{"id":"https://openalex.org/W7160828073","doi":"https://doi.org/10.1093/bib/bbag219","title":"Computational paradigms for antimicrobial resistance prediction: integrating multi-omics, structural modeling, and foundation artificial intelligence systems","display_name":"Computational paradigms for antimicrobial resistance prediction: integrating multi-omics, structural modeling, and foundation artificial intelligence systems","publication_year":2026,"publication_date":"2026-04-21","ids":{"openalex":"https://openalex.org/W7160828073","doi":"https://doi.org/10.1093/bib/bbag219","pmid":"https://pubmed.ncbi.nlm.nih.gov/42108632"},"language":"en","primary_location":{"id":"doi:10.1093/bib/bbag219","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbag219","pdf_url":null,"source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1093/bib/bbag219","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5133199344","display_name":"Elias Hossain","orcid":null},"institutions":[{"id":"https://openalex.org/I106165777","display_name":"University of Central Florida","ror":"https://ror.org/036nfer12","country_code":"US","type":"education","lineage":["https://openalex.org/I106165777"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Elias Hossain","raw_affiliation_strings":["Department of Industrial Engineering and Management Systems, University of Central Florida , 12800 Pegasus Dr, Orlando, FL 32816 ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Industrial Engineering and Management Systems, University of Central Florida , 12800 Pegasus Dr, Orlando, FL 32816 ,","institution_ids":["https://openalex.org/I106165777"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5054474613","display_name":"Niloofar Yousefi","orcid":"https://orcid.org/0009-0005-0071-733X"},"institutions":[{"id":"https://openalex.org/I106165777","display_name":"University of Central Florida","ror":"https://ror.org/036nfer12","country_code":"US","type":"education","lineage":["https://openalex.org/I106165777"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Niloofar Yousefi","raw_affiliation_strings":["Department of Industrial Engineering and Management Systems, University of Central Florida , 12800 Pegasus Dr, Orlando, FL 32816 ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Industrial Engineering and Management Systems, University of Central Florida , 12800 Pegasus Dr, Orlando, FL 32816 ,","institution_ids":["https://openalex.org/I106165777"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I106165777"],"apc_list":{"value":3885,"currency":"USD","value_usd":3885},"apc_paid":{"value":3885,"currency":"USD","value_usd":3885},"fwci":6.1962,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.9669992,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":94,"max":97},"biblio":{"volume":"27","issue":"3","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.1720000058412552,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.1720000058412552,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12576","display_name":"vaccines and immunoinformatics approaches","score":0.08330000191926956,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10897","display_name":"Antibiotic Use and Resistance","score":0.07840000092983246,"subfield":{"id":"https://openalex.org/subfields/2402","display_name":"Applied Microbiology and Biotechnology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/resistome","display_name":"Resistome","score":0.4878999888896942},{"id":"https://openalex.org/keywords/vulnerability","display_name":"Vulnerability (computing)","score":0.4431999921798706},{"id":"https://openalex.org/keywords/antibiotic-resistance","display_name":"Antibiotic resistance","score":0.4426000118255615},{"id":"https://openalex.org/keywords/computational-model","display_name":"Computational model","score":0.33640000224113464},{"id":"https://openalex.org/keywords/resistance","display_name":"Resistance (ecology)","score":0.33079999685287476},{"id":"https://openalex.org/keywords/foundation","display_name":"Foundation (evidence)","score":0.3190999925136566},{"id":"https://openalex.org/keywords/systems-biology","display_name":"Systems biology","score":0.31290000677108765},{"id":"https://openalex.org/keywords/computational-intelligence","display_name":"Computational intelligence","score":0.2939999997615814}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5871000289916992},{"id":"https://openalex.org/C2522767166","wikidata":"https://www.wikidata.org/wiki/Q2374463","display_name":"Data science","level":1,"score":0.5001999735832214},{"id":"https://openalex.org/C2776666601","wikidata":"https://www.wikidata.org/wiki/Q3457855","display_name":"Resistome","level":5,"score":0.4878999888896942},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.4837000072002411},{"id":"https://openalex.org/C95713431","wikidata":"https://www.wikidata.org/wiki/Q631425","display_name":"Vulnerability (computing)","level":2,"score":0.4431999921798706},{"id":"https://openalex.org/C94665300","wikidata":"https://www.wikidata.org/wiki/Q63391344","display_name":"Antibiotic