{"id":"https://openalex.org/W7134814210","doi":"https://doi.org/10.1093/bib/bbag103","title":"An integrative association analysis for complex diseases in underrepresented groups by leveraging the trans-ethnic genetic similarity","display_name":"An integrative association analysis for complex diseases in underrepresented groups by leveraging the trans-ethnic genetic similarity","publication_year":2026,"publication_date":"2026-02-16","ids":{"openalex":"https://openalex.org/W7134814210","doi":"https://doi.org/10.1093/bib/bbag103","pmid":"https://pubmed.ncbi.nlm.nih.gov/41802284"},"language":"en","primary_location":{"id":"doi:10.1093/bib/bbag103","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbag103","pdf_url":null,"source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1093/bib/bbag103","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5128637247","display_name":"Shuo Zhang","orcid":null},"institutions":[{"id":"https://openalex.org/I177388780","display_name":"Xuzhou Medical College","ror":"https://ror.org/04fe7hy80","country_code":"CN","type":"education","lineage":["https://openalex.org/I177388780"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Shuo Zhang","raw_affiliation_strings":["Department of Biostatistics , School of Public Health, Xuzhou Medical University, No. 209 Tongshan Road, Yunlong District, Xuzhou, Jiangsu 221004,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biostatistics , School of Public Health, Xuzhou Medical University, No. 209 Tongshan Road, Yunlong District, Xuzhou, Jiangsu 221004,","institution_ids":["https://openalex.org/I177388780"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101283596","display_name":"Jike Qi","orcid":null},"institutions":[{"id":"https://openalex.org/I177388780","display_name":"Xuzhou Medical College","ror":"https://ror.org/04fe7hy80","country_code":"CN","type":"education","lineage":["https://openalex.org/I177388780"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jike Qi","raw_affiliation_strings":["Department of Biostatistics , School of Public Health, Xuzhou Medical University, No. 209 Tongshan Road, Yunlong District, Xuzhou, Jiangsu 221004,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biostatistics , School of Public Health, Xuzhou Medical University, No. 209 Tongshan Road, Yunlong District, Xuzhou, Jiangsu 221004,","institution_ids":["https://openalex.org/I177388780"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063124087","display_name":"Yue Jiang","orcid":"https://orcid.org/0000-0003-0024-0605"},"institutions":[{"id":"https://openalex.org/I177388780","display_name":"Xuzhou Medical College","ror":"https://ror.org/04fe7hy80","country_code":"CN","type":"education","lineage":["https://openalex.org/I177388780"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yuchen Jiang","raw_affiliation_strings":["Department of Biostatistics , School of Public Health, Xuzhou Medical University, No. 209 Tongshan Road, Yunlong District, Xuzhou, Jiangsu 221004,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biostatistics , School of Public Health, Xuzhou Medical University, No. 209 Tongshan Road, Yunlong District, Xuzhou, Jiangsu 221004,","institution_ids":["https://openalex.org/I177388780"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089395588","display_name":"Hua Lin","orcid":"https://orcid.org/0000-0001-5393-0322"},"institutions":[{"id":"https://openalex.org/I177388780","display_name":"Xuzhou Medical College","ror":"https://ror.org/04fe7hy80","country_code":"CN","type":"education","lineage":["https://openalex.org/I177388780"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hua Lin","raw_affiliation_strings":["Department of Biostatistics , School of Public Health, Xuzhou Medical University, No. 209 Tongshan Road, Yunlong District, Xuzhou, Jiangsu 221004,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biostatistics , School of Public Health, Xuzhou Medical University, No. 209 Tongshan Road, Yunlong District, Xuzhou, Jiangsu 221004,","institution_ids":["https://openalex.org/I177388780"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103077450","display_name":"Xinyi Wang","orcid":"https://orcid.org/0000-0003-4255-6595"},"institutions":[{"id":"https://openalex.org/I177388780","display_name":"Xuzhou Medical College","ror":"https://ror.org/04fe7hy80","country_code":"CN","type":"education","lineage":["https://openalex.org/I177388780"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xinyi