{"id":"https://openalex.org/W4413111718","doi":"https://doi.org/10.1093/bib/bbaf353","title":"An advanced network pharmacology investigation of Shufeng Jiedu formula in the treatment for respiratory tract infection based on LC\u2013MS, data mining, molecular docking, and molecular dynamic simulation","display_name":"An advanced network pharmacology investigation of Shufeng Jiedu formula in the treatment for respiratory tract infection based on LC\u2013MS, data mining, molecular docking, and molecular dynamic simulation","publication_year":2025,"publication_date":"2025-07-01","ids":{"openalex":"https://openalex.org/W4413111718","doi":"https://doi.org/10.1093/bib/bbaf353","pmid":"https://pubmed.ncbi.nlm.nih.gov/40794954"},"language":"en","primary_location":{"id":"doi:10.1093/bib/bbaf353","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbaf353","pdf_url":"https://academic.oup.com/bib/article-pdf/26/4/bbaf353/63999181/bbaf353.pdf","source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://academic.oup.com/bib/article-pdf/26/4/bbaf353/63999181/bbaf353.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5102782532","display_name":"Zhang Yan","orcid":"https://orcid.org/0000-0003-1070-4960"},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]},{"id":"https://openalex.org/I4210141683","display_name":"China Academy of Chinese Medical Sciences","ror":"https://ror.org/042pgcv68","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210141683"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yan Zhang","raw_affiliation_strings":["China Academy of Chinese Medical Sciences, Institute of Chinese Materia Medica , No. 16, Dongzhimen Nei Nanxiao Street, Dongcheng District, Beijing 100700 ,","China Academy of Chinese Medical Sciences, Institute of Chinese Materia Medica, No. 16, Dongzhimen Nei Nanxiao Street, Dongcheng District, Beijing 100700, China"],"affiliations":[{"raw_affiliation_string":"China Academy of Chinese Medical Sciences, Institute of Chinese Materia Medica , No. 16, Dongzhimen Nei Nanxiao Street, Dongcheng District, Beijing 100700 ,","institution_ids":["https://openalex.org/I200296433","https://openalex.org/I4210141683"]},{"raw_affiliation_string":"China Academy of Chinese Medical Sciences, Institute of Chinese Materia Medica, No. 16, Dongzhimen Nei Nanxiao Street, Dongcheng District, Beijing 100700, China","institution_ids":["https://openalex.org/I200296433","https://openalex.org/I4210141683"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100416395","display_name":"Huijun Wang","orcid":"https://orcid.org/0000-0001-6319-498X"},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]},{"id":"https://openalex.org/I4210141683","display_name":"China Academy of Chinese Medical Sciences","ror":"https://ror.org/042pgcv68","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210141683"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Huijun Wang","raw_affiliation_strings":["China Academy of Chinese Medical Sciences, Institute of Chinese Materia Medica , No. 16, Dongzhimen Nei Nanxiao Street, Dongcheng District, Beijing 100700 ,","China Academy of Chinese Medical Sciences, Institute of Chinese Materia Medica, No. 16, Dongzhimen Nei Nanxiao Street, Dongcheng District, Beijing 100700, China"],"affiliations":[{"raw_affiliation_string":"China Academy of Chinese Medical Sciences, Institute of Chinese Materia Medica , No. 16, Dongzhimen Nei Nanxiao Street, Dongcheng District, Beijing 100700 ,","institution_ids":["https://openalex.org/I200296433","https://openalex.org/I4210141683"]},{"raw_affiliation_string":"China Academy of Chinese Medical Sciences, Institute of Chinese Materia Medica, No. 16, Dongzhimen Nei Nanxiao Street, Dongcheng District, Beijing 100700, China","institution_ids":["https://openalex.org/I200296433","https://openalex.org/I4210141683"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101759333","display_name":"Chaochao Wang","orcid":"https://orcid.org/0000-0002-0637-6696"},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]},{"id":"https://openalex.org/I4210141683","display_name":"China Academy of Chinese Medical Sciences","ror":"https://ror.org/042pgcv68","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210141683"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chaochao Wang","raw_affiliation_strings":["China Academy of Chinese Medical Sciences, Institute of Chinese Materia Medica , No. 16, Dongzhimen Nei Nanxiao Street, Dongcheng District, Beijing 100700 ,","China Academy of Chinese Medical Sciences, Institute of Chinese Materia Medica, No. 16, Dongzhimen