{"id":"https://openalex.org/W4412856413","doi":"https://doi.org/10.1093/bib/bbaf385","title":"BloodProST: prediction of blood-secretory proteins through self-training","display_name":"BloodProST: prediction of blood-secretory proteins through self-training","publication_year":2025,"publication_date":"2025-07-01","ids":{"openalex":"https://openalex.org/W4412856413","doi":"https://doi.org/10.1093/bib/bbaf385","pmid":"https://pubmed.ncbi.nlm.nih.gov/40748326"},"language":"en","primary_location":{"id":"doi:10.1093/bib/bbaf385","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbaf385","pdf_url":null,"source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1093/bib/bbaf385","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113243397","display_name":"Xuechen Mu","orcid":"https://orcid.org/0000-0003-1006-2830"},"institutions":[{"id":"https://openalex.org/I194450716","display_name":"Jilin University","ror":"https://ror.org/00js3aw79","country_code":"CN","type":"education","lineage":["https://openalex.org/I194450716"]},{"id":"https://openalex.org/I3045169105","display_name":"Southern University of Science and Technology","ror":"https://ror.org/049tv2d57","country_code":"CN","type":"education","lineage":["https://openalex.org/I3045169105"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Xuechen Mu","raw_affiliation_strings":["Department of Human Cell Biology and Genetics, SUSTech Homeostatic Medicine Institute, School of Medicine, Southern University of Science and Technology , Shenzhen 518055, Guangdong ,","Key University Laboratory of Metabolism and Health of Guangdong, Southern University of Science and Technology , Shenzhen 518055 ,","SUSTech Homeostatic Medicine Institute, School of Medicine, Southern University of Science and Technology , Shenzhen 518055 ,","School of Mathematics, Jilin University , Changchun 130012, Jilin ,","Department of Human Cell Biology and Genetics, SUSTech Homeostatic Medicine Institute, School of Medicine, Southern University of Science and Technology, Shenzhen 518055, Guangdong, China","School of Mathematics, Jilin University, Changchun 130012, Jilin, China","SUSTech Homeostatic Medicine Institute, School of Medicine, Southern University of Science and Technology, Shenzhen 518055, China","Key University Laboratory of Metabolism and Health of Guangdong, Southern University of Science and Technology, Shenzhen 518055, China"],"affiliations":[{"raw_affiliation_string":"Department of Human Cell Biology and Genetics, SUSTech Homeostatic Medicine Institute, School of Medicine, Southern University of Science and Technology , Shenzhen 518055, Guangdong ,","institution_ids":["https://openalex.org/I3045169105"]},{"raw_affiliation_string":"Key University Laboratory of Metabolism and Health of Guangdong, Southern University of Science and Technology , Shenzhen 518055 ,","institution_ids":["https://openalex.org/I3045169105"]},{"raw_affiliation_string":"SUSTech Homeostatic Medicine Institute, School of Medicine, Southern University of Science and Technology , Shenzhen 518055 ,","institution_ids":["https://openalex.org/I3045169105"]},{"raw_affiliation_string":"School of Mathematics, Jilin University , Changchun 130012, Jilin ,","institution_ids":["https://openalex.org/I194450716"]},{"raw_affiliation_string":"Department of Human Cell Biology and Genetics, SUSTech Homeostatic Medicine Institute, School of Medicine, Southern University of Science and Technology, Shenzhen 518055, Guangdong, China","institution_ids":["https://openalex.org/I3045169105"]},{"raw_affiliation_string":"School of Mathematics, Jilin University, Changchun 130012, Jilin, China","institution_ids":["https://openalex.org/I194450716"]},{"raw_affiliation_string":"SUSTech Homeostatic Medicine Institute, School of Medicine, Southern University of Science and Technology, Shenzhen 518055, China","institution_ids":["https://openalex.org/I3045169105"]},{"raw_affiliation_string":"Key University Laboratory of Metabolism and Health of Guangdong, Southern University of Science and Technology, Shenzhen 518055, China","institution_ids":["https://openalex.org/I3045169105"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073497072","display_name":"Long Xu","orcid":"https://orcid.org/0000-0002-7801-4627"},"institutions":[{"id":"https://openalex.org/I3045169105","display_name":"Southern University of Science and Technology","ror":"https://ror.org/049tv2d57","country_code":"CN","type":"education","lineage":["https://openalex.org/I3045169105"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Long Xu","raw_affiliation_strings":["Department of Human