{"id":"https://openalex.org/W4414003120","doi":"https://doi.org/10.1093/bib/bbaf452","title":"Mapping cancer heterogeneity: a consensus network approach to subtypes and pathways","display_name":"Mapping cancer heterogeneity: a consensus network approach to subtypes and pathways","publication_year":2025,"publication_date":"2025-08-18","ids":{"openalex":"https://openalex.org/W4414003120","doi":"https://doi.org/10.1093/bib/bbaf452","pmid":"https://pubmed.ncbi.nlm.nih.gov/40905375"},"language":"en","primary_location":{"id":"doi:10.1093/bib/bbaf452","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbaf452","pdf_url":"https://academic.oup.com/bib/article-pdf/26/5/bbaf452/64205797/bbaf452.pdf","source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://academic.oup.com/bib/article-pdf/26/5/bbaf452/64205797/bbaf452.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5054653813","display_name":"Geng\u2010Ming Hu","orcid":null},"institutions":[{"id":"https://openalex.org/I134161618","display_name":"National Taiwan Normal University","ror":"https://ror.org/059dkdx38","country_code":"TW","type":"education","lineage":["https://openalex.org/I134161618"]}],"countries":["TW"],"is_corresponding":true,"raw_author_name":"Geng-Ming Hu","raw_affiliation_strings":["Department of Physics, National Taiwan Normal University , 88 Sec.4 Ting-Chou Rd., Taipei 116 ,","Department of Physics, National Taiwan Normal University, 88 Sec.4 Ting-Chou Rd., Taipei 116, Taiwan"],"affiliations":[{"raw_affiliation_string":"Department of Physics, National Taiwan Normal University , 88 Sec.4 Ting-Chou Rd., Taipei 116 ,","institution_ids":["https://openalex.org/I134161618"]},{"raw_affiliation_string":"Department of Physics, National Taiwan Normal University, 88 Sec.4 Ting-Chou Rd., Taipei 116, Taiwan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112059505","display_name":"Hsin-Wei Chen","orcid":null},"institutions":[{"id":"https://openalex.org/I134161618","display_name":"National Taiwan Normal University","ror":"https://ror.org/059dkdx38","country_code":"TW","type":"education","lineage":["https://openalex.org/I134161618"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Hsin-Wei Chen","raw_affiliation_strings":["Department of Physics, National Taiwan Normal University , 88 Sec.4 Ting-Chou Rd., Taipei 116 ,","Department of Physics, National Taiwan Normal University, 88 Sec.4 Ting-Chou Rd., Taipei 116, Taiwan"],"affiliations":[{"raw_affiliation_string":"Department of Physics, National Taiwan Normal University , 88 Sec.4 Ting-Chou Rd., Taipei 116 ,","institution_ids":["https://openalex.org/I134161618"]},{"raw_affiliation_string":"Department of Physics, National Taiwan Normal University, 88 Sec.4 Ting-Chou Rd., Taipei 116, Taiwan","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5103151159","display_name":"Chi\u2010Ming Chen","orcid":"https://orcid.org/0000-0003-2202-2318"},"institutions":[{"id":"https://openalex.org/I134161618","display_name":"National Taiwan Normal University","ror":"https://ror.org/059dkdx38","country_code":"TW","type":"education","lineage":["https://openalex.org/I134161618"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Chi-Ming Chen","raw_affiliation_strings":["Department of Physics, National Taiwan Normal University , 88 Sec.4 Ting-Chou Rd., Taipei 116 ,","Department of Physics, National Taiwan Normal University, 88 Sec.4 Ting-Chou Rd., Taipei 116, Taiwan"],"affiliations":[{"raw_affiliation_string":"Department of Physics, National Taiwan Normal University , 88 Sec.4 Ting-Chou Rd., Taipei 116 ,","institution_ids":["https://openalex.org/I134161618"]},{"raw_affiliation_string":"Department of Physics, National Taiwan Normal University, 88 Sec.4 Ting-Chou Rd., Taipei 116, Taiwan","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5054653813"],"corresponding_institution_ids":["https://openalex.org/I134161618"],"apc_list":{"value":4011,"currency":"USD","value_usd":4011},"apc_paid":{"value":4011,"currency":"USD","value_usd":4011},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.21863389,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"26","issue":"5","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11297","display_name":"Ferroptosis and cancer prognosis","score":0.9988999962806702,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.9987000226974487,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.48159024119377136},{"id":"https://openalex.org/keywords/critical-pathways","display_name":"Critical