{"id":"https://openalex.org/W4413970867","doi":"https://doi.org/10.1093/bib/bbaf391","title":"ProDualNet: dual-target protein sequence design method based on protein language model and structure model","display_name":"ProDualNet: dual-target protein sequence design method based on protein language model and structure model","publication_year":2025,"publication_date":"2025-07-01","ids":{"openalex":"https://openalex.org/W4413970867","doi":"https://doi.org/10.1093/bib/bbaf391","pmid":"https://pubmed.ncbi.nlm.nih.gov/40856523"},"language":"en","primary_location":{"id":"doi:10.1093/bib/bbaf391","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbaf391","pdf_url":null,"source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1093/bib/bbaf391","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103657385","display_name":"Liu Cheng","orcid":null},"institutions":[{"id":"https://openalex.org/I4210162648","display_name":"Shanghai Center For Bioinformation Technology","ror":"https://ror.org/04nyf1f54","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210162648"]},{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Liu Cheng","raw_affiliation_strings":["Department of Bioinformatics and Biostatistics, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University , Shanghai ,","Department of Bioinformatics and Biostatistics, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, China"],"affiliations":[{"raw_affiliation_string":"Department of Bioinformatics and Biostatistics, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University , Shanghai ,","institution_ids":["https://openalex.org/I4210162648","https://openalex.org/I183067930"]},{"raw_affiliation_string":"Department of Bioinformatics and Biostatistics, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, China","institution_ids":["https://openalex.org/I183067930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101793509","display_name":"Ting Wei","orcid":"https://orcid.org/0000-0003-2892-1066"},"institutions":[{"id":"https://openalex.org/I4210162648","display_name":"Shanghai Center For Bioinformation Technology","ror":"https://ror.org/04nyf1f54","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210162648"]},{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ting Wei","raw_affiliation_strings":["Department of Bioinformatics and Biostatistics, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University , Shanghai ,","Department of Bioinformatics and Biostatistics, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, China"],"affiliations":[{"raw_affiliation_string":"Department of Bioinformatics and Biostatistics, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University , Shanghai ,","institution_ids":["https://openalex.org/I4210162648","https://openalex.org/I183067930"]},{"raw_affiliation_string":"Department of Bioinformatics and Biostatistics, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, China","institution_ids":["https://openalex.org/I183067930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062083547","display_name":"Xiaojiang Cui","orcid":"https://orcid.org/0000-0002-6843-736X"},"institutions":[{"id":"https://openalex.org/I4210153682","display_name":"Intelligent Health (United Kingdom)","ror":"https://ror.org/0576zak10","country_code":"GB","type":"company","lineage":["https://openalex.org/I4210153682"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Xiaochen Cui","raw_affiliation_strings":["Intelligent Medicine Original (Shanghai) Co., Ltd. , Shanghai ,","Intelligent Medicine Original (Shanghai) Co., Ltd., Shanghai, China"],"affiliations":[{"raw_affiliation_string":"Intelligent Medicine Original (Shanghai) Co., Ltd. , Shanghai ,","institution_ids":["https://openalex.org/I4210153682"]},{"raw_affiliation_string":"Intelligent Medicine Original (Shanghai) Co., Ltd., Shanghai, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100456783","display_name":"Haifeng Chen","orcid":"https://orcid.org/0000-0002-7496-4182"},"institutions":[{"id":"https://openalex.org/I4210162648","display_name":"Shanghai Center For Bioinformation Technology","ror":"https://ror.org/04nyf1f54","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210162648"]},{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hai-Feng Chen","raw_affiliation_strings":["Department of Bioinformatics and Biostatistics, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University , Shanghai ,","Department of Bioinformatics and Biostatistics, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, China"],"affiliations":[{"raw_affiliation_string":"Department of Bioinformatics and Biostatistics, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University , Shanghai ,","institution_ids":["https://openalex.org/I4210162648","https://openalex.org/I183067930"]},{"raw_affiliation_string":"Department of Bioinformatics and Biostatistics, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, China","institution_ids":["https://openalex.org/I183067930"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5086936559","display_name":"Zhangsheng Yu","orcid":"https://orcid.org/0000-0002-8189-5330"},"institutions":[{"id":"https://openalex.org/I4210162648","display_name":"Shanghai Center For Bioinformation Technology","ror":"https://ror.org/04nyf1f54","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210162648"]},{"id":"https://openalex.org/I4210158445","display_name":"Institute of Natural Science","ror":"https://ror.org/004tze884","country_code":"KP","type":"education","lineage":["https://openalex.org/I4210158445"]},{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]}],"countries":["CN","KP"],"is_corresponding":false,"raw_author_name":"Zhangsheng Yu","raw_affiliation_strings":["Center for Biomedical Data Science, Translational