Nei Nanxiao Street, Dongcheng District, Beijing 100700, China"],"affiliations":[{"raw_affiliation_string":"China Academy of Chinese Medical Sciences, Institute of Chinese Materia Medica , No. 16, Dongzhimen Nei Nanxiao Street, Dongcheng District, Beijing 100700 ,","institution_ids":["https://openalex.org/I200296433","https://openalex.org/I4210141683"]},{"raw_affiliation_string":"China Academy of Chinese Medical Sciences, Institute of Chinese Materia Medica, No. 16, Dongzhimen Nei Nanxiao Street, Dongcheng District, Beijing 100700, China","institution_ids":["https://openalex.org/I200296433","https://openalex.org/I4210141683"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053159837","display_name":"Xiaolan Cui","orcid":"https://orcid.org/0000-0003-4023-6424"},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]},{"id":"https://openalex.org/I4210141683","display_name":"China Academy of Chinese Medical Sciences","ror":"https://ror.org/042pgcv68","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210141683"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaolan Cui","raw_affiliation_strings":["China Academy of Chinese Medical Sciences, Institute of Chinese Materia Medica , No. 16, Dongzhimen Nei Nanxiao Street, Dongcheng District, Beijing 100700 ,","China Academy of Chinese Medical Sciences, Institute of Chinese Materia Medica, No. 16, Dongzhimen Nei Nanxiao Street, Dongcheng District, Beijing 100700, China"],"affiliations":[{"raw_affiliation_string":"China Academy of Chinese Medical Sciences, Institute of Chinese Materia Medica , No. 16, Dongzhimen Nei Nanxiao Street, Dongcheng District, Beijing 100700 ,","institution_ids":["https://openalex.org/I200296433","https://openalex.org/I4210141683"]},{"raw_affiliation_string":"China Academy of Chinese Medical Sciences, Institute of Chinese Materia Medica, No. 16, Dongzhimen Nei Nanxiao Street, Dongcheng District, Beijing 100700, China","institution_ids":["https://openalex.org/I200296433","https://openalex.org/I4210141683"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103227830","display_name":"Shanshan Guo","orcid":"https://orcid.org/0000-0001-8230-9922"},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]},{"id":"https://openalex.org/I4210141683","display_name":"China Academy of Chinese Medical Sciences","ror":"https://ror.org/042pgcv68","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210141683"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shanshan Guo","raw_affiliation_strings":["China Academy of Chinese Medical Sciences, Institute of Chinese Materia Medica , No. 16, Dongzhimen Nei Nanxiao Street, Dongcheng District, Beijing 100700 ,","China Academy of Chinese Medical Sciences, Institute of Chinese Materia Medica, No. 16, Dongzhimen Nei Nanxiao Street, Dongcheng District, Beijing 100700, China"],"affiliations":[{"raw_affiliation_string":"China Academy of Chinese Medical Sciences, Institute of Chinese Materia Medica , No. 16, Dongzhimen Nei Nanxiao Street, Dongcheng District, Beijing 100700 ,","institution_ids":["https://openalex.org/I200296433","https://openalex.org/I4210141683"]},{"raw_affiliation_string":"China Academy of Chinese Medical Sciences, Institute of Chinese Materia Medica, No. 16, Dongzhimen Nei Nanxiao Street, Dongcheng District, Beijing 100700, China","institution_ids":["https://openalex.org/I200296433","https://openalex.org/I4210141683"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101830855","display_name":"Junyi Zhou","orcid":"https://orcid.org/0000-0003-4540-7771"},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]},{"id":"https://openalex.org/I4210141683","display_name":"China Academy of Chinese Medical Sciences","ror":"https://ror.org/042pgcv68","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210141683"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Junyi Zhou","raw_affiliation_strings":["China Academy of Chinese Medical Sciences, Institute of Chinese Materia Medica , No. 16, Dongzhimen Nei Nanxiao Street, Dongcheng District, Beijing 100700 ,","China Academy of Chinese Medical Sciences, Institute of Chinese Materia Medica, No. 16, Dongzhimen Nei Nanxiao Street, Dongcheng District, Beijing 100700, China"],"affiliations":[{"raw_affiliation_string":"China Academy of Chinese Medical Sciences, Institute of Chinese Materia Medica , No. 16, Dongzhimen Nei Nanxiao Street, Dongcheng District, Beijing 100700 ,","institution_ids":["https://openalex.org/I200296433","https://openalex.org/I4210141683"]},{"raw_affiliation_string":"China Academy of Chinese Medical Sciences, Institute