Wang","raw_affiliation_strings":["Department of Biostatistics , School of Public Health, Xuzhou Medical University, No. 209 Tongshan Road, Yunlong District, Xuzhou, Jiangsu 221004,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biostatistics , School of Public Health, Xuzhou Medical University, No. 209 Tongshan Road, Yunlong District, Xuzhou, Jiangsu 221004,","institution_ids":["https://openalex.org/I177388780"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5128677795","display_name":"Ting Wang","orcid":null},"institutions":[{"id":"https://openalex.org/I177388780","display_name":"Xuzhou Medical College","ror":"https://ror.org/04fe7hy80","country_code":"CN","type":"education","lineage":["https://openalex.org/I177388780"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ting Wang","raw_affiliation_strings":["Department of Biostatistics , School of Public Health, Xuzhou Medical University, No. 209 Tongshan Road, Yunlong District, Xuzhou, Jiangsu 221004,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biostatistics , School of Public Health, Xuzhou Medical University, No. 209 Tongshan Road, Yunlong District, Xuzhou, Jiangsu 221004,","institution_ids":["https://openalex.org/I177388780"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5128643352","display_name":"Hongyan Cao","orcid":null},"institutions":[{"id":"https://openalex.org/I17721919","display_name":"Shanxi Medical University","ror":"https://ror.org/0265d1010","country_code":"CN","type":"education","lineage":["https://openalex.org/I17721919"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hongyan Cao","raw_affiliation_strings":["Department of Health Statistics , Shanxi Provincial Key Laboratory of Major Diseases Risk Assessment, School of Public Health, Shanxi Medical Unive rsity, No. 56 South Xinjian Road, Yingze District, Taiyuan, Shanxi 030001,"],"raw_orcid":"https://orcid.org/0000-0002-0315-7156","affiliations":[{"raw_affiliation_string":"Department of Health Statistics , Shanxi Provincial Key Laboratory of Major Diseases Risk Assessment, School of Public Health, Shanxi Medical Unive rsity, No. 56 South Xinjian Road, Yingze District, Taiyuan, Shanxi 030001,","institution_ids":["https://openalex.org/I17721919"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5128687872","display_name":"Ping Zeng","orcid":null},"institutions":[{"id":"https://openalex.org/I177388780","display_name":"Xuzhou Medical College","ror":"https://ror.org/04fe7hy80","country_code":"CN","type":"education","lineage":["https://openalex.org/I177388780"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ping Zeng","raw_affiliation_strings":["Department of Biostatistics , School of Public Health, Xuzhou Medical University, No. 209 Tongshan Road, Yunlong District, Xuzhou, Jiangsu 221004,","Jiangsu Engineering Research Center of Biological Data Mining and Healthcare Transformation , Xuzhou Medical University, No. 209 Tongshan Road, Yunlong District, Xuzhou, Jiangsu 221004,"],"raw_orcid":"https://orcid.org/0000-0003-2710-3440","affiliations":[{"raw_affiliation_string":"Department of Biostatistics , School of Public Health, Xuzhou Medical University, No. 209 Tongshan Road, Yunlong District, Xuzhou, Jiangsu 221004,","institution_ids":["https://openalex.org/I177388780"]},{"raw_affiliation_string":"Jiangsu Engineering Research Center of Biological Data Mining and Healthcare Transformation , Xuzhou Medical University, No. 209 Tongshan Road, Yunlong District, Xuzhou, Jiangsu 221004,","institution_ids":["https://openalex.org/I177388780"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":8,"corresponding_author_ids":["https://openalex.org/A5128637247"],"corresponding_institution_ids":["https://openalex.org/I177388780"],"apc_list":{"value":4011,"currency":"USD","value_usd":4011},"apc_paid":{"value":4011,"currency":"USD","value_usd":4011},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.54434327,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"27","issue":"2","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.9980999827384949,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.9980999827384949,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11577","display_name":"Cognitive Abilities and Testing","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/3205","display_name":"Experimental