resistance","level":3,"score":0.4426000118255615},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.34540000557899475},{"id":"https://openalex.org/C66024118","wikidata":"https://www.wikidata.org/wiki/Q1122506","display_name":"Computational model","level":2,"score":0.33640000224113464},{"id":"https://openalex.org/C57473165","wikidata":"https://www.wikidata.org/wiki/Q7315604","display_name":"Resistance (ecology)","level":2,"score":0.33079999685287476},{"id":"https://openalex.org/C112930515","wikidata":"https://www.wikidata.org/wiki/Q4389547","display_name":"Risk analysis (engineering)","level":1,"score":0.33000001311302185},{"id":"https://openalex.org/C2780966255","wikidata":"https://www.wikidata.org/wiki/Q5474306","display_name":"Foundation (evidence)","level":2,"score":0.3190999925136566},{"id":"https://openalex.org/C152662350","wikidata":"https://www.wikidata.org/wiki/Q815297","display_name":"Systems biology","level":2,"score":0.31290000677108765},{"id":"https://openalex.org/C139502532","wikidata":"https://www.wikidata.org/wiki/Q1122090","display_name":"Computational intelligence","level":2,"score":0.2939999997615814},{"id":"https://openalex.org/C539667460","wikidata":"https://www.wikidata.org/wiki/Q2414942","display_name":"Management science","level":1,"score":0.29249998927116394},{"id":"https://openalex.org/C95423123","wikidata":"https://www.wikidata.org/wiki/Q622178","display_name":"Workgroup","level":2,"score":0.2842999994754791},{"id":"https://openalex.org/C2994067223","wikidata":"https://www.wikidata.org/wiki/Q380546","display_name":"Genomic sequencing","level":4,"score":0.2822999954223633},{"id":"https://openalex.org/C75684735","wikidata":"https://www.wikidata.org/wiki/Q858810","display_name":"Big data","level":2,"score":0.2782999873161316},{"id":"https://openalex.org/C114851261","wikidata":"https://www.wikidata.org/wiki/Q12147416","display_name":"Drug resistance","level":2,"score":0.2770000100135803},{"id":"https://openalex.org/C189708586","wikidata":"https://www.wikidata.org/wiki/Q1504425","display_name":"Systematic review","level":3,"score":0.26409998536109924},{"id":"https://openalex.org/C189206191","wikidata":"https://www.wikidata.org/wiki/Q222046","display_name":"Genomics","level":4,"score":0.26249998807907104},{"id":"https://openalex.org/C107327155","wikidata":"https://www.wikidata.org/wiki/Q330268","display_name":"Decision support system","level":2,"score":0.25870001316070557},{"id":"https://openalex.org/C163763905","wikidata":"https://www.wikidata.org/wiki/Q17075943","display_name":"Precision medicine","level":2,"score":0.2556999921798706},{"id":"https://openalex.org/C19443361","wikidata":"https://www.wikidata.org/wiki/Q5282533","display_name":"Disparate system","level":2,"score":0.25360000133514404}],"mesh":[{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000095028","descriptor_name":"Multiomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000095028","descriptor_name":"Multiomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000095028","descriptor_name":"Multiomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000095028","descriptor_name":"Multiomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000095028","descriptor_name":"Multiomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000095028","descriptor_name":"Multiomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D001185","descriptor_name":"Artificial Intelligence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001185","descriptor_name":"Artificial Intelligence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001185","descriptor_name":"Artificial Intelligence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001185","descriptor_name":"Artificial Intelligence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001185","descriptor_name":"Artificial Intelligence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001185","descriptor_name":"Artificial Intelligence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D024881","descriptor_name":"Drug Resistance, Bacterial","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D024881","descriptor_name":"Drug Resistance, Bacterial","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D024881","descriptor_name":"Drug Resistance, Bacterial","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D024881","descriptor_name":"Drug Resistance, Bacterial","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D024881","descriptor_name":"Drug Resistance, Bacterial","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D024881","descriptor_name":"Drug Resistance, Bacterial","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1093/bib/bbag219","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbag219","pdf_url":null,"source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},{"id":"pmid:42108632","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42108632","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in