{"id":"https://openalex.org/W4412077038","doi":"https://doi.org/10.1093/bib/bbag148","title":"Statistical knockoffs improve biomarker discovery from transcriptomic data","display_name":"Statistical knockoffs improve biomarker discovery from transcriptomic data","publication_year":2026,"publication_date":"2026-05-01","ids":{"openalex":"https://openalex.org/W4412077038","doi":"https://doi.org/10.1093/bib/bbag148","pmid":"https://pubmed.ncbi.nlm.nih.gov/42153762"},"language":"en","primary_location":{"id":"doi:10.1093/bib/bbag148","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbag148","pdf_url":null,"source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1093/bib/bbag148","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5043428774","display_name":"J. Cartier","orcid":null},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I2746051580","display_name":"Universit\u00e9 Paris Sciences et Lettres","ror":"https://ror.org/013cjyk83","country_code":"FR","type":"education","lineage":["https://openalex.org/I2746051580"]},{"id":"https://openalex.org/I39804081","display_name":"Sorbonne Universit\u00e9","ror":"https://ror.org/02en5vm52","country_code":"FR","type":"education","lineage":["https://openalex.org/I39804081"]},{"id":"https://openalex.org/I4210154688","display_name":"H\u00f4pital Saint-Michel","ror":"https://ror.org/057v2pg43","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210154688"]},{"id":"https://openalex.org/I70768539","display_name":"\u00c9cole Nationale Sup\u00e9rieure des Mines de Paris","ror":"https://ror.org/04y8cs423","country_code":"FR","type":"education","lineage":["https://openalex.org/I190752583","https://openalex.org/I2746051580","https://openalex.org/I70768539"]},{"id":"https://openalex.org/I80043","display_name":"Institut Curie","ror":"https://ror.org/04t0gwh46","country_code":"FR","type":"nonprofit","lineage":["https://openalex.org/I80043"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"Julie Cartier","raw_affiliation_strings":["Centre for Computational Biology, Mines Paris, PSL University , 60 bd Saint-Michel, 75272 Paris,","Institut Curie, PSL University, 11 rue Pierre et Marie Curie , 75005 Paris,","U1331, INSERM, 11 rue Pierre et Marie Curie , 75005 Paris,","CBIO - Centre de Bioinformatique (60, Boulevard Saint Michel, 75006 PARIS - France)","Centre for Computational Biology, MinesParis, PSL University, 60 bd Saint-Michel, 75272, Paris, France","Institut Curie, PSL University, 11 rue Pierre et Marie Curie, 75005, Paris, France","U11, INSERM, 11 rue Pierre et Marie Curie, 75005, Paris, France"],"raw_orcid":"https://orcid.org/0009-0006-7745-0634","affiliations":[{"raw_affiliation_string":"Centre for Computational Biology, Mines Paris, PSL University , 60 bd Saint-Michel, 75272 Paris,","institution_ids":["https://openalex.org/I2746051580","https://openalex.org/I70768539"]},{"raw_affiliation_string":"Institut Curie, PSL University, 11 rue Pierre et Marie Curie , 75005 Paris,","institution_ids":["https://openalex.org/I2746051580","https://openalex.org/I39804081","https://openalex.org/I80043"]},{"raw_affiliation_string":"U1331, INSERM, 11 rue Pierre et Marie Curie , 75005 Paris,","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I39804081"]},{"raw_affiliation_string":"CBIO - Centre de Bioinformatique (60, Boulevard Saint Michel, 75006 PARIS - France)","institution_ids":["https://openalex.org/I4210154688"]},{"raw_affiliation_string":"Centre for Computational Biology, MinesParis, PSL University, 60 bd Saint-Michel, 75272, Paris, France","institution_ids":["https://openalex.org/I2746051580","https://openalex.org/I70768539"]},{"raw_affiliation_string":"Institut Curie, PSL University, 11 rue Pierre et Marie Curie, 75005, Paris, France","institution_ids":["https://openalex.org/I2746051580","https://openalex.org/I39804081","https://openalex.org/I80043"]},{"raw_affiliation_string":"U11, INSERM, 11 rue Pierre et Marie Curie, 75005, Paris, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I39804081"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5118843337","display_name":"Johanna