Science Institute, Shanghai Jiao Tong University School of Medicine , Shanghai ,","Clinical Research Institute, Shanghai Jiao Tong University School of Medicine , Shanghai ,","Department of Bioinformatics and Biostatistics, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University , Shanghai ,","SJTU-Yale Joint Center for Biostatistics and Data Science, Shanghai Jiao Tong University , Shanghai ,","SJTU-Yale Joint Center for Biostatistics and Data Science, Shanghai Jiao Tong University, Shanghai, China","Clinical Research Institute, Shanghai Jiao Tong University School of Medicine, Shanghai, China","Center for Biomedical Data Science, Translational Science Institute, Shanghai Jiao Tong University School of Medicine, Shanghai, China","Department of Bioinformatics and Biostatistics, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, China"],"affiliations":[{"raw_affiliation_string":"Center for Biomedical Data Science, Translational Science Institute, Shanghai Jiao Tong University School of Medicine , Shanghai ,","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I4210158445"]},{"raw_affiliation_string":"Clinical Research Institute, Shanghai Jiao Tong University School of Medicine , Shanghai ,","institution_ids":["https://openalex.org/I183067930"]},{"raw_affiliation_string":"Department of Bioinformatics and Biostatistics, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University , Shanghai ,","institution_ids":["https://openalex.org/I4210162648","https://openalex.org/I183067930"]},{"raw_affiliation_string":"SJTU-Yale Joint Center for Biostatistics and Data Science, Shanghai Jiao Tong University , Shanghai ,","institution_ids":["https://openalex.org/I183067930"]},{"raw_affiliation_string":"SJTU-Yale Joint Center for Biostatistics and Data Science, Shanghai Jiao Tong University, Shanghai, China","institution_ids":["https://openalex.org/I183067930"]},{"raw_affiliation_string":"Clinical Research Institute, Shanghai Jiao Tong University School of Medicine, Shanghai, China","institution_ids":["https://openalex.org/I183067930"]},{"raw_affiliation_string":"Center for Biomedical Data Science, Translational Science Institute, Shanghai Jiao Tong University School of Medicine, Shanghai, China","institution_ids":["https://openalex.org/I183067930"]},{"raw_affiliation_string":"Department of Bioinformatics and Biostatistics, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, China","institution_ids":["https://openalex.org/I183067930"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5103657385"],"corresponding_institution_ids":["https://openalex.org/I183067930","https://openalex.org/I4210162648"],"apc_list":{"value":4011,"currency":"USD","value_usd":4011},"apc_paid":{"value":4011,"currency":"USD","value_usd":4011},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.25380507,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"26","issue":"4","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12254","display_name":"Machine Learning in Bioinformatics","score":0.9994000196456909,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12254","display_name":"Machine Learning in Bioinformatics","score":0.9994000196456909,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.9988999962806702,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.9968000054359436,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6310943961143494},{"id":"https://openalex.org/keywords/dual","display_name":"Dual (grammatical number)","score":0.6260659098625183},{"id":"https://openalex.org/keywords/sequence","display_name":"Sequence (biology)","score":0.5617339611053467},{"id":"https://openalex.org/keywords/protein-design","display_name":"Protein design","score":0.47797033190727234},{"id":"https://openalex.org/keywords/protein-sequencing","display_name":"Protein sequencing","score":0.4453071653842926},{"id":"https://openalex.org/keywords/protein-structure","display_name":"Protein structure","score":0.40786510705947876},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.40337589383125305},{"id":"https://openalex.org/keywords/natural-language-processing","display_name":"Natural language processing","score":0.38827502727508545},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.34383299946784973},{"id":"https://openalex.org/keywords/peptide-sequence","display_name":"Peptide sequence","score":0.28074926137924194},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.15893739461898804},{"id":"https://openalex.org/keywords/linguistics","display_name":"Linguistics","score":0.1453065574169159},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.11447867751121521},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.09506648778915405},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.09054884314537048}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6310943961143494},{"id":"https://openalex.org/C2780980858","wikidata":"https://www.wikidata.org/wiki/Q110022","display_name":"Dual (grammatical number)","level":2,"score":0.6260659098625183},{"id":"https://openalex.org/C2778112365","wikidata":"https://www.wikidata.org/wiki/Q3511065","display_name":"Sequence (biology)","level":2,"score":0.5617339611053467},{"id":"https://openalex.org/C152769699","wikidata":"https://www.wikidata.org/wiki/Q410814","display_name":"Protein design","level":3,"score":0.47797033190727234},{"id":"https://openalex.org/C10010492","wikidata":"https://www.wikidata.org/wiki/Q3142557","display_name":"Protein sequencing","level":4,"score":0.4453071653842926},{"id":"https://openalex.org/C47701112","wikidata":"https://www.wikidata.org/wiki/Q735188","display_name":"Protein structure","level":2,"score":0.40786510705947876},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.40337589383125305},{"id":"https://openalex.org/C204321447","wikidata":"https://www.wikidata.org/wiki/Q30642","display_name":"Natural