{"id":"https://openalex.org/W4416625073","doi":"https://doi.org/10.1093/bib/bbaf624","title":"BridgeSyn: a bridging fusion framework for drug combination synergy prediction","display_name":"BridgeSyn: a bridging fusion framework for drug combination synergy prediction","publication_year":2025,"publication_date":"2025-11-01","ids":{"openalex":"https://openalex.org/W4416625073","doi":"https://doi.org/10.1093/bib/bbaf624","pmid":"https://pubmed.ncbi.nlm.nih.gov/41269282"},"language":"en","primary_location":{"id":"doi:10.1093/bib/bbaf624","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbaf624","pdf_url":"https://academic.oup.com/bib/article-pdf/26/6/bbaf624/65450783/bbaf624.pdf","source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://academic.oup.com/bib/article-pdf/26/6/bbaf624/65450783/bbaf624.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5076228802","display_name":"Qingyu Wang","orcid":"https://orcid.org/0000-0002-5293-2024"},"institutions":[{"id":"https://openalex.org/I83519826","display_name":"Nanjing Medical University","ror":"https://ror.org/059gcgy73","country_code":"CN","type":"education","lineage":["https://openalex.org/I83519826"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Qingyu Wang","raw_affiliation_strings":["Department of Medical Informatics , School of Biomedical Engineering and Informatics, Nanjing Medical University, 101 Longmian Avenue, Jiangning District, Nanjing, 211166 Jiangsu,","Department of Medical Informatics, School of Biomedical Engineering and Informatics, Nanjing Medical University, 101 Longmian Avenue, Jiangning District, Nanjing, 211166 Jiangsu, China"],"affiliations":[{"raw_affiliation_string":"Department of Medical Informatics , School of Biomedical Engineering and Informatics, Nanjing Medical University, 101 Longmian Avenue, Jiangning District, Nanjing, 211166 Jiangsu,","institution_ids":["https://openalex.org/I83519826"]},{"raw_affiliation_string":"Department of Medical Informatics, School of Biomedical Engineering and Informatics, Nanjing Medical University, 101 Longmian Avenue, Jiangning District, Nanjing, 211166 Jiangsu, China","institution_ids":["https://openalex.org/I83519826"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010557504","display_name":"Sheng-Xun Mao","orcid":null},"institutions":[{"id":"https://openalex.org/I83519826","display_name":"Nanjing Medical University","ror":"https://ror.org/059gcgy73","country_code":"CN","type":"education","lineage":["https://openalex.org/I83519826"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Suwan Mao","raw_affiliation_strings":["Department of Medical Informatics , School of Biomedical Engineering and Informatics, Nanjing Medical University, 101 Longmian Avenue, Jiangning District, Nanjing, 211166 Jiangsu,","Department of Medical Informatics, School of Biomedical Engineering and Informatics, Nanjing Medical University, 101 Longmian Avenue, Jiangning District, Nanjing, 211166 Jiangsu, China"],"affiliations":[{"raw_affiliation_string":"Department of Medical Informatics , School of Biomedical Engineering and Informatics, Nanjing Medical University, 101 Longmian Avenue, Jiangning District, Nanjing, 211166 Jiangsu,","institution_ids":["https://openalex.org/I83519826"]},{"raw_affiliation_string":"Department of Medical Informatics, School of Biomedical Engineering and Informatics, Nanjing Medical University, 101 Longmian Avenue, Jiangning District, Nanjing, 211166 Jiangsu, China","institution_ids":["https://openalex.org/I83519826"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054513626","display_name":"Xiaoyan Liu","orcid":"https://orcid.org/0000-0002-2409-8941"},"institutions":[{"id":"https://openalex.org/I204983213","display_name":"Harbin Institute of Technology","ror":"https://ror.org/01yqg2h08","country_code":"CN","type":"education","lineage":["https://openalex.org/I204983213"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaoyan Liu","raw_affiliation_strings":["Faculty of Computing , Harbin Institute of Technology, 92 West Dazhi Street, Nangang District, Harbin, 150001 Heilongjiang,","Faculty of Computing, Harbin Institute of Technology, 92 West Dazhi Street, Nangang District, Harbin, 150001 Heilongjiang, China"],"affiliations":[{"raw_affiliation_string":"Faculty of Computing , Harbin Institute of Technology, 92 West Dazhi Street, Nangang District, Harbin, 150001 Heilongjiang,","institution_ids":["https://openalex.org/I204983213"]},{"raw_affiliation_string":"Faculty of Computing, Harbin Institute of Technology, 92 West Dazhi Street, Nangang District, Harbin, 150001 Heilongjiang, China","institution_ids":["https://openalex.org/I204983213"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017426085","display_name":"Quan Zou","orcid":"https://orcid.org/0000-0001-6406-1142"},"institutions":[{"id":"https://openalex.org/I150229711","display_name":"University