{"id":"https://openalex.org/W7114914445","doi":"https://doi.org/10.1093/bib/bbaf631.031","title":"Surveying the molecular landscape of pediatric brain tumors via spatially resolved transcriptomics","display_name":"Surveying the molecular landscape of pediatric brain tumors via spatially resolved transcriptomics","publication_year":2025,"publication_date":"2025-12-01","ids":{"openalex":"https://openalex.org/W7114914445","doi":"https://doi.org/10.1093/bib/bbaf631.031"},"language":"en","primary_location":{"id":"doi:10.1093/bib/bbaf631.031","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbaf631.031","pdf_url":"https://academic.oup.com/bib/article-pdf/26/Supplement_1/i22/65854551/bbaf631.031.pdf","source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://academic.oup.com/bib/article-pdf/26/Supplement_1/i22/65854551/bbaf631.031.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Javier Escudero Morlanes","orcid":null},"institutions":[{"id":"https://openalex.org/I86987016","display_name":"KTH Royal Institute of Technology","ror":"https://ror.org/026vcq606","country_code":"SE","type":"education","lineage":["https://openalex.org/I86987016"]}],"countries":["SE"],"is_corresponding":true,"raw_author_name":"Javier Escudero Morlanes","raw_affiliation_strings":["Department of Gene Technology, KTH Royal Institute of Technology, Science for Life Laboratory , Solna ,"],"affiliations":[{"raw_affiliation_string":"Department of Gene Technology, KTH Royal Institute of Technology, Science for Life Laboratory , Solna ,","institution_ids":["https://openalex.org/I86987016"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Timo-Pekka Lehto","orcid":null},"institutions":[{"id":"https://openalex.org/I133731052","display_name":"University of Helsinki","ror":"https://ror.org/040af2s02","country_code":"FI","type":"education","lineage":["https://openalex.org/I133731052"]},{"id":"https://openalex.org/I2800394112","display_name":"Helsinki University Hospital","ror":"https://ror.org/02e8hzf44","country_code":"FI","type":"healthcare","lineage":["https://openalex.org/I2800394112","https://openalex.org/I4210166427"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Timo-Pekka Lehto","raw_affiliation_strings":["Department of Pathology, University of Helsinki and Helsinki University Hospital , Helsinki ,","Department of Urology, University of Helsinki and Helsinki University Hospital , Helsinki ,","Research Program in Systems Oncology, Faculty of Medicine, University of Helsinki , Helsinki ,"],"affiliations":[{"raw_affiliation_string":"Department of Pathology, University of Helsinki and Helsinki University Hospital , Helsinki ,","institution_ids":["https://openalex.org/I133731052","https://openalex.org/I2800394112"]},{"raw_affiliation_string":"Department of Urology, University of Helsinki and Helsinki University Hospital , Helsinki ,","institution_ids":["https://openalex.org/I133731052","https://openalex.org/I2800394112"]},{"raw_affiliation_string":"Research Program in Systems Oncology, Faculty of Medicine, University of Helsinki , Helsinki ,","institution_ids":["https://openalex.org/I133731052"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Ludvig Larsson","orcid":null},"institutions":[{"id":"https://openalex.org/I86987016","display_name":"KTH Royal Institute of Technology","ror":"https://ror.org/026vcq606","country_code":"SE","type":"education","lineage":["https://openalex.org/I86987016"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Ludvig Larsson","raw_affiliation_strings":["Department of Gene Technology, KTH Royal Institute of Technology, Science for Life Laboratory , Solna ,"],"affiliations":[{"raw_affiliation_string":"Department of Gene Technology, KTH Royal Institute of Technology, Science for Life Laboratory , Solna ,","institution_ids":["https://openalex.org/I86987016"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Leire Alonso Galicia","orcid":null},"institutions":[{"id":"https://openalex.org/I86987016","display_name":"KTH Royal Institute of Technology","ror":"https://ror.org/026vcq606","country_code":"SE","type":"education","lineage":["https://openalex.org/I86987016"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Leire Alonso Galicia","raw_affiliation_strings":["Department of Gene Technology, KTH Royal Institute of Technology, Science for Life Laboratory , Solna ,"],"affiliations":[{"raw_affiliation_string":"Department