bioinformatics","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13158128","is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13158128/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Brief Bioinform","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1093/bib/bbag219","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbag219","pdf_url":null,"source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.5071855187416077,"id":"https://metadata.un.org/sdg/9","display_name":"Industry, innovation and infrastructure"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":188,"referenced_works":["https://openalex.org/W1528782506","https://openalex.org/W1965037740","https://openalex.org/W1982290306","https://openalex.org/W1993860350","https://openalex.org/W2003347102","https://openalex.org/W2008274231","https://openalex.org/W2058686178","https://openalex.org/W2071921819","https://openalex.org/W2080528409","https://openalex.org/W2081169676","https://openalex.org/W2089493916","https://openalex.org/W2091076764","https://openalex.org/W2096128575","https://openalex.org/W2106676963","https://openalex.org/W2118688136","https://openalex.org/W2134852597","https://openalex.org/W2155591307","https://openalex.org/W2155900219","https://openalex.org/W2158700061","https://openalex.org/W2162955464","https://openalex.org/W2163584430","https://openalex.org/W2267183746","https://openalex.org/W2274251352","https://openalex.org/W2325192560","https://openalex.org/W2397054603","https://openalex.org/W2416070789","https://openalex.org/W2417151890","https://openalex.org/W2430356171","https://openalex.org/W2471503074","https://openalex.org/W2497101904","https://openalex.org/W2551089731","https://openalex.org/W2557776122","https://openalex.org/W2566745148","https://openalex.org/W2573647331","https://openalex.org/W2588866969","https://openalex.org/W2594138301","https://openalex.org/W2604119841","https://openalex.org/W2620992520","https://openalex.org/W2754494334","https://openalex.org/W2761330137","https://openalex.org/W2766175727","https://openalex.org/W2766902857","https://openalex.org/W2767117391","https://openalex.org/W2790977261","https://openalex.org/W2791097450","https://openalex.org/W2792103240","https://openalex.org/W2794172338","https://openalex.org/W2807891945","https://openalex.org/W2808845633","https://openalex.org/W2889178232","https://openalex.org/W2897587353","https://openalex.org/W2899015035","https://openalex.org/W2899879084","https://openalex.org/W2920984376","https://openalex.org/W2943163666","https://openalex.org/W2944367280","https://openalex.org/W2945144912","https://openalex.org/W2945668305","https://openalex.org/W2950190620","https://openalex.org/W2950511618","https://openalex.org/W2950985821","https://openalex.org/W2951209840","https://openalex.org/W2951274106","https://openalex.org/W2967125766","https://openalex.org/W2976122667","https://openalex.org/W2982531601","https://openalex.org/W2995464967","https://openalex.org/W3003192283","https://openalex.org/W3004493607","https://openalex.org/W3006176809","https://openalex.org/W3006574710","https://openalex.org/W3029701017","https://openalex.org/W3036863343","https://openalex.org/W3039127696","https://openalex.org/W3096150463","https://openalex.org/W3109477407","https://openalex.org/W3125330584","https://openalex.org/W3133917645","https://openalex.org/W3133926724","https://openalex.org/W3161774116","https://openalex.org/W3161777250","https://openalex.org/W3176308329","https://openalex.org/W3184260509","https://openalex.org/W3203901993","https://openalex.org/W4206737630","https://openalex.org/W4210476749","https://openalex.org/W4210634826","https://openalex.org/W4220905034","https://openalex.org/W4221077960","https://openalex.org/W4224076057","https://openalex.org/W4225141898","https://openalex.org/W4225687252","https://openalex.org/W4241111610","https://openalex.org/W4281397798","https://openalex.org/W4281691464","https://openalex.org/W4291633822","https://openalex.org/W4298004332","https://openalex.org/W4309467503","https://openalex.org/W4311243615","https://openalex.org/W4312210063","https://openalex.org/W4313216330","https://openalex.org/W4317831275","https://openalex.org/W4318821784","https://openalex.org/W4321615393","https://openalex.org/W4323438792","https://openalex.org/W4362633294","https://openalex.org/W4365135621","https://openalex.org/W4382630944","https://openalex.org/W4383273076","https://openalex.org/W4383340501","https://openalex.org/W4385227045","https://openalex.org/W4385786370","https://openalex.org/W4387994442","https://openalex.org/W4388283707","https://openalex.org/W4389056425","https://openalex.org/W4389524207","https://openalex.org/W4389611677","https://openalex.org/W4390399518","https://openalex.org/W4390702533","https://openalex.org/W4390745633","https://openalex.org/W4390790220","https://openalex.org/W4391338550","https://openalex.org/W4392201430","https://openalex.org/W4392349824","https://openalex.org/W4392798827","https://openalex.org/W4393159659","https://openalex.org/W4393233207","https://openalex.org/W4393404242","https://openalex.org/W4394769044","https://openalex.org