Cell Biology and Genetics, SUSTech Homeostatic Medicine Institute, School of Medicine, Southern University of Science and Technology , Shenzhen 518055, Guangdong ,","Key University Laboratory of Metabolism and Health of Guangdong, Southern University of Science and Technology , Shenzhen 518055 ,","SUSTech Homeostatic Medicine Institute, School of Medicine, Southern University of Science and Technology , Shenzhen 518055 ,","SUSTech Homeostatic Medicine Institute, School of Medicine, Southern University of Science and Technology, Shenzhen 518055, China","Department of Human Cell Biology and Genetics, SUSTech Homeostatic Medicine Institute, School of Medicine, Southern University of Science and Technology, Shenzhen 518055, Guangdong, China","Key University Laboratory of Metabolism and Health of Guangdong, Southern University of Science and Technology, Shenzhen 518055, China"],"affiliations":[{"raw_affiliation_string":"Department of Human Cell Biology and Genetics, SUSTech Homeostatic Medicine Institute, School of Medicine, Southern University of Science and Technology , Shenzhen 518055, Guangdong ,","institution_ids":["https://openalex.org/I3045169105"]},{"raw_affiliation_string":"Key University Laboratory of Metabolism and Health of Guangdong, Southern University of Science and Technology , Shenzhen 518055 ,","institution_ids":["https://openalex.org/I3045169105"]},{"raw_affiliation_string":"SUSTech Homeostatic Medicine Institute, School of Medicine, Southern University of Science and Technology , Shenzhen 518055 ,","institution_ids":["https://openalex.org/I3045169105"]},{"raw_affiliation_string":"SUSTech Homeostatic Medicine Institute, School of Medicine, Southern University of Science and Technology, Shenzhen 518055, China","institution_ids":["https://openalex.org/I3045169105"]},{"raw_affiliation_string":"Department of Human Cell Biology and Genetics, SUSTech Homeostatic Medicine Institute, School of Medicine, Southern University of Science and Technology, Shenzhen 518055, Guangdong, China","institution_ids":["https://openalex.org/I3045169105"]},{"raw_affiliation_string":"Key University Laboratory of Metabolism and Health of Guangdong, Southern University of Science and Technology, Shenzhen 518055, China","institution_ids":["https://openalex.org/I3045169105"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002916689","display_name":"Zhenyu Huang","orcid":"https://orcid.org/0009-0009-0029-1729"},"institutions":[{"id":"https://openalex.org/I194450716","display_name":"Jilin University","ror":"https://ror.org/00js3aw79","country_code":"CN","type":"education","lineage":["https://openalex.org/I194450716"]},{"id":"https://openalex.org/I3045169105","display_name":"Southern University of Science and Technology","ror":"https://ror.org/049tv2d57","country_code":"CN","type":"education","lineage":["https://openalex.org/I3045169105"]},{"id":"https://openalex.org/I4210134929","display_name":"Jilin Province Science and Technology Department","ror":"https://ror.org/049x38272","country_code":"CN","type":"government","lineage":["https://openalex.org/I4210134929"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhenyu Huang","raw_affiliation_strings":["College of Computer Science and Technology, Jilin University , Changchun 130012, Jilin ,","Department of Human Cell Biology and Genetics, SUSTech Homeostatic Medicine Institute, School of Medicine, Southern University of Science and Technology , Shenzhen 518055, Guangdong ,","Key University Laboratory of Metabolism and Health of Guangdong, Southern University of Science and Technology , Shenzhen 518055 ,","SUSTech Homeostatic Medicine Institute, School of Medicine, Southern University of Science and Technology , Shenzhen 518055 ,","College of Computer Science and Technology, Jilin University, Changchun 130012, Jilin, China","Department of Human Cell Biology and Genetics, SUSTech Homeostatic Medicine Institute, School of Medicine, Southern University of Science and Technology, Shenzhen 518055, Guangdong, China","Key University Laboratory of Metabolism and Health of Guangdong, Southern University of Science and Technology, Shenzhen 518055, China","SUSTech Homeostatic Medicine Institute, School of Medicine, Southern University of Science and Technology, Shenzhen 518055, China"],"affiliations":[{"raw_affiliation_string":"College of Computer Science and Technology, Jilin University , Changchun 130012, Jilin ,","institution_ids":["https://openalex.org/I4210134929"]},{"raw_affiliation_string":"Department of Human Cell Biology and Genetics, SUSTech Homeostatic Medicine Institute, School of