{"id":"https://openalex.org/W7117386704","doi":"https://doi.org/10.1093/bib/bbaf692","title":"Protrec2: tissue-specific network-based missing protein recovery method","display_name":"Protrec2: tissue-specific network-based missing protein recovery method","publication_year":2025,"publication_date":"2025-11-01","ids":{"openalex":"https://openalex.org/W7117386704","doi":"https://doi.org/10.1093/bib/bbaf692","pmid":"https://pubmed.ncbi.nlm.nih.gov/41451539"},"language":"en","primary_location":{"id":"doi:10.1093/bib/bbaf692","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbaf692","pdf_url":null,"source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1093/bib/bbaf692","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5102005276","display_name":"Weijia Kong","orcid":"https://orcid.org/0009-0002-0307-6214"},"institutions":[{"id":"https://openalex.org/I165932596","display_name":"National University of Singapore","ror":"https://ror.org/01tgyzw49","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596"]},{"id":"https://openalex.org/I172675005","display_name":"Nanyang Technological University","ror":"https://ror.org/02e7b5302","country_code":"SG","type":"education","lineage":["https://openalex.org/I172675005"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Weijia Kong","raw_affiliation_strings":["Lee Kong Chian School of Medicine, Nanyang Technological University , Experimental Medicine Building, 59 Nanyang Drive, Singapore 636798 ,","School of Biological Sciences, Nanyang Technological University , 60 Nanyang Drive, Singapore 636798 ,","School of Computing, National University of Singapore , 13 Computing Drive, Singapore 117417 ,"],"raw_orcid":"https://orcid.org/0009-0002-0307-6214","affiliations":[{"raw_affiliation_string":"Lee Kong Chian School of Medicine, Nanyang Technological University , Experimental Medicine Building, 59 Nanyang Drive, Singapore 636798 ,","institution_ids":["https://openalex.org/I172675005"]},{"raw_affiliation_string":"School of Biological Sciences, Nanyang Technological University , 60 Nanyang Drive, Singapore 636798 ,","institution_ids":["https://openalex.org/I172675005"]},{"raw_affiliation_string":"School of Computing, National University of Singapore , 13 Computing Drive, Singapore 117417 ,","institution_ids":["https://openalex.org/I165932596"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5121401433","display_name":"Wilson Wen Bin Goh","orcid":null},"institutions":[{"id":"https://openalex.org/I172675005","display_name":"Nanyang Technological University","ror":"https://ror.org/02e7b5302","country_code":"SG","type":"education","lineage":["https://openalex.org/I172675005"]},{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB","SG"],"is_corresponding":false,"raw_author_name":"Wilson Wen Bin Goh","raw_affiliation_strings":["Center for Biomedical Informatics, Nanyang Technological University , Singapore 636798 ,","Center of AI in Medicine, Nanyang Technological University , Centre for Biomedical Informatics, Experimental Medicine Building, 59 Nanyang Drive, Singapore 636798 ,","Division of Neurology, Department of Brain Sciences, Faculty of Medicine, Imperial College London , South Kensington Campus, London SW7 2AZ, England, ,","Lee Kong Chian School of Medicine, Nanyang Technological University , Experimental Medicine Building, 59 Nanyang Drive, Singapore 636798 ,","School of Biological Sciences, Nanyang Technological University , 60 Nanyang Drive, Singapore 636798 ,"],"raw_orcid":"https://orcid.org/0000-0003-3863-7501","affiliations":[{"raw_affiliation_string":"Center for Biomedical Informatics, Nanyang Technological University , Singapore 636798 ,","institution_ids":["https://openalex.org/I172675005"]},{"raw_affiliation_string":"Center of AI in Medicine, Nanyang Technological University , Centre for Biomedical Informatics, Experimental Medicine Building, 59 Nanyang Drive, Singapore 636798 ,","institution_ids":["https://openalex.org/I172675005"]},{"raw_affiliation_string":"Division of Neurology, Department of Brain Sciences, Faculty of Medicine, Imperial College London , South Kensington Campus, London SW7 2AZ, England, ,","institution_ids":["https://openalex.org/I47508984"]},{"raw_affiliation_string":"Lee Kong Chian School of Medicine, Nanyang Technological University , Experimental Medicine Building, 59 Nanyang Drive, Singapore 636798 ,","institution_ids":["https://openalex.org/I172675005"]},{"raw_affiliation_string":"School of Biological Sciences, Nanyang Technological University , 60 Nanyang Drive, Singapore 636798 ,","institution_ids":["https://openalex.org/I172675005"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5121372512","display_name":"Limsoon Wong","orcid":null},"institutions":[{"id":"https://openalex.org/I165932596","display_name":"National University of Singapore","ror":"https://ror.org/01tgyzw49","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Limsoon Wong","raw_affiliation_strings":["School of Computing, National University of Singapore , 13 Computing Drive, Singapore 117417 ,"],"raw_orcid":"https://orcid.org/0000-0003-1241-5441","affiliations":[{"raw_affiliation_string":"School of Computing, National University of Singapore , 13 Computing Drive, Singapore 117417 ,","institution_ids":["https://openalex.org/I165932596"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4011,"currency":"USD","value_usd":4011},"apc_paid":{"value":4011,"currency":"USD","value_usd":4011},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.58012882,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"26","issue":"6","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12254","display_name":"Machine Learning in Bioinformatics","score":0.3292999863624573,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12254","display_name":"Machine Learning in Bioinformatics","score":0.3292999863624573,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10519","display_name":"Advanced Proteomics Techniques and Applications","score":0.23669999837875366,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.19030000269412994,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/proteome","display_name":"Proteome","score":0.6359999775886536},{"id":"https://openalex.org/keywords/proteomics","display_name":"Proteomics","score":0.5802000164985657},{"id":"https://openalex.org/keywords/human-proteome-project","display_name":"Human proteome project","score":0.4702000021934509},{"id":"https://openalex.org/keywords/inference","display_name":"Inference","score":0.4341000020503998},{"id":"https://openalex.org/keywords/biological-pathway","display_name":"Biological pathway","score":0.3587000072002411},{"id":"https://openalex.org/keywords/bayesian-network","display_name":"Bayesian network","score":0.3549000024795532},{"id":"https://openalex.org/keywords/set","display_name":"Set (abstract data type)","score":0.351500004529953},{"id":"https://openalex.org/keywords/protein\u2013protein-interaction","display_name":"Protein\u2013protein interaction","score":0.34630000591278076}],"concepts":[{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.6470000147819519},{"id":"https://openalex.org/C104397665","wikidata":"https://www.wikidata.org/wiki/Q860947","display_name":"Proteome","level":2,"score":0.6359999775886536},{"id":"https://openalex.org/C46111723","wikidata":"https://www.wikidata.org/wiki/Q471857","display_name":"Proteomics","level":3,"score":0.5802000164985657},{"id":"https://openalex.org/C94795543","wikidata":"https://www.wikidata.org/wiki/Q3813754","display_name":"Human proteome project","level":4,"score":0.4702000021934509},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4449000060558319},{"id":"https://openalex.org/C2776214188","wikidata":"https://www.wikidata.org/wiki/Q408386","display_name":"Inference","level":2,"score":0.4341000020503998},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.38089999556541443},{"id":"https://openalex.org/C9927688","wikidata":"https://www.wikidata.org/wiki/Q4915012","display_name":"Biological pathway","level":4,"score":0.3587000072002411},{"id":"https://openalex.org/C33724603","wikidata":"https://www.wikidata.org/wiki/Q812540","display_name":"Bayesian network","level":2,"score":0.3549000024795532},{"id":"https://openalex.org/C177264268","wikidata":"https://www.wikidata.org/wiki/Q1514741","display_name":"Set (abstract data type)","level":2,"score":0.351500004529953},{"id":"https://openalex.org/C11804247","wikidata":"https://www.wikidata.org/wiki/Q896177","display_name":"Protein\u2013protein interaction","level":2,"score":0.34630000591278076},{"id":"https://openalex.org/C161078062","wikidata":"https://www.wikidata.org/wiki/Q1068690","display_name":"Functional genomics","level":5,"score":0.3138999938964844},{"id":"https://openalex.org/C49937458","wikidata":"https://www.wikidata.org/wiki/Q2599292","display_name":"Probabilistic logic","level":2,"score":0.30979999899864197},{"id":"https://openalex.org/C2777366897","wikidata":"https://www.wikidata.org/wiki/Q847482","display_name":"HeLa","level":3,"score":0.3041999936103821},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.2874000072479248},{"id":"https://openalex.org/C207201462","wikidata":"https://www.wikidata.org/wiki/Q182505","display_name":"Bayes' theorem","level":3,"score":0.2858000099658966},{"id":"https://openalex.org/C2777212361","wikidata":"https://www.wikidata.org/wiki/Q5127848","display_name":"Class (philosophy)","level":2,"score":0.28279998898506165},{"id":"https://openalex.org/C107673813","wikidata":"https://www.wikidata.org/wiki/Q812534","display_name":"Bayesian probability","level":2,"score":0.28220000863075256},{"id":"https://openalex.org/C2910703447","wikidata":"https://www.wikidata.org/wiki/Q494918","display_name":"Protein Array Analysis","level":5,"score":0.26669999957084656},{"id":"https://openalex.org/C80311884","wikidata":"https://www.wikidata.org/wiki/Q7268939","display_name":"Quantitative proteomics","level":4,"score":0.25699999928474426},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.2513999938964844},{"id":"https://openalex.org/C81729549","wikidata":"https://www.wikidata.org/wiki/Q4649475","display_name":"A549 cell","level":3,"score":0.250900000333786}],"mesh":[{"descriptor_ui":"D000072283","descriptor_name":"A549 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000072283","descriptor_name":"A549 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000072283","descriptor_name":"A549 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000072283","descriptor_name":"A549 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001499","descriptor_name":"Bayes Theorem","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001499","descriptor_name":"Bayes Theorem","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001499","descriptor_name":"Bayes Theorem","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001499","descriptor_name":"Bayes Theorem","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006367","descriptor_name":"HeLa Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006367","descriptor_name":"HeLa Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006367","descriptor_name":"HeLa Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006367","descriptor_name":"HeLa Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009928","descriptor_name":"Organ Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009928","descriptor_name":"Organ Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009928","descriptor_name":"Organ Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009928","descriptor_name":"Organ Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D020543","descriptor_name":"Proteome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020543","descriptor_name":"Proteome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020543","descriptor_name":"Proteome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020543","descriptor_name":"Proteome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D040901","descriptor_name":"Proteomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D040901","descriptor_name":"Proteomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D040901","descriptor_name":"Proteomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D040901","descriptor_name":"Proteomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1093/bib/bbaf692","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbaf692","pdf_url":null,"source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},{"id":"pmid:41451539","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41451539","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in bioinformatics","raw_type":null},{"id":"pmh:oai:dr.ntu.edu.sg:10356/208683","is_oa":true,"landing_page_url":"https://hdl.handle.net/10356/208683","pdf_url":null,"source":{"id":"https://openalex.org/S4306402609","display_name":"DR-NTU (Nanyang Technological University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I172675005","host_organization_name":"Nanyang Technological University","host_organization_lineage":["https://openalex.org/I172675005"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:12741561","is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12741561/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12741561/pdf/bbaf692.