{"id":"https://openalex.org/W4415002553","doi":"https://doi.org/10.1093/bib/bbaf531","title":"Cell-type-specific cis-eQTLs in pancreatic cell types identify novel risk genes for type 2 diabetes","display_name":"Cell-type-specific cis-eQTLs in pancreatic cell types identify novel risk genes for type 2 diabetes","publication_year":2025,"publication_date":"2025-08-31","ids":{"openalex":"https://openalex.org/W4415002553","doi":"https://doi.org/10.1093/bib/bbaf531","pmid":"https://pubmed.ncbi.nlm.nih.gov/41066696"},"language":"en","primary_location":{"id":"doi:10.1093/bib/bbaf531","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbaf531","pdf_url":null,"source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1093/bib/bbaf531","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5022525333","display_name":"Xiaocao Miao","orcid":"https://orcid.org/0000-0003-4511-6552"},"institutions":[{"id":"https://openalex.org/I4210110011","display_name":"Shanghai Cancer Institute","ror":"https://ror.org/01ty4bg86","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210110011"]},{"id":"https://openalex.org/I4210138900","display_name":"State Key Laboratory of Oncogene and Related Genes","ror":"https://ror.org/03xt1x768","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210138900"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiao-Cao Miao","raw_affiliation_strings":["State Key Laboratory of Systems Medicine for Cancer, Shanghai Cancer Institute, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University , 800 Dongchuan Road, Minhang District, Shanghai 200240 ,"],"raw_orcid":"https://orcid.org/0000-0003-4511-6552","affiliations":[{"raw_affiliation_string":"State Key Laboratory of Systems Medicine for Cancer, Shanghai Cancer Institute, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University , 800 Dongchuan Road, Minhang District, Shanghai 200240 ,","institution_ids":["https://openalex.org/I4210110011","https://openalex.org/I4210138900"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100632607","display_name":"Hui Li","orcid":"https://orcid.org/0000-0001-6523-8771"},"institutions":[{"id":"https://openalex.org/I4210110011","display_name":"Shanghai Cancer Institute","ror":"https://ror.org/01ty4bg86","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210110011"]},{"id":"https://openalex.org/I4210138900","display_name":"State Key Laboratory of Oncogene and Related Genes","ror":"https://ror.org/03xt1x768","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210138900"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hui Li","raw_affiliation_strings":["State Key Laboratory of Systems Medicine for Cancer, Shanghai Cancer Institute, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University , 800 Dongchuan Road, Minhang District, Shanghai 200240 ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Systems Medicine for Cancer, Shanghai Cancer Institute, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University , 800 Dongchuan Road, Minhang District, Shanghai 200240 ,","institution_ids":["https://openalex.org/I4210110011","https://openalex.org/I4210138900"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100404154","display_name":"Qing Li","orcid":"https://orcid.org/0000-0003-0251-9159"},"institutions":[{"id":"https://openalex.org/I4210110011","display_name":"Shanghai Cancer Institute","ror":"https://ror.org/01ty4bg86","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210110011"]},{"id":"https://openalex.org/I4210138900","display_name":"State Key Laboratory of Oncogene and Related Genes","ror":"https://ror.org/03xt1x768","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210138900"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qing Li","raw_affiliation_strings":["State Key Laboratory of Systems Medicine for Cancer, Shanghai Cancer Institute, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University , 800 Dongchuan Road, Minhang District, Shanghai 200240 ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Systems Medicine for Cancer, Shanghai Cancer Institute, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University , 800 Dongchuan Road, Minhang District, Shanghai 200240 ,","institution_ids":["https://openalex.org/I4210110011","https://openalex.org/I4210138900"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100685881","display_name":"Lei Zhu","orcid":"https://orcid.org/0009-0004-3602-1281"},"institutions":[{"id":"https://openalex.org/I4210110011","display_name":"Shanghai Cancer