of Chinese Materia Medica, No. 16, Dongzhimen Nei Nanxiao Street, Dongcheng District, Beijing 100700, China","institution_ids":["https://openalex.org/I200296433","https://openalex.org/I4210141683"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100354353","display_name":"Lihua Chen","orcid":"https://orcid.org/0000-0002-6313-6496"},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]},{"id":"https://openalex.org/I4210141683","display_name":"China Academy of Chinese Medical Sciences","ror":"https://ror.org/042pgcv68","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210141683"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lihua Chen","raw_affiliation_strings":["China Academy of Chinese Medical Sciences, Institute of Chinese Materia Medica , No. 16, Dongzhimen Nei Nanxiao Street, Dongcheng District, Beijing 100700 ,","China Academy of Chinese Medical Sciences, Institute of Chinese Materia Medica, No. 16, Dongzhimen Nei Nanxiao Street, Dongcheng District, Beijing 100700, China"],"affiliations":[{"raw_affiliation_string":"China Academy of Chinese Medical Sciences, Institute of Chinese Materia Medica , No. 16, Dongzhimen Nei Nanxiao Street, Dongcheng District, Beijing 100700 ,","institution_ids":["https://openalex.org/I200296433","https://openalex.org/I4210141683"]},{"raw_affiliation_string":"China Academy of Chinese Medical Sciences, Institute of Chinese Materia Medica, No. 16, Dongzhimen Nei Nanxiao Street, Dongcheng District, Beijing 100700, China","institution_ids":["https://openalex.org/I200296433","https://openalex.org/I4210141683"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041997172","display_name":"Xiaolu Wei","orcid":"https://orcid.org/0000-0001-9952-3757"},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]},{"id":"https://openalex.org/I4210141683","display_name":"China Academy of Chinese Medical Sciences","ror":"https://ror.org/042pgcv68","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210141683"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaolu Wei","raw_affiliation_strings":["China Academy of Chinese Medical Sciences, Institute of Chinese Materia Medica , No. 16, Dongzhimen Nei Nanxiao Street, Dongcheng District, Beijing 100700 ,","China Academy of Chinese Medical Sciences, Institute of Chinese Materia Medica, No. 16, Dongzhimen Nei Nanxiao Street, Dongcheng District, Beijing 100700, China"],"affiliations":[{"raw_affiliation_string":"China Academy of Chinese Medical Sciences, Institute of Chinese Materia Medica , No. 16, Dongzhimen Nei Nanxiao Street, Dongcheng District, Beijing 100700 ,","institution_ids":["https://openalex.org/I200296433","https://openalex.org/I4210141683"]},{"raw_affiliation_string":"China Academy of Chinese Medical Sciences, Institute of Chinese Materia Medica, No. 16, Dongzhimen Nei Nanxiao Street, Dongcheng District, Beijing 100700, China","institution_ids":["https://openalex.org/I200296433","https://openalex.org/I4210141683"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5057243753","display_name":"Haiyu Zhao","orcid":null},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]},{"id":"https://openalex.org/I4210141683","display_name":"China Academy of Chinese Medical Sciences","ror":"https://ror.org/042pgcv68","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210141683"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Haiyu Zhao","raw_affiliation_strings":["China Academy of Chinese Medical Sciences, Institute of Chinese Materia Medica , No. 16, Dongzhimen Nei Nanxiao Street, Dongcheng District, Beijing 100700 ,","China Academy of Chinese Medical Sciences, Institute of Chinese Materia Medica, No. 16, Dongzhimen Nei Nanxiao Street, Dongcheng District, Beijing 100700, China"],"affiliations":[{"raw_affiliation_string":"China Academy of Chinese Medical Sciences, Institute of Chinese Materia Medica , No. 16, Dongzhimen Nei Nanxiao Street, Dongcheng District, Beijing 100700 ,","institution_ids":["https://openalex.org/I200296433","https://openalex.org/I4210141683"]},{"raw_affiliation_string":"China Academy of Chinese Medical Sciences, Institute of Chinese Materia Medica, No. 16, Dongzhimen Nei Nanxiao Street, Dongcheng District, Beijing 100700, China","institution_ids":["https://openalex.org/I200296433","https://openalex.org/I4210141683"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":9,"corresponding_author_ids":["https://openalex.org/A5102782532"],"corresponding_institution_ids":["https://openalex.org/I200296433","https://openalex.org/I4210141683"],"apc_list":{"value":4011,"currency":"USD","value_usd":4011},"apc_paid":{"value":4011,"currency":"USD","value_usd":4011},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.32402569,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"26","issue":"4","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11709","display_name":"Traditional