Medicine, Southern University of Science and Technology , Shenzhen 518055, Guangdong ,","institution_ids":["https://openalex.org/I3045169105"]},{"raw_affiliation_string":"Key University Laboratory of Metabolism and Health of Guangdong, Southern University of Science and Technology , Shenzhen 518055 ,","institution_ids":["https://openalex.org/I3045169105"]},{"raw_affiliation_string":"SUSTech Homeostatic Medicine Institute, School of Medicine, Southern University of Science and Technology , Shenzhen 518055 ,","institution_ids":["https://openalex.org/I3045169105"]},{"raw_affiliation_string":"College of Computer Science and Technology, Jilin University, Changchun 130012, Jilin, China","institution_ids":["https://openalex.org/I4210134929","https://openalex.org/I194450716"]},{"raw_affiliation_string":"Department of Human Cell Biology and Genetics, SUSTech Homeostatic Medicine Institute, School of Medicine, Southern University of Science and Technology, Shenzhen 518055, Guangdong, China","institution_ids":["https://openalex.org/I3045169105"]},{"raw_affiliation_string":"Key University Laboratory of Metabolism and Health of Guangdong, Southern University of Science and Technology, Shenzhen 518055, China","institution_ids":["https://openalex.org/I3045169105"]},{"raw_affiliation_string":"SUSTech Homeostatic Medicine Institute, School of Medicine, Southern University of Science and Technology, Shenzhen 518055, China","institution_ids":["https://openalex.org/I3045169105"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113884939","display_name":"Jing Yan","orcid":null},"institutions":[{"id":"https://openalex.org/I194450716","display_name":"Jilin University","ror":"https://ror.org/00js3aw79","country_code":"CN","type":"education","lineage":["https://openalex.org/I194450716"]},{"id":"https://openalex.org/I3045169105","display_name":"Southern University of Science and Technology","ror":"https://ror.org/049tv2d57","country_code":"CN","type":"education","lineage":["https://openalex.org/I3045169105"]},{"id":"https://openalex.org/I4210134929","display_name":"Jilin Province Science and Technology Department","ror":"https://ror.org/049x38272","country_code":"CN","type":"government","lineage":["https://openalex.org/I4210134929"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jing Yan","raw_affiliation_strings":["College of Computer Science and Technology, Jilin University , Changchun 130012, Jilin ,","Department of Human Cell Biology and Genetics, SUSTech Homeostatic Medicine Institute, School of Medicine, Southern University of Science and Technology , Shenzhen 518055, Guangdong ,","Key University Laboratory of Metabolism and Health of Guangdong, Southern University of Science and Technology , Shenzhen 518055 ,","SUSTech Homeostatic Medicine Institute, School of Medicine, Southern University of Science and Technology , Shenzhen 518055 ,","SUSTech Homeostatic Medicine Institute, School of Medicine, Southern University of Science and Technology, Shenzhen 518055, China","Key University Laboratory of Metabolism and Health of Guangdong, Southern University of Science and Technology, Shenzhen 518055, China","College of Computer Science and Technology, Jilin University, Changchun 130012, Jilin, China","Department of Human Cell Biology and Genetics, SUSTech Homeostatic Medicine Institute, School of Medicine, Southern University of Science and Technology, Shenzhen 518055, Guangdong, China"],"affiliations":[{"raw_affiliation_string":"College of Computer Science and Technology, Jilin University , Changchun 130012, Jilin ,","institution_ids":["https://openalex.org/I4210134929"]},{"raw_affiliation_string":"Department of Human Cell Biology and Genetics, SUSTech Homeostatic Medicine Institute, School of Medicine, Southern University of Science and Technology , Shenzhen 518055, Guangdong ,","institution_ids":["https://openalex.org/I3045169105"]},{"raw_affiliation_string":"Key University Laboratory of Metabolism and Health of Guangdong, Southern University of Science and Technology , Shenzhen 518055 ,","institution_ids":["https://openalex.org/I3045169105"]},{"raw_affiliation_string":"SUSTech Homeostatic Medicine Institute, School of Medicine, Southern University of Science and Technology , Shenzhen 518055 ,","institution_ids":["https://openalex.org/I3045169105"]},{"raw_affiliation_string":"SUSTech Homeostatic Medicine Institute, School of Medicine, Southern University of Science and Technology, Shenzhen 518055, China","institution_ids":["https://openalex.org/I3045169105"]},{"raw_affiliation_string":"Key University Laboratory of Metabolism and Health