Institute","ror":"https://ror.org/01ty4bg86","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210110011"]},{"id":"https://openalex.org/I4210138900","display_name":"State Key Laboratory of Oncogene and Related Genes","ror":"https://ror.org/03xt1x768","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210138900"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lei Zhu","raw_affiliation_strings":["State Key Laboratory of Systems Medicine for Cancer, Shanghai Cancer Institute, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University , 800 Dongchuan Road, Minhang District, Shanghai 200240 ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Systems Medicine for Cancer, Shanghai Cancer Institute, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University , 800 Dongchuan Road, Minhang District, Shanghai 200240 ,","institution_ids":["https://openalex.org/I4210110011","https://openalex.org/I4210138900"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057202795","display_name":"Yanqiu Yu","orcid":"https://orcid.org/0000-0002-7953-6320"},"institutions":[{"id":"https://openalex.org/I1099802","display_name":"Shenyang Medical College","ror":"https://ror.org/02y9xvd02","country_code":"CN","type":"education","lineage":["https://openalex.org/I1099802"]},{"id":"https://openalex.org/I4210087991","display_name":"Shenyang Science and Technology Bureau","ror":"https://ror.org/007medz62","country_code":"CN","type":"government","lineage":["https://openalex.org/I4210087991"]},{"id":"https://openalex.org/I91656880","display_name":"China Medical University","ror":"https://ror.org/032d4f246","country_code":"CN","type":"education","lineage":["https://openalex.org/I91656880"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yan-Qiu Yu","raw_affiliation_strings":["Department of Pathophysiology, School of Basic Medicine, China Medical University , No. 77 Puhe Road, Shenbei New District, Shenyang 110122 , Liaoning Province,","Shenyang Engineering Technology R&D Center of Cell Therapy Co., Ltd , No. 400-8, 2nd Zhihui Street, Hunnan District, Shenyang 110174 , Liaoning Province,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathophysiology, School of Basic Medicine, China Medical University , No. 77 Puhe Road, Shenbei New District, Shenyang 110122 , Liaoning Province,","institution_ids":["https://openalex.org/I1099802","https://openalex.org/I91656880"]},{"raw_affiliation_string":"Shenyang Engineering Technology R&D Center of Cell Therapy Co., Ltd , No. 400-8, 2nd Zhihui Street, Hunnan District, Shenyang 110174 , Liaoning Province,","institution_ids":["https://openalex.org/I4210087991"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022420177","display_name":"Jianguang Ji","orcid":"https://orcid.org/0000-0003-0324-9496"},"institutions":[{"id":"https://openalex.org/I204512498","display_name":"University of Macau","ror":"https://ror.org/01r4q9n85","country_code":"MO","type":"education","lineage":["https://openalex.org/I204512498"]}],"countries":["MO"],"is_corresponding":false,"raw_author_name":"Jian-Guang Ji","raw_affiliation_strings":["Cancer Center, Faculty of Health Sciences, University of Macau , S22 Avenida da Universidade, Taipa, Macau SAR 999078,","Department of Public Health and Medicinal Administration, Faculty of Health Sciences, University of Macau , S22 Avenida da Universidade, Taipa, Macau SAR 999078,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Center, Faculty of Health Sciences, University of Macau , S22 Avenida da Universidade, Taipa, Macau SAR 999078,","institution_ids":["https://openalex.org/I204512498"]},{"raw_affiliation_string":"Department of Public Health and Medicinal Administration, Faculty of Health Sciences, University of Macau , S22 Avenida da Universidade, Taipa, Macau SAR 999078,","institution_ids":["https://openalex.org/I204512498"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100357759","display_name":"Tao Chen","orcid":"https://orcid.org/0000-0002-6254-1414"},"institutions":[{"id":"https://openalex.org/I4210094836","display_name":"Ganzhou People's Hospital","ror":"https://ror.org/00r398124","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210094836"]},{"id":"https://openalex.org/I4210153921","display_name":"Guangzhou Medical University Cancer Hospital","ror":"https://ror.org/046c18a90","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210153921"]},{"id":"https://openalex.org/I58200834","display_name":"Southern Medical University","ror":"https://ror.org/01vjw4z39","country_code":"CN","type":"education","lineage":["https://openalex.org/I58200834"]},{"id":"https://openalex.org/I92039509","display_name":"Guangzhou