{"id":"https://openalex.org/W7121228036","doi":"https://doi.org/10.1093/bib/bbaf711","title":"UBD: incorporating uncertainty in cell type proportion estimates from bulk samples to infer cell-type-specific profiles","display_name":"UBD: incorporating uncertainty in cell type proportion estimates from bulk samples to infer cell-type-specific profiles","publication_year":2026,"publication_date":"2026-01-01","ids":{"openalex":"https://openalex.org/W7121228036","doi":"https://doi.org/10.1093/bib/bbaf711","pmid":"https://pubmed.ncbi.nlm.nih.gov/41520227"},"language":"en","primary_location":{"id":"doi:10.1093/bib/bbaf711","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbaf711","pdf_url":"https://academic.oup.com/bib/article-pdf/27/1/bbaf711/66342054/bbaf711.pdf","source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://academic.oup.com/bib/article-pdf/27/1/bbaf711/66342054/bbaf711.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5021482512","display_name":"Youshu Cheng","orcid":"https://orcid.org/0009-0006-6398-2082"},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]},{"id":"https://openalex.org/I4210086971","display_name":"VA Connecticut Healthcare System","ror":"https://ror.org/000rgm762","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210086971","https://openalex.org/I4210095851"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Youshu Cheng","raw_affiliation_strings":["Department of Biostatistics, Yale School of Public Health , 47 College St, New Haven, CT 06510 ,","VA Connecticut Healthcare System , 950 Campbell Ave, West Haven, CT 06516 ,"],"raw_orcid":"https://orcid.org/0009-0006-6398-2082","affiliations":[{"raw_affiliation_string":"Department of Biostatistics, Yale School of Public Health , 47 College St, New Haven, CT 06510 ,","institution_ids":["https://openalex.org/I32971472"]},{"raw_affiliation_string":"VA Connecticut Healthcare System , 950 Campbell Ave, West Haven, CT 06516 ,","institution_ids":["https://openalex.org/I4210086971"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101777221","display_name":"Chen Lin","orcid":"https://orcid.org/0000-0001-9821-2578"},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chen Lin","raw_affiliation_strings":["Department of Biostatistics, Yale School of Public Health , 47 College St, New Haven, CT 06510 ,"],"raw_orcid":"https://orcid.org/0000-0001-9821-2578","affiliations":[{"raw_affiliation_string":"Department of Biostatistics, Yale School of Public Health , 47 College St, New Haven, CT 06510 ,","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100402314","display_name":"Hongyu Li","orcid":"https://orcid.org/0000-0003-4736-7857"},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hongyu Li","raw_affiliation_strings":["Department of Biostatistics, Yale School of Public Health , 47 College St, New Haven, CT 06510 ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biostatistics, Yale School of Public Health , 47 College St, New Haven, CT 06510 ,","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5122725103","display_name":"Ke Xu","orcid":null},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]},{"id":"https://openalex.org/I4210086971","display_name":"VA Connecticut Healthcare System","ror":"https://ror.org/000rgm762","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210086971","https://openalex.org/I4210095851"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ke Xu","raw_affiliation_strings":["Department of Psychiatry, Yale School of Medicine , 300 George St, New Haven, CT 06510 ,","VA Connecticut Healthcare System , 950 Campbell Ave, West Haven, CT 06516 ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry, Yale School of Medicine , 300 George St, New Haven, CT 06510 ,","institution_ids":["https://openalex.org/I32971472"]},{"raw_affiliation_string":"VA Connecticut Healthcare System , 950 Campbell Ave, West Haven, CT 06516 ,","institution_ids":["https://openalex.org/I4210086971"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110688847","display_name":"H. Zhao","orcid":null},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]},{"id":"https://openalex.org/I4210086971","display_name":"VA Connecticut Healthcare System","ror":"https://ror.org/000rgm762","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210086971","https://openalex.org/I4210095851"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hongyu