of Guangdong, Southern University of Science and Technology, Shenzhen 518055, China","institution_ids":["https://openalex.org/I3045169105"]},{"raw_affiliation_string":"College of Computer Science and Technology, Jilin University, Changchun 130012, Jilin, China","institution_ids":["https://openalex.org/I4210134929","https://openalex.org/I194450716"]},{"raw_affiliation_string":"Department of Human Cell Biology and Genetics, SUSTech Homeostatic Medicine Institute, School of Medicine, Southern University of Science and Technology, Shenzhen 518055, Guangdong, China","institution_ids":["https://openalex.org/I3045169105"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068003715","display_name":"Bocheng Shi","orcid":null},"institutions":[{"id":"https://openalex.org/I3045169105","display_name":"Southern University of Science and Technology","ror":"https://ror.org/049tv2d57","country_code":"CN","type":"education","lineage":["https://openalex.org/I3045169105"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Bocheng Shi","raw_affiliation_strings":["Department of Human Cell Biology and Genetics, SUSTech Homeostatic Medicine Institute, School of Medicine, Southern University of Science and Technology , Shenzhen 518055, Guangdong ,","Key University Laboratory of Metabolism and Health of Guangdong, Southern University of Science and Technology , Shenzhen 518055 ,","SUSTech Homeostatic Medicine Institute, School of Medicine, Southern University of Science and Technology , Shenzhen 518055 ,"],"affiliations":[{"raw_affiliation_string":"Department of Human Cell Biology and Genetics, SUSTech Homeostatic Medicine Institute, School of Medicine, Southern University of Science and Technology , Shenzhen 518055, Guangdong ,","institution_ids":["https://openalex.org/I3045169105"]},{"raw_affiliation_string":"Key University Laboratory of Metabolism and Health of Guangdong, Southern University of Science and Technology , Shenzhen 518055 ,","institution_ids":["https://openalex.org/I3045169105"]},{"raw_affiliation_string":"SUSTech Homeostatic Medicine Institute, School of Medicine, Southern University of Science and Technology , Shenzhen 518055 ,","institution_ids":["https://openalex.org/I3045169105"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027329732","display_name":"Yishi Wang","orcid":"https://orcid.org/0009-0004-6021-0357"},"institutions":[{"id":"https://openalex.org/I3045169105","display_name":"Southern University of Science and Technology","ror":"https://ror.org/049tv2d57","country_code":"CN","type":"education","lineage":["https://openalex.org/I3045169105"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yishi Wang","raw_affiliation_strings":["Department of Human Cell Biology and Genetics, SUSTech Homeostatic Medicine Institute, School of Medicine, Southern University of Science and Technology , Shenzhen 518055, Guangdong ,","Key University Laboratory of Metabolism and Health of Guangdong, Southern University of Science and Technology , Shenzhen 518055 ,","SUSTech Homeostatic Medicine Institute, School of Medicine, Southern University of Science and Technology , Shenzhen 518055 ,","Department of Human Cell Biology and Genetics, SUSTech Homeostatic Medicine Institute, School of Medicine, Southern University of Science and Technology, Shenzhen 518055, Guangdong, China","Key University Laboratory of Metabolism and Health of Guangdong, Southern University of Science and Technology, Shenzhen 518055, China","SUSTech Homeostatic Medicine Institute, School of Medicine, Southern University of Science and Technology, Shenzhen 518055, China"],"affiliations":[{"raw_affiliation_string":"Department of Human Cell Biology and Genetics, SUSTech Homeostatic Medicine Institute, School of Medicine, Southern University of Science and Technology , Shenzhen 518055, Guangdong ,","institution_ids":["https://openalex.org/I3045169105"]},{"raw_affiliation_string":"Key University Laboratory of Metabolism and Health of Guangdong, Southern University of Science and Technology , Shenzhen 518055 ,","institution_ids":["https://openalex.org/I3045169105"]},{"raw_affiliation_string":"SUSTech Homeostatic Medicine Institute, School of Medicine, Southern University of Science and Technology , Shenzhen 518055 ,","institution_ids":["https://openalex.org/I3045169105"]},{"raw_affiliation_string":"Department of Human Cell Biology and Genetics, SUSTech Homeostatic Medicine Institute, School of Medicine, Southern University of Science and Technology, Shenzhen 518055, Guangdong, China","institution_ids":["https://openalex.org/I3045169105"]},{"raw_affiliation_string":"Key