Medical University","ror":"https://ror.org/00zat6v61","country_code":"CN","type":"education","lineage":["https://openalex.org/I92039509"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Tao Chen","raw_affiliation_strings":["Department of Gastrointestinal and hernia surgery, Ganzhou Hospital-Nanfang Hospital, Southern Medical University , No. 16 Meiguan Avenue, Zhanggong District, Ganzhou, Jiangxi 341000,","Department of General Surgery & Guangdong Provincial Key Laboratory of Precision Medicine for Gastrointestinal Tumor, Nanfang Hospital, Southern Medical University , No. 1838 North Guangzhou Avenue, Baiyun District, Guangzhou, Guangdong 510000,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastrointestinal and hernia surgery, Ganzhou Hospital-Nanfang Hospital, Southern Medical University , No. 16 Meiguan Avenue, Zhanggong District, Ganzhou, Jiangxi 341000,","institution_ids":["https://openalex.org/I4210094836"]},{"raw_affiliation_string":"Department of General Surgery & Guangdong Provincial Key Laboratory of Precision Medicine for Gastrointestinal Tumor, Nanfang Hospital, Southern Medical University , No. 1838 North Guangzhou Avenue, Baiyun District, Guangzhou, Guangdong 510000,","institution_ids":["https://openalex.org/I4210153921","https://openalex.org/I58200834","https://openalex.org/I92039509"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100373986","display_name":"Zhigang Zhang","orcid":"https://orcid.org/0000-0001-8965-223X"},"institutions":[{"id":"https://openalex.org/I4210110011","display_name":"Shanghai Cancer Institute","ror":"https://ror.org/01ty4bg86","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210110011"]},{"id":"https://openalex.org/I4210138900","display_name":"State Key Laboratory of Oncogene and Related Genes","ror":"https://ror.org/03xt1x768","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210138900"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Zhi-Gang Zhang","raw_affiliation_strings":["State Key Laboratory of Systems Medicine for Cancer, Shanghai Cancer Institute, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University , 800 Dongchuan Road, Minhang District, Shanghai 200240 ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Systems Medicine for Cancer, Shanghai Cancer Institute, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University , 800 Dongchuan Road, Minhang District, Shanghai 200240 ,","institution_ids":["https://openalex.org/I4210110011","https://openalex.org/I4210138900"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5076412291","display_name":"Dong\u2010Xue Li","orcid":null},"institutions":[{"id":"https://openalex.org/I4210110011","display_name":"Shanghai Cancer Institute","ror":"https://ror.org/01ty4bg86","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210110011"]},{"id":"https://openalex.org/I4210138900","display_name":"State Key Laboratory of Oncogene and Related Genes","ror":"https://ror.org/03xt1x768","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210138900"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Dong-Xue Li","raw_affiliation_strings":["State Key Laboratory of Systems Medicine for Cancer, Shanghai Cancer Institute, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University , 800 Dongchuan Road, Minhang District, Shanghai 200240 ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Systems Medicine for Cancer, Shanghai Cancer Institute, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University , 800 Dongchuan Road, Minhang District, Shanghai 200240 ,","institution_ids":["https://openalex.org/I4210110011","https://openalex.org/I4210138900"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":10,"corresponding_author_ids":["https://openalex.org/A5076412291","https://openalex.org/A5100357759","https://openalex.org/A5100373986"],"corresponding_institution_ids":["https://openalex.org/I4210094836","https://openalex.org/I4210110011","https://openalex.org/I4210138900","https://openalex.org/I4210153921","https://openalex.org/I58200834","https://openalex.org/I92039509"],"apc_list":{"value":4011,"currency":"USD","value_usd":4011},"apc_paid":{"value":4011,"currency":"USD","value_usd":4011},"fwci":1.096,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.80611934,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":94,"max":97},"biblio":{"volume":"26","issue":"5","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.9986000061035156,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.9986000061035156,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11289","display_name":"Single-cell