Zhao","raw_affiliation_strings":["Department of Biostatistics, Yale School of Public Health , 47 College St, New Haven, CT 06510 ,","VA Connecticut Healthcare System , 950 Campbell Ave, West Haven, CT 06516 ,"],"raw_orcid":"https://orcid.org/0000-0003-1195-9607","affiliations":[{"raw_affiliation_string":"Department of Biostatistics, Yale School of Public Health , 47 College St, New Haven, CT 06510 ,","institution_ids":["https://openalex.org/I32971472"]},{"raw_affiliation_string":"VA Connecticut Healthcare System , 950 Campbell Ave, West Haven, CT 06516 ,","institution_ids":["https://openalex.org/I4210086971"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5021482512"],"corresponding_institution_ids":["https://openalex.org/I32971472","https://openalex.org/I4210086971"],"apc_list":{"value":4011,"currency":"USD","value_usd":4011},"apc_paid":{"value":4011,"currency":"USD","value_usd":4011},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.06161137,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"27","issue":"1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12859","display_name":"Cell Image Analysis Techniques","score":0.6201000213623047,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12859","display_name":"Cell Image Analysis Techniques","score":0.6201000213623047,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11289","display_name":"Single-cell and spatial transcriptomics","score":0.27649998664855957,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.011699999682605267,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/deconvolution","display_name":"Deconvolution","score":0.9221000075340271},{"id":"https://openalex.org/keywords/bayesian-probability","display_name":"Bayesian probability","score":0.574400007724762},{"id":"https://openalex.org/keywords/type","display_name":"Type (biology)","score":0.5375000238418579},{"id":"https://openalex.org/keywords/ground-truth","display_name":"Ground truth","score":0.4765999913215637},{"id":"https://openalex.org/keywords/uncertainty-quantification","display_name":"Uncertainty quantification","score":0.4733000099658966},{"id":"https://openalex.org/keywords/prior-information","display_name":"Prior information","score":0.4203000068664551},{"id":"https://openalex.org/keywords/estimation-theory","display_name":"Estimation theory","score":0.40389999747276306},{"id":"https://openalex.org/keywords/statistical-model","display_name":"Statistical model","score":0.34200000762939453},{"id":"https://openalex.org/keywords/estimation","display_name":"Estimation","score":0.3301999866962433}],"concepts":[{"id":"https://openalex.org/C174576160","wikidata":"https://www.wikidata.org/wiki/Q1183700","display_name":"Deconvolution","level":2,"score":0.9221000075340271},{"id":"https://openalex.org/C107673813","wikidata":"https://www.wikidata.org/wiki/Q812534","display_name":"Bayesian probability","level":2,"score":0.574400007724762},{"id":"https://openalex.org/C2777299769","wikidata":"https://www.wikidata.org/wiki/Q3707858","display_name":"Type (biology)","level":2,"score":0.5375000238418579},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4968999922275543},{"id":"https://openalex.org/C146849305","wikidata":"https://www.wikidata.org/wiki/Q370766","display_name":"Ground truth","level":2,"score":0.4765999913215637},{"id":"https://openalex.org/C32230216","wikidata":"https://www.wikidata.org/wiki/Q7882499","display_name":"Uncertainty quantification","level":2,"score":0.4733000099658966},{"id":"https://openalex.org/C186060115","wikidata":"https://www.wikidata.org/wiki/Q30336093","display_name":"Biological system","level":1,"score":0.43639999628067017},{"id":"https://openalex.org/C3020402766","wikidata":"https://www.wikidata.org/wiki/Q104376712","display_name":"Prior information","level":2,"score":0.4203000068664551},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.4133000075817108},{"id":"https://openalex.org/C167928553","wikidata":"https://www.wikidata.org/wiki/Q1376021","display_name":"Estimation theory","level":2,"score":0.40389999747276306},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.3587999939918518},{"id":"https://openalex.org/C11413529","wikidata":"https://www.wikidata.org/wiki/Q8366","display_name":"Algorithm","level":1,"score":0.34929999709129333},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.3434999883174896},{"id":"https://openalex.org/C114289077","wikidata":"https://www.wikidata.org/wiki/Q3284399","display_name":"Statistical