University Laboratory of Metabolism and Health of Guangdong, Southern University of Science and Technology, Shenzhen 518055, China","institution_ids":["https://openalex.org/I3045169105"]},{"raw_affiliation_string":"SUSTech Homeostatic Medicine Institute, School of Medicine, Southern University of Science and Technology, Shenzhen 518055, China","institution_ids":["https://openalex.org/I3045169105"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080764231","display_name":"Binyue Liu","orcid":null},"institutions":[{"id":"https://openalex.org/I3045169105","display_name":"Southern University of Science and Technology","ror":"https://ror.org/049tv2d57","country_code":"CN","type":"education","lineage":["https://openalex.org/I3045169105"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Binyue Liu","raw_affiliation_strings":["Department of Human Cell Biology and Genetics, SUSTech Homeostatic Medicine Institute, School of Medicine, Southern University of Science and Technology , Shenzhen 518055, Guangdong ,","Key University Laboratory of Metabolism and Health of Guangdong, Southern University of Science and Technology , Shenzhen 518055 ,","SUSTech Homeostatic Medicine Institute, School of Medicine, Southern University of Science and Technology , Shenzhen 518055 ,","Department of Human Cell Biology and Genetics, SUSTech Homeostatic Medicine Institute, School of Medicine, Southern University of Science and Technology, Shenzhen 518055, Guangdong, China","SUSTech Homeostatic Medicine Institute, School of Medicine, Southern University of Science and Technology, Shenzhen 518055, China","Key University Laboratory of Metabolism and Health of Guangdong, Southern University of Science and Technology, Shenzhen 518055, China"],"affiliations":[{"raw_affiliation_string":"Department of Human Cell Biology and Genetics, SUSTech Homeostatic Medicine Institute, School of Medicine, Southern University of Science and Technology , Shenzhen 518055, Guangdong ,","institution_ids":["https://openalex.org/I3045169105"]},{"raw_affiliation_string":"Key University Laboratory of Metabolism and Health of Guangdong, Southern University of Science and Technology , Shenzhen 518055 ,","institution_ids":["https://openalex.org/I3045169105"]},{"raw_affiliation_string":"SUSTech Homeostatic Medicine Institute, School of Medicine, Southern University of Science and Technology , Shenzhen 518055 ,","institution_ids":["https://openalex.org/I3045169105"]},{"raw_affiliation_string":"Department of Human Cell Biology and Genetics, SUSTech Homeostatic Medicine Institute, School of Medicine, Southern University of Science and Technology, Shenzhen 518055, Guangdong, China","institution_ids":["https://openalex.org/I3045169105"]},{"raw_affiliation_string":"SUSTech Homeostatic Medicine Institute, School of Medicine, Southern University of Science and Technology, Shenzhen 518055, China","institution_ids":["https://openalex.org/I3045169105"]},{"raw_affiliation_string":"Key University Laboratory of Metabolism and Health of Guangdong, Southern University of Science and Technology, Shenzhen 518055, China","institution_ids":["https://openalex.org/I3045169105"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100323927","display_name":"Kai Zhang","orcid":"https://orcid.org/0000-0001-9959-319X"},"institutions":[{"id":"https://openalex.org/I194450716","display_name":"Jilin University","ror":"https://ror.org/00js3aw79","country_code":"CN","type":"education","lineage":["https://openalex.org/I194450716"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Kai Zhang","raw_affiliation_strings":["School of Mathematics, Jilin University , Changchun 130012, Jilin ,","School of Mathematics, Jilin University, Changchun 130012, Jilin, China"],"affiliations":[{"raw_affiliation_string":"School of Mathematics, Jilin University , Changchun 130012, Jilin ,","institution_ids":["https://openalex.org/I194450716"]},{"raw_affiliation_string":"School of Mathematics, Jilin University, Changchun 130012, Jilin, China","institution_ids":["https://openalex.org/I194450716"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5020171946","display_name":"Ying Xu","orcid":"https://orcid.org/0000-0002-7856-3343"},"institutions":[{"id":"https://openalex.org/I3045169105","display_name":"Southern University of Science and Technology","ror":"https://ror.org/049tv2d57","country_code":"CN","type":"education","lineage":["https://openalex.org/I3045169105"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ying Xu","raw_affiliation_strings":["Department of Human Cell Biology and Genetics, SUSTech Homeostatic Medicine