and spatial transcriptomics","score":0.9957000017166138,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11928","display_name":"Genetic Syndromes and Imprinting","score":0.9919999837875366,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chromatin","display_name":"Chromatin","score":0.7738000154495239},{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"Type 2 diabetes","score":0.6431999802589417},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.6046000123023987},{"id":"https://openalex.org/keywords/single-nucleotide-polymorphism","display_name":"Single-nucleotide polymorphism","score":0.4797999858856201},{"id":"https://openalex.org/keywords/trait","display_name":"Trait","score":0.4291999936103821},{"id":"https://openalex.org/keywords/quantitative-trait-locus","display_name":"Quantitative trait locus","score":0.42660000920295715},{"id":"https://openalex.org/keywords/pancreatic-cancer","display_name":"Pancreatic cancer","score":0.4221999943256378},{"id":"https://openalex.org/keywords/diabetes-mellitus","display_name":"Diabetes mellitus","score":0.4117000102996826},{"id":"https://openalex.org/keywords/genetic-association","display_name":"Genetic association","score":0.40290001034736633},{"id":"https://openalex.org/keywords/transcriptome","display_name":"Transcriptome","score":0.4023999869823456}],"concepts":[{"id":"https://openalex.org/C83640560","wikidata":"https://www.wikidata.org/wiki/Q180951","display_name":"Chromatin","level":3,"score":0.7738000154495239},{"id":"https://openalex.org/C2777180221","wikidata":"https://www.wikidata.org/wiki/Q3025883","display_name":"Type 2 diabetes","level":3,"score":0.6431999802589417},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.6046000123023987},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5593000054359436},{"id":"https://openalex.org/C153209595","wikidata":"https://www.wikidata.org/wiki/Q501128","display_name":"Single-nucleotide polymorphism","level":4,"score":0.4797999858856201},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.4424000084400177},{"id":"https://openalex.org/C106934330","wikidata":"https://www.wikidata.org/wiki/Q1971873","display_name":"Trait","level":2,"score":0.4291999936103821},{"id":"https://openalex.org/C81941488","wikidata":"https://www.wikidata.org/wiki/Q853421","display_name":"Quantitative trait locus","level":3,"score":0.42660000920295715},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.4239000082015991},{"id":"https://openalex.org/C2780210213","wikidata":"https://www.wikidata.org/wiki/Q212961","display_name":"Pancreatic cancer","level":3,"score":0.4221999943256378},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.4117000102996826},{"id":"https://openalex.org/C186413461","wikidata":"https://www.wikidata.org/wiki/Q744727","display_name":"Genetic association","level":5,"score":0.40290001034736633},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.4023999869823456},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.39879998564720154},{"id":"https://openalex.org/C189014844","wikidata":"https://www.wikidata.org/wiki/Q189118","display_name":"Cell type","level":3,"score":0.388700008392334},{"id":"https://openalex.org/C167227067","wikidata":"https://www.wikidata.org/wiki/Q5113739","display_name":"Chromatin remodeling","level":4,"score":0.3752000033855438},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.3707999885082245},{"id":"https://openalex.org/C106208931","wikidata":"https://www.wikidata.org/wiki/Q1098876","display_name":"Genome-wide association study","level":5,"score":0.3700999915599823},{"id":"https://openalex.org/C46699223","wikidata":"https://www.wikidata.org/wiki/Q11078","display_name":"Endocrine system","level":3,"score":0.3598000109195709},{"id":"https://openalex.org/C2776828364","wikidata":"https://www.wikidata.org/wiki/Q1767180","display_name":"Beta cell","level":4,"score":0.34929999709129333},{"id":"https://openalex.org/C2910068830","wikidata":"https://www.wikidata.org/wiki/Q3025883","display_name":"Type 2 Diabetes Mellitus","level":3,"score":0.3490999937057495},{"id":"https://openalex.org/C165864922","wikidata":"https://www.wikidata.org/wiki/Q411391","display_name":"Regulation of gene