/W4394846681","https://openalex.org/W4394876256","https://openalex.org/W4395031884","https://openalex.org/W4396504490","https://openalex.org/W4396663706","https://openalex.org/W4396831657","https://openalex.org/W4399069394","https://openalex.org/W4399305008","https://openalex.org/W4399510363","https://openalex.org/W4399768250","https://openalex.org/W4401305713","https://openalex.org/W4401798478","https://openalex.org/W4401912470","https://openalex.org/W4402393183","https://openalex.org/W4402567773","https://openalex.org/W4402827557","https://openalex.org/W4403184079","https://openalex.org/W4403488216","https://openalex.org/W4403836322","https://openalex.org/W4404138521","https://openalex.org/W4404199762","https://openalex.org/W4404377296","https://openalex.org/W4404485589","https://openalex.org/W4404708476","https://openalex.org/W4406183015","https://openalex.org/W4406728221","https://openalex.org/W4406783055","https://openalex.org/W4406893733","https://openalex.org/W4407320072","https://openalex.org/W4408501948","https://openalex.org/W4409016129","https://openalex.org/W4409111965","https://openalex.org/W4409279395","https://openalex.org/W4409381465","https://openalex.org/W4409825362","https://openalex.org/W4410040536","https://openalex.org/W4410120373","https://openalex.org/W4410457764","https://openalex.org/W4410475717","https://openalex.org/W4410550221","https://openalex.org/W4411210055","https://openalex.org/W4411429166","https://openalex.org/W4411758878","https://openalex.org/W4412088072","https://openalex.org/W4412354852","https://openalex.org/W4412491618","https://openalex.org/W4412795766","https://openalex.org/W4412972857","https://openalex.org/W4414018835","https://openalex.org/W4414023833","https://openalex.org/W4414418749","https://openalex.org/W4415360436","https://openalex.org/W4415686194","https://openalex.org/W4415960960","https://openalex.org/W4415999016","https://openalex.org/W4416034115","https://openalex.org/W4416091869","https://openalex.org/W4417150452","https://openalex.org/W4417172490"],"related_works":[],"abstract_inverted_index":{"Antimicrobial":[0],"resistance":[1,155],"(AMR)":[2],"poses":[3],"an":[4],"escalating":[5],"threat":[6],"to":[7,149,173],"global":[8],"health,":[9],"as":[10],"multidrug-resistant":[11],"pathogens":[12],"undermine":[13],"therapeutic":[14],"efficacy":[15],"and":[16,22,54,76,82,86,89,99,117,120,147,170,183],"surveillance":[17,191],"systems.":[18],"Although":[19],"whole-genome":[20],"sequencing":[21],"phenotypic":[23],"drug":[24],"susceptibility":[25],"testing":[26],"have":[27],"strengthened":[28],"resistome":[29],"profiling,":[30],"translating":[31],"multi-omics":[32],"data":[33],"into":[34,70],"reliable,":[35],"clinically":[36,184],"deployable":[37],"intelligence":[38,123,162],"remains":[39],"computationally":[40],"fragmented.":[41],"Following":[42],"PRISMA":[43],"2020":[44],"guidelines,":[45],"we":[46,104],"systematically":[47],"reviewed":[48],"156":[49],"records":[50],"published":[51],"between":[52],"2016":[53],"2025,":[55],"of":[56,144],"which":[57],"93":[58],"studies":[59],"were":[60],"included":[61],"in":[62,134],"the":[63],"final":[64],"synthesis.":[65],"We":[66,157],"organize":[67],"AMR":[68,161],"modeling":[69],"three":[71],"methodological":[72],"strata:":[73],"(i)":[74],"classical":[75],"interpretable":[77],"machine-learning":[78],"frameworks,":[79],"(ii)":[80],"structural":[81],"deep":[83],"genomic":[84,177],"architectures,":[85],"(iii)":[87],"transformer-based":[88],"applied":[90],"large":[91],"language":[92],"model":[93],"systems":[94,124,187],"that":[95,159],"integrate":[96,164],"genomic,":[97],"clinical,":[98],"epidemiological":[100],"signals.":[101],"Across":[102],"studies,":[103],"identify":[105],"four":[106],"converging":[107],"integrative":[108],"directions:":[109],"embedding-level":[110],"multimodal":[111],"fusion,":[112],"knowledge-graph-guided":[113],"causal":[114],"reasoning,":[115],"evolutionary":[116],"temporal":[118],"forecasting,":[119],"agentic":[121],"artificial":[122],"enabling":[125],"autonomous,":[126],"evidence-grounded":[127],"workflows.":[128],"Comparative":[129],"analysis":[130],"reveals":[131],"substantial":[132],"heterogeneity":[133],"dataset":[135],"scale,":[136],"frequent":[137],"reliance":[138],"on":[139],"internal":[140],"validation,":[141],"limited":[142],"assessment":[143],"cross-site":[145],"robustness,":[146],"vulnerability":[148],"distribution":[150],"shift,":[151],"particularly":[152],"for":[153],"minority":[154],"phenotypes.":[156],"argue":[158],"future":[160],"must":[163],"uncertainty-aware":[165],"modeling,":[166],"standardized":[167],"validation":[168],"protocols,":[169],"FAIR-compliant":[171],"infrastructures":[172],"transition":[174],"from":[175],"static":[176],"classification":[178],"toward":[179],"interpretable,":[180],"temporally":[181],"adaptive,":[182],"actionable":[185],"decision":[186],"within":[188],"One":[189],"Health":[190],"ecosystems.":[192]},"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-08-21T09:56:20.448147","created_date":"2026-05-12T00:00:00"}