of Electronic Science and Technology of China","ror":"https://ror.org/04qr3zq92","country_code":"CN","type":"education","lineage":["https://openalex.org/I150229711"]},{"id":"https://openalex.org/I4210123686","display_name":"Quzhou University","ror":"https://ror.org/024nfx323","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210123686"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Quan Zou","raw_affiliation_strings":["Institute of Fundamental and Frontier Sciences , University of Electronic Science and Technology of China, 2006 Xiyuan Avenue, West Hi-tech Zone, Chengdu, 611731 Sichuan,","Yangtze Delta Region Institute (Quzhou) , University of Electronic Science and Technology of China, 1 Chengdian Road, Kecheng District, Quzhou, 324000 Zhejiang,","Yangtze Delta Region Institute (Quzhou), University of Electronic Science and Technology of China, 1 Chengdian Road, Kecheng District, Quzhou, 324000 Zhejiang, China"],"affiliations":[{"raw_affiliation_string":"Institute of Fundamental and Frontier Sciences , University of Electronic Science and Technology of China, 2006 Xiyuan Avenue, West Hi-tech Zone, Chengdu, 611731 Sichuan,","institution_ids":["https://openalex.org/I150229711"]},{"raw_affiliation_string":"Yangtze Delta Region Institute (Quzhou) , University of Electronic Science and Technology of China, 1 Chengdian Road, Kecheng District, Quzhou, 324000 Zhejiang,","institution_ids":["https://openalex.org/I4210123686"]},{"raw_affiliation_string":"Yangtze Delta Region Institute (Quzhou), University of Electronic Science and Technology of China, 1 Chengdian Road, Kecheng District, Quzhou, 324000 Zhejiang, China","institution_ids":["https://openalex.org/I4210123686"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100345256","display_name":"Qing Liu","orcid":"https://orcid.org/0000-0003-3733-9078"},"institutions":[{"id":"https://openalex.org/I3017480383","display_name":"Southwest Medical University","ror":"https://ror.org/00g2rqs52","country_code":"CN","type":"funder","lineage":["https://openalex.org/I3017480383"]},{"id":"https://openalex.org/I4210086248","display_name":"Affiliated Hospital of Southwest Medical University","ror":"https://ror.org/0014a0n68","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210086248"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qing Liu","raw_affiliation_strings":["Department of Anesthesiology , Hospital (T.C.M) Affiliated To Southwest Medical University, 182 Chunhui Road, Longmatan District, Luzhou, 646000 Sichuan,","Department of Anesthesiology, Hospital (T.C.M) Affiliated To Southwest Medical University, 182 Chunhui Road, Longmatan District, Luzhou, 646000 Sichuan, China"],"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology , Hospital (T.C.M) Affiliated To Southwest Medical University, 182 Chunhui Road, Longmatan District, Luzhou, 646000 Sichuan,","institution_ids":["https://openalex.org/I3017480383","https://openalex.org/I4210086248"]},{"raw_affiliation_string":"Department of Anesthesiology, Hospital (T.C.M) Affiliated To Southwest Medical University, 182 Chunhui Road, Longmatan District, Luzhou, 646000 Sichuan, China","institution_ids":["https://openalex.org/I3017480383","https://openalex.org/I4210086248"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081124399","display_name":"Xi Su","orcid":"https://orcid.org/0000-0003-3235-8114"},"institutions":[{"id":"https://openalex.org/I4210098387","display_name":"Foshan Maternity and Child Health Care Hospital","ror":"https://ror.org/00rg8e315","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210098387"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xi Su","raw_affiliation_strings":["The Affiliated Foshan Women and Children Hospital , Guangdong Medical University, 11 Renmin West Road, Chancheng District, Foshan, 528000 Guangdong,","The Affiliated Foshan Women and Children Hospital, Guangdong Medical University, 11 Renmin West Road, Chancheng District, Foshan, 528000 Guangdong, China"],"affiliations":[{"raw_affiliation_string":"The Affiliated Foshan Women and Children Hospital , Guangdong Medical University, 11 Renmin West Road, Chancheng District, Foshan, 528000 Guangdong,","institution_ids":["https://openalex.org/I4210098387"]},{"raw_affiliation_string":"The Affiliated Foshan Women and Children Hospital, Guangdong Medical University, 11 Renmin West Road, Chancheng District, Foshan, 528000 Guangdong, China","institution_ids":["https://openalex.org/I4210098387"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100395816","display_name":"Junjie Wang","orcid":"https://orcid.org/0000-0003-0732-051X"},"institutions":[{"id":"https://openalex.org/I83519826","display_name":"Nanjing Medical University","ror":"https://ror.org/059gcgy73","country_code":"CN","type":"education","lineage":["https://openalex.org/I83519826"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Junjie