Institute, School of Medicine, Southern University of Science and Technology , Shenzhen 518055, Guangdong ,","Key University Laboratory of Metabolism and Health of Guangdong, Southern University of Science and Technology , Shenzhen 518055 ,","SUSTech Homeostatic Medicine Institute, School of Medicine, Southern University of Science and Technology , Shenzhen 518055 ,","SUSTech Homeostatic Medicine Institute, School of Medicine, Southern University of Science and Technology, Shenzhen 518055, China","Key University Laboratory of Metabolism and Health of Guangdong, Southern University of Science and Technology, Shenzhen 518055, China","Department of Human Cell Biology and Genetics, SUSTech Homeostatic Medicine Institute, School of Medicine, Southern University of Science and Technology, Shenzhen 518055, Guangdong, China"],"affiliations":[{"raw_affiliation_string":"Department of Human Cell Biology and Genetics, SUSTech Homeostatic Medicine Institute, School of Medicine, Southern University of Science and Technology , Shenzhen 518055, Guangdong ,","institution_ids":["https://openalex.org/I3045169105"]},{"raw_affiliation_string":"Key University Laboratory of Metabolism and Health of Guangdong, Southern University of Science and Technology , Shenzhen 518055 ,","institution_ids":["https://openalex.org/I3045169105"]},{"raw_affiliation_string":"SUSTech Homeostatic Medicine Institute, School of Medicine, Southern University of Science and Technology , Shenzhen 518055 ,","institution_ids":["https://openalex.org/I3045169105"]},{"raw_affiliation_string":"SUSTech Homeostatic Medicine Institute, School of Medicine, Southern University of Science and Technology, Shenzhen 518055, China","institution_ids":["https://openalex.org/I3045169105"]},{"raw_affiliation_string":"Key University Laboratory of Metabolism and Health of Guangdong, Southern University of Science and Technology, Shenzhen 518055, China","institution_ids":["https://openalex.org/I3045169105"]},{"raw_affiliation_string":"Department of Human Cell Biology and Genetics, SUSTech Homeostatic Medicine Institute, School of Medicine, Southern University of Science and Technology, Shenzhen 518055, Guangdong, China","institution_ids":["https://openalex.org/I3045169105"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":9,"corresponding_author_ids":["https://openalex.org/A5113243397"],"corresponding_institution_ids":["https://openalex.org/I194450716","https://openalex.org/I3045169105"],"apc_list":{"value":4011,"currency":"USD","value_usd":4011},"apc_paid":{"value":4011,"currency":"USD","value_usd":4011},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.17364291,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"26","issue":"4","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12254","display_name":"Machine Learning in Bioinformatics","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12254","display_name":"Machine Learning in Bioinformatics","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.9977999925613403,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10015","display_name":"Genomics and Phylogenetic Studies","score":0.9975000023841858,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.707851767539978},{"id":"https://openalex.org/keywords/convolutional-neural-network","display_name":"Convolutional neural network","score":0.6528753638267517},{"id":"https://openalex.org/keywords/interpretability","display_name":"Interpretability","score":0.650807797908783},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.6235546469688416},{"id":"https://openalex.org/keywords/discriminative-model","display_name":"Discriminative model","score":0.602207601070404},{"id":"https://openalex.org/keywords/robustness","display_name":"Robustness (evolution)","score":0.565660297870636},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.5510511994361877},{"id":"https://openalex.org/keywords/pattern-recognition","display_name":"Pattern recognition (psychology)","score":0.36831605434417725},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.33827221393585205},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.183212548494339}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.707851767539978},{"id":"https://openalex.org/C81363708","wikidata":"https://www.wikidata.org/wiki/Q17084460","display_name":"Convolutional neural network","level":2,"score":0.6528753638267517},{"id":"https://openalex.org/C2781067378","wikidata":"https://www.wikidata.org/wiki/Q17027399","display_name":"Interpretability","level":2,"score":0.650807797908783},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.6235546469688416},{"id":"https://openalex.org/C97931131","wikidata":"https://www.wikidata.org/wiki/Q5282087","display_name":"Discriminative