and Cognitive Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T10594","display_name":"Genetic and phenotypic traits in livestock","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/biobank","display_name":"Biobank","score":0.8633999824523926},{"id":"https://openalex.org/keywords/robustness","display_name":"Robustness (evolution)","score":0.6265000104904175},{"id":"https://openalex.org/keywords/genetic-association","display_name":"Genetic association","score":0.5690000057220459},{"id":"https://openalex.org/keywords/association-test","display_name":"Association test","score":0.5228999853134155},{"id":"https://openalex.org/keywords/similarity","display_name":"Similarity (geometry)","score":0.492000013589859},{"id":"https://openalex.org/keywords/genome-wide-association-study","display_name":"Genome-wide association study","score":0.48420000076293945},{"id":"https://openalex.org/keywords/genetic-similarity","display_name":"Genetic similarity","score":0.4523000121116638},{"id":"https://openalex.org/keywords/snp","display_name":"SNP","score":0.4275999963283539},{"id":"https://openalex.org/keywords/type-i-and-type-ii-errors","display_name":"Type I and type II errors","score":0.38519999384880066}],"concepts":[{"id":"https://openalex.org/C116567970","wikidata":"https://www.wikidata.org/wiki/Q864217","display_name":"Biobank","level":2,"score":0.8633999824523926},{"id":"https://openalex.org/C63479239","wikidata":"https://www.wikidata.org/wiki/Q7353546","display_name":"Robustness (evolution)","level":3,"score":0.6265000104904175},{"id":"https://openalex.org/C186413461","wikidata":"https://www.wikidata.org/wiki/Q744727","display_name":"Genetic association","level":5,"score":0.5690000057220459},{"id":"https://openalex.org/C2994538360","wikidata":"https://www.wikidata.org/wiki/Q774081","display_name":"Association test","level":5,"score":0.5228999853134155},{"id":"https://openalex.org/C103278499","wikidata":"https://www.wikidata.org/wiki/Q254465","display_name":"Similarity (geometry)","level":3,"score":0.492000013589859},{"id":"https://openalex.org/C106208931","wikidata":"https://www.wikidata.org/wiki/Q1098876","display_name":"Genome-wide association study","level":5,"score":0.48420000076293945},{"id":"https://openalex.org/C2992929089","wikidata":"https://www.wikidata.org/wiki/Q748695","display_name":"Genetic similarity","level":4,"score":0.4523000121116638},{"id":"https://openalex.org/C139275648","wikidata":"https://www.wikidata.org/wiki/Q17134011","display_name":"SNP","level":5,"score":0.4275999963283539},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.421099990606308},{"id":"https://openalex.org/C40696583","wikidata":"https://www.wikidata.org/wiki/Q989120","display_name":"Type I and type II errors","level":2,"score":0.38519999384880066},{"id":"https://openalex.org/C142853389","wikidata":"https://www.wikidata.org/wiki/Q744778","display_name":"Association (psychology)","level":2,"score":0.3677999973297119},{"id":"https://openalex.org/C188198153","wikidata":"https://www.wikidata.org/wiki/Q1613840","display_name":"Limiting","level":2,"score":0.36419999599456787},{"id":"https://openalex.org/C68873052","wikidata":"https://www.wikidata.org/wiki/Q349856","display_name":"Genetic variation","level":3,"score":0.3560999929904938},{"id":"https://openalex.org/C96608239","wikidata":"https://www.wikidata.org/wiki/Q1199823","display_name":"Statistical power","level":2,"score":0.3452000021934509},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.34220001101493835},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3179999887943268},{"id":"https://openalex.org/C2992519594","wikidata":"https://www.wikidata.org/wiki/Q870433","display_name":"Genetic model","level":3,"score":0.3156000077724457},{"id":"https://openalex.org/C2993967602","wikidata":"https://www.wikidata.org/wiki/Q5532932","display_name":"Genetic variants","level":4,"score":0.3147999942302704},{"id":"https://openalex.org/C89611455","wikidata":"https://www.wikidata.org/wiki/Q6804646","display_name":"Mechanism (biology)","level":2,"score":0.311599999666214},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.30790001153945923},{"id":"https://openalex.org/C40583040","wikidata":"https://www.wikidata.org/wiki/Q1502105","display_name":"Human genetic