Chinese Medicine Analysis","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11709","display_name":"Traditional Chinese Medicine Analysis","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11889","display_name":"Ginseng Biological Effects and Applications","score":0.995199978351593,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13095","display_name":"Plant-based Medicinal Research","score":0.9897000193595886,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pharmacology","display_name":"Pharmacology","score":0.3703497052192688},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.3611027002334595},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.2623351216316223}],"concepts":[{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3703497052192688},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.3611027002334595},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2623351216316223}],"mesh":[{"descriptor_ui":"D000091484","descriptor_name":"Network Pharmacology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000091484","descriptor_name":"Network Pharmacology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000091484","descriptor_name":"Network Pharmacology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000097922","descriptor_name":"Liquid Chromatography-Mass Spectrometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000097922","descriptor_name":"Liquid Chromatography-Mass Spectrometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000097922","descriptor_name":"Liquid Chromatography-Mass Spectrometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002853","descriptor_name":"Chromatography, Liquid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002853","descriptor_name":"Chromatography, Liquid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002853","descriptor_name":"Chromatography, Liquid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004365","descriptor_name":"Drugs, Chinese Herbal","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D004365","descriptor_name":"Drugs, Chinese Herbal","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D004365","descriptor_name":"Drugs, Chinese Herbal","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D004365","descriptor_name":"Drugs, Chinese Herbal","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D004365","descriptor_name":"Drugs, Chinese Herbal","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D004365","descriptor_name":"Drugs, Chinese Herbal","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D004365","descriptor_name":"Drugs, Chinese Herbal","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D004365","descriptor_name":"Drugs, Chinese Herbal","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D004365","descriptor_name":"Drugs, Chinese Herbal","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012141","descriptor_name":"Respiratory Tract Infections","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D012141","descriptor_name":"Respiratory Tract Infections","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D012141","descriptor_name":"Respiratory Tract Infections","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D012141","descriptor_name":"Respiratory Tract Infections","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012141","descriptor_name":"Respiratory Tract Infections","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012141","descriptor_name":"Respiratory Tract Infections","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D056004","descriptor_name":"Molecular Dynamics Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056004","descriptor_name":"Molecular Dynamics Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056004","descriptor_name":"Molecular Dynamics Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057225","descriptor_name":"Data Mining","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057225","descriptor_name":"Data Mining","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057225","descriptor_name":"Data Mining","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D062105","descriptor_name":"Molecular Docking Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D062105","descriptor_name":"Molecular