model","level":2,"score":0.34200000762939453},{"id":"https://openalex.org/C96250715","wikidata":"https://www.wikidata.org/wiki/Q965330","display_name":"Estimation","level":2,"score":0.3301999866962433},{"id":"https://openalex.org/C68022304","wikidata":"https://www.wikidata.org/wiki/Q842217","display_name":"Bayes estimator","level":3,"score":0.3095000088214874},{"id":"https://openalex.org/C2986587452","wikidata":"https://www.wikidata.org/wiki/Q938438","display_name":"Statistical analysis","level":2,"score":0.3059000074863434},{"id":"https://openalex.org/C153180895","wikidata":"https://www.wikidata.org/wiki/Q7148389","display_name":"Pattern recognition (psychology)","level":2,"score":0.29409998655319214},{"id":"https://openalex.org/C2984074130","wikidata":"https://www.wikidata.org/wiki/Q73539779","display_name":"R package","level":2,"score":0.29179999232292175},{"id":"https://openalex.org/C138958017","wikidata":"https://www.wikidata.org/wiki/Q190087","display_name":"Data type","level":2,"score":0.28839999437332153},{"id":"https://openalex.org/C177803969","wikidata":"https://www.wikidata.org/wiki/Q29205","display_name":"Uncertainty analysis","level":2,"score":0.2883000075817108},{"id":"https://openalex.org/C207201462","wikidata":"https://www.wikidata.org/wiki/Q182505","display_name":"Bayes' theorem","level":3,"score":0.2874999940395355},{"id":"https://openalex.org/C30044814","wikidata":"https://www.wikidata.org/wiki/Q11334452","display_name":"Blind deconvolution","level":3,"score":0.2865000069141388},{"id":"https://openalex.org/C177769412","wikidata":"https://www.wikidata.org/wiki/Q278090","display_name":"Prior probability","level":3,"score":0.28529998660087585},{"id":"https://openalex.org/C137209882","wikidata":"https://www.wikidata.org/wiki/Q1403517","display_name":"Measurement uncertainty","level":2,"score":0.2840999960899353},{"id":"https://openalex.org/C19619285","wikidata":"https://www.wikidata.org/wiki/Q196372","display_name":"Observational error","level":2,"score":0.27709999680519104},{"id":"https://openalex.org/C160234255","wikidata":"https://www.wikidata.org/wiki/Q812535","display_name":"Bayesian inference","level":3,"score":0.265500009059906},{"id":"https://openalex.org/C202799725","wikidata":"https://www.wikidata.org/wiki/Q272035","display_name":"Accuracy and precision","level":2,"score":0.2632000148296356},{"id":"https://openalex.org/C189014844","wikidata":"https://www.wikidata.org/wiki/Q189118","display_name":"Cell type","level":3,"score":0.2621999979019165}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001499","descriptor_name":"Bayes Theorem","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001499","descriptor_name":"Bayes Theorem","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001499","descriptor_name":"Bayes Theorem","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001499","descriptor_name":"Bayes Theorem","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001499","descriptor_name":"Bayes Theorem","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D035501","descriptor_name":"Uncertainty","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D035501","descriptor_name":"Uncertainty","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D035501","descriptor_name":"Uncertainty","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D035501","descriptor_name":"Uncertainty","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D035501","descriptor_name":"Uncertainty","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1093/bib/bbaf711","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbaf711","pdf_url":"https://academic.oup.com/bib/article-pdf/27/1/bbaf711/66342054/bbaf711.pdf","source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},{"id":"pmid:41520227","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41520227","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in bioinformatics","raw_type":null},{"id":"pmh:oai:europepmc.org:11702340","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/12895075","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:12895075","is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12895075/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Brief