of Gene Technology, KTH Royal Institute of Technology, Science for Life Laboratory , Solna ,","institution_ids":["https://openalex.org/I86987016"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Annelie Mollbrink","orcid":null},"institutions":[{"id":"https://openalex.org/I86987016","display_name":"KTH Royal Institute of Technology","ror":"https://ror.org/026vcq606","country_code":"SE","type":"education","lineage":["https://openalex.org/I86987016"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Annelie Mollbrink","raw_affiliation_strings":["Department of Gene Technology, KTH Royal Institute of Technology, Science for Life Laboratory , Solna ,"],"affiliations":[{"raw_affiliation_string":"Department of Gene Technology, KTH Royal Institute of Technology, Science for Life Laboratory , Solna ,","institution_ids":["https://openalex.org/I86987016"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Alia Shamikh","orcid":null},"institutions":[{"id":"https://openalex.org/I1335113835","display_name":"Karolinska University Hospital","ror":"https://ror.org/00m8d6786","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I1335113835"]},{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Alia Shamikh","raw_affiliation_strings":["Clinical Pathology and Cancer Diagnostics, Karolinska University Hospital , Stockholm ,","Department of Oncology-Pathology, Karolinska Institutet , Stockholm ,"],"affiliations":[{"raw_affiliation_string":"Clinical Pathology and Cancer Diagnostics, Karolinska University Hospital , Stockholm ,","institution_ids":["https://openalex.org/I1335113835"]},{"raw_affiliation_string":"Department of Oncology-Pathology, Karolinska Institutet , Stockholm ,","institution_ids":["https://openalex.org/I28166907"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Elisa Basmaci","orcid":null},"institutions":[{"id":"https://openalex.org/I1335113835","display_name":"Karolinska University Hospital","ror":"https://ror.org/00m8d6786","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I1335113835"]},{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Elisa Basmaci","raw_affiliation_strings":["Clinical Pathology and Cancer Diagnostics, Karolinska University Hospital , Stockholm ,","Department of Oncology-Pathology, Karolinska Institutet , Stockholm ,"],"affiliations":[{"raw_affiliation_string":"Clinical Pathology and Cancer Diagnostics, Karolinska University Hospital , Stockholm ,","institution_ids":["https://openalex.org/I1335113835"]},{"raw_affiliation_string":"Department of Oncology-Pathology, Karolinska Institutet , Stockholm ,","institution_ids":["https://openalex.org/I28166907"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Gabriela Prochazka","orcid":null},"institutions":[{"id":"https://openalex.org/I1335113835","display_name":"Karolinska University Hospital","ror":"https://ror.org/00m8d6786","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I1335113835"]},{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Gabriela Prochazka","raw_affiliation_strings":["Clinical Pathology and Cancer Diagnostics, Karolinska University Hospital , Stockholm ,","Department of Oncology-Pathology, Karolinska Institutet , Stockholm ,"],"affiliations":[{"raw_affiliation_string":"Clinical Pathology and Cancer Diagnostics, Karolinska University Hospital , Stockholm ,","institution_ids":["https://openalex.org/I1335113835"]},{"raw_affiliation_string":"Department of Oncology-Pathology, Karolinska Institutet , Stockholm ,","institution_ids":["https://openalex.org/I28166907"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Teresita Diaz De St\u00e5hl","orcid":null},"institutions":[{"id":"https://openalex.org/I1335113835","display_name":"Karolinska University Hospital","ror":"https://ror.org/00m8d6786","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I1335113835"]},{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Teresita Diaz De St\u00e5hl","raw_affiliation_strings":["Clinical Pathology and Cancer Diagnostics, Karolinska University Hospital , Stockholm ,","Department of Oncology-Pathology, Karolinska Institutet , Stockholm ,"],"affiliations":[{"raw_affiliation_string":"Clinical Pathology and Cancer Diagnostics, Karolinska University Hospital , Stockholm ,","institution_ids":["https://openalex.org/I1335113835"]},{"raw_affiliation_string":"Department of Oncology-Pathology, Karolinska Institutet , Stockholm ,","institution_ids":["https://openalex.org/I28166907"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Johanna Sandgren","orcid":null},"institutions":[{"id":"https://openalex.org/I1335113835","display_name":"Karolinska University Hospital","ror":"https://ror.org/00m8d6786","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I1335113835"]},{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Johanna Sandgren","raw_affiliation_strings":["Clinical Pathology and Cancer Diagnostics, Karolinska University Hospital , Stockholm ,","Department of Oncology-Pathology, Karolinska Institutet , Stockholm ,"],"affiliations":[{"raw_affiliation_string":"Clinical Pathology and Cancer Diagnostics, Karolinska University Hospital , Stockholm ,","institution_ids":["https://openalex.org/I1335113835"]},{"raw_affiliation_string":"Department of Oncology-Pathology, Karolinska Institutet , Stockholm ,","institution_ids":["https://openalex.org/I28166907"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Fulya Taylan","orcid":null},"institutions":[{"id":"https://openalex.org/I1335113835","display_name":"Karolinska University Hospital","ror":"https://ror.org/00m8d6786","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I1335113835"]},{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Fulya Taylan","raw_affiliation_strings":["Clinical Genetics and Genomics, Karolinska University Hospital , Solna ,","Department of Molecular Medicine and Surgery, Karolinska Institutet , Stockholm ,"],"affiliations":[{"raw_affiliation_string":"Clinical Genetics and Genomics, Karolinska University Hospital , Solna ,","institution_ids":["https://openalex.org/I1335113835"]},{"raw_affiliation_string":"Department of Molecular Medicine and Surgery, Karolinska Institutet , Stockholm ,","institution_ids":["https://openalex.org/I28166907"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Bianca Tesi","orcid":null},"institutions":[{"id":"https://openalex.org/I1335113835","display_name":"Karolinska University Hospital","ror":"https://ror.org/00m8d6786","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I1335113835"]},{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Bianca Tesi","raw_affiliation_strings":["Department of Clinical Genetics and Genomics, Karolinska University Hospital , Stockholm ,","Department of Molecular Medicine and Surgery, Karolinska Institutet , Stockholm ,"],"affiliations":[{"raw_affiliation_string":"Department of Clinical Genetics and Genomics, Karolinska University Hospital , Stockholm ,","institution_ids":["https://openalex.org/I1335113835"]},{"raw_affiliation_string":"Department of Molecular Medicine and Surgery, Karolinska Institutet , Stockholm ,","institution_ids":["https://openalex.org/I28166907"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Ann Nordgren","orcid":null},"institutions":[{"id":"https://openalex.org/I1335113835","display_name":"Karolinska University Hospital","ror":"https://ror.org/00m8d6786","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I1335113835"]},{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Ann Nordgren","raw_affiliation_strings":["Department of Clinical Genetics and Genomics, Karolinska University Hospital , Stockholm ,","Department of Molecular Medicine and Surgery, Karolinska Institutet , Stockholm ,"],"affiliations":[{"raw_affiliation_string":"Department of Clinical Genetics and Genomics, Karolinska University Hospital , Stockholm ,","institution_ids":["https://openalex.org/I1335113835"]},{"raw_affiliation_string":"Department of Molecular Medicine and Surgery, Karolinska Institutet , Stockholm ,","institution_ids":["https://openalex.org/I28166907"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Andrew Erickson","orcid":null},"institutions":[{"id":"https://openalex.org/I133731052","display_name":"University of Helsinki","ror":"https://ror.org/040af2s02","country_code":"FI","type":"education","lineage":["https://openalex.org/I133731052"]},{"id":"https://openalex.org/I2801809904","display_name":"Nuffield Orthopaedic Centre","ror":"https://ror.org/0036ate90","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2801809904","https://openalex.org/I4210147381"]}],"countries":["FI","GB"],"is_corresponding":false,"raw_author_name":"Andrew Erickson","raw_affiliation_strings":["Nuffield Department of Surgical Sciences, University of Oxford ,","Systems Oncology, Faculty