model","level":2,"score":0.602207601070404},{"id":"https://openalex.org/C63479239","wikidata":"https://www.wikidata.org/wiki/Q7353546","display_name":"Robustness (evolution)","level":3,"score":0.565660297870636},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.5510511994361877},{"id":"https://openalex.org/C153180895","wikidata":"https://www.wikidata.org/wiki/Q7148389","display_name":"Pattern recognition (psychology)","level":2,"score":0.36831605434417725},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.33827221393585205},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.183212548494339},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001798","descriptor_name":"Blood Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001798","descriptor_name":"Blood Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001798","descriptor_name":"Blood Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001798","descriptor_name":"Blood Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D016571","descriptor_name":"Neural Networks, Computer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016571","descriptor_name":"Neural Networks, Computer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016571","descriptor_name":"Neural Networks, Computer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016571","descriptor_name":"Neural Networks, Computer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D030562","descriptor_name":"Databases, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030562","descriptor_name":"Databases, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030562","descriptor_name":"Databases, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030562","descriptor_name":"Databases, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1093/bib/bbaf385","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbaf385","pdf_url":null,"source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},{"id":"pmid:40748326","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40748326","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in bioinformatics","raw_type":null},{"id":"pmh:oai:europepmc.org:11127943","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/12315548","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1093/bib/bbaf385","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbaf385","pdf_url":null,"source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.7099999785423279,"display_name":"Reduced inequalities","id":"https://metadata.un.org/sdg/10"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":73,"referenced_works":["https://openalex.org/W104793819","https://openalex.org/W1562415691","https://openalex.org/W1595159159","https://openalex.org/W1863266496","https://openalex.org/W1974124768","https://openalex.org/W1977556410","https://openalex.org/W1981070004","https://openalex.org/W1981295186","https://openalex.org/W1986553481","https://openalex.org/W1994525010","https://openalex.org/W2012034410","https://openalex.org/W2026623315","https://openalex.org/W2029163288","https://openalex.org/W2049177626","https://openalex.org/W2064675550","https://openalex.org/W2064874066","https://openalex.org/W2074844290","https://openalex.org/W2080195234","https://openalex.org/W2089417302","https://openalex.org/W2095483652","https://openalex.org/W2096324068","https://openalex.org/W2112796928","https://openalex.org/W2115701223","https://openalex.org/W2118217143","https://openalex.org/W2119387367","https://openalex.org/W2127921600","https://openalex.org/W2132292391","https://openalex.org/W2145957695","https://openalex.org/W2146980885","https://openalex.org/W2152800101","https://openalex.org/W2160061958","https://openalex.org/W2187089797","https://openalex.org/W2405808131","https://openalex.org/W2518479197","https://openalex.org/W2550451727","https://openalex.org/W2730472814","https://openalex.org/W2759592955","https://openalex.org/W2776525063","https://openalex.org/W2809254203","https://openalex.org/W2823613278","https://openalex.org/W2918702104","https://openalex.org/W2962862931","https://openalex.org/W2989951885","https://openalex.org/W3004850558","https://openalex.org/W3005063595","https://openalex.org/W3038391784","https://openalex.org/W3040044993","https://openalex.org/W3040056619","https://openalex.org/W3103608651","https://openalex.org/W3104092632","https://openalex.org/W3136918052","https://openalex.org/W3146063182","https://openalex.org/W3177283014","https