LAGOAS","orcid":null},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I22248866","display_name":"AgroParisTech","ror":"https://ror.org/02kbmgc12","country_code":"FR","type":"education","lineage":["https://openalex.org/I22248866","https://openalex.org/I277688954"]},{"id":"https://openalex.org/I2746051580","display_name":"Universit\u00e9 Paris Sciences et Lettres","ror":"https://ror.org/013cjyk83","country_code":"FR","type":"education","lineage":["https://openalex.org/I2746051580"]},{"id":"https://openalex.org/I277688954","display_name":"Universit\u00e9 Paris-Saclay","ror":"https://ror.org/03xjwb503","country_code":"FR","type":"education","lineage":["https://openalex.org/I277688954"]},{"id":"https://openalex.org/I39804081","display_name":"Sorbonne Universit\u00e9","ror":"https://ror.org/02en5vm52","country_code":"FR","type":"education","lineage":["https://openalex.org/I39804081"]},{"id":"https://openalex.org/I4210154688","display_name":"H\u00f4pital Saint-Michel","ror":"https://ror.org/057v2pg43","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210154688"]},{"id":"https://openalex.org/I70768539","display_name":"\u00c9cole Nationale Sup\u00e9rieure des Mines de Paris","ror":"https://ror.org/04y8cs423","country_code":"FR","type":"education","lineage":["https://openalex.org/I190752583","https://openalex.org/I2746051580","https://openalex.org/I70768539"]},{"id":"https://openalex.org/I80043","display_name":"Institut Curie","ror":"https://ror.org/04t0gwh46","country_code":"FR","type":"nonprofit","lineage":["https://openalex.org/I80043"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Johanna Lagoas","raw_affiliation_strings":["Centre for Computational Biology, Mines Paris, PSL University , 60 bd Saint-Michel, 75272 Paris,","Institut Curie, PSL University, 11 rue Pierre et Marie Curie , 75005 Paris,","U1331, INSERM, 11 rue Pierre et Marie Curie , 75005 Paris,","AgroParisTech, Paris-Saclay University, 22 place de l'Agronomie, 91123, Palaiseau, France","CBIO - Centre de Bioinformatique (60, Boulevard Saint Michel, 75006 PARIS - France)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Computational Biology, Mines Paris, PSL University , 60 bd Saint-Michel, 75272 Paris,","institution_ids":["https://openalex.org/I2746051580","https://openalex.org/I70768539"]},{"raw_affiliation_string":"Institut Curie, PSL University, 11 rue Pierre et Marie Curie , 75005 Paris,","institution_ids":["https://openalex.org/I2746051580","https://openalex.org/I39804081","https://openalex.org/I80043"]},{"raw_affiliation_string":"U1331, INSERM, 11 rue Pierre et Marie Curie , 75005 Paris,","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I39804081"]},{"raw_affiliation_string":"AgroParisTech, Paris-Saclay University, 22 place de l'Agronomie, 91123, Palaiseau, France","institution_ids":["https://openalex.org/I22248866","https://openalex.org/I277688954"]},{"raw_affiliation_string":"CBIO - Centre de Bioinformatique (60, Boulevard Saint Michel, 75006 PARIS - France)","institution_ids":["https://openalex.org/I4210154688"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5120543653","display_name":"Youmna AYADI","orcid":null},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I2746051580","display_name":"Universit\u00e9 Paris Sciences et Lettres","ror":"https://ror.org/013cjyk83","country_code":"FR","type":"education","lineage":["https://openalex.org/I2746051580"]},{"id":"https://openalex.org/I39804081","display_name":"Sorbonne Universit\u00e9","ror":"https://ror.org/02en5vm52","country_code":"FR","type":"education","lineage":["https://openalex.org/I39804081"]},{"id":"https://openalex.org/I70768539","display_name":"\u00c9cole Nationale Sup\u00e9rieure des Mines de Paris","ror":"https://ror.org/04y8cs423","country_code":"FR","type":"education","lineage":["https://openalex.org/I190752583","https://openalex.org/I2746051580","https://openalex.org/I70768539"]},{"id":"https://openalex.org/I80043","display_name":"Institut