Bioinform","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1093/bib/bbaf711","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbaf711","pdf_url":"https://academic.oup.com/bib/article-pdf/27/1/bbaf711/66342054/bbaf711.pdf","source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G1683497207","display_name":null,"funder_award_id":"R01DA061926","funder_id":"https://openalex.org/F4320337347","funder_display_name":"National Institute on Drug Abuse"},{"id":"https://openalex.org/G2706030474","display_name":null,"funder_award_id":"R01DA047820","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G3679365667","display_name":null,"funder_award_id":"U24 HG012108","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G4323100451","display_name":null,"funder_award_id":"U01 HG013840","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G7680006314","display_name":null,"funder_award_id":"R01DA047820","funder_id":"https://openalex.org/F4320337347","funder_display_name":"National Institute on Drug Abuse"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337347","display_name":"National Institute on Drug Abuse","ror":"https://ror.org/00fq5cm18"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7121228036.pdf","grobid_xml":"https://content.openalex.org/works/W7121228036.grobid-xml"},"referenced_works_count":38,"referenced_works":["https://openalex.org/W1994899118","https://openalex.org/W2041722189","https://openalex.org/W2047978125","https://openalex.org/W2091797506","https://openalex.org/W2100697281","https://openalex.org/W2107018762","https://openalex.org/W2114104545","https://openalex.org/W2152824262","https://openalex.org/W2158266063","https://openalex.org/W2171090495","https://openalex.org/W2209701692","https://openalex.org/W2316537321","https://openalex.org/W2560510482","https://openalex.org/W2750423895","https://openalex.org/W2803323905","https://openalex.org/W2808263729","https://openalex.org/W2809330972","https://openalex.org/W2890558526","https://openalex.org/W2897546067","https://openalex.org/W2919386822","https://openalex.org/W2942610007","https://openalex.org/W2953866345","https://openalex.org/W2965166405","https://openalex.org/W2973820537","https://openalex.org/W3145087249","https://openalex.org/W3197041122","https://openalex.org/W4205475060","https://openalex.org/W4224470052","https://openalex.org/W4225145267","https://openalex.org/W4322719629","https://openalex.org/W4386895550","https://openalex.org/W4391609537","https://openalex.org/W4403434614","https://openalex.org/W4403466475","https://openalex.org/W4403516090","https://openalex.org/W4405666966","https://openalex.org/W4409211490","https://openalex.org/W4417221460"],"related_works":[],"abstract_inverted_index":{"Statistical":[0],"deconvolution":[1],"methods":[2,24,55],"offer":[3],"a":[4,19],"powerful":[5],"solution":[6],"for":[7],"estimating":[8],"cell-type-specific":[9],"(CTS)":[10],"profiles":[11,122],"from":[12],"readily":[13],"available":[14],"bulk":[15,39,50],"tissue":[16],"data.":[17,40],"However,":[18],"critical":[20],"limitation":[21],"of":[22,31,35,45,120,131],"existing":[23],"is":[25],"that":[26,114],"they":[27],"require":[28],"the":[29,38,42,57,62,70,95,98,118,129],"knowledge":[30],"cell":[32,46,88,103],"type":[33,47,89,104],"proportions":[34,48,59,105],"individuals":[36],"in":[37,49,69,87,97,138],"While":[41],"ground":[43],"truth":[44],"samples":[51],"are":[52],"unknown,":[53],"those":[54],"use":[56],"estimated":[58],"to":[60,84,133,141],"approximate":[61],"truth,":[63],"which":[64],"potentially":[65],"introduces":[66],"additional":[67],"uncertainties":[68],"inferred":[71],"CTS":[72,109,121,136],"profiles.":[73],"To":[74],"address":[75],"this":[76],"challenge,":[77],"we":[78],"propose":[79],"Uncertainty-aware":[80],"Bayesian":[81],"Deconvolution":[82],"(UBD)":[83],"incorporate":[85],"uncertainty":[86,96],"proportion":[90],"estimates.":[91],"By":[92],"explicitly":[93],"modeling":[94],"initial":[99],"estimates,":[100],"UBD":[101,115,132],"refines":[102],"and":[106],"estimates":[107,119],"sample-level":[108],"data":[110],"simultaneously.":[111],"We":[112,126],"show":[113],"can":[116],"improve":[117],"through":[123],"extensive":[124],"simulations.":[125],"further":[127],"demonstrate":[128],"utility":[130],"reveal":[134],"more":[135],"signals":[137],"its":[139],"applications":[140],"two":[142],"real":[143],"datasets.":[144]},"counts_by_year":[],"updated_date":"2026-03-14T06:41:57.775601","created_date":"2026-01-11T00:00:00"}