language processing","level":1,"score":0.38827502727508545},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.34383299946784973},{"id":"https://openalex.org/C167625842","wikidata":"https://www.wikidata.org/wiki/Q899763","display_name":"Peptide sequence","level":3,"score":0.28074926137924194},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.15893739461898804},{"id":"https://openalex.org/C41895202","wikidata":"https://www.wikidata.org/wiki/Q8162","display_name":"Linguistics","level":1,"score":0.1453065574169159},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.11447867751121521},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.09506648778915405},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.09054884314537048},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1093/bib/bbaf391","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbaf391","pdf_url":null,"source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},{"id":"pmid:40856523","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40856523","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in bioinformatics","raw_type":null},{"id":"pmh:oai:europepmc.org:11187531","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/12378908","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1093/bib/bbaf391","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbaf391","pdf_url":null,"source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":46,"referenced_works":["https://openalex.org/W1993174731","https://openalex.org/W2102245393","https://openalex.org/W2342374505","https://openalex.org/W2627077205","https://openalex.org/W2950954328","https://openalex.org/W2953103783","https://openalex.org/W2953835350","https://openalex.org/W2997668390","https://openalex.org/W3177828909","https://openalex.org/W3182945054","https://openalex.org/W3215514970","https://openalex.org/W4210861939","https://openalex.org/W4296032638","https://openalex.org/W4327550249","https://openalex.org/W4375856225","https://openalex.org/W4378212143","https://openalex.org/W4379471679","https://openalex.org/W4383957026","https://openalex.org/W4384820649","https://openalex.org/W4385930396","https://openalex.org/W4387687322","https://openalex.org/W4391308485","https://openalex.org/W4392044981","https://openalex.org/W4394623467","https://openalex.org/W4396660597","https://openalex.org/W4396721167","https://openalex.org/W4396959365","https://openalex.org/W4398243369","https://openalex.org/W4400313991","https://openalex.org/W4400985732","https://openalex.org/W4401406616","https://openalex.org/W4402441163","https://openalex.org/W4402666674","https://openalex.org/W4403253127","https://openalex.org/W4403398964","https://openalex.org/W4403682541","https://openalex.org/W4403951310","https://openalex.org/W4404577932","https://openalex.org/W4404906899","https://openalex.org/W4405783300","https://openalex.org/W4406728167","https://openalex.org/W4407510444","https://openalex.org/W4409150232","https://openalex.org/W4409978832","https://openalex.org/W4412467067","https://openalex.org/W6959808396"],"related_works":["https://openalex.org/W3140270587","https://openalex.org/W3174670732","https://openalex.org/W2170120749","https://openalex.org/W4281626490","https://openalex.org/W2067576503","https://openalex.org/W2199134476","https://openalex.org/W4372348062","https://openalex.org/W2170285690","https://openalex.org/W1988730649","https://openalex.org/W2095784700"],"abstract_inverted_index":{"Proteins":[0],"typically":[1],"interact":[2],"with":[3,40,95],"multiple":[4,14,120],"partners":[5],"to":[6,54,77,130],"regulate":[7],"biological":[8],"processes,":[9],"and":[10,90,126,144,157],"peptide":[11],"drugs":[12],"targeting":[13],"receptors":[15,76],"have":[16],"shown":[17],"strong":[18],"therapeutic":[19],"potential,":[20],"emphasizing":[21],"the":[22,46,104],"need":[23],"for":[24,88,99,151],"multi-target":[25],"strategies":[26],"in":[27],"protein":[28,33,80,109],"design.":[29],"However,":[30],"most":[31],"current":[32],"sequence":[34,67],"design":[35,68,78,133],"methods":[36],"focus":[37],"on":[38],"interactions":[39],"a":[41,65,84],"single":[42],"receptor,":[43],"often":[44],"neglecting":[45],"complexity":[47],"of":[48,106,114,138],"designing":[49,152],"proteins":[50],"that":[51,70],"can":[52],"bind":[53],"two":[55,75],"distinct":[56],"receptors.":[57],"We":[58],"introduced":[59],"Protein":[60],"Dual-Target":[61],"Design":[62],"Network":[63],"(ProDualNet),":[64],"structure-based":[66],"method":[69],"integrates":[71],"sequence-structure":[72],"information":[73],"from":[74],"dual-target":[79,97,108,141,153],"sequences.":[81],"ProDualNet":[82,115],"used":[83],"heterogeneous":[85],"graph":[86],"network":[87],"pretraining":[89],"combines":[91],"noise-augmented":[92],"single-target":[93],"data":[94,98],"real":[96],"fine-tuning.":[100],"This":[101],"approach":[102],"addressed":[103],"challenge":[105],"limited":[107],"experimental":[110],"structures.":[111],"The":[112],"efficacy":[113],"has":[116],"been":[117],"validated":[118],"across":[119],"test":[121],"sets,":[122],"demonstrating":[123],"better":[124],"recovery":[125],"success":[127],"rates":[128],"compared":[129],"other":[131],"multi-state":[132],"methods.":[134],"In":[135],"silico":[136],"evaluation":[137],"cases":[139],"like":[140],"allosteric":[142],"binding":[143,147,154],"non-overlapping":[145],"interface":[146],"highlights":[148],"its":[149],"potential":[150],"proteins.":[155],"Data":[156],"code":[158],"are":[159],"available":[160],"at":[161],"https://github.com/chengliu97/ProDualNet.":[162]},"counts_by_year":[],"updated_date":"2025-12-21T23:12:01.093139","created_date":"2025-10-10T00:00:00"}