Curie","ror":"https://ror.org/04t0gwh46","country_code":"FR","type":"nonprofit","lineage":["https://openalex.org/I80043"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Youmna Ayadi","raw_affiliation_strings":["Centre for Computational Biology, Mines Paris, PSL University , 60 bd Saint-Michel, 75272 Paris,","Institut Curie, PSL University, 11 rue Pierre et Marie Curie , 75005 Paris,","U1331, INSERM, 11 rue Pierre et Marie Curie , 75005 Paris,","Califrais (France)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Computational Biology, Mines Paris, PSL University , 60 bd Saint-Michel, 75272 Paris,","institution_ids":["https://openalex.org/I2746051580","https://openalex.org/I70768539"]},{"raw_affiliation_string":"Institut Curie, PSL University, 11 rue Pierre et Marie Curie , 75005 Paris,","institution_ids":["https://openalex.org/I2746051580","https://openalex.org/I39804081","https://openalex.org/I80043"]},{"raw_affiliation_string":"U1331, INSERM, 11 rue Pierre et Marie Curie , 75005 Paris,","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I39804081"]},{"raw_affiliation_string":"Califrais (France)","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Adeline Fermanian","orcid":null},"institutions":[{"id":"https://openalex.org/I158043002","display_name":"Sofradir (France)","ror":"https://ror.org/00j681549","country_code":"FR","type":"company","lineage":["https://openalex.org/I158043002"]},{"id":"https://openalex.org/I4210154688","display_name":"H\u00f4pital Saint-Michel","ror":"https://ror.org/057v2pg43","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210154688"]},{"id":"https://openalex.org/I4210161110","display_name":"H\u00f4pital du Valais","ror":"https://ror.org/0579hyr20","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I4210161110"]}],"countries":["CH","FR"],"is_corresponding":false,"raw_author_name":"Adeline Fermanian","raw_affiliation_strings":["LOPF, LOPF Califrais\u2019Machine Learning Lab , 4 Quai du Val de Loire,\u00a094550 Chevilly Larue,","CBIO - Centre de Bioinformatique (60, Boulevard Saint Michel, 75006 PARIS - France)","LOPF, LOPF Califrais'Machine Learning Lab, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"LOPF, LOPF Califrais\u2019Machine Learning Lab , 4 Quai du Val de Loire,\u00a094550 Chevilly Larue,","institution_ids":["https://openalex.org/I4210161110"]},{"raw_affiliation_string":"CBIO - Centre de Bioinformatique (60, Boulevard Saint Michel, 75006 PARIS - France)","institution_ids":["https://openalex.org/I4210154688"]},{"raw_affiliation_string":"LOPF, LOPF Califrais'Machine Learning Lab, Paris, France","institution_ids":["https://openalex.org/I158043002"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114376683","display_name":"Chlo\u00e9\u2010Agathe Azencott","orcid":"https://orcid.org/0000-0003-1003-301X"},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I2746051580","display_name":"Universit\u00e9 Paris Sciences et Lettres","ror":"https://ror.org/013cjyk83","country_code":"FR","type":"education","lineage":["https://openalex.org/I2746051580"]},{"id":"https://openalex.org/I39804081","display_name":"Sorbonne Universit\u00e9","ror":"https://ror.org/02en5vm52","country_code":"FR","type":"education","lineage":["https://openalex.org/I39804081"]},{"id":"https://openalex.org/I4210113863","display_name":"G\u00e9nomique Bioinformatique et Applications","ror":"https://ror.org/0264vhs54","country_code":"FR","type":"facility","lineage":["https://openalex.org/I124158823","https://openalex.org/I4210113863","https://openalex.org/I4210134562"]},{"id":"https://openalex.org/I4210154688","display_name":"H\u00f4pital Saint-Michel","ror":"https://ror.org/057v2pg43","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210154688"]},{"id":"https://openalex.org/I4387153074","display_name":"Cancer et g\u00e9nome: Bioinformatique, biostatistiques et \u00e9pid\u00e9miologie des syst\u00e8mes