{"id":"https://openalex.org/W4414382510","doi":"https://doi.org/10.1093/bib/bbaf463","title":"IBI-DT: a novel approach combining individualized Bayesian inference and decision tree for identifying cancer drivers and their interactions","display_name":"IBI-DT: a novel approach combining individualized Bayesian inference and decision tree for identifying cancer drivers and their interactions","publication_year":2025,"publication_date":"2025-08-31","ids":{"openalex":"https://openalex.org/W4414382510","doi":"https://doi.org/10.1093/bib/bbaf463","pmid":"https://pubmed.ncbi.nlm.nih.gov/40975833"},"language":"en","primary_location":{"id":"doi:10.1093/bib/bbaf463","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbaf463","pdf_url":"https://academic.oup.com/bib/article-pdf/26/5/bbaf463/64333830/bbaf463.pdf","source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://academic.oup.com/bib/article-pdf/26/5/bbaf463/64333830/bbaf463.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5036965193","display_name":"Md Asad Rahman","orcid":null},"institutions":[{"id":"https://openalex.org/I20382870","display_name":"Missouri University of Science and Technology","ror":"https://ror.org/00scwqd12","country_code":"US","type":"education","lineage":["https://openalex.org/I20382870"]},{"id":"https://openalex.org/I2800717037","display_name":"University of Florida Health","ror":"https://ror.org/04tk2gy88","country_code":"US","type":"education","lineage":["https://openalex.org/I2800717037"]},{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]},{"id":"https://openalex.org/I94062374","display_name":"Florida College","ror":"https://ror.org/010bgev76","country_code":"US","type":"education","lineage":["https://openalex.org/I94062374"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Md Asad Rahman","raw_affiliation_strings":["Department of Engineering Management and Systems Engineering, Missouri University of Science and Technology , 600 W 14th St, Rolla, MO 65409 ,","Department of Epidemiology, College of Public Health and Health Professions and College of Medicine, University of Florida , 2004 Mowry Road, Gainesville, FL 32610 ,","Department of Epidemiology, College of Public Health and Health Professions and College of Medicine, University of Florida, 2004 Mowry Road, Gainesville, FL 32610, United States","Department of Engineering Management and Systems Engineering, Missouri University of Science and Technology, 600 W 14th St, Rolla, MO 65409, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Engineering Management and Systems Engineering, Missouri University of Science and Technology , 600 W 14th St, Rolla, MO 65409 ,","institution_ids":["https://openalex.org/I20382870"]},{"raw_affiliation_string":"Department of Epidemiology, College of Public Health and Health Professions and College of Medicine, University of Florida , 2004 Mowry Road, Gainesville, FL 32610 ,","institution_ids":["https://openalex.org/I94062374","https://openalex.org/I2800717037"]},{"raw_affiliation_string":"Department of Epidemiology, College of Public Health and Health Professions and College of Medicine, University of Florida, 2004 Mowry Road, Gainesville, FL 32610, United States","institution_ids":["https://openalex.org/I33213144"]},{"raw_affiliation_string":"Department of Engineering Management and Systems Engineering, Missouri University of Science and Technology, 600 W 14th St, Rolla, MO 65409, United States","institution_ids":["https://openalex.org/I20382870"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039985406","display_name":"Gregory F. Cooper","orcid":"https://orcid.org/0000-0002-9276-773X"},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gregory F Cooper","raw_affiliation_strings":["Department of Biomedical Informatics, University of Pittsburgh , 5607 Baum Blvd, Pittsburgh, PA 15206 ,","Department of Biomedical Informatics, University of Pittsburgh, 5607 Baum Blvd, Pittsburgh, PA 15206, United States"],"raw_orcid":"https://orcid.org/0000-0002-9276-773X","affiliations":[{"raw_affiliation_string":"Department of Biomedical Informatics, University of Pittsburgh , 5607 Baum Blvd, Pittsburgh, PA 15206 ,","institution_ids":["https://openalex.org/I170201317"]},{"raw_affiliation_string":"Department of Biomedical Informatics, University of Pittsburgh, 5607 Baum Blvd, Pittsburgh, PA 15206, United States","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060021431","display_name":"Jinying Zhao","orcid":"https://orcid.org/0000-0003-3243-2660"},"institutions":[{"id":"https://openalex.org/I2800717037","display_name":"University of Florida Health","ror":"https://ror.org/04tk2gy88","country_code":"US","type":"education","lineage":["https://openalex.org/I2800717037"]},{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]},{"id":"https://openalex.org/I94062374","display_name":"Florida College","ror":"https://ror.org/010bgev76","country_code":"US","type":"education","lineage":["https://openalex.org/I94062374"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jinying Zhao","raw_affiliation_strings":["Department of