{"id":"https://openalex.org/W4415217547","doi":"https://doi.org/10.1093/bib/bbaf546","title":"Integrative genetic analysis reveals new relationships between intraocular pressure, glaucoma, and ischemic stroke risk: a study based on combined SNP-to-gene, Mendelian randomization and pathway investigations","display_name":"Integrative genetic analysis reveals new relationships between intraocular pressure, glaucoma, and ischemic stroke risk: a study based on combined SNP-to-gene, Mendelian randomization and pathway investigations","publication_year":2025,"publication_date":"2025-08-31","ids":{"openalex":"https://openalex.org/W4415217547","doi":"https://doi.org/10.1093/bib/bbaf546","pmid":"https://pubmed.ncbi.nlm.nih.gov/41092061"},"language":"en","primary_location":{"id":"doi:10.1093/bib/bbaf546","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbaf546","pdf_url":"https://academic.oup.com/bib/article-pdf/26/5/bbaf546/64711729/bbaf546.pdf","source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://academic.oup.com/bib/article-pdf/26/5/bbaf546/64711729/bbaf546.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100348829","display_name":"Qi Zhang","orcid":"https://orcid.org/0000-0001-7041-643X"},"institutions":[{"id":"https://openalex.org/I199305430","display_name":"Nantong University","ror":"https://ror.org/02afcvw97","country_code":"CN","type":"education","lineage":["https://openalex.org/I199305430"]},{"id":"https://openalex.org/I4210122818","display_name":"Taizhou People's Hospital","ror":"https://ror.org/02fvevm64","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210122818"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qi Zhang","raw_affiliation_strings":["Department of Neurology, The Affiliated Taizhou People\u2019s Hospital of Nanjing Medical University, Taizhou School of Clinical Medicine, Nanjing Medical University , Taizhou, Jiangsu 225300 ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, The Affiliated Taizhou People\u2019s Hospital of Nanjing Medical University, Taizhou School of Clinical Medicine, Nanjing Medical University , Taizhou, Jiangsu 225300 ,","institution_ids":["https://openalex.org/I4210122818","https://openalex.org/I199305430"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007263000","display_name":"Di Hu","orcid":"https://orcid.org/0000-0002-1627-014X"},"institutions":[{"id":"https://openalex.org/I4210159329","display_name":"Children's Hospital of Fudan University","ror":"https://ror.org/05n13be63","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210159329"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Di Hu","raw_affiliation_strings":["Department of Ophthalmology, Children\u2019s Hospital of Fudan University , Shanghai 201102 ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology, Children\u2019s Hospital of Fudan University , Shanghai 201102 ,","institution_ids":["https://openalex.org/I4210159329"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089552125","display_name":"Zenan Lin","orcid":"https://orcid.org/0000-0001-5501-6657"},"institutions":[{"id":"https://openalex.org/I199305430","display_name":"Nantong University","ror":"https://ror.org/02afcvw97","country_code":"CN","type":"education","lineage":["https://openalex.org/I199305430"]},{"id":"https://openalex.org/I4210122818","display_name":"Taizhou People's Hospital","ror":"https://ror.org/02fvevm64","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210122818"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zenan Lin","raw_affiliation_strings":["Department of Ophthalmology, The Affiliated Taizhou People\u2019s Hospital of Nanjing Medical University, Taizhou School of Clinical Medicine, Nanjing Medical University , Taizhou, Jiangsu 225300 ,"],"raw_orcid":"https://orcid.org/0000-0001-5501-6657","affiliations":[{"raw_affiliation_string":"Department of Ophthalmology, The Affiliated Taizhou People\u2019s Hospital of Nanjing Medical University, Taizhou School of Clinical Medicine, Nanjing Medical University , Taizhou, Jiangsu 225300 ,","institution_ids":["https://openalex.org/I4210122818","https://openalex.org/I199305430"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5031042628","display_name":"Junhong Jiang","orcid":"https://orcid.org/0000-0001-6205-9567"},"institutions":[{"id":"https://openalex.org/I4210092517","display_name":"Shanghai Eye Disease Prevention & Treatment Center","ror":"https://ror.org/0048a4976","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210092517"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Junhong Jiang","raw_affiliation_strings":["Department of Ophthalmology, Shanghai Eye Disease Prevention & Treatment Center/Shanghai Eye Hospital, School of Medicine, Tongji University , Shanghai 200041 ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology, Shanghai Eye Disease Prevention & Treatment Center/Shanghai Eye Hospital, School of Medicine, Tongji University , Shanghai 200041 ,","institution_ids":["https://openalex.org/I4210092517"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4011,"currency":"USD","value_usd":4011},"apc_paid":{"value":4011,"currency":"USD","value_usd":4011},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.37306886,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"26","issue":"5","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10250","display_name":"Glaucoma and retinal disorders","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10250","display_name":"Glaucoma and retinal disorders","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10170","display_name":"Retinal Diseases and Treatments","score":0.9936000108718872,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11929","display_name":"Cerebral Venous Sinus Thrombosis","score":0.9927999973297119,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mendelian-randomization","display_name":"Mendelian randomization","score":0.949999988079071},{"id":"https://openalex.org/keywords/single-nucleotide-polymorphism","display_name":"Single-nucleotide polymorphism","score":0.7394999861717224},{"id":"https://openalex.org/keywords/glaucoma","display_name":"Glaucoma","score":0.5486999750137329},{"id":"https://openalex.org/keywords/genome-wide-association-study","display_name":"Genome-wide association study","score":0.5457000136375427},{"id":"https://openalex.org/keywords/snp","display_name":"SNP","score":0.5307000279426575},{"id":"https://openalex.org/keywords/concordance","display_name":"Concordance","score":0.5117999911308289},{"id":"https://openalex.org/keywords/causal-inference","display_name":"Causal inference","score":0.4278999865055084},{"id":"https://openalex.org/keywords/genetic-association","display_name":"Genetic association","score":0.4120999872684479}],"concepts":[{"id":"https://openalex.org/C2779901538","wikidata":"https://www.wikidata.org/wiki/Q6816584","display_name":"Mendelian randomization","level":5,"score":0.949999988079071},{"id":"https://openalex.org/C153209595","wikidata":"https://www.wikidata.org/wiki/Q501128","display_name":"Single-nucleotide polymorphism","level":4,"score":0.7394999861717224},{"id":"https://openalex.org/C2778527774","wikidata":"https://www.wikidata.org/wiki/Q159701","display_name":"Glaucoma","level":2,"score":0.5486999750137329},{"id":"https://openalex.org/C106208931","wikidata":"https://www.wikidata.org/wiki/Q1098876","display_name":"Genome-wide association study","level":5,"score":0.5457000136375427},{"id":"https://openalex.org/C139275648","wikidata":"https://www.wikidata.org/wiki/Q17134011","display_name":"SNP","level":5,"score":0.5307000279426575},{"id":"https://openalex.org/C160798450","wikidata":"https://www.wikidata.org/wiki/Q4230870","display_name":"Concordance","level":2,"score":0.5117999911308289},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4620000123977661},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.43299999833106995},{"id":"https://openalex.org/C158600405","wikidata":"https://www.wikidata.org/wiki/Q5054566","display_name":"Causal inference","level":2,"score":0.4278999865055084},{"id":"https://openalex.org/C186413461","wikidata":"https://www.wikidata.org/wiki/Q744727","display_name":"Genetic association","level":5,"score":0.4120999872684479},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4083000123500824},{"id":"https://openalex.org/C77350462","wikidata":"https://www.wikidata.org/wiki/Q1125472","display_name":"Confounding","level":2,"score":0.40549999475479126},{"id":"https://openalex.org/C69991583","wikidata":"https://www.wikidata.org/wiki/Q1423575","display_name":"Candidate gene","level":3,"score":0.3898000121116638},{"id":"https://openalex.org/C175783326","wikidata":"https://www.wikidata.org/wiki/Q185055","display_name":"Mendelian inheritance","level":3,"score":0.37860000133514404},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3560999929904938},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3368000090122223},{"id":"https://openalex.org/C2781092963","wikidata":"https://www.wikidata.org/wiki/Q650050","display_name":"Intraocular pressure","level":2,"score":0.3197999894618988},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3188000023365021},{"id":"https://openalex.org/C2991772755","wikidata":"https://www.wikidata.org/wiki/Q751748","display_name":"Gene interaction","level":3,"score":0.3125999867916107},{"id":"https://openalex.org/C89611455","wikidata":"https://www.wikidata.org/wiki/Q6804646","display_name":"Mechanism (biology)","level":2,"score":0.29899999499320984},{"id":"https://openalex.org/C2780645631","wikidata":"https://www.wikidata.org/wiki/Q671554","display_name":"Stroke (engine)","level":2,"score":0.2892000079154968},{"id":"https://openalex.org/C2780265364","wikidata":"https://www.wikidata.org/wiki/Q5009957","display_name":"CDKN2A","level":3,"score":0.2842999994754791},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.25679999589920044},{"id":"https://openalex.org/C84597430","wikidata":"https://www.wikidata.org/wiki/Q106227","display_name":"Locus (genetics)","level":3,"score":0.2563999891281128},{"id":"https://openalex.org/C11671645","wikidata":"https://www.wikidata.org/wiki/Q5054567","display_name":"Causal model","level":2,"score":0.2529999911785126}],"mesh":[{"descriptor_ui":"D000083242","descriptor_name":"Ischemic Stroke","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000083242","descriptor_name":"Ischemic Stroke","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000083242","descriptor_name":"Ischemic Stroke","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000083242","descriptor_name":"Ischemic Stroke","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D005901","descriptor_name":"Glaucoma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D005901","descriptor_name":"Glaucoma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D005901","descriptor_name":"Glaucoma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D005901","descriptor_name":"Glaucoma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D005902","descriptor_name":"Glaucoma, Open-Angle","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D005902","descriptor_name":"Glaucoma, Open-Angle","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D005902","descriptor_name":"Glaucoma, Open-Angle","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D005902","descriptor_name":"Glaucoma, Open-Angle","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007429","descriptor_name":"Intraocular Pressure","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D007429","descriptor_name":"Intraocular Pressure","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D007429","descriptor_name":"Intraocular Pressure","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D007429","descriptor_name":"Intraocular Pressure","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D057182","descriptor_name":"Mendelian Randomization Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D057182","descriptor_name":"Mendelian Randomization Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D057182","descriptor_name":"Mendelian Randomization Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D057182","descriptor_name":"Mendelian Randomization Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1093/bib/bbaf546","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbaf546","pdf_url":"https://academic.oup.com/bib/article-pdf/26/5/bbaf546/64711729/bbaf546.pdf","source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},{"id":"pmid:41092061","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41092061","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in bioinformatics","raw_type":null},{"id":"pmh:oai:europepmc.org:11332237","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/12527246","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1093/bib/bbaf546","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbaf546","pdf_url":"https://academic.oup.com/bib/article-pdf/26/5/bbaf546/64711729/bbaf546.pdf","source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4415217547.pdf","grobid_xml":"https://content.openalex.org/works/W4415217547.grobid-xml"},"referenced_works_count":70,"referenced_works":["https://openalex.org/W1844405070","https://openalex.org/W1922859108","https://openalex.org/W1968210590","https://openalex.org/W1973886069","https://openalex.org/W1976135887","https://openalex.org/W2003338843","https://openalex.org/W2013954714","https://openalex.org/W2015310445","https://openalex.org/W2016414531","https://openalex.org/W2024191665","https://openalex.org/W2035620169","https://openalex.org/W2036198235","https://openalex.org/W2043355615","https://openalex.org/W2045381980","https://openalex.org/W2046525828","https://openalex.org/W2071254482","https://openalex.org/W2071762518","https://openalex.org/W2073836327","https://openalex.org/W2082188082","https://openalex.org/W2089961311","https://openalex.org/W2110032606","https://openalex.org/W2127380915","https://openalex.org/W2151549808","https://openalex.org/W2153860431","https://openalex.org/W2213426807","https://openalex.org/W2266290735","https://openalex.org/W2274924551","https://openalex.org/W2521776509","https://openalex.org/