://openalex.org/W3177828909","https://openalex.org/W3205873152","https://openalex.org/W4224215508","https://openalex.org/W4225529283","https://openalex.org/W4283068628","https://openalex.org/W4306764865","https://openalex.org/W4320930577","https://openalex.org/W4383550115","https://openalex.org/W4385245566","https://openalex.org/W4386136017","https://openalex.org/W4386420840","https://openalex.org/W4388976017","https://openalex.org/W4392741075","https://openalex.org/W4394009853","https://openalex.org/W6639093311","https://openalex.org/W6639824700","https://openalex.org/W6644682428","https://openalex.org/W6737947904","https://openalex.org/W6739901393","https://openalex.org/W6746023985"],"related_works":["https://openalex.org/W2905433371","https://openalex.org/W2888392564","https://openalex.org/W4310278675","https://openalex.org/W4388422664","https://openalex.org/W4390569940","https://openalex.org/W4361193272","https://openalex.org/W2963326959","https://openalex.org/W2809283485","https://openalex.org/W4293768783","https://openalex.org/W4288347394"],"abstract_inverted_index":{"Accurate":[0],"identification":[1],"of":[2,23,70,154,197],"proteins":[3],"secreted":[4],"into":[5,159],"the":[6,21,59,98,103,151,160,194],"bloodstream":[7],"is":[8,20],"essential":[9],"for":[10,32,229],"discovering":[11],"diagnostic":[12],"biomarkers":[13],"and":[14,107,118,189,205,208,232],"therapeutic":[15],"targets.":[16],"A":[17],"significant":[18],"challenge":[19],"scarcity":[22],"experimentally":[24],"validated":[25],"blood-secretory":[26,54],"proteins,":[27,156],"limiting":[28],"labeled":[29,60],"datasets":[30],"required":[31],"robust":[33],"model":[34,77],"training.":[35],"To":[36],"address":[37],"this":[38],"issue,":[39],"we":[40],"propose":[41],"BloodProST,":[42],"a":[43,48,67,113,124,225],"novel":[44],"machine-learning":[45],"framework":[46],"leveraging":[47],"self-training":[49],"strategy":[50],"to":[51,101,164,212],"reliably":[52],"predict":[53],"proteins.":[55],"BloodProST":[56,86,111,175],"iteratively":[57],"expands":[58],"dataset":[61],"by":[62],"generating":[63],"high-confidence":[64],"pseudo-labels":[65],"from":[66,130,142],"large":[68],"pool":[69],"unlabeled":[71],"protein":[72,143],"sequences,":[73],"thereby":[74],"progressively":[75],"enhancing":[76],"predictions":[78,198],"without":[79],"continuous":[80],"manual":[81],"annotation.":[82],"At":[83],"its":[84],"core,":[85],"incorporates":[87],"an":[88,134],"unsupervised":[89],"feature":[90],"selection":[91],"module":[92],"based":[93],"on":[94],"differential":[95],"evolution,":[96],"optimizing":[97],"Silhouette":[99],"score":[100],"identify":[102],"most":[104],"discriminative":[105],"physicochemical":[106],"sequence-derived":[108],"features.":[109],"Additionally,":[110],"employs":[112],"dual-pathway":[114],"convolutional":[115],"neural":[116],"network":[117],"long":[119],"short-term":[120],"memory":[121],"(CNN)-(LSTM)":[122],"architecture:":[123],"CNN-based":[125],"pathway":[126,136],"captures":[127],"local":[128],"information":[129],"pre-constructed":[131],"features,":[132],"whereas":[133],"LSTM-based":[135],"extracts":[137],"high-level":[138],"sequential":[139],"dependencies":[140],"directly":[141],"sequences.":[144],"Furthermore,":[145],"domain-specific":[146],"biological":[147,195,237],"priors,":[148],"such":[149,215],"as":[150,216,224],"expected":[152],"proportion":[153],"secretory":[155],"are":[157],"integrated":[158],"model's":[161],"loss":[162],"function":[163],"guide":[165],"training":[166],"toward":[167],"biologically":[168],"plausible":[169],"predictions.":[170],"Extensive":[171],"evaluation":[172],"demonstrates":[173],"that":[174],"significantly":[176],"outperforms":[177],"14":[178],"state-of-the-art":[179],"models":[180],"across":[181,235],"multiple":[182],"metrics,":[183],"achieving":[184],"superior":[185],"predictive":[186],"accuracy,":[187],"robustness,":[188],"interpretability.":[190],"Validation":[191],"analyses":[192],"confirm":[193],"relevance":[196],"through":[199],"secretion-related":[200],"markers":[201],"(e.g.":[202],"signal":[203],"peptides":[204],"transmembrane":[206],"regions)":[207],"demonstrate":[209],"effective":[210],"generalization":[211],"other":[213],"biofluids,":[214],"urine.":[217],"Collectively,":[218],"these":[219],"results":[220],"illustrate":[221],"BloodProST's":[222],"potential":[223],"versatile":[226],"computational":[227],"tool":[228],"secretion":[230],"prediction":[231],"biomarker":[233],"discovery":[234],"diverse":[236],"fluids.":[238]},"counts_by_year":[],"updated_date":"2026-03-27T14:29:43.386196","created_date":"2025-10-10T00:00:00"}