Epidemiology, College of Public Health and Health Professions and College of Medicine, University of Florida , 2004 Mowry Road, Gainesville, FL 32610 ,","Department of Epidemiology, College of Public Health and Health Professions and College of Medicine, University of Florida, 2004 Mowry Road, Gainesville, FL 32610, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Epidemiology, College of Public Health and Health Professions and College of Medicine, University of Florida , 2004 Mowry Road, Gainesville, FL 32610 ,","institution_ids":["https://openalex.org/I94062374","https://openalex.org/I2800717037"]},{"raw_affiliation_string":"Department of Epidemiology, College of Public Health and Health Professions and College of Medicine, University of Florida, 2004 Mowry Road, Gainesville, FL 32610, United States","institution_ids":["https://openalex.org/I33213144"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046515259","display_name":"Xinghua Lu","orcid":"https://orcid.org/0000-0002-8599-2269"},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xinghua Lu","raw_affiliation_strings":["Department of Biomedical Informatics, University of Pittsburgh , 5607 Baum Blvd, Pittsburgh, PA 15206 ,","Department of Biomedical Informatics, University of Pittsburgh, 5607 Baum Blvd, Pittsburgh, PA 15206, United States"],"raw_orcid":"https://orcid.org/0000-0002-8599-2269","affiliations":[{"raw_affiliation_string":"Department of Biomedical Informatics, University of Pittsburgh , 5607 Baum Blvd, Pittsburgh, PA 15206 ,","institution_ids":["https://openalex.org/I170201317"]},{"raw_affiliation_string":"Department of Biomedical Informatics, University of Pittsburgh, 5607 Baum Blvd, Pittsburgh, PA 15206, United States","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5060876714","display_name":"Jinling Liu","orcid":"https://orcid.org/0000-0002-5001-1328"},"institutions":[{"id":"https://openalex.org/I2800717037","display_name":"University of Florida Health","ror":"https://ror.org/04tk2gy88","country_code":"US","type":"education","lineage":["https://openalex.org/I2800717037"]},{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]},{"id":"https://openalex.org/I94062374","display_name":"Florida College","ror":"https://ror.org/010bgev76","country_code":"US","type":"education","lineage":["https://openalex.org/I94062374"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Jinling Liu","raw_affiliation_strings":["Department of Epidemiology, College of Public Health and Health Professions and College of Medicine, University of Florida , 2004 Mowry Road, Gainesville, FL 32610 ,","Department of Epidemiology, College of Public Health and Health Professions and College of Medicine, University of Florida, 2004 Mowry Road, Gainesville, FL 32610, United States"],"raw_orcid":"https://orcid.org/0000-0002-5001-1328","affiliations":[{"raw_affiliation_string":"Department of Epidemiology, College of Public Health and Health Professions and College of Medicine, University of Florida , 2004 Mowry Road, Gainesville, FL 32610 ,","institution_ids":["https://openalex.org/I94062374","https://openalex.org/I2800717037"]},{"raw_affiliation_string":"Department of Epidemiology, College of Public Health and Health Professions and College of Medicine, University of Florida, 2004 Mowry Road, Gainesville, FL 32610, United States","institution_ids":["https://openalex.org/I33213144"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5060876714"],"corresponding_institution_ids":["https://openalex.org/I2800717037","https://openalex.org/I33213144","https://openalex.org/I94062374"],"apc_list":{"value":4011,"currency":"USD","value_usd":4011},"apc_paid":{"value":4011,"currency":"USD","value_usd":4011},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.25337121,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"26","issue":"5","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11396","display_name":"Artificial Intelligence in Healthcare","score":0.935699999332428,"subfield":{"id":"https://openalex.org/subfields/3605","display_name":"Health Information Management"},"field":{"id":"https://openalex.org/fields/36","display_name":"Health Professions"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11396","display_name":"Artificial Intelligence in Healthcare","score":0.935699999332428,"subfield":{"id":"https://openalex.org/subfields/3605","display_name":"Health Information Management"},"field":{"id":"https://openalex.org/fields/36","display_name":"Health Professions"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/inference","display_name":"Inference","score":0.7208999991416931},{"id":"https://openalex.org/keywords/cancer","display_name":"Cancer","score":0.6934000253677368},{"id":"https://openalex.org/keywords/decision-tree","display_name":"Decision tree","score":0.536300003528595},{"id":"https://openalex.org/keywords/bayesian-probability","display_name":"Bayesian probability","score":0.5333999991416931},{"id":"https://openalex.org/keywords/trait","display_name":"Trait","score":0.4738999903202057},{"id":"https://openalex.org/keywords/tree","display_name":"Tree (set theory)","score":0.4708999991416931},{"id":"https://openalex.org/keywords/bayesian-network","display_name":"Bayesian network","score":0.44940000772476196},{"id":"https://openalex.org/keywords/bayesian-inference","display_name":"Bayesian inference","score":0.4018000066280365}],"concepts":[{"id":"https://openalex.org/C2776214188","wikidata":"https://www.wikidata.org/wiki/Q408386","display_name":"Inference","level":2,"score":0.7208999991416931},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.6934000253677368},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5372999906539917},{"id":"https://openalex.org/C84525736","wikidata":"https://www.wikidata.org/wiki/Q831366","display_name":"Decision tree","level":2,"score":0.536300003528595},{"id":"https://openalex.org/C107673813","wikidata":"https://www.wikidata.org/wiki/Q812534","display_name":"Bayesian probability","level":2,"score":0.5333999991416931},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.511900007724762},{"id":"https://openalex.org/C106934330","wikidata":"https://www.wikidata.org/wiki/Q1971873","display_name":"Trait","level":2,"score":0.4738999903202057},{"id":"https://openalex.org/C113174947","wikidata":"https://www.wikidata.org/wiki/Q2859736","display_name":"Tree (set theory)","level":2,"score":0.4708999991416931},{"id":"https://openalex.org/C33724603","wikidata":"https://www.wikidata.org/wiki/Q812540","display_name":"Bayesian network","level":2,"score":0.44940000772476196},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.4472000002861023},{"id":"https://openalex.org/C160234255","wikidata":"https://www.wikidata.org/wiki/Q812535","display_name":"Bayesian inference","level":3,"score":0.4018000066280365},{"id":"https://openalex.org/C189206191","wikidata":"https://www.wikidata.org/wiki/Q222046","display_name":"Genomics","level":4,"score":0.3944999873638153},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.39399999380111694},{"id":"https://openalex.org/C169258074","wikidata":"https://www.wikidata.org/wiki/Q245748","display_name":"Random forest","level":2,"score":0.3718000054359436},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.34940001368522644},{"id":"https://openalex.org/C2776207758","wikidata":"https://www.wikidata.org/wiki/Q5303302","display_name":"Downstream (manufacturing)","level":2,"score":0.3472000062465668},{"id":"https://openalex.org/C90559484","wikidata":"https://www.wikidata.org/wiki/Q778379","display_name":"Expression (computer science)","level":2,"score":0.3384000062942505},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.33559998869895935},{"id":"https://openalex.org/C9287583","wikidata":"https://www.wikidata.org/wiki/Q5532883","display_name":"Genetic architecture","level":4,"score":0.3073999881744385},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.30720001459121704},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.29269999265670776},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.28040000796318054},{"id":"https://openalex.org/C67339327","wikidata":"https://www.wikidata.org/wiki/Q1502576","display_name":"Gene regulatory network","level":4,"score":0.2720000147819519},{"id":"https://openalex.org/C82142266","wikidata":"https://www.wikidata.org/wiki/Q3456604","display_name":"Dynamic Bayesian network","level":3,"score":0.2702000141143799},{"id":"https://openalex.org/C207201462","wikidata":"https://www.wikidata.org/wiki/Q182505","display_name":"Bayes' theorem","level":3,"score":0.26190000772476196},{"id":"https://openalex.org/C81941488","wikidata":"https://www.wikidata.org/wiki/Q853421","display_name":"Quantitative trait locus","level":3,"score":0.2513999938964844}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001499","descriptor_name":"Bayes Theorem","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001499","descriptor_name":"Bayes Theorem","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001499","descriptor_name":"Bayes Theorem","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001499","descriptor_name":"Bayes Theorem","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001499","descriptor_name":"Bayes Theorem","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003663","descriptor_name":"Decision Trees","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003663","descriptor_name":"Decision Trees","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003663","descriptor_name":"Decision Trees","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003663","descriptor_name":"Decision Trees","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003663","descriptor_name":"Decision Trees","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1093/bib/bbaf463","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbaf463","pdf_url":"https://academic.oup.com/bib/article-pdf/26/5/bbaf463/64333830/bbaf463.pdf","source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},{"id":"pmid:40975833","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40975833","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in