Wang","raw_affiliation_strings":["Department of Medical Informatics , School of Biomedical Engineering and Informatics, Nanjing Medical University, 101 Longmian Avenue, Jiangning District, Nanjing, 211166 Jiangsu,","Department of Medical Informatics, School of Biomedical Engineering and Informatics, Nanjing Medical University, 101 Longmian Avenue, Jiangning District, Nanjing, 211166 Jiangsu, China"],"affiliations":[{"raw_affiliation_string":"Department of Medical Informatics , School of Biomedical Engineering and Informatics, Nanjing Medical University, 101 Longmian Avenue, Jiangning District, Nanjing, 211166 Jiangsu,","institution_ids":["https://openalex.org/I83519826"]},{"raw_affiliation_string":"Department of Medical Informatics, School of Biomedical Engineering and Informatics, Nanjing Medical University, 101 Longmian Avenue, Jiangning District, Nanjing, 211166 Jiangsu, China","institution_ids":["https://openalex.org/I83519826"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101450908","display_name":"Wen Gao","orcid":"https://orcid.org/0000-0002-8130-6073"},"institutions":[{"id":"https://openalex.org/I83519826","display_name":"Nanjing Medical University","ror":"https://ror.org/059gcgy73","country_code":"CN","type":"education","lineage":["https://openalex.org/I83519826"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wen Gao","raw_affiliation_strings":["Department of Oncology , The First Affiliated Hospital of Nanjing Medical University, 300 Guangzhou Road, Gulou District, Nanjing, 210029 Jiangsu,","Department of Oncology, The First Affiliated Hospital of Nanjing Medical University, 300 Guangzhou Road, Gulou District, Nanjing, 210029 Jiangsu, China"],"affiliations":[{"raw_affiliation_string":"Department of Oncology , The First Affiliated Hospital of Nanjing Medical University, 300 Guangzhou Road, Gulou District, Nanjing, 210029 Jiangsu,","institution_ids":["https://openalex.org/I83519826"]},{"raw_affiliation_string":"Department of Oncology, The First Affiliated Hospital of Nanjing Medical University, 300 Guangzhou Road, Gulou District, Nanjing, 210029 Jiangsu, China","institution_ids":["https://openalex.org/I83519826"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5047610631","display_name":"Ximei Luo","orcid":null},"institutions":[{"id":"https://openalex.org/I150229711","display_name":"University of Electronic Science and Technology of China","ror":"https://ror.org/04qr3zq92","country_code":"CN","type":"education","lineage":["https://openalex.org/I150229711"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ximei Luo","raw_affiliation_strings":["Institute of Fundamental and Frontier Sciences , University of Electronic Science and Technology of China, 2006 Xiyuan Avenue, West Hi-tech Zone, Chengdu, 611731 Sichuan,","Institute of Fundamental and Frontier Sciences, University of Electronic Science and Technology of China, 2006 Xiyuan Avenue, West Hi-tech Zone, Chengdu, 611731 Sichuan, China"],"affiliations":[{"raw_affiliation_string":"Institute of Fundamental and Frontier Sciences , University of Electronic Science and Technology of China, 2006 Xiyuan Avenue, West Hi-tech Zone, Chengdu, 611731 Sichuan,","institution_ids":["https://openalex.org/I150229711"]},{"raw_affiliation_string":"Institute of Fundamental and Frontier Sciences, University of Electronic Science and Technology of China, 2006 Xiyuan Avenue, West Hi-tech Zone, Chengdu, 611731 Sichuan, China","institution_ids":["https://openalex.org/I150229711"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":9,"corresponding_author_ids":["https://openalex.org/A5076228802"],"corresponding_institution_ids":["https://openalex.org/I83519826"],"apc_list":{"value":4011,"currency":"USD","value_usd":4011},"apc_paid":{"value":4011,"currency":"USD","value_usd":4011},"fwci":1.5627,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.88784495,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":97,"max":99},"biblio":{"volume":"26","issue":"6","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.7617999911308289,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.7617999911308289,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12254","display_name":"Machine Learning in Bioinformatics","score":0.09780000150203705,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12859","display_name":"Cell Image Analysis Techniques","score":0.041099999099969864,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bridging","display_name":"Bridging (networking)","score":0.843500018119812},{"id":"https://openalex.org/keywords/fusion-mechanism","display_name":"Fusion mechanism","score":0.7343000173568726},{"id":"https://openalex.org/keywords/fusion","display_name":"Fusion","score":0.5221999883651733},{"id":"https://openalex.org/keywords/set","display_name":"Set (abstract data