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Brief Bioinform","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1093/bib/bbaf692","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbaf692","pdf_url":null,"source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G1482925484","display_name":null,"funder_award_id":"Tier 1","funder_id":"https://openalex.org/F4320320751","funder_display_name":"Ministry of Education - Singapore"},{"id":"https://openalex.org/G5711554658","display_name":null,"funder_award_id":"RS08/21","funder_id":"https://openalex.org/F4320320751","funder_display_name":"Ministry of Education - Singapore"},{"id":"https://openalex.org/G8391161409","display_name":null,"funder_award_id":"RT11/21","funder_id":"https://openalex.org/F4320320751","funder_display_name":"Ministry of Education - Singapore"}],"funders":[{"id":"https://openalex.org/F4320320751","display_name":"Ministry of Education - Singapore","ror":"https://ror.org/01kcva023"},{"id":"https://openalex.org/F4320334626","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517"},{"id":"https://openalex.org/F4320334737","display_name":"National Medical Research Council","ror":"https://ror.org/04x3cxs03"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":28,"referenced_works":["https://openalex.org/W1981409633","https://openalex.org/W1984952667","https://openalex.org/W2028133290","https://openalex.org/W2036733146","https://openalex.org/W2069400465","https://openalex.org/W2075418882","https://openalex.org/W2083663335","https://openalex.org/W2103017472","https://openalex.org/W2155443196","https://openalex.org/W2171118759","https://openalex.org/W2739999456","https://openalex.org/W2891586944","https://openalex.org/W2912937988","https://openalex.org/W2932401127","https://openalex.org/W2957376989","https://openalex.org/W3023989388","https://openalex.org/W3177304367","https://openalex.org/W3178998527","https://openalex.org/W3201962527","https://openalex.org/W3210712771","https://openalex.org/W4210256096","https://openalex.org/W4243979784","https://openalex.org/W4248681815","https://openalex.org/W4308834893","https://openalex.org/W4311040368","https://openalex.org/W4318023227","https://openalex.org/W4386532751","https://openalex.org/W4389265304"],"related_works":[],"abstract_inverted_index":{"Despite":[0],"technological":[1],"advances,":[2],"missing":[3,198],"proteins":[4,11,116,150,155,164],"remain":[5],"a":[6,21,192],"challenge":[7],"in":[8,90,94,117,123,176,204],"proteomics,":[9],"obscuring":[10],"that":[12,24],"are":[13,170],"biologically":[14,37,194],"or":[15],"clinically":[16],"important.":[17],"We":[18,40,132],"present":[19,38],"Protrec2,":[20],"probabilistic":[22],"framework":[23],"integrates":[25],"tissue-specific":[26],"protein":[27,199],"complex":[28],"annotations":[29],"with":[30,153,201],"Bayesian":[31],"inference":[32],"to":[33,88,135,172],"recover":[34],"unreported":[35],"but":[36,55],"proteins.":[39],"benchmarked":[41],"Protrec2":[42,63,106,134,190],"on":[43],"HeLa":[44,95],"and":[45,50,77,92,96,99,121,141,158,182,207],"A549-derived":[46],"proteomes":[47],"under":[48],"\"upper-bound\"":[49],"\"lower-bound\"":[51],"scenarios,":[52],"reflecting":[53],"distinct":[54],"complementary":[56],"real-world":[57],"use":[58],"cases.":[59],"In":[60,103],"upper-bound":[61],"evaluations,":[62,105],"consistently":[64],"outperformed":[65],"state-of-the-art":[66],"methods":[67,127],"such":[68],"as":[69,191],"PROTein":[70],"RECovery,":[71],"Functional":[72],"Class":[73],"Scoring,":[74],"Hypergeometric":[75],"Enrichment,":[76],"Gene":[78],"Set":[79],"Enrichment":[80],"Analysis,":[81],"achieving":[82],"the":[83,118,180],"highest":[84],"recovery":[85],"rates:":[86],"up":[87],"98.4%":[89],"A549":[91,119],"96.5%":[93],"validating":[97,110],"650":[98],"453":[100],"proteins,":[101],"respectively.":[102],"lower-bound":[104],"maintained":[107],"superior":[108],"precision,":[109],"over":[111],"90%":[112],"of":[113,148,185],"its":[114],"predicted":[115,149],"dataset":[120],"74.6%":[122],"HeLa,":[124],"while":[125],"other":[126],"exhibited":[128],"significant":[129],"performance":[130],"drops.":[131],"applied":[133],"six":[136],"matched":[137],"lung":[138,177],"tumor-normal":[139],"pairs":[140],"validated":[142],"predictions":[143],"against":[144],"CPTAC.":[145],"Over":[146],"85%":[147],"were":[151],"supported,":[152],"cancer-specific":[154],"mostly":[156],"upregulated":[157],"normal-exclusive":[159],"ones":[160],"downregulated.":[161],"Frequently":[162],"recovered":[163],"(e.g.":[165],"P4HA3,":[166],"SNX1,":[167],"HIP1R,":[168],"NOS2)":[169],"known":[171],"play":[173],"key":[174],"roles":[175],"cancer,":[178],"highlighting":[179],"biological":[181],"clinical":[183],"relevance":[184],"Protrec2.":[186],"These":[187],"findings":[188],"establish":[189],"robust,":[193],"grounded":[195],"tool":[196],"for":[197],"recovery,":[200],"broad":[202],"applicability":[203],"discovery":[205],"proteomics":[206],"translational":[208],"research.":[209]},"counts_by_year":[],"updated_date":"2026-06-11T09:08:48.828518","created_date":"2025-12-27T00:00:00"}