bioinformatics","raw_type":null},{"id":"pmh:oai:europepmc.org:11259740","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/12450346","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:12450346","is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12450346/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Brief Bioinform","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1093/bib/bbaf463","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbaf463","pdf_url":"https://academic.oup.com/bib/article-pdf/26/5/bbaf463/64333830/bbaf463.pdf","source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G1074945578","display_name":null,"funder_award_id":"R01LM012011","funder_id":"https://openalex.org/F4320337372","funder_display_name":"U.S. National Library of Medicine"},{"id":"https://openalex.org/G1729794176","display_name":null,"funder_award_id":"K01HL161538","funder_id":"https://openalex.org/F4320337372","funder_display_name":"U.S. National Library of Medicine"},{"id":"https://openalex.org/G3826160147","display_name":null,"funder_award_id":"R01 HL164835","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G4130713346","display_name":null,"funder_award_id":"[K01HL161538 and R03HL168984 to JL] and [R01HL164835 to GFC]","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G6356492895","display_name":null,"funder_award_id":"K01 HL161538","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G7212985251","display_name":null,"funder_award_id":"R03 HL168984","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G7797826970","display_name":null,"funder_award_id":"R01 LM012011","funder_id":"https://openalex.org/F4320337372","funder_display_name":"U.S. National Library of Medicine"},{"id":"https://openalex.org/G8012080071","display_name":null,"funder_award_id":"R01LM012011 to XL","funder_id":"https://openalex.org/F4320337372","funder_display_name":"U.S. National Library of Medicine"}],"funders":[{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337372","display_name":"U.S. National Library of Medicine","ror":"https://ror.org/0060t0j89"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4414382510.pdf","grobid_xml":"https://content.openalex.org/works/W4414382510.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":[],"abstract_inverted_index":{"Cancer":[0],"is":[1,140],"mainly":[2],"caused":[3],"by":[4,98],"a":[5,21,50,62,70,110,124,167,238],"relatively":[6],"small":[7,168],"portion":[8],"of":[9,24,53,88,151,170,210,241],"somatic":[10],"genome":[11],"alterations":[12],"(SGAs),":[13],"called":[14,65],"cancer":[15,25,47,80,171,179,191,200,227,243],"drivers.":[16,95],"Despite":[17],"success":[18],"in":[19,127,199,223],"identifying":[20,224],"good":[22],"number":[23],"drivers,":[26,228,232],"many":[27],"more":[28],"remain":[29],"to":[30,33,42,118,147,189,205],"be":[31],"discovered":[32],"explain":[34,166],"various":[35],"cancers.":[36],"Moreover,":[37],"limited":[38],"tools":[39],"are":[40],"available":[41],"identify":[43,119,178,190],"potential":[44],"interactions":[45],"among":[46,79],"drivers":[48,180,192],"for":[49,154,237],"better":[51,239],"understanding":[52,240],"oncogenesis.":[54],"To":[55],"tackle":[56],"these":[57],"challenges,":[58],"we":[59],"have":[60,93,183],"developed":[61],"novel":[63],"approach":[64],"individualized":[66],"Bayesian":[67],"inference":[68],"using":[69,109],"decision":[71,111],"tree":[72,112],"(IBI-DT).":[73],"IBI-DT":[74,96,175,188,220],"recognizes":[75],"the":[76,120,134,149,155,194,206,230,242],"genetic":[77,104],"heterogeneity":[78],"patients,":[81],"where":[82],"different":[83,94],"individuals":[84],"or":[85],"patient":[86],"subgroups":[87,101],"distinct":[89,141],"genomic":[90],"makeup":[91,105],"may":[92,164,182],"works":[97],"constructing":[99],"smaller":[100],"with":[102],"similar":[103],"(i.e.":[106],"patient-like-me":[107],"subgroups)":[108],"structure":[113],"and":[114,136,202,233],"analyzing":[115],"multiple":[116],"trees":[117],"SGAs":[121,162],"that":[122,163,181,219],"play":[123],"significant":[125],"role":[126],"regulating":[128,193],"downstream":[129,195],"gene":[130,197],"expression":[131,198,211],"patterns":[132],"at":[133],"subgroup":[135,169],"individual":[137],"levels.":[138],"This":[139],"from":[142],"population-based":[143,208],"approaches,":[144],"which":[145],"tend":[146],"evaluate":[148],"influence":[150],"an":[152],"SGA":[153],"entire":[156],"population,":[157],"thereby":[158],"likely":[159],"missing":[160],"low-frequency":[161,231],"well":[165,222],"patients.":[172],"Also":[173],"importantly,":[174],"can":[176],"efficiently":[177],"functional":[184],"interactions.":[185],"We":[186],"applied":[187],"differential":[196],"patients":[201],"compared":[203],"it":[204],"standard,":[207],"method":[209],"quantitative":[212],"trait":[213],"loci":[214],"analysis.":[215],"Our":[216],"results":[217],"show":[218],"performs":[221],"both":[225],"important":[226],"especially":[229],"their":[234],"interactions,":[235],"allowing":[236],"signaling":[244],"pathways.":[245]},"counts_by_year":[],"updated_date":"2026-06-24T13:16:06.693445","created_date":"2025-10-10T00:00:00"}