type)","score":0.4587000012397766},{"id":"https://openalex.org/keywords/drug","display_name":"Drug","score":0.43959999084472656},{"id":"https://openalex.org/keywords/fuse","display_name":"Fuse (electrical)","score":0.4350000023841858},{"id":"https://openalex.org/keywords/bridge","display_name":"Bridge (graph theory)","score":0.40119999647140503}],"concepts":[{"id":"https://openalex.org/C174348530","wikidata":"https://www.wikidata.org/wiki/Q188635","display_name":"Bridging (networking)","level":2,"score":0.843500018119812},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.7653999924659729},{"id":"https://openalex.org/C173414695","wikidata":"https://www.wikidata.org/wiki/Q5510276","display_name":"Fusion mechanism","level":4,"score":0.7343000173568726},{"id":"https://openalex.org/C158525013","wikidata":"https://www.wikidata.org/wiki/Q2593739","display_name":"Fusion","level":2,"score":0.5221999883651733},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.5049999952316284},{"id":"https://openalex.org/C177264268","wikidata":"https://www.wikidata.org/wiki/Q1514741","display_name":"Set (abstract data type)","level":2,"score":0.4587000012397766},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.43959999084472656},{"id":"https://openalex.org/C141353440","wikidata":"https://www.wikidata.org/wiki/Q182221","display_name":"Fuse (electrical)","level":2,"score":0.4350000023841858},{"id":"https://openalex.org/C100776233","wikidata":"https://www.wikidata.org/wiki/Q2532492","display_name":"Bridge (graph theory)","level":2,"score":0.40119999647140503},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.3831999897956848},{"id":"https://openalex.org/C45374587","wikidata":"https://www.wikidata.org/wiki/Q12525525","display_name":"Computation","level":2,"score":0.375900000333786},{"id":"https://openalex.org/C74187038","wikidata":"https://www.wikidata.org/wiki/Q1418791","display_name":"Drug discovery","level":2,"score":0.37389999628067017},{"id":"https://openalex.org/C2989108626","wikidata":"https://www.wikidata.org/wiki/Q904407","display_name":"Drug target","level":2,"score":0.3271999955177307},{"id":"https://openalex.org/C774472","wikidata":"https://www.wikidata.org/wiki/Q6760393","display_name":"Margin (machine learning)","level":2,"score":0.3131999969482422},{"id":"https://openalex.org/C89611455","wikidata":"https://www.wikidata.org/wiki/Q6804646","display_name":"Mechanism (biology)","level":2,"score":0.31279999017715454},{"id":"https://openalex.org/C64903051","wikidata":"https://www.wikidata.org/wiki/Q2198549","display_name":"Drug development","level":3,"score":0.27489998936653137},{"id":"https://openalex.org/C184337299","wikidata":"https://www.wikidata.org/wiki/Q1437428","display_name":"Semantics (computer science)","level":2,"score":0.27489998936653137},{"id":"https://openalex.org/C113843644","wikidata":"https://www.wikidata.org/wiki/Q901882","display_name":"Interface (matter)","level":4,"score":0.2676999866962433},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.25859999656677246},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.2549999952316284}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004338","descriptor_name":"Drug Combinations","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004338","descriptor_name":"Drug Combinations","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004338","descriptor_name":"Drug Combinations","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004338","descriptor_name":"Drug Combinations","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004357","descriptor_name":"Drug Synergism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004357","descriptor_name":"Drug Synergism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004357","descriptor_name":"Drug Synergism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004357","descriptor_name":"Drug Synergism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1093/bib/bbaf624","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbaf624","pdf_url":"https://academic.oup.com/bib/article-pdf/26/6/bbaf624/65450783/bbaf624.pdf","source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},{"id":"pmid:41269282","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41269282","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in