pathways","score":0.4518054723739624},{"id":"https://openalex.org/keywords/cancer","display_name":"Cancer","score":0.4301831126213074},{"id":"https://openalex.org/keywords/consensus-conference","display_name":"Consensus conference","score":0.424545019865036},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.333546906709671},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.17338263988494873},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.07826489210128784},{"id":"https://openalex.org/keywords/library-science","display_name":"Library science","score":0.07271027565002441},{"id":"https://openalex.org/keywords/process-management","display_name":"Process management","score":0.07036083936691284},{"id":"https://openalex.org/keywords/business","display_name":"Business","score":0.06794178485870361}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.48159024119377136},{"id":"https://openalex.org/C2908965694","wikidata":"https://www.wikidata.org/wiki/Q1774706","display_name":"Critical pathways","level":2,"score":0.4518054723739624},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4301831126213074},{"id":"https://openalex.org/C3017605391","wikidata":"https://www.wikidata.org/wiki/Q1021509","display_name":"Consensus conference","level":2,"score":0.424545019865036},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.333546906709671},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.17338263988494873},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.07826489210128784},{"id":"https://openalex.org/C161191863","wikidata":"https://www.wikidata.org/wiki/Q199655","display_name":"Library science","level":1,"score":0.07271027565002441},{"id":"https://openalex.org/C195094911","wikidata":"https://www.wikidata.org/wiki/Q14167904","display_name":"Process management","level":1,"score":0.07036083936691284},{"id":"https://openalex.org/C144133560","wikidata":"https://www.wikidata.org/wiki/Q4830453","display_name":"Business","level":0,"score":0.06794178485870361}],"mesh":[{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016000","descriptor_name":"Cluster Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016000","descriptor_name":"Cluster Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016000","descriptor_name":"Cluster Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016000","descriptor_name":"Cluster Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018740","descriptor_name":"Genetic Heterogeneity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018740","descriptor_name":"Genetic Heterogeneity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018740","descriptor_name":"Genetic Heterogeneity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018740","descriptor_name":"Genetic Heterogeneity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1093/bib/bbaf452","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbaf452","pdf_url":"https://academic.oup.com/bib/article-pdf/26/5/bbaf452/64205797/bbaf452.pdf","source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},{"id":"pmid:40905375","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40905375","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in bioinformatics","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:12409415","is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12409415/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Brief Bioinform","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1093/bib/bbaf452","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbaf452","pdf_url":"https://academic.oup.com/bib/article-pdf/26/5/bbaf452/64205797/bbaf452.pdf","source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320331164","display_name":"National Science and Technology Council","ror":"https://ror.org/00wnb9798"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4414003120.pdf","grobid_xml":"https://content.openalex.org/works/W4414003120.grobid-xml"},"referenced_works_count":53,"referenced_works":["https://openalex.org/W1651586605","https://openalex.org/W1967220865","https://openalex.org/W1987219048","https://openalex.org/W1994861981","https://openalex.org/W2001258296","https://openalex.org/W2002798737","https://openalex.org/W2042673772","https://openalex.org/W2046387002","https://openalex.org/W2048881325","https://openalex.org/W2049674541","https://openalex.org/W2097255042","https://openalex.org/W2100039832","https://openalex.org/W2109363337","https://openalex.org/W2111547563","https://openalex.org/W2113570557","https://openalex.org