complexes","ror":"https://ror.org/0095dt357","country_code":null,"type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I190752583","https://openalex.org/I2746051580","https://openalex.org/I2746051580","https://openalex.org/I4387153074","https://openalex.org/I70768539","https://openalex.org/I80043"]},{"id":"https://openalex.org/I70768539","display_name":"\u00c9cole Nationale Sup\u00e9rieure des Mines de Paris","ror":"https://ror.org/04y8cs423","country_code":"FR","type":"education","lineage":["https://openalex.org/I190752583","https://openalex.org/I2746051580","https://openalex.org/I70768539"]},{"id":"https://openalex.org/I80043","display_name":"Institut Curie","ror":"https://ror.org/04t0gwh46","country_code":"FR","type":"nonprofit","lineage":["https://openalex.org/I80043"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Chlo\u00e9-Agathe Azencott","raw_affiliation_strings":["Centre for Computational Biology, Mines Paris, PSL University , 60 bd Saint-Michel, 75272 Paris,","Institut Curie, PSL University, 11 rue Pierre et Marie Curie , 75005 Paris,","U1331, INSERM, 11 rue Pierre et Marie Curie , 75005 Paris,","CBIO - Centre de Bioinformatique (60, Boulevard Saint Michel, 75006 PARIS - France)","Cancer et g\u00e9nome: Bioinformatique, biostatistiques et \u00e9pid\u00e9miologie d'un syst\u00e8me complexe (26 rue d'Ulm - 75248 Paris cedex 05 - France)","Centre for Computational Biology, MinesParis, PSL University, 60 bd Saint-Michel, 75272, Paris, France","Institut Curie, PSL University, 11 rue Pierre et Marie Curie, 75005, Paris, France","U11, INSERM, 11 rue Pierre et Marie Curie, 75005, Paris, France"],"raw_orcid":"https://orcid.org/0000-0003-1003-301X","affiliations":[{"raw_affiliation_string":"Centre for Computational Biology, Mines Paris, PSL University , 60 bd Saint-Michel, 75272 Paris,","institution_ids":["https://openalex.org/I2746051580","https://openalex.org/I70768539"]},{"raw_affiliation_string":"Institut Curie, PSL University, 11 rue Pierre et Marie Curie , 75005 Paris,","institution_ids":["https://openalex.org/I2746051580","https://openalex.org/I39804081","https://openalex.org/I80043"]},{"raw_affiliation_string":"U1331, INSERM, 11 rue Pierre et Marie Curie , 75005 Paris,","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I39804081"]},{"raw_affiliation_string":"CBIO - Centre de Bioinformatique (60, Boulevard Saint Michel, 75006 PARIS - France)","institution_ids":["https://openalex.org/I4210154688"]},{"raw_affiliation_string":"Cancer et g\u00e9nome: Bioinformatique, biostatistiques et \u00e9pid\u00e9miologie d'un syst\u00e8me complexe (26 rue d'Ulm - 75248 Paris cedex 05 - France)","institution_ids":["https://openalex.org/I4210113863","https://openalex.org/I4387153074"]},{"raw_affiliation_string":"Centre for Computational Biology, MinesParis, PSL University, 60 bd Saint-Michel, 75272, Paris, France","institution_ids":["https://openalex.org/I2746051580","https://openalex.org/I70768539"]},{"raw_affiliation_string":"Institut Curie, PSL University, 11 rue Pierre et Marie Curie, 75005, Paris, France","institution_ids":["https://openalex.org/I2746051580","https://openalex.org/I39804081","https://openalex.org/I80043"]},{"raw_affiliation_string":"U11, INSERM, 11 rue Pierre et Marie Curie, 75005, Paris, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I39804081"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5090202113","display_name":"Florian Massip","orcid":"https://orcid.org/0000-0001-5855-0935"},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I2746051580","display_name":"Universit\u00e9 Paris Sciences et Lettres","ror":"https://ror.org/013cjyk83","country_code":"FR","type":"education","lineage":["https://openalex.org/I2746051580"]},{"id":"https://openalex.org/I39804081","display_name":"Sorbonne Universit\u00e9","ror":"https://ror.org/02en5vm52","country_code":"FR","type":"education","lineage":["https://openalex.org/I39804081"]},{"id":"https://openalex.org/I70768539","display_name":"\u00c9cole Nationale Sup\u00e9rieure des Mines de