of Medicine, University of Helsinki , Helsinki ,"],"affiliations":[{"raw_affiliation_string":"Nuffield Department of Surgical Sciences, University of Oxford ,","institution_ids":["https://openalex.org/I2801809904"]},{"raw_affiliation_string":"Systems Oncology, Faculty of Medicine, University of Helsinki , Helsinki ,","institution_ids":["https://openalex.org/I133731052"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Alastair D Lamb","orcid":null},"institutions":[{"id":"https://openalex.org/I133731052","display_name":"University of Helsinki","ror":"https://ror.org/040af2s02","country_code":"FI","type":"education","lineage":["https://openalex.org/I133731052"]},{"id":"https://openalex.org/I2801809904","display_name":"Nuffield Orthopaedic Centre","ror":"https://ror.org/0036ate90","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2801809904","https://openalex.org/I4210147381"]},{"id":"https://openalex.org/I4210147381","display_name":"Oxford University Hospitals NHS Trust","ror":"https://ror.org/03h2bh287","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I4210147381"]}],"countries":["FI","GB"],"is_corresponding":false,"raw_author_name":"Alastair D Lamb","raw_affiliation_strings":["Department of Urology, Oxford University Hospitals NHS Foundation Trust ,","Nuffield Department of Surgical Sciences, University of Oxford ,","Systems Oncology, Faculty of Medicine, University of Helsinki , Helsinki ,"],"affiliations":[{"raw_affiliation_string":"Department of Urology, Oxford University Hospitals NHS Foundation Trust ,","institution_ids":["https://openalex.org/I4210147381"]},{"raw_affiliation_string":"Nuffield Department of Surgical Sciences, University of Oxford ,","institution_ids":["https://openalex.org/I2801809904"]},{"raw_affiliation_string":"Systems Oncology, Faculty of Medicine, University of Helsinki , Helsinki ,","institution_ids":["https://openalex.org/I133731052"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Klas Blomgren","orcid":null},"institutions":[{"id":"https://openalex.org/I1335113835","display_name":"Karolinska University Hospital","ror":"https://ror.org/00m8d6786","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I1335113835"]},{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Klas Blomgren","raw_affiliation_strings":["Department of Paediatric Oncology, Karolinska University Hospital , Stockholm ,","Department of Women\u2019s and Children\u2019s Health, Karolinska Institutet , Stockholm ,"],"affiliations":[{"raw_affiliation_string":"Department of Paediatric Oncology, Karolinska University Hospital , Stockholm ,","institution_ids":["https://openalex.org/I1335113835"]},{"raw_affiliation_string":"Department of Women\u2019s and Children\u2019s Health, Karolinska Institutet , Stockholm ,","institution_ids":["https://openalex.org/I28166907"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Monica Nist\u00e9r","orcid":null},"institutions":[{"id":"https://openalex.org/I1335113835","display_name":"Karolinska University Hospital","ror":"https://ror.org/00m8d6786","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I1335113835"]},{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Monica Nist\u00e9r","raw_affiliation_strings":["Clinical Pathology and Cancer Diagnostics, Karolinska University Hospital , Stockholm ,","Department of Oncology-Pathology, Karolinska Institutet , Stockholm ,"],"affiliations":[{"raw_affiliation_string":"Clinical Pathology and Cancer Diagnostics, Karolinska University Hospital , Stockholm ,","institution_ids":["https://openalex.org/I1335113835"]},{"raw_affiliation_string":"Department of Oncology-Pathology, Karolinska Institutet , Stockholm ,","institution_ids":["https://openalex.org/I28166907"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Joakim Lundeberg","orcid":null},"institutions":[{"id":"https://openalex.org/I86987016","display_name":"KTH Royal Institute of Technology","ror":"https://ror.org/026vcq606","country_code":"SE","type":"education","lineage":["https://openalex.org/I86987016"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Joakim Lundeberg","raw_affiliation_strings":["Department of Gene Technology, KTH Royal Institute of Technology, Science for Life Laboratory , Solna ,"],"affiliations":[{"raw_affiliation_string":"Department of Gene Technology, KTH Royal Institute of Technology, Science for Life Laboratory , Solna ,","institution_ids":["https://openalex.org/I86987016"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Reza Mirzazadeh","orcid":null},"institutions":[{"id":"https://openalex.org/I86987016","display_name":"KTH Royal Institute of Technology","ror":"https://ror.org/026vcq606","country_code":"SE","type":"education","lineage":["https://openalex.org/I86987016"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Reza Mirzazadeh","raw_affiliation_strings":["Department of Gene Technology, KTH Royal Institute of Technology, Science for Life Laboratory , Solna ,"],"affiliations":[{"raw_affiliation_string":"Department of Gene Technology, KTH Royal Institute of Technology, Science for Life Laboratory , Solna ,","institution_ids":["https://openalex.org/I86987016"]}]},{"author_position":"last","author":{"id":null,"display_name":"Linda Kvastad","orcid":null},"institutions":[{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]},{"id":"https://openalex.org/I86987016","display_name":"KTH Royal Institute of Technology","ror":"https://ror.org/026vcq606","country_code":"SE","type":"education","lineage":["https://openalex.org/I86987016"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Linda Kvastad","raw_affiliation_strings":["Current affiliation: Department of Cell and Molecular Biology, Karolinska Institute , Solna ,","Department of Gene Technology, KTH Royal Institute of Technology, Science for Life Laboratory , Solna ,"],"affiliations":[{"raw_affiliation_string":"Current affiliation: Department of Cell and Molecular Biology, Karolinska Institute , Solna ,","institution_ids":["https://openalex.org/I28166907"]},{"raw_affiliation_string":"Department of Gene Technology, KTH Royal Institute of Technology, Science for Life Laboratory , Solna ,","institution_ids":["https://openalex.org/I86987016"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":20,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I86987016"],"apc_list":{"value":4011,"currency":"USD","value_usd":4011},"apc_paid":{"value":4011,"currency":"USD","value_usd":4011},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.73840238,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"26","issue":"Supplement_1","first_page":"i22","last_page":"i23"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.77920001745224,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.77920001745224,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11289","display_name":"Single-cell and spatial transcriptomics","score":0.04050000011920929,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11213","display_name":"Genomic variations and chromosomal abnormalities","score":0.017899999395012856,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/transcriptome","display_name":"Transcriptome","score":0.6927000284194946},{"id":"https://openalex.org/keywords/lineage","display_name":"Lineage (genetic)","score":0.4535999894142151},{"id":"https://openalex.org/keywords/pilocytic-astrocytoma","display_name":"Pilocytic astrocytoma","score":0.4375},{"id":"https://openalex.org/keywords/gene-expression-profiling","display_name":"Gene expression profiling","score":0.37529999017715454},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.3646000027656555},{"id":"https://openalex.org/keywords/profiling","display_name":"Profiling (computer programming)","score":0.3107999861240387}],"concepts":[{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.6927000284194946},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5791000127792358},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5613999962806702},{"id":"https://openalex.org/C2776817793","wikidata":"https://www.wikidata.org/wiki/Q6553369","display_name":"Lineage (genetic)","level":3,"score":0.4535999894142151},{"id":"https://openalex.org/C2777722931","wikidata":"https://www.wikidata.org/wiki/Q2095252","display_name":"Pilocytic astrocytoma","level":4,"score":0.4375},{"id":"https://openalex.org/C78458016","wikidata":"https://www.wikidata.org/wiki/Q840400","display_name":"Evolutionary biology","level":1,"score":0.388700008392334},{"id":"https://openalex.org/C18431079","wikidata":"https://www.wikidata.org/wiki/Q1502169","display_name":"Gene expression profiling","level":4,"score":0.37529999017715454},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3646000027656555},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.33640000224113464},{"id":"https://openalex.org/C187191949","wikidata":"https://www.wikidata.org/wiki/Q1138496","display_name":"Profiling (computer programming)","level":2,"score":0.3107999861240387},{"id":"https://openalex.org/C2779130545","wikidata":"https://www.wikidata.org/wiki/Q233309","display_name":"Brain tumor","level":2,"score":0.30889999866485596},{"id":"https://openalex.org/C2781192897","wikidata":"https://www.wikidata.org/wiki/Q822050","display_name":"White matter","level":3,"score":0.2964000105857849},{"id":"https://openalex.org/C2777670902","wikidata":"https://www.wikidata.org/wiki/Q492038","display_name":"Human brain","level":2,"score":0.296099990606308},{"id":"https://openalex.org/C158709400","wikidata":"https://www.wikidata.org/wiki/Q3578586","display_name":"Spatial ecology","level":2,"score":0.2759999930858612},{"id":"https://openalex.org/C534262118","wikidata":"https://www.wikidata.org/wiki/Q177719","display_name":"Medical diagnosis","level":2,"score":0.2720000147819519},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.25769999623298645}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1093/bib/bbaf631.031","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbaf631.031","pdf_url":"https://academic.oup.com/bib/article-pdf/26/Supplement_1/i22/65854551/bbaf631.031.pdf","source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:12699643","is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12699643/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12699643/pdf/bbaf631.031.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Brief Bioinform","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1093/bib/bbaf631.031","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbaf631.031","pdf_url":"https://academic.oup.com/bib/article-pdf/26/Supplement_1/i22/65854551/bbaf631.031.pdf","source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.46776282787323,"display_name":"Good health and well-being"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7114914445.pdf","grobid_xml":"https://content.openalex.org/works/W7114914445.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":[],"abstract_inverted_index":{"Abstract":[0],"Due":[1],"to":[2,68,79,91,97,143,168],"their":[3],"intrinsic":[4],"heterogeneity":[5],"and":[6,54,96,112,159],"plasticity,":[7],"pediatric":[8,162],"brain":[9,163],"tumors":[10],"present":[11],"highly":[12],"complex":[13],"clinical":[14],"challenges.":[15],"To":[16],"provide":[17,153],"insight":[18],"into":[19,156],"the":[20,42,127,157],"molecular":[21],"scene":[22],"of":[23,36,41,71,129,161],"these":[24,151],"tumors,":[25,164],"we":[26,58,104,120],"generated":[27],"spatial":[28,81,107,140],"transcriptomics":[29],"data":[30],"from":[31],"19":[32],"distinct":[33,98],"patients,":[34],"7":[35],"which":[37,86],"suffered":[38],"a":[39],"relapse":[40],"disease.":[43],"In":[44],"this":[45],"cohort,":[46],"spanning":[47],"59":[48],"tissue":[49],"sections":[50],"across":[51],"8":[52],"diagnoses":[53],"4":[55,80],"tumor":[56,132],"grades,":[57],"recovered":[59],"diagnosis-specific":[60],"gene":[61],"expression":[62],"patterns":[63],"that":[64],"could":[65,87],"be":[66,89,169],"linked":[67],"processes":[69],"characteristic":[70],"developmental":[72,110],"stages.":[73],"We":[74],"also":[75],"identified":[76],"between":[77,109],"2":[78],"archetypal":[82],"niches":[83],"per":[84],"section,":[85],"then":[88,137],"related":[90,138],"11":[92],"main":[93],"biological":[94],"themes,":[95],"celltype-like":[99],"transcriptomic":[100],"signatures.":[101,149],"For":[102],"example,":[103],"noted":[105],"strong":[106,146],"correlations":[108],"archetypes":[111],"oligodendrocyte":[113],"lineage":[114],"signal":[115],"in":[116,171],"pilocytic":[117],"astrocytoma.":[118],"Lastly,":[119],"utilised":[121],"spatially":[122],"inferred":[123],"copy-number":[124],"variants":[125],"for":[126],"profiling":[128],"relapse-associated":[130],"tentative":[131],"clones.":[133],"These":[134],"clones":[135],"were":[136],"via":[139],"geographical":[141],"analysis":[142],"regions":[144],"with":[145],"blood":[147],"vessel":[148],"Overall,":[150],"results":[152],"vital":[154],"details":[155],"progression":[158],"maintenance":[160],"offering":[165],"novel":[166],"edges":[167],"exploited":[170],"personalized":[172],"medicine.":[173]},"counts_by_year":[],"updated_date":"2026-03-12T06:13:28.667946","created_date":"2025-12-12T00:00:00"}