Docking Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D062105","descriptor_name":"Molecular Docking Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1093/bib/bbaf353","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbaf353","pdf_url":"https://academic.oup.com/bib/article-pdf/26/4/bbaf353/63999181/bbaf353.pdf","source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},{"id":"pmid:40794954","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40794954","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in bioinformatics","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:12342880","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/12342880","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Brief Bioinform","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1093/bib/bbaf353","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbaf353","pdf_url":"https://academic.oup.com/bib/article-pdf/26/4/bbaf353/63999181/bbaf353.pdf","source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.8299999833106995,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"awards":[{"id":"https://openalex.org/G2087396116","display_name":null,"funder_award_id":"China","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G2802911279","display_name":null,"funder_award_id":"Young","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G3317480652","display_name":null,"funder_award_id":"Science","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G391238517","display_name":null,"funder_award_id":", and","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G4020255992","display_name":null,"funder_award_id":"Project","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G4820453383","display_name":null,"funder_award_id":"CI2023C020YL","funder_id":"https://openalex.org/F4320323485","funder_display_name":"China Academy of Chinese Medical Sciences"},{"id":"https://openalex.org/G5994120800","display_name":null,"funder_award_id":"Natural","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G6258415954","display_name":null,"funder_award_id":"Chinese","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G7776017555","display_name":null,"funder_award_id":"82141206","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320310931","display_name":"Capital Normal University","ror":"https://ror.org/005edt527"},{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320322935","display_name":"Beijing University of Chinese Medicine","ror":"https://ror.org/05damtm70"},{"id":"https://openalex.org/F4320323485","display_name":"China Academy of Chinese Medical Sciences","ror":"https://ror.org/042pgcv68"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4413111718.pdf","grobid_xml":"https://content.openalex.org/works/W4413111718.grobid-xml"},"referenced_works_count":65,"referenced_works":["https://openalex.org/W1792613151","https://openalex.org/W1966772446","https://openalex.org/W1980928891","https://openalex.org/W1984890913","https://openalex.org/W2034302618","https://openalex.org/W2066404464","https://openalex.org/W2069759916","https://openalex.org/W2078146191","https://openalex.org/W2090640877","https://openalex.org/W2099561371","https://openalex.org/W2103912979","https://openalex.org/W2107103600","https://openalex.org/W2109108939","https://openalex.org/W2162011385","https://openalex.org/W2211610211","https://openalex.org/W2254027440","https://openalex.org/W2294516783","https://openalex.org/W2325011840","https://openalex.org/W2743962954","https://openalex.org/W2903471893","https://openalex.org/W2946412700","https://openalex.org/W2947106758","https://openalex.org/W2963295412","https://openalex.org/W2968404967","https://openalex.org/W2987074373","https://openalex.org/W2996840115","https://openalex.org/W3005274932","https://openalex.org/W3009127406","https://openalex.org/W3043309438","https://openalex.org/W3087825975","https://openalex.org/W3094152374","https://openalex.org/W3096888171","https://openalex.org/W3107527779","https://openalex.org/W3108013492","https://openalex.org/W3110001393","https://openalex.org/W3114494924","https://openalex.org/W3122870545","https://openalex.org/W3139097217","https://openalex.org/W3150953038","https://openalex.org/W3201959323","https://openalex.org/W3215730977","https://openalex.org/W4200569709","https://openalex.org/W4211173829","https://openalex.org/W4220654676","https://openalex.org/W4226152961","https://openalex.org/W4282569760","https://openalex.org/W4283389101","https://openalex.org/W4289317252","https://openalex.org/W4290930266","https://openalex.org/W4294204339","https://openalex.org/W4322625417","