/W2114918971","https://openalex.org/W2115462905","https://openalex.org/W2137506169","https://openalex.org/W2145552137","https://openalex.org/W2152026276","https://openalex.org/W2162141568","https://openalex.org/W2169589032","https://openalex.org/W2319533183","https://openalex.org/W2558380406","https://openalex.org/W2581082771","https://openalex.org/W2752775557","https://openalex.org/W2796153844","https://openalex.org/W2806741085","https://openalex.org/W2951209146","https://openalex.org/W3005329126","https://openalex.org/W3010398944","https://openalex.org/W3094742237","https://openalex.org/W3119426777","https://openalex.org/W3126210657","https://openalex.org/W3127975644","https://openalex.org/W3155057571","https://openalex.org/W3157190375","https://openalex.org/W3178186398","https://openalex.org/W3182450603","https://openalex.org/W4200496834","https://openalex.org/W4220831425","https://openalex.org/W4293560733","https://openalex.org/W4296886862","https://openalex.org/W4317840276","https://openalex.org/W4318192687","https://openalex.org/W4318715179","https://openalex.org/W4385871875","https://openalex.org/W4389037125","https://openalex.org/W4400387910","https://openalex.org/W4402007652","https://openalex.org/W4402580790","https://openalex.org/W4403842276","https://openalex.org/W4407588465"],"related_works":["https://openalex.org/W4391375266","https://openalex.org/W4200407670","https://openalex.org/W3037909725","https://openalex.org/W4405112912","https://openalex.org/W2375584271","https://openalex.org/W1997105855","https://openalex.org/W4301030387","https://openalex.org/W2414286769","https://openalex.org/W2013223288","https://openalex.org/W3014749029"],"abstract_inverted_index":{"We":[0],"introduce":[1],"consensus":[2],"MSClustering,":[3],"an":[4],"unsupervised":[5],"hierarchical":[6],"network":[7],"approach":[8],"that":[9],"integrates":[10],"multi-omics":[11],"data":[12],"to":[13,43,52,179],"identify":[14],"molecular":[15,61,74,161],"subtypes":[16],"and":[17,71,94,107,136,143,166,187],"conserved":[18],"pathways":[19],"across":[20,119],"diverse":[21],"cancers.":[22],"Using":[23],"a":[24,151],"novel":[25,79],"heterogeneity":[26,118],"index,":[27],"we":[28],"selected":[29],"167":[30],"key":[31,128],"genes":[32],"with":[33,59,139],"functionally":[34],"coherent":[35],"roles":[36],"validated":[37],"through":[38],"Gene":[39],"Ontology":[40],"analysis.":[41],"Applied":[42],"2439":[44],"tumors":[45,54],"spanning":[46],"10":[47],"cancer":[48,69,73,117,155],"types-and":[49],"successfully":[50],"extended":[51],"2675":[53],"(12":[55],"types)":[56],"including":[57],"cases":[58],"incomplete":[60],"data-MSClustering":[62],"demonstrated:":[63],"(i)":[64],"precise":[65],"classification":[66,103],"of":[67,78,169,177,183],"major":[68],"types":[70],"breast":[72,116],"subtypes;":[75],"(ii)":[76],"discovery":[77],"pan-cancer":[80],"squamous":[81],"metaplastic":[82],"signatures;":[83],"(iii)":[84],"exceptional":[85],"prognostic":[86,164],"stratification":[87],"(log-rank":[88],"P":[89],"=":[90],"2.3":[91],"\u00d7":[92],"10-46);":[93],"(iv)":[95],"superior":[96],"performance":[97],"over":[98],"existing":[99],"methods":[100],"(COCA/SNF)":[101],"in":[102,141,154,192],"accuracy,":[104],"cluster":[105],"robustness,":[106],"computational":[108],"efficiency.":[109],"The":[110],"method's":[111],"multi-scale":[112],"architecture":[113],"uniquely":[114],"resolves":[115],"biological":[120],"resolution":[121],"levels.":[122],"Pathway":[123],"analysis":[124],"further":[125],"revealed":[126],"four":[127],"oncogenic":[129],"programs-proteoglycan":[130],"signaling,":[131],"chromosomal":[132],"stability,":[133],"VEGF-mediated":[134],"angiogenesis,":[135],"drug":[137],"metabolism-along":[138],"disruptions":[140],"immune":[142],"digestive":[144],"system":[145],"functions.":[146],"This":[147],"integrative":[148],"framework":[149],"marks":[150],"significant":[152],"advancement":[153],"genomics":[156],"by":[157],"enabling":[158],"more":[159,189],"refined":[160],"classification,":[162],"enhanced":[163],"insights,":[165],"deeper":[167],"understanding":[168],"disease":[170],"mechanisms.":[171],"These":[172],"results":[173],"highlight":[174],"the":[175,181],"potential":[176],"MSClustering":[178],"inform":[180],"development":[182],"clinically":[184],"relevant":[185],"biomarkers":[186],"support":[188],"personalized":[190],"strategies":[191],"precision":[193],"oncology.":[194]},"counts_by_year":[],"updated_date":"2026-03-10T16:38:18.471706","created_date":"2025-10-10T00:00:00"}
