms":[111],"conserved":[113],"phenotypic":[114],"responses":[115],"than":[116],"alternative":[117],"approaches.":[119],"These":[120],"results":[121],"establish":[122],"as":[124],"scalable":[126],"framework":[127],"for":[128],"discovery":[130],"guide":[132],"efficient":[133],"follow-up":[134],"investigation":[135],"from":[136],"datasets.":[139]},"counts_by_year":[],"updated_date":"2026-07-18T07:39:51.176621","created_date":"2026-05-25T00:00:00"}