Paris","ror":"https://ror.org/04y8cs423","country_code":"FR","type":"education","lineage":["https://openalex.org/I190752583","https://openalex.org/I2746051580","https://openalex.org/I70768539"]},{"id":"https://openalex.org/I80043","display_name":"Institut Curie","ror":"https://ror.org/04t0gwh46","country_code":"FR","type":"nonprofit","lineage":["https://openalex.org/I80043"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"Florian Massip","raw_affiliation_strings":["Centre for Computational Biology, Mines Paris, PSL University , 60 bd Saint-Michel, 75272 Paris,","Institut Curie, PSL University, 11 rue Pierre et Marie Curie , 75005 Paris,","U1331, INSERM, 11 rue Pierre et Marie Curie , 75005 Paris,","Centre for Computational Biology, MinesParis, PSL University, 60 bd Saint-Michel, 75272, Paris, France","Institut Curie, PSL University, 11 rue Pierre et Marie Curie, 75005, Paris, France","U11, INSERM, 11 rue Pierre et Marie Curie, 75005, Paris, France"],"raw_orcid":"https://orcid.org/0000-0001-5855-0935","affiliations":[{"raw_affiliation_string":"Centre for Computational Biology, Mines Paris, PSL University , 60 bd Saint-Michel, 75272 Paris,","institution_ids":["https://openalex.org/I2746051580","https://openalex.org/I70768539"]},{"raw_affiliation_string":"Institut Curie, PSL University, 11 rue Pierre et Marie Curie , 75005 Paris,","institution_ids":["https://openalex.org/I2746051580","https://openalex.org/I39804081","https://openalex.org/I80043"]},{"raw_affiliation_string":"U1331, INSERM, 11 rue Pierre et Marie Curie , 75005 Paris,","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I39804081"]},{"raw_affiliation_string":"Centre for Computational Biology, MinesParis, PSL University, 60 bd Saint-Michel, 75272, Paris, France","institution_ids":["https://openalex.org/I2746051580","https://openalex.org/I70768539"]},{"raw_affiliation_string":"Institut Curie, PSL University, 11 rue Pierre et Marie Curie, 75005, Paris, France","institution_ids":["https://openalex.org/I2746051580","https://openalex.org/I39804081","https://openalex.org/I80043"]},{"raw_affiliation_string":"U11, INSERM, 11 rue Pierre et Marie Curie, 75005, Paris, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I39804081"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":12,"corresponding_author_ids":["https://openalex.org/A5043428774","https://openalex.org/A5090202113"],"corresponding_institution_ids":["https://openalex.org/I154526488","https://openalex.org/I2746051580","https://openalex.org/I39804081","https://openalex.org/I4210154688","https://openalex.org/I70768539","https://openalex.org/I80043"],"apc_list":{"value":3885,"currency":"USD","value_usd":3885},"apc_paid":{"value":3885,"currency":"USD","value_usd":3885},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.00372578,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"27","issue":"3","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.9991000294685364,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.9991000294685364,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12254","display_name":"Machine Learning in Bioinformatics","score":0.9890000224113464,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9857000112533569,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.515007495880127},{"id":"https://openalex.org/keywords/biomarker-discovery","display_name":"Biomarker discovery","score":0.503570020198822},{"id":"https://openalex.org/keywords/transcriptome","display_name":"Transcriptome","score":0.500516414642334},{"id":"https://openalex.org/keywords/data-science","display_name":"Data science","score":0.4774356782436371},{"id":"https://openalex.org/keywords/biomarker","display_name":"Biomarker","score":0.43166491389274597},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.3755277693271637},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.3295653462409973},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.15451759099960327},{"id":"https://openalex.org/keywords/proteomics","display_name":"Proteomics","score":0.11809533834457397}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.515007495880127},{"id":"https://openalex.org/C124535831","wikidata":"https://www.wikidata.org/wiki/Q4915074","display_name":"Biomarker