bioinformatics","raw_type":null},{"id":"pmh:oai:europepmc.org:11443682","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/12636530","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1093/bib/bbaf624","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbaf624","pdf_url":"https://academic.oup.com/bib/article-pdf/26/6/bbaf624/65450783/bbaf624.pdf","source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G1392825124","display_name":null,"funder_award_id":"6227117","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G2087396116","display_name":null,"funder_award_id":"China","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G2656599839","display_name":null,"funder_award_id":"32270786","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G3111323395","display_name":null,"funder_award_id":"62271174","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G3317480652","display_name":null,"funder_award_id":"Science","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G391238517","display_name":null,"funder_award_id":", and","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G4020255992","display_name":null,"funder_award_id":"Project","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G5939423041","display_name":null,"funder_award_id":"Technology","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G5994120800","display_name":null,"funder_award_id":"Natural","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G6707444068","display_name":null,"funder_award_id":"20001008","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G8369339599","display_name":null,"funder_award_id":"122022","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G8597864016","display_name":null,"funder_award_id":"62102191","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G8955107213","display_name":null,"funder_award_id":"Major","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G970936269","display_name":null,"funder_award_id":"2024ZD0531800","funder_id":"https://openalex.org/F4320329860","funder_display_name":"National Science and Technology Major Project"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320329860","display_name":"National Science and Technology Major Project","ror":null}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4416625073.pdf","grobid_xml":"https://content.openalex.org/works/W4416625073.grobid-xml"},"referenced_works_count":36,"referenced_works":["https://openalex.org/W1966889884","https://openalex.org/W1976666735","https://openalex.org/W1985829224","https://openalex.org/W1998596454","https://openalex.org/W2018798914","https://openalex.org/W2057921766","https://openalex.org/W2058841871","https://openalex.org/W2061061337","https://openalex.org/W2073479915","https://openalex.org/W2268194897","https://openalex.org/W2299417213","https://openalex.org/W2608863179","https://openalex.org/W2609464715","https://openalex.org/W2775061087","https://openalex.org/W2949524414","https://openalex.org/W2960677646","https://openalex.org/W3102269903","https://openalex.org/W3107514561","https://openalex.org/W3164087725","https://openalex.org/W3172530361","https://openalex.org/W3177500196","https://openalex.org/W3203908308","https://openalex.org/W4293214728","https://openalex.org/W4312114349","https://openalex.org/W4323304388","https://openalex.org/W4385751491","https://openalex.org/W4391005764","https://openalex.org/W4391724175","https://openalex.org/W4393374578","https://openalex.org/W4394812234","https://openalex.org/W4403240116","https://openalex.org/W4404260603","https://openalex.org/W4406234938","https://openalex.org/W4406298483","https://openalex.org/W4411054984","https://openalex.org/W4411949398"],"related_works":[],"abstract_inverted_index":{"Drug":[0],"combination":[1],"is":[2],"a":[3,12,29,40,69,75,87],"promising":[4],"therapeutic":[5],"strategy":[6],"for":[7,45],"complex":[8,113],"diseases.":[9],"However,":[10],"only":[11],"small":[13],"fraction":[14],"of":[15,26,77,95],"potential":[16],"drug":[17,27,46,61,96],"combinations":[18],"exhibit":[19],"true":[20],"synergistic":[21],"effects,":[22],"making":[23],"the":[24,51,93],"prediction":[25,119],"synergy":[28,47],"critical":[30],"yet":[31],"challenging":[32],"task.":[33],"In":[34],"this":[35,107],"study,":[36],"we":[37],"propose":[38],"BridgeSyn,":[39],"novel":[41],"bridge":[42],"fusion":[43,71,108],"framework":[44],"prediction.":[48],"BridgeSyn":[49,110,129],"leverages":[50],"knowledge":[52,105],"from":[53,82],"pretrained":[54],"biological":[55,103,114],"language":[56],"models":[57],"to":[58,90],"enrich":[59],"both":[60],"compound":[62],"and":[63,98,116],"cell":[64,99],"line":[65],"representations.":[66],"We":[67],"introduce":[68],"bridging":[70],"mechanism":[72],"that":[73,128],"employs":[74],"set":[76],"shared":[78],"latent":[79],"tokens":[80],"derived":[81],"global":[83],"features,":[84],"serving":[85],"as":[86],"semantic":[88],"interface":[89],"effectively":[91],"fuse":[92],"representations":[94],"pairs":[97],"lines.":[100],"By":[101],"combining":[102],"prior":[104],"with":[106],"strategy,":[109],"can":[111],"capture":[112],"interactions":[115],"achieve":[117],"superior":[118],"results.":[120],"Extensive":[121],"experiments":[122],"on":[123],"two":[124],"public":[125],"datasets":[126],"demonstrate":[127],"consistently":[130],"outperforms":[131],"existing":[132],"computation":[133],"methods.":[134]},"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-03-22T08:09:32.410652","created_date":"2025-11-23T00:00:00"}