expression","level":3,"score":0.33739998936653137},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.33239999413490295},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.3287999927997589},{"id":"https://openalex.org/C39263347","wikidata":"https://www.wikidata.org/wiki/Q14913892","display_name":"TCF7L2","level":5,"score":0.31349998712539673},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3050000071525574},{"id":"https://openalex.org/C2778764654","wikidata":"https://www.wikidata.org/wiki/Q9618","display_name":"Pancreas","level":2,"score":0.30149999260902405},{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.2888000011444092},{"id":"https://openalex.org/C2777402240","wikidata":"https://www.wikidata.org/wiki/Q6783436","display_name":"Masking (illustration)","level":2,"score":0.2809000015258789},{"id":"https://openalex.org/C27153228","wikidata":"https://www.wikidata.org/wiki/Q3787274","display_name":"Transcriptional regulation","level":4,"score":0.27900001406669617},{"id":"https://openalex.org/C186836561","wikidata":"https://www.wikidata.org/wiki/Q1931516","display_name":"Microarray","level":4,"score":0.2660999894142151},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.26460000872612},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.25690001249313354},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.25589999556541443},{"id":"https://openalex.org/C139275648","wikidata":"https://www.wikidata.org/wiki/Q17134011","display_name":"SNP","level":5,"score":0.25459998846054077}],"mesh":[{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010179","descriptor_name":"Pancreas","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D010179","descriptor_name":"Pancreas","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D010179","descriptor_name":"Pancreas","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D010179","descriptor_name":"Pancreas","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D010179","descriptor_name":"Pancreas","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010179","descriptor_name":"Pancreas","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010179","descriptor_name":"Pancreas","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010179","descriptor_name":"Pancreas","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010179","descriptor_name":"Pancreas","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D010179","descriptor_name":"Pancreas","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D010179","descriptor_name":"Pancreas","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D010179","descriptor_name":"Pancreas","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D040641","descriptor_name":"Quantitative Trait Loci","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D040641","descriptor_name":"Quantitative Trait Loci","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D040641","descriptor_name":"Quantitative Trait Loci","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D040641","descriptor_name":"Quantitative Trait Loci","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D055106","descriptor_name":"Genome-Wide Association Study","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055106","descriptor_name":"Genome-Wide Association Study","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055106","descriptor_name":"Genome-Wide Association Study","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055106","descriptor_name":"Genome-Wide Association Study","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1093/bib/bbaf531","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbaf531","pdf_url":null,"source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},{"id":"pmid:41066696","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41066696","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in bioinformatics","raw_type":null},{"id":"pmh:oai:europepmc.org:11318283","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/12510404","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1093/bib/bbaf531","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbaf531","pdf_url":null,"source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G3401929180","display_name":null,"funder_award_id":"20181708","funder_id":"https://openalex.org/F4320321881","funder_display_name":"Shanghai Municipal Education Commission"},{"id":"https://openalex.org/G4141428870","display_name":null,"funder_award_id":"82230087","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G6574872017","display_name":null,"funder_award_id":"82350123","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G7818941457","display_name":null,"funder_award_id":"82203228","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G8172185251","display_name":null,"funder_award_id":"92168111","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320321881","display_name":"Shanghai