variation","level":5,"score":0.305400013923645},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.30230000615119934},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.2978000044822693},{"id":"https://openalex.org/C2776085556","wikidata":"https://www.wikidata.org/wiki/Q183361","display_name":"Chen","level":2,"score":0.29750001430511475},{"id":"https://openalex.org/C89128539","wikidata":"https://www.wikidata.org/wiki/Q1949963","display_name":"Statistic","level":2,"score":0.2849999964237213},{"id":"https://openalex.org/C2993807623","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genetic data","level":3,"score":0.2759000062942505},{"id":"https://openalex.org/C91682802","wikidata":"https://www.wikidata.org/wiki/Q620538","display_name":"Multidimensional scaling","level":2,"score":0.27129998803138733},{"id":"https://openalex.org/C111442797","wikidata":"https://www.wikidata.org/wiki/Q7291446","display_name":"Rand index","level":3,"score":0.2572999894618988},{"id":"https://openalex.org/C87007009","wikidata":"https://www.wikidata.org/wiki/Q210832","display_name":"Statistical hypothesis testing","level":2,"score":0.25459998846054077},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.25119999051094055}],"mesh":[{"descriptor_ui":"D005006","descriptor_name":"Ethnicity","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D005006","descriptor_name":"Ethnicity","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D044465","descriptor_name":"White People","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D044465","descriptor_name":"White People","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D044466","descriptor_name":"Asian People","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D044466","descriptor_name":"Asian People","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D055106","descriptor_name":"Genome-Wide Association Study","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D055106","descriptor_name":"Genome-Wide Association Study","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1093/bib/bbag103","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbag103","pdf_url":null,"source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},{"id":"pmid:41802284","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41802284","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in bioinformatics","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:12971055","is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12971055/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Brief Bioinform","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1093/bib/bbag103","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbag103","pdf_url":null,"source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G2010934636","display_name":null,"funder_award_id":"82574203","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G6109285545","display_name":null,"funder_award_id":"82173630","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":94,"referenced_works":["https://openalex.org/W1533942137","https://openalex.org/W1574244515","https://openalex.org/W1847429134","https://openalex.org/W1975909559","https://openalex.org/W1978145421","https://openalex.org/W1985417036","https://openalex.org/W1993893889","https://openalex.org/W2003283154","https://openalex.org/W2054164742","https://openalex.org/W2060270800","https://openalex.org/W2095829498","https://openalex.org/W2101605059","https://openalex.org/W2104902006","https://openalex.org/W2117904018","https://openalex.org/W2131142658","https://openalex.org/W2133107210","https://openalex.org/W2136967659","https://openalex.org/W2152095543","https://openalex.org/W2152982969","https://openalex.org/W2163953557","https://openalex.org/W2195783463","https://openalex.org/W2438256301","https://openalex.org/W2466079708","https://openalex.org/W2531587846","https://openalex.org/W2553123256","https://openalex.org/W2598022332","https://openalex.org/W2725988230","https://openalex.org/W2750937220","https://openalex.org/W2759086237","https://openalex.org/W2763645739","https://openalex.org/W2769205163","https://openalex.org/W2770092353","https://openalex.org/W2783602503","https://openalex.org/W2789833091","https://openalex.org/W2802367710","https://openalex.org/W2883415719","https://openalex.org/W2889418962","https://openalex.org/W2895486342","https://openalex.org/W2898134536","https://openalex.org/W2907099021","https://openalex.org/W2922534626","https://