discovery","level":4,"score":0.503570020198822},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.500516414642334},{"id":"https://openalex.org/C2522767166","wikidata":"https://www.wikidata.org/wiki/Q2374463","display_name":"Data science","level":1,"score":0.4774356782436371},{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.43166491389274597},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3755277693271637},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.3295653462409973},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.15451759099960327},{"id":"https://openalex.org/C46111723","wikidata":"https://www.wikidata.org/wiki/Q471857","display_name":"Proteomics","level":3,"score":0.11809533834457397},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D055106","descriptor_name":"Genome-Wide Association Study","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055106","descriptor_name":"Genome-Wide Association Study","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055106","descriptor_name":"Genome-Wide Association Study","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055106","descriptor_name":"Genome-Wide Association Study","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055106","descriptor_name":"Genome-Wide Association Study","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059467","descriptor_name":"Transcriptome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D059467","descriptor_name":"Transcriptome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D059467","descriptor_name":"Transcriptome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D059467","descriptor_name":"Transcriptome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D059467","descriptor_name":"Transcriptome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.1093/bib/bbag148","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbag148","pdf_url":null,"source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},{"id":"doi:10.1101/2025.07.04.663147","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2025.07.04.663147","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2025/07/07/2025.07.04.663147.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmid:42153762","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42153762","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in bioinformatics","raw_type":"Journal Article"},{"id":"pmh:oai:HAL:hal-05272631v1","is_oa":false,"landing_page_url":"https://minesparis-psl.hal.science/hal-05272631","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL (Le Centre pour la Communication Scientifique Directe)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1294671590","host_organization_name":"Centre National de la Recherche Scientifique","host_organization_lineage":["https://openalex.org/I1294671590"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"2025","raw_type":"info:eu-repo/semantics/preprint"},{"id":"pmh:oai:pubmedcentral.nih.gov:13184975","is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13184975/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Brief Bioinform","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1093/bib/bbag148","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbag148","pdf_url":null,"source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G3010527862","display_name":null,"funder_award_id":"ANR\u201019","funder_id":"https://openalex.org/F4320320883","funder_display_name":"Agence Nationale de la Recherche"},{"id":"https://openalex.org/G5838787665","display_name":"PaRis Artificial Intelligence Research InstitutE","funder_award_id":"ANR-19-P3IA-0001","funder_id":"https://openalex.org/F4320320883","funder_display_name":"Agence Nationale de la Recherche"}],"funders":[{"id":"https://openalex.org/F4320319985","display_name":"Cancer Research UK","ror":"https://ror.org/054225q67"},{"id":"https://openalex.org/F4320320883","display_name":"Agence