https://openalex.org/W4362506045","https://openalex.org/W4366991846","https://openalex.org/W4367057144","https://openalex.org/W4377195289","https://openalex.org/W4379790822","https://openalex.org/W4385707753","https://openalex.org/W4387357845","https://openalex.org/W4387541793","https://openalex.org/W4389338900","https://openalex.org/W4389495228","https://openalex.org/W4390413985","https://openalex.org/W4399053153","https://openalex.org/W4401157935","https://openalex.org/W4403524270"],"related_works":["https://openalex.org/W4391375266","https://openalex.org/W2899084033","https://openalex.org/W2748952813","https://openalex.org/W2390279801","https://openalex.org/W4391913857","https://openalex.org/W2358668433","https://openalex.org/W4396701345","https://openalex.org/W2376932109","https://openalex.org/W2001405890","https://openalex.org/W4396696052"],"abstract_inverted_index":{"Respiratory":[0],"tract":[1],"infection":[2,294],"(RTI)":[3],"continues":[4],"to":[5,42,114,167,255,296],"be":[6],"a":[7,20,268,285],"non-negligible":[8],"cause":[9],"of":[10,38,52,74,97,126,142,198,208,260],"global":[11],"incidence":[12],"rate":[13],"and":[14,66,78,99,102,109,120,128,136,158,170,185,213,222,226,237,248,262],"mortality.":[15],"Shufeng":[16],"Jiedu":[17],"formula":[18],"(SFJD),":[19],"traditional":[21],"Chinese":[22],"remedy,":[23],"is":[24],"used":[25],"for":[26,49],"treating":[27],"RTI,":[28],"though":[29],"its":[30],"mechanisms":[31,47],"are":[32],"not":[33],"well":[34,189],"understood.":[35],"The":[36,72,173,240],"objective":[37],"this":[39],"research":[40],"was":[41,175],"uncover":[43],"the":[44,50,60,121,134,176,205,234,252,273],"underlying":[45],"molecular":[46],"responsible":[48],"effectiveness":[51],"SFJD":[53],"on":[54,272,277,301],"RTI.":[55],"Using":[56],"UHPLC-Q-Orbitrap":[57],"HRMS":[58],"assays,":[59],"chemical":[61],"compounds":[62,77,130,144,187,200,299],"in":[63,133,155],"SFJD's":[64],"ethanol":[65,137],"aqueous":[67,135],"extracts":[68],"fractions":[69],"were":[70,81,89,112,131,194,201,228],"identified.":[71],"targets":[73,80,88,119],"these":[75,143],"herbal":[76],"RTI-related":[79],"acquired":[82],"from":[83,244],"various":[84],"database.":[85],"Key":[86],"SFJD-RTI":[87],"analyzed":[90],"using":[91],"Gene":[92],"Ontology":[93],"(GO),":[94],"Kyoto":[95],"Encyclopedia":[96],"Genes":[98],"Genomes":[100],"(KEGG)":[101],"tissue/organ-specific":[103],"analyses.":[104],"Molecular":[105],"docking,":[106],"data":[107],"mining":[108],"dynamic":[110],"simulations":[111],"employed":[113],"evaluate":[115],"interactions":[116,219],"between":[117],"major":[118],"main":[122],"compounds.":[123],"A":[124,196],"total":[125],"94":[127],"31":[129],"determined":[132],"extract":[138],"fraction,":[139],"respectively.":[140,224],"Many":[141],"demonstrated":[145],"good":[146],"oral":[147],"bio-availability":[148],"(60/99).":[149],"GO":[150],"analysis":[151,250],"revealed":[152],"significant":[153],"involvement":[154],"inflammatory":[156],"response":[157],"gene":[159],"silencing":[160],"processes,":[161],"while":[162],"KEGG":[163],"pathways":[164],"highlighted":[165,251],"connections":[166],"viral":[168],"infections":[169],"signaling":[171],"pathways.":[172],"lung":[174],"primary":[177],"target":[178],"organ":[179],"screed":[180],"out":[181],"by":[182],"Biogps":[183],"databases":[184],"15":[186,199],"as":[188,190,230,257],"eight":[191,209],"key":[192],"genes":[193,232],"associated.":[195],"set":[197],"virtually":[202],"fitted":[203],"into":[204],"active":[206],"site":[207],"critical":[210],"targets.":[211],"Isaindigotone":[212],"resveratrol":[214,266],"could":[215],"form":[216],"hydrogen":[217],"bond":[218],"with":[220,291],"FOS":[221,225,261],"JUN,":[223],"JUN":[227,263],"classified":[229],"differential":[231],"after":[233],"COVID-2019,":[235],"HCoV-229E":[236],"H1N1":[238],"infected.":[239],"comprehensive":[241],"results":[242],"obtained":[243],"MD":[245],"simulation,":[246],"MMPBSA,":[247],"SASA":[249],"compounds'":[253],"potential":[254],"serve":[256],"effective":[258],"inhibitors":[259],"proteins.":[264],"Lastly,":[265],"exerted":[267],"high":[269],"inhibitory":[270],"effect":[271],"influenza":[274],"virus":[275,293],"based":[276,300],"MDCK":[278],"cells.":[279],"In":[280],"summary,":[281],"we":[282],"have":[283],"provided":[284],"framework":[286],"that":[287],"integrated":[288],"network":[289,302],"pharmacology":[290],"multiple":[292],"models":[295],"identify":[297],"synergistic":[298],"topology.":[303]},"counts_by_year":[],"updated_date":"2026-03-22T08:09:32.410652","created_date":"2025-10-10T00:00:00"}