openalex.org/W2932671560","https://openalex.org/W2944545583","https://openalex.org/W2950565052","https://openalex.org/W2951230144","https://openalex.org/W2951393041","https://openalex.org/W2952013316","https://openalex.org/W2955214642","https://openalex.org/W2963920902","https://openalex.org/W3009980214","https://openalex.org/W3010089023","https://openalex.org/W3026380245","https://openalex.org/W3033304694","https://openalex.org/W3046567422","https://openalex.org/W3049154296","https://openalex.org/W3129698543","https://openalex.org/W3158903754","https://openalex.org/W3166269789","https://openalex.org/W3177062225","https://openalex.org/W3202209876","https://openalex.org/W3203332356","https://openalex.org/W3205412600","https://openalex.org/W3205693805","https://openalex.org/W4200493506","https://openalex.org/W4210420136","https://openalex.org/W4211005061","https://openalex.org/W4220711675","https://openalex.org/W4220711829","https://openalex.org/W4291019306","https://openalex.org/W4293569112","https://openalex.org/W4296806669","https://openalex.org/W4304698823","https://openalex.org/W4305013890","https://openalex.org/W4315644439","https://openalex.org/W4317390883","https://openalex.org/W4380362767","https://openalex.org/W4380480171","https://openalex.org/W4380730560","https://openalex.org/W4381158079","https://openalex.org/W4384925653","https://openalex.org/W4385628946","https://openalex.org/W4386136485","https://openalex.org/W4390345401","https://openalex.org/W4390501120","https://openalex.org/W4390588003","https://openalex.org/W4390614142","https://openalex.org/W4392615468","https://openalex.org/W4405425234","https://openalex.org/W4406238226","https://openalex.org/W4407108196","https://openalex.org/W4407190443","https://openalex.org/W4407229335","https://openalex.org/W4411428667","https://openalex.org/W4413020599"],"related_works":[],"abstract_inverted_index":{"Genome-wide":[0],"association":[1,38,174],"studies":[2],"(GWASs)":[3],"have":[4,25],"been":[5],"conducted":[6],"primarily":[7],"in":[8,41,74,159],"European":[9],"(EUR)":[10],"populations,":[11,43],"limiting":[12],"insights":[13],"into":[14],"underrepresented":[15],"groups":[16],"such":[17,150],"as":[18,64],"East":[19],"Asian":[20],"(EAS),":[21],"but":[22],"cross-ancestry":[23],"GWASs":[24],"demonstrated":[26],"high":[27],"trans-ethnic":[28,55],"genetic":[29,56,72,102,132,186],"similarity":[30,57],"between":[31,188],"EUR":[32,63,136],"and":[33,76,95,113,169,179,191],"non-EUR":[34],"populations.":[35,193],"To":[36],"enhance":[37],"analysis":[39,175],"power":[40,98],"EAS":[42],"we":[44],"propose":[45],"tranScore,":[46],"a":[47,167],"novel":[48],"summary-statistics-based":[49],"transfer":[50,182],"learning":[51,183],"method":[52],"that":[53,86],"leverages":[54],"through":[58,181],"hierarchical":[59],"modeling.":[60],"By":[61],"considering":[62],"auxiliary":[65,75,190],"population,":[66,137],"tranScore":[67,87,138,165],"performs":[68],"joint":[69],"testing":[70],"of":[71,90,120,134,154,176,184],"effects":[73],"target":[77,192],"populations":[78],"via":[79],"well-established":[80],"P-value":[81],"combination":[82],"procedures.":[83],"Simulations":[84],"demonstrate":[85],"maintains":[88],"control":[89],"type":[91],"I":[92],"error":[93],"rates":[94],"provides":[96],"substantial":[97],"gains":[99],"for":[100,173],"diverse":[101],"architectures,":[103],"showing":[104],"robustness":[105],"against":[106],"various":[107],"challenges":[108],"including":[109],"incomplete":[110],"SNP":[111],"overlap":[112],"effect":[114],"heterogeneity.":[115],"In":[116],"the":[117,124,131,135,144,160,189],"real-data":[118],"application":[119],"eight":[121],"diseases":[122,178],"from":[123],"China":[125],"Kadoorie":[126],"Biobank":[127,161],"(CKB),":[128],"after":[129],"incorporating":[130],"information":[133],"identified":[139],"significantly":[140],"more":[141],"genes":[142,156],"than":[143],"traditional":[145],"score":[146],"test":[147],"which":[148],"ignored":[149],"information.":[151],"Approximately":[152],"41.9%":[153],"discovered":[155],"were":[157],"replicated":[158],"Japan":[162],"cohort.":[163],"Overall,":[164],"represents":[166],"flexible":[168],"powerful":[170],"statistical":[171],"approach":[172],"complex":[177],"traits":[180],"shared":[185],"similarities":[187]},"counts_by_year":[],"updated_date":"2026-03-11T06:17:14.884878","created_date":"2026-03-11T00:00:00"}