Municipal Education Commission","ror":"https://ror.org/05tewj457"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":58,"referenced_works":["https://openalex.org/W1518684923","https://openalex.org/W1810028515","https://openalex.org/W1978215768","https://openalex.org/W2035451872","https://openalex.org/W2035618305","https://openalex.org/W2048755332","https://openalex.org/W2069089843","https://openalex.org/W2073836327","https://openalex.org/W2092334563","https://openalex.org/W2099143842","https://openalex.org/W2101359494","https://openalex.org/W2131478115","https://openalex.org/W2133128468","https://openalex.org/W2135199713","https://openalex.org/W2136939537","https://openalex.org/W2146512944","https://openalex.org/W2158783782","https://openalex.org/W2159707944","https://openalex.org/W2166914762","https://openalex.org/W2171874894","https://openalex.org/W2328393125","https://openalex.org/W2411397641","https://openalex.org/W2463988862","https://openalex.org/W2523419694","https://openalex.org/W2523620612","https://openalex.org/W2551194178","https://openalex.org/W2784630408","https://openalex.org/W2805983714","https://openalex.org/W2921398065","https://openalex.org/W2921967571","https://openalex.org/W2979643002","https://openalex.org/W3001475835","https://openalex.org/W3016974908","https://openalex.org/W3030009475","https://openalex.org/W3045603521","https://openalex.org/W3083216853","https://openalex.org/W3131915824","https://openalex.org/W3133859624","https://openalex.org/W3197364483","https://openalex.org/W4200026682","https://openalex.org/W4220682865","https://openalex.org/W4223893712","https://openalex.org/W4224995860","https://openalex.org/W4226118244","https://openalex.org/W4289261763","https://openalex.org/W4296034620","https://openalex.org/W4298008143","https://openalex.org/W4317390883","https://openalex.org/W4376225088","https://openalex.org/W4386311086","https://openalex.org/W4386442688","https://openalex.org/W4393262032","https://openalex.org/W4399135427","https://openalex.org/W4403013111","https://openalex.org/W4403321014","https://openalex.org/W4404283194","https://openalex.org/W4406061774","https://openalex.org/W4406338463"],"related_works":[],"abstract_inverted_index":{"Type":[0],"2":[1],"diabetes":[2,151],"(T2D)":[3],"is":[4],"a":[5],"complex":[6],"metabolic":[7,106],"disorder":[8],"strongly":[9],"influenced":[10],"by":[11,31],"genetics.":[12],"Most":[13],"genetic":[14,148],"studies,":[15],"including":[16],"expression":[17],"quantitative":[18],"trait":[19],"loci":[20],"(eQTL)":[21],"analyses,":[22],"use":[23],"bulk":[24],"pancreatic":[25,48,111],"tissue,":[26],"masking":[27],"cell-specific":[28,147],"mechanisms.":[29],"Here,":[30],"integrating":[32],"single-cell":[33],"RNA":[34],"sequencing,":[35],"chromatin":[36,95],"accessibility,":[37],"and":[38,63,70,77,86,109,125,135,152],"genome-wide":[39],"association":[40],"studies":[41],"(GWAS)":[42],"data,":[43],"we":[44],"systematically":[45],"identified":[46],"328":[47],"cell-type-specific":[49],"cis-eQTLs":[50,122],"associated":[51],"with":[52,94],"T2D.":[53],"We":[54],"pinpointed":[55],"nine":[56],"key":[57],"genes":[58,99],"(including":[59],"STIL":[60],"in":[61,67,79,83,88,103,132,150],"beta":[62,89],"delta":[64,80],"cells;":[65,72,81,85],"ZSWIM5":[66],"alpha,":[68],"delta,":[69],"ductal":[71],"IL1RN,":[73],"ANP32E,":[74],"IPP,":[75],"MLLT11,":[76],"SLC23A3":[78],"SNX4":[82],"gamma":[84],"RBMS1":[87],"cells)":[90],"whose":[91],"SNPs":[92],"overlapped":[93],"accessibility":[96],"peaks.":[97],"These":[98],"highlight":[100],"regulatory":[101,130],"pathways":[102],"beta-cell":[104],"dysfunction,":[105],"stress":[107],"responses,":[108],"disrupted":[110],"homeostasis.":[112],"A":[113],"public":[114],"database,":[115],"CTPeQTLs":[116],"(https://ctpeqtls.netlify.app/),":[117],"was":[118],"developed":[119],"to":[120],"explore":[121],"across":[123],"diabetic":[124],"non-diabetic":[126],"cohorts,":[127],"revealing":[128],"distinct":[129],"patterns":[131],"both":[133],"endocrine":[134],"exocrine":[136],"cells,":[137],"as":[138,140],"well":[139],"disease-associated":[141],"transcriptional":[142],"dysregulation.":[143],"Our":[144],"findings":[145],"uncover":[146],"mechanisms":[149],"provide":[153],"potential":[154],"therapeutic":[155],"targets,":[156],"supporting":[157],"precision":[158],"medicine":[159],"strategies.":[160]},"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-07-30T17:31:21.811387","created_date":"2025-10-10T00:00:00"}