W2561013679","https://openalex.org/W2585605401","https://openalex.org/W2619337459","https://openalex.org/W2742680365","https://openalex.org/W2744159340","https://openalex.org/W2771217310","https://openalex.org/W2791863121","https://openalex.org/W2805983714","https://openalex.org/W2904614042","https://openalex.org/W2908698255","https://openalex.org/W2913338554","https://openalex.org/W2966743893","https://openalex.org/W2982692626","https://openalex.org/W3013017078","https://openalex.org/W3026068192","https://openalex.org/W3030250839","https://openalex.org/W3128686966","https://openalex.org/W3147383836","https://openalex.org/W3174355950","https://openalex.org/W3197233575","https://openalex.org/W3199661592","https://openalex.org/W4206622785","https://openalex.org/W4213147030","https://openalex.org/W4213291594","https://openalex.org/W4220866878","https://openalex.org/W4226134665","https://openalex.org/W4282915079","https://openalex.org/W4285491641","https://openalex.org/W4304002579","https://openalex.org/W4306810370","https://openalex.org/W4316036796","https://openalex.org/W4366822376","https://openalex.org/W4386444271","https://openalex.org/W4389728702","https://openalex.org/W4390692723","https://openalex.org/W4390752428","https://openalex.org/W4391986510","https://openalex.org/W4394622471","https://openalex.org/W4395032056","https://openalex.org/W4399423840","https://openalex.org/W4408951936","https://openalex.org/W4410762210"],"related_works":[],"abstract_inverted_index":{"Ischemic":[0],"stroke":[1],"(IS)":[2],"is":[3],"a":[4,37,50,216,267],"leading":[5],"cause":[6],"of":[7,81,145,229],"death":[8],"in":[9,199,219,276],"elderly":[10],"people.":[11],"Previous":[12],"studies":[13,67],"exploring":[14,271],"the":[15,58,79,82,86,108,143,161,169,186,200,212,220,226,243,272],"association":[16],"between":[17,61,234,246],"intraocular":[18],"pressure":[19],"(IOP),":[20],"glaucoma,":[21,63],"and":[22,45,64,73,97,129,147,172,192,202,208,232,236,249,251,255],"IS":[23,120,154,178,204],"have":[24],"provided":[25],"inconsistent":[26],"results.":[27],"Here,":[28],"we":[29,189],"aimed":[30],"to":[31,56,77,104,124,141,160,176],"clarify":[32],"this":[33],"causal":[34,59,83,117,151,227,244,274],"relationship,":[35],"as":[36,69,92,215,266],"better":[38],"understanding":[39],"may":[40,174],"reveal":[41],"novel":[42,109,268],"therapeutic":[43],"targets":[44],"preventive":[46],"strategies.":[47],"We":[48,133],"performed":[49,135],"bidirectional":[51],"Mendelian":[52,138],"randomization":[53,139],"(MR)":[54],"study":[55,140,263],"explore":[57],"relationship":[60],"IOP,":[62,247],"IS.":[65,237],"Complementary":[66],"such":[68],"MR-Egger":[70],"regression,":[71],"MR-PRESSO,":[72],"MRlap":[74],"were":[75,102,121,157],"conducted":[76],"assess":[78],"robustness":[80],"associations.":[84],"Next,":[85],"single":[87,136],"nucleotide":[88],"polymorphisms":[89],"(SNPs)":[90],"selected":[91],"instrumental":[93],"variables":[94],"for":[95,257,270],"IOP":[96,146,171],"primary":[98],"open-angle":[99],"glaucoma":[100,148],"(POAG)":[101],"mapped":[103],"relevant":[105],"genes":[106,194,230,256],"by":[107],"combined":[110],"SNP-to-gene":[111],"(cS2G)":[112],"method.":[113],"Genes":[114],"showing":[115],"significant":[116,150],"effects":[118],"on":[119,153],"further":[122,224],"subjected":[123],"gene":[125],"ontology":[126],"(GO),":[127],"pathway,":[128],"colocalization":[130],"(COLOC)":[131],"analyses.":[132],"also":[134],"SNP":[137],"identify":[142],"SNPs":[144],"with":[149],"influence":[152],"risk,":[155,179,205],"which":[156],"then":[158],"introduced":[159],"cytogenetic":[162],"investigation.":[163],"The":[164],"MR":[165],"results":[166],"supported":[167],"that":[168],"elevated":[170],"POAG":[173,235],"contribute":[175],"increased":[177],"but":[180],"not":[181],"vice":[182],"versa.":[183],"By":[184],"using":[185],"cS2G":[187],"approach,":[188],"identified":[190],"31":[191],"3":[193],"potentially":[195],"playing":[196],"key":[197],"roles":[198],"IOP-":[201],"POAG-induced":[203],"respectively.":[206],"GO":[207],"pathway":[209,214,254],"analyses":[210],"indicated":[211],"olfactory":[213],"crucial":[217],"mechanism":[218],"IOP-associated":[221],"risk.":[222],"COLOC":[223],"strengthened":[225],"implications":[228,245],"CDKN2A":[231],"CDKN2B-AS1":[233],"This":[238],"work":[239],"provides":[240],"evidence":[241],"supporting":[242],"POAG,":[248],"IS,":[250],"highlights":[252],"putative":[253],"managing":[258],"both":[259],"conditions.":[260],"Moreover,":[261],"our":[262],"could":[264],"serve":[265],"paradigm":[269],"in-depth":[273],"relationships":[275],"other":[277],"diseases.":[278]},"counts_by_year":[],"updated_date":"2026-05-21T06:26:12.895304","created_date":"2025-10-16T00:00:00"}