Nationale de la Recherche","ror":"https://ror.org/00rbzpz17"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":27,"referenced_works":["https://openalex.org/W1977868384","https://openalex.org/W2109177042","https://openalex.org/W2146739527","https://openalex.org/W2153491803","https://openalex.org/W2157132621","https://openalex.org/W2593485618","https://openalex.org/W2625479840","https://openalex.org/W2749613778","https://openalex.org/W2792135005","https://openalex.org/W2891979008","https://openalex.org/W2901837190","https://openalex.org/W2907070554","https://openalex.org/W2947402981","https://openalex.org/W2952631895","https://openalex.org/W2963371845","https://openalex.org/W2982140687","https://openalex.org/W3089311484","https://openalex.org/W3106936777","https://openalex.org/W3109708108","https://openalex.org/W3120816783","https://openalex.org/W3204813719","https://openalex.org/W4221068576","https://openalex.org/W4282978140","https://openalex.org/W4294541781","https://openalex.org/W4387725146","https://openalex.org/W4394578001","https://openalex.org/W4403891771"],"related_works":["https://openalex.org/W112583468","https://openalex.org/W96119380","https://openalex.org/W3023706879","https://openalex.org/W4298030740","https://openalex.org/W4404588215","https://openalex.org/W2108949684","https://openalex.org/W1965976436","https://openalex.org/W2012655824","https://openalex.org/W3177170977","https://openalex.org/W2326771431"],"abstract_inverted_index":{"Advances":[0],"in":[1,73,127,149],"sequencing":[2],"technologies":[3],"have":[4],"enabled":[5],"the":[6,42,49,53,61,64,75,98,104,111,118,121,143,146,150,158,174,183,193,212],"generation":[7],"of":[8,11,52,63,120,145,152,176,214],"large":[9],"amounts":[10],"data,":[12,87],"offering":[13],"new":[14],"possibilities":[15],"to":[16,41,96,141,172,188],"identify":[17,97],"relationships":[18],"between":[19,107],"biological":[20,86],"units":[21],"(e.g.":[22,27],"genes)":[23],"and":[24,48,71,167,204],"phenotypic":[25],"traits":[26],"disease":[28],"outcomes).":[29],"Yet,":[30],"identifying":[31],"these":[32,57],"associations":[33],"using":[34,137,169],"variable":[35,77,164],"selection":[36,78,165],"methods":[37,208],"remains":[38],"challenging":[39],"due":[40],"high":[43],"dimension":[44],"($p":[45],"\\gg":[46],"n$)":[47],"correlation":[50,105],"structure":[51,106],"data.":[54],"To":[55],"address":[56],"challenges,":[58],"we":[59,116],"study":[60,117,136],"applicability":[62,119],"knockoff":[65],"(KO)":[66],"procedure.":[67],"Introduced":[68],"by":[69,102],"Barber":[70],"Cand\u00e8s":[72],"2015,":[74],"KO":[76,122,147,159,170,177,194],"procedure":[79,123],"has":[80],"shown":[81],"promising":[82],"results":[83],"on":[84,124],"real":[85,138,190],"such":[88],"as":[89],"Genome-Wide":[90],"Association":[91],"Studies.":[92],"This":[93],"method":[94],"seeks":[95],"truly":[99],"important":[100],"predictors":[101],"overcoming":[103],"variables":[108],"while":[109,181],"controlling":[110],"false":[112],"discovery":[113],"rate.":[114],"Here,":[115],"transcriptomic":[125,139,191],"data":[126,140],"a":[128],"classification":[129],"setting.":[130],"We":[131,155],"conduct":[132],"an":[133],"extensive":[134],"simulation":[135],"evaluate":[142],"performance":[144],"framework":[148,160,195],"context":[151],"high-dimensional":[153],"classification.":[154],"find":[156],"that":[157,168,206],"outperforms":[161],"widely":[162],"used":[163],"models,":[166],"aggregation":[171],"mitigate":[173],"effect":[175],"stochasticity":[178],"improves":[179],"stability":[180],"maintaining":[182],"same":[184],"power.":[185],"Finally,":[186],"applied":[187],"three":[189],"datasets,":[192],"made":[196],"very":[197],"few":[198],"discoveries,":[199],"highlighting":[200],"its":[201],"conservative":[202],"nature":[203],"suggesting":[205],"other":[207],"may":[209],"substantially":[210],"overestimate":[211],"number":[213],"relevant":[215],"features.":[216]},"counts_by_year":[],